Download or read book Na Channels from Phyla to Function written by and published by Academic Press. This book was released on 2016-08-29 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Na Channels from Phyla to Function, the latest volume in the Current Topics in Membranes series, is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up-to-date presentation of the current knowledge in the field of Na Channels. Written by leading experts in the field of Na Channels Contains original material, both textual and illustrative, that make it a very relevant reference Presented in a very comprehensive manner Both researchers in the field and general readers will find this book relevant and up-to-date with regard to its information

Download or read book Voltage gated Sodium Channels Structure Function and Channelopathies written by Mohamed Chahine and published by Springer. This book was released on 2018-06-04 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Download or read book Toxins and Signal Transduction written by Yehuda Gutman and published by CRC Press. This book was released on 1997-05-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage. This volume contains useful information for the experimentalist interested in toxins or in signal transduction, as well as for the reader interested in gaining a comprehensive overview of the field. The Cellular and Molecular Mechanisms of Toxin Action series will include monographs on signal transduction, secretory systems, cytoskeleton, selective neurotoxicity of natural, recombinant and chimeric toxins giving a broader emphasis on the mechanism of action, structure-function relationship, and use of toxins as research tools and their therapeutic applications.

Download or read book Hayes Principles and Methods of Toxicology Sixth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.

Download or read book Ion Channels written by James N. C. Kew and published by . This book was released on 2010 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.

Download or read book Cellular Mechanisms of Conditioning and Behavioral Plasticity written by D.L. Alkon and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: I would like first to thank Charles Woody and his organizing committee for arranging the symposium on the "Cellular Mechanisms of Conditioning and Behavioral Plasticity," which was also a satellite meeting of the International Union of Physiological Sciences 30th International Congress. The proceedings of this symposium are represented by the chapters that follow. During the 1970s, Dr. Woody and co-workers were able to carry out a remarkable series of microelectrode studies, both intracellular and extracellular, of cortical nerve cells during conditioning of the eye-blink response to sound in the intact waking cat. He demonstrated enduring changes in excitability and membrane resistance in pericruciate cortical cells during associative conditioning of the eye blink, changes that are facilitated by ACh and cGMP and reinforced by stimulation of the hypothalamus (the latter con firming the original studies of Voronin). These findings have been of considerable im portance in our attempt to understand the conditioning process at the cellular level.

Download or read book Advances in Genetics written by and published by Academic Press. This book was released on 1992-01-21 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Genetics

Download or read book Principles and Methods of Toxicology Fifth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2007-09-25 with total page 2304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Download or read book Membrane Transport Proteins Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Transport Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Membrane Transport Proteins. The editors have built Membrane Transport Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Membrane Transport Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Membrane Transport Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Ion Channels Down Under written by and published by Academic Press. This book was released on 2017-05-18 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels Down Under, Volume 79 provides up-to-date information on ion channel pharmacology, their pharmacological modulators, and role in a diverse range of poorly treated medical conditions. Contributors include prominent scientists and highly-recognized experts with major accomplishments in the field of ion channel pharmacology. Topics covered include the role of ion channels in health and disease, ion channels as therapeutic targets and the molecular pharmacology of ion channels. Provides a must read book on ion channel pharmacology Contains up-to-date information on a number of ion channels, their pharmacological modulators, and their role in a diverse range of poorly treated medical conditions Contains contributions from prominent scientists and highly-recognized experts with major accomplishments in the field

Download or read book Natural Toxins 2 written by Bal Ram Singh and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.

Download or read book Marine Toxins as Research Tools written by Nobuhiro Fusetani and published by Springer Science & Business Media. This book was released on 2009-01-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools. Accordingly, interest in using such compounds as reagents has increased. Marine toxins are some of the most popular research tools and have already contributed much to our understanding of biological processes and disease mechanisms.

Download or read book Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease written by Venkataramana K Sidhaye and published by Academic Press. This book was released on 2017-03-09 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences

Download or read book Experimental Neurochemistry written by Abel Lajtha and published by Springer. This book was released on 1982-12-01 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.

Download or read book The Cell Surface and Neuronal Function written by Carl W. Cotman and published by North-Holland. This book was released on 1980 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Muscles as Molecular and Metabolic Machines written by Peter W. Hochachka and published by CRC Press. This book was released on 2019-06-04 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1994, this book explores the paradigm of muscles as molecular and metabolic machines in which all structures and functions are exquisitely integrated and matched to each other. The analysis begins with a standard reductionist approach-reviewing the integrated machine parts. The key working components of the complete muscle machine are proteins (soluble, organelle, or membrane localized), and a conservative count indicates that today more than 100 such machine parts are known, essentially all occurring as cell specific isoforms. Random assortment of these machine parts or protein isoforms could generate an astronomical number of "muscle machines" and an equally enormous number of muscle fiber types. The question is, why aren't such large numbers ever seen? To attack this problem, the reductionist approach is complemented with an integrationist/adaptational one. Evidence is presented that the more highly specialized the muscle type, the further one moves from the above extreme; in the most highly specialized muscles, typically only one fiber type is found. It is argued that instead of random assortment of isoforms or machine parts, only specific and often unique combinations can work in appropriate fashion. A few established examples of this fundamental principle are reviewed, but emphasis is placed on the fact that we know dreadfully little about why this is so and what kinds of further studies are needed. The issue of why the very large numbers of fiber types theoretically possible are never even approximately realized has never before been addressed. Indeed, it is rarely recognized. Muscles as Molecular and Metabolic Machines is the first work of its kind on the subject.

Download or read book Biophysics of Membrane Transport written by and published by . This book was released on 1992 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: