Download or read book N Acetylaspartate written by John Moffett and published by Springer Science & Business Media. This book was released on 2006-10-21 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: N-acetylaspartate (NAA), the acetylated form of the amino acid aspartate, is one of the most highly concentrated chemicals in the brains of humans, yet its function remains elusive. NAA is used in nonsurgical analyses of nerve cell dysfunction, and it is implicated in a disorder known as Canavan’s disease. This book reviews research from around the world in the study of NAA, and the roles it plays in neuronal development and functioning.
Download or read book The Metabolism Release and Transport of N acetylaspartate NAA in Primary Cultures of Rat Cerebellar Cells and Murine Brain Cells written by Omar H. Saab and published by . This book was released on 1992 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book N acetylaspartate in Brain written by Mattias Tranberg and published by . This book was released on 2006 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progressive Brain Disorders in Childhood written by Juan M. Pascual and published by Cambridge University Press. This book was released on 2017-04-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.
Download or read book Quantification of N acetylaspartate and Choline Using 1H Magnetic Resonance Spectroscopy in a Mouse Model of Rett Syndrome written by Elisabeth M. Hersman and published by . This book was released on 2008 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Invisible Universe Revealed written by Gerrit L. Verschuur and published by . This book was released on 1987 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Therapy of the Central Nervous System From Bench to Bedside written by Michael G. Kaplitt and published by Elsevier. This book was released on 2005-11-11 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use
Download or read book Magnetic Resonance in Epilepsy written by Ruben Kuzniecky and published by Academic Press. This book was released on 2005-01-19 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders. *Provides a crucial update of recent advances in imaging techniques*Timely publication as subject of neuroimaging is a very "hot" area in both clinical epilepsy and basic neuroscience research*Editors are well-respected in this field
Download or read book Molecular Insights Into N acetylaspartate Metabolism in Canavan Disease written by Yasanandana Supunsiri Wijayasinghe and published by . This book was released on 2014 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Canavan disease (CD) is a fatal, childhood neurological disorder with altered N-acetylaspartate (NAA) metabolism. This disease is caused by mutations in the gene that encodes the enzyme aspartoacylase (ASPA) in the brain. The deficiency of aspartoacylase activity leads to the hallmark symptoms of CD. Sixteen different ASPA clinical mutations have been examined for their biophysical properties. Each of these recombinant mutant enzymes was found to have measureable catalytic activity, ranging from 0.3% to 35% of the native enzyme. Many of these mutants show either decreased thermal stability or decreased conformational stability. These results suggest that the loss of catalytic activity of ASPA is at least partially a consequence of decreased protein stability. To study the possible structural defects caused by non-conservative amino acid changes in ASPA, four aspartoacylase mutations have been structurally characterized. The mutant enzymes each have similar overall structures to the native ASPA enzyme, but with varying degrees of alterations that offer explanations for the respective loss of catalytic activity. The loss of van der Waals contacts in the F295S mutation, and the loss of both hydrophobic and hydrogen bonding interactions in the Y231C mutation lead to a local collapse of the hydrophobic core structure contributing to a decrease in protein stability. The E285A mutant structure shows that loss of hydrogen bond interactions with the side chain carboxyl of Glu285 disturbs the active site architecture, leading to altered substrate binding and diminished enzymatic activity. Since many of the ASPA clinical missense mutations were found to have compromised stability, screening of a small molecule library was performed to identify compounds that can potentially bind and stabilize these defective enzymes. Three compounds (Glutathione, Patulin, and Ellagic acid) show significant protection against thermal denaturation of E285A, but they have negligible effect on the native enzyme. Optimization of these compounds, guided by kinetics and structural studies, could lead to drugs that have the potential to reverse the effect of these mutations in Canavan patients. N-acetylaspartate is an enigmatic metabolite whose biological function is yet to be completely defined. In order to understand the physiological role of NAA in the brain and to find a treatment therapy for CD, the NAA biosynthetic enzyme aspartate N-acetyltransferase (AspNAT) was selected for examination. A codon optimized gene of AspNAT (NAT8L) was cloned with different fusion tags to enhance the solubility. The thioredoxin-tagged AspNAT was found to express as a soluble protein with low yield. This enzyme construct was partially purified using Ni affinity chromatography and was found to have N-acetyltransferase activity. Further optimizations are being carried out to obtain sufficient enzyme for biochemical characterization.
