Download or read book N 3 Polyunsaturated Fatty Acids Insulin Sensitivity and Inflammation written by L. Browning and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Latest Findings Of Omega 3 Long Chain Polyunsaturated Fatty Acids From Molecular Mechanisms To New Applications In Health And Diseases written by Maricela Rodriguez Cruz and published by Bentham Science Publishers. This book was released on 2011 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This E-book covers the main aspects about the benefits of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) to human health. The knowledge of physiological effects of LC-PUFAs at different levels is constantly expanding. Topics covered over 10 chapters thoroughly detail the role of omega-3 LCPUFAs in nutrition (gene regulation) and disease (clinical applications); information about food sources and recent intake recommendations is also explained. This book also discusses current data concerning the role of LC-PUFAs during pregnancy and lactation, in cognitive function, immune response.
Download or read book Modulation of Adipokines by N 3 Polyunsaturated Fatty Acids and Ensuing Changes in Skeletal Muscle Metabolic Response and Inflammation written by Justine Tishinsky and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolic Syndrome Pathophysiology written by Undurti N. Das and published by John Wiley & Sons. This book was released on 2010-02-23 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurologic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes mellitus, obesity, autoimmune diseases and hypertension.
Download or read book Metabolic Benefits of Plant based N 3 Polyunsaturated Fatty Acids on Brown Thermogenesis written by Kyung Ho Park and published by . This book was released on 2020 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are two essential fatty acids for humans, a-linolenic acid (ALA) and linoleic acid (LA), which should be taken from foods to maintain health. Once incorporated into cells, ALA and LA, which are omega-3 poly unsaturated fatty acid (n-3 PUFA) and n-6 PUFA respectively, undergo elongation and desaturation to generate longer and more unsaturated fatty acids influencing inflammation and immunological responses. Numerous studies showed a dietary reduction of n-6/n-3 PUFA ratio improves cardiovascular health, inflammation, and insulin resistance. Fish oil, the main resource for n-3 PUFA, is shown to increase these health benefits. In our lab, we investigated the efficacy of ALA-enriched butter (n3Bu) as an alternative to fish oil for n-3 PUFA. n3Bufed mice showed increased bioconversion of ALA to long-chain n-3 PUFA (LC n-3 PUFA) and attenuated high fat (HF) diet-induced insulin resistance and inflammation. Besides, these health benefits, n-3 PUFA is shown to improve obesity and its related diseases by regulating lipid metabolism in both white adipose tissue (WAT) and brown adipose tissue (BAT). Fish oil abundant with n-3 PUFA promotes BAT formation and increases its thermogenic activity in cold acclimation. However, the impact of ALAenriched agricultural products on the BAT function is unknown. In this study, we investigated the effect of ALA-biofortified butter (n3Bu) on lipid metabolism and thermogenic functions in BAT. Intake of n3Bu significantly reduced the whitening of BAT and increased the thermogenesis in response to acute-cold treatment. Consumption of n3Bu promoted bioconversion of LC n-3 PUFA, fatty acid elongation and desaturation, and mitochondrial biogenesis. Taken together, our results support that ALA-biofortified butter is a novel source of n-3 PUFA that potentiates the BAT thermogenic function.
Download or read book Omega 3 Fatty Acids written by Mahabaleshwar V. Hegde and published by Humana Press. This book was released on 2016-09-15 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health. An indispensable text designed for nutritionists, dietitians, clinicians and health related professionals, Omega-3 Fatty Acids: Keys to Nutritional Health presents a comprehensive assessment of the current knowledge about the nutritional effects of Omega-3 fatty acids and their delivery in foods.
Download or read book The Effect of Long term High dose N 3 PUFA on Glucose and Protein Metabolism in Subjects with Impaired Glucose Regulation written by Louise Frances Clark and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: N-3 polyunsaturated fatty acids (n-3 PUFA) have been postulated to improve the insulin resistance associated with type 2 diabetes since the 1960s when observational studies in the Alaskan Inuit noted a reduced prevalence of type 2 diabetes when this population consumed a traditional diet. These findings were supported by animal studies but results of human intervention studies have been variable with most showing no change in glucose metabolism. More recent studies in growing farm animals suggested that muscle membrane phospholipids required to be enriched to a minimum of 14% n-3 PUFA in order for a change in insulin sensitivity to occur. This study sought to establish the effect of long-term (9 month) high-dose (3g/day) supplement of the n-3 PUFA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on insulin sensitivity of glucose and protein metabolism. Thirty-three subjects with impaired glucose regulation underwent hyperinsulinaemic-euglycaemic-euaminoacidaemic clamps pre- and postintervention of n-3 PUFA or a control (maize) oil. A second cohort who all received n-3 PUFA supplementation underwent pre- and post-intervention muscle biopsies. Secondary outcomes included an assessment of inflammatory status and determining whether erythrocyte membrane phospholipid could act as a surrogate for muscle membrane phospholipid. In the clamp cohort, there were no changes in glucose metabolism postintervention; however, there was an increase in insulin-stimulated protein metabolism following the fish oil intervention. In the biopsy cohort, no subject achieved 14% PUFA enrichment in muscle membrane phospholipids; however, all subjects who received n-3 PUFA supplementation did achieve a minimum of 14% enrichment of n-3 PUFA in erythrocyte membrane phospholipid. In agreement with the majority of the literature, n-3 PUFA did not affect glucose metabolism. Insulin-stimulated protein metabolism was improved supporting the findings of another recent human study. These changes in protein metabolism may reduce the sarcopenia associated with aging, potentially delaying the progression of frailty.
Download or read book Fat Detection written by Jean-Pierre Montmayeur and published by CRC Press. This book was released on 2009-09-14 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se
Download or read book Medicinal Fatty Acids in Inflammation written by J. Kremer and published by Springer. This book was released on 2013-03-11 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Inflammation Research is a unique compilation of work performed by a wide spectrum of investigators from different medical disciplines. It is fascinating that dietary alterations of fatty acid intake can result in a range of salutory changes in a great variety of medical conditions. Most of the good scien tific work which has led to these observations has been performed over just the last two decades. This is of course not a very long time in the context of the history of the human species. Recently performed analysis of fat intake from paleolithic times has indicated that our hunter-gatherer ancestors consumed as much cholesterol as modern Western man, but strikingly less saturated fatty acid and more polyunsatu rates, including n-3 fatty acids. Wild game has the terrestrial source of n-3 incorpo rated in its fat since browsing animals derive 18:3n-3 (alpha-linolenic acid) natural ly from leafy plants. There is, however, little opportunity for modern Western man to get n-3 fatty acids from the diet if one does not consume fish. Modern agribusiness provides ani mal feeds high in n-6 fatty acids, mostly derived from linoleic acid (18:2n-6) in corn feed. Therefore, grazing animals have no access to alternative fatty acids in either feed or grasses, the latter containing little or none of these potentially beneficial highly polyunsaturated fatty acids.
Download or read book Metabolic Effects of Omega 3 Long chain Polyunsaturated Fatty Acids written by Benjamin B. Albert and published by . This book was released on 2016 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity and its associated cardiometabolic disorders are among the world's greatest health problems. However, non-surgical weight-loss treatments are ineffective. Treatments that can reduce cardiometabolic risk in the overweight and obese are urgently needed. Further, as the offspring of obese and/or diabetic women are programmed to become obese and insulin resistant with age, interventions in pregnancy could have substantial long-term impacts on public health. Supplemental omega-3 fatty acids appear promising as they modulate important metabolic pathways and are insulin-sensitising in rats. The central hypothesis in this thesis is that long chain omega-3 polyunsaturated fatty acids, can modify the effects of gene-environment interactions to improve aspects of glucose and lipid metabolism. Four predictions were tested 1) that an n-3 PUFA supplement would be insulin sensitising in overweight men and 2) that an n-3 PUFA supplement used in a model of insulin resistant pregnancy would have metabolic benefits to the offspring 3) that fish oils sold at retail would have excessive oxidation, and 4) that an oxidised fish oil supplement