Download or read book Neuroimaging written by and published by Newnes. This book was released on 2016-07-12 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimaging, Part One, a text from The Handbook of Clinical Neurology illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This first volume specifically covers a description of imaging techniques used in the adult brain, aiming to bring a comprehensive view of the field of neuroimaging to a varying audience. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, and the entire field is moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to this new horizon in the study of neurological disorders. Provides a relevant description of the technologies used in neuroimaging, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and several others Ideal resource for anyone studying the nervous system, from beginners to specialists interested in recent advances in neuroimaging of the adult brain Discusses the application of imaging techniques to the study of brain and spinal cord disease and its use in various syndromes Contains vibrant, colorful images to illustrate key points
Download or read book Investigation of the Neuronal Marker N acetylaspartate as a Potential Biomarker for Neurological Diseases written by Samuel Marsh and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroimaging in Developmental Clinical Neuroscience written by Judith M. Rumsey and published by Cambridge University Press. This book was released on 2009-02-19 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern neuroimaging offers tremendous opportunities for gaining insights into normative development and a wide array of developmental neuropsychiatric disorders. Focusing on ontogeny, this text covers basic processes involved in both healthy and atypical maturation, and also addresses the range of neuroimaging techniques most widely used for studying children. This book will enable you to understand normative structural and functional brain maturation and the mechanisms underlying basic developmental processes; become familiar with current knowledge and hypotheses concerning the neural bases of developmental neuropsychiatric disorders; and learn about neuroimaging techniques, including their unique strengths and limitations. Coverage includes normal developmental processes, atypical processing in developmental neuropsychiatric disorders, ethical issues, neuroimaging techniques and their integration with psychopharmacologic and molecular genetic research approaches, and future directions. This comprehensive volume is an essential resource for neurologists, neuropsychologists, psychiatrists, pediatricians, and radiologists concerned with normal development and developmental neuropsychiatric disorders.
Download or read book Global N acetylaspartate Concentration in Benign and Non benign Multiple Sclerosis Patients of Long Disease Duration written by Lutz Achtnichts and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunocytochemical Localization of N acetylaspartateglutamate and N acetylaspartate in the Turtle Retina written by Carrie A. Joneckis and published by . This book was released on 1993 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diseases of the Brain Head and Neck Spine 2020 2023 written by Juerg Hodler and published by Springer Nature. This book was released on 2020-02-14 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.
Download or read book Magnetic Resonance Spectroscopy Diagnosis of Neurological Diseases written by Else Rubaek Danielsen and published by CRC Press. This book was released on 1999-02-16 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates how MRS offers a useful tool for the noninvasive biochemical analysis of the brain. The book covers over 70 clinical cases and more than 100 spectra that enhance skills at interpreting MRS, including minimizing errors, highlighting artifacts, and expanding the clinical usefulness of this diagnostic modality.
Download or read book Movement Control written by Paul Cordo and published by Cambridge University Press. This book was released on 1994-05-27 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement is arguably the most fundamental and important function of the nervous system. Purposive movement requires the coordination of actions within many areas of the cerebral cortex, cerebellum, basal ganglia, spinal cord, and peripheral nerves and sensory receptors, which together must control a highly complex biomechanical apparatus made up of the skeleton and muscles. Beginning at the level of biomechanics and spinal reflexes and proceeding upward to brain structures in the cerebellum, brainstem and cerebral cortex, the chapters in this book highlight the important issues in movement control. Commentaries provide a balanced treatment of the articles that have been written by experts in a variety of areas concerned with movement, including behaviour, physiology, robotics, and mathematics.