would not have benefits to the offspring when used during pregnancy. I used a randomised controlled crossover trial to investigate the metabolic effects of krill/salmon blended oil on insulin sensitivity in overweight men. At baseline, higher n-3 PUFA levels were associated with greater insulin sensitivity. However, supplementation with the marine oil led to reduced insulin sensitivity, suggesting increased cardiometabolic risk. In an animal model of insulin-resistant pregnancy (maternal high-fat diet supplementation with unoxidized fish oil prevented the development of insulin resistance in the adult offspring. I found that fish oil products purchased at retail were substantially oxidised and did not meet labelled n-3 PUFA content. I then assessed the effects of oxidised fish oil supplementation during rat pregnancy, and found a substantial increase in neonatal mortality and persistent maternal insulin resistance. I have shown that oxidation changes the metabolic effects of n-3 PUFA rich supplements. It is possible that there are negative consequences to consuming oxidised fish oil during human pregnancy, and unrecognised oxidation may have confounded the n-3 PUFA clinical trial literature. Whether n-3 PUFAs have insulin-sensitising effects in humans remains unresolved
Download or read book Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome written by Debasis Bagchi and published by Academic Press. This book was released on 2012-01-31 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus affects approximately 20 million people in the US, or nearly 7% of the population. It is expected to increase by 70% within the next 25 years, and numerous epidemiologic studies have demonstrated that type 2 diabetes increases the risk of cardiovascular morbidity and mortality. It is estimated to cost over $92 billion in health care costs and lost productivity. The increased risk is due to the detrimental vascular effects of prolonged exposure to a hyperglycemic, oxidant-rich environment yielding associated cardiovascular risk factors: atherosclerosis, hypertension and clotting abnormalities. Hypertension and dyslipidemia in diabetic patients produces substantial decreases in cardiovascular and microvascular diseases. Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome provides an overview of the current epidemic, outlines the consequences of this crisis and lays out strategies to forestall and prevent diabetes, obesity and other intricate issues of metabolic syndrome. The contributing experts from around the world give this book relevant and up-to-date global approaches to the critical consequences of metabolic syndrome and make it an important reference for those working with the treatment, evaluation or public health planning for the effects of metabolic syndrome and diabetes. Scientific discussion of the epidemiology and pathophysiology of the relationship between diabetes and metabolic syndrome Includes coverage of Pre-diabetes conditions plus both Type I and Type II Diabetes Presents both prevention and treatment options
Download or read book Polyunsaturated Fatty Acid Metabolism written by Graham C. Burdge and published by Elsevier. This book was released on 2018-05-04 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. - Provides a comprehensive view of polyunsaturated fatty acid metabolism - Describes underlying metabolism on lipids that include polyunsaturated fatty acids - Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism
Download or read book The interaction between dietary fatty acids and inflammation on insulin sensitivity written by Jolene McMonagle and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Omega 3 Fatty Acids and Health written by Joyce A. Nettleton and published by Springer Science & Business Media. This book was released on 1995-12-31 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to fatty acids; Omega-3 fatty acids and health; Omega-3 fatty acids and heart disease; Omega-3 fatty acids and the vascular system; Omega-3 fatty acids and immune/inflammatory responses; Omega-3 fatty acids in early human development; Omega-3 fatty acids in other diseases.
Download or read book Modulation of Lipopolysaccharide Stimulated Adipokine Synthesis and Secretion by N 3 and N 6 Polyunsaturated Fatty Acids written by Mary Cranmer-Byng and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fatty Acids and Lipids written by International Society for the Study of Fatty Acids and Lipids. Congress and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication at hand gives an outline of recent advances in both of these topics, including a general discussion on fatty acid nutrition amd metabolism. Moreover, issues such as vascular functions, inflammation, bone metabolism, cancer, obesity and lipoprotein metabolism are dealt with in this context. Finally, the book also contains new findings on bioactive lipids such as anandamide and related compounds, as well as on conjugated linoleic acid. Scientists interested in nutrition, cardiovascular disease, behavior and psychiatry as well as fatty acid metabolism and lipids in general will find this publication a most welcome source of information.
Download or read book Omega 3 Fatty Acids in Health and Disease written by Lindsay Brown and published by MDPI. This book was released on 2018-09-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Omega-3 Fatty Acids in Health and Disease" that was published in JCM
