Download or read book Myogenesis in Development and Disease written by and published by Academic Press. This book was released on 2018-01-03 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myogenesis in Development and Disease, Volume 126, the latest volume in the Current Topics in Developmental Biology series, covers major topics of research in myogenesis, with a particular emphasis on regeneration and muscle disease. It includes contributions from an international board of authors, providing a comprehensive set of reviews. Covers major topics of research in myogenesis Contains invaluable contributions from an international board of authors Provides a comprehensive set of reviews

Download or read book Muscle Development in Drosophilia written by Helen Sink and published by Springer Science & Business Media. This book was released on 2006-02-02 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.

Download or read book Myogenesis written by Grace Pavlath and published by Academic Press. This book was released on 2011-06-08 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myogenesis is the formation of muscular tissue, in particular during embryonic development. This new volume in the "Current topics in Developmental Biology" series covers chapters on such topics as Control of nuclear import during myogenesis, Pathways contributing to fibrosis in skeletal muscle, and Ferlin family members in myogenesis. With an international team of authors, this volume is a must-have addition for researchers and students alike. This new volume in the "Current topics in Developmental Biology" series covers chapters on such topics as Control of nuclear import during myogenesis, Pathways contributing to fibrosis in skeletal muscle, and Ferlin family members in myogenesis With an international team of authors, this volume is a must-have addition for researchers and students alike

Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Building the Most Complex Structure on Earth written by Nelson R Cabej and published by Newnes. This book was released on 2013-04-01 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building the Most Complex Structure on Earth provides readers with a basic biological education an easy and understandable introduction into a new epigenetic theory of development and evolution. This is a novel theory that describes the epigenetic mechanisms of the development and evolution of animals and explains the colossal evolution and diversification of animals from a new post-genetic perspective. Modern biology has demonstrated the existence of a common genetic toolkit in the animal kingdom, but neither the number of genes nor the evolution of new genes is responsible for the development and evolution of animals. The failure to understand how the same genetic toolkit is used to produce millions of widely different animal forms remains a perplexing conundrum in modern biology. The novel theory shows that the development and evolution of the animal kingdom are functions of epigenetic mechanisms, which are the competent users of the genetic toolkit. Provides a comprehensive view of the epigenetic aspects of reproduction, development, and evolution. Highly rigorous, but simple enough for readers with only a basic knowledge of biology.

Download or read book Beyond Borders Myotonic Dystrophies A European Perception written by Benedikt Schoser and published by Frontiers Media SA. This book was released on 2019-01-21 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myotonic dystrophies (DMs) are pleotropic multisystemic diseases. These dominantly transmitted repeat disorders affect multiple organs of the human body at all ages – from the newborns to the elderly. The present Research Topic represents a timely addition to the expanding body of evidence which aims to provide novel perspectives in our understanding of myotonic dystrophies. This collection of original contributions and standpoint reviews from multiple leading DM centres in Europe describes the state of the art for the characterization of the DMs diseases, the development of molecular strategies to target its multisystemic nature, and provides evidence of screening and testing novel therapeutic avenues.

Download or read book Myogenesis in Development and Disease written by and published by Academic Press. This book was released on 2018-01-18 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myogenesis in Development and Disease, Volume 126, the latest volume in the Current Topics in Developmental Biology series, covers major topics of research in myogenesis, with a particular emphasis on regeneration and muscle disease. It includes contributions from an international board of authors, providing a comprehensive set of reviews. Covers major topics of research in myogenesis Contains invaluable contributions from an international board of authors Provides a comprehensive set of reviews

Download or read book Myofibrillogenesis written by Dipak K. Dube and published by Springer Science & Business Media. This book was released on 2001-10-19 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.

Download or read book Neuromuscular Development and Disease written by Alan M. Kelly and published by Raven Press (ID). This book was released on 1992 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizes the most significant research at the molecular and cellular levels on the development and maintenance of the neuromuscular system and the pathogenesis of neuromuscular diseases.

Download or read book Hormones Metabolism and the Benefits of Exercise written by Bruce Spiegelman and published by Springer. This book was released on 2018-03-07 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Download or read book Muscle Homeostasis and Regeneration written by Antonio Musarò and published by MDPI. This book was released on 2020-11-20 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.

Download or read book Modeling of Skeletal Muscle Development and Disease Using Human Stem Cells written by Saowanee Jiwlawat and published by . This book was released on 2017 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell technology provides a new critical cell resource for basic and translational research, and their unique properties of indefinite proliferation and multi-cell lineage differentiation greatly benefit cellular modeling and therapy. By simulating small molecule signaling during embryonic myogenesis, myogenic progenitors can be successfully generated from human induced-pluripotent stem cells (iPSCs). The main objective of this thesis is to prepare skeletal muscles using human pluripotent stem cells, and to explore their ability as [in vitro] models to study skeletal muscle development and disorders. First, we tested the hypothesis of how differentiation duration, culture surface coatings, and nutrient supplements affect muscle development (especially myotube and sarcomere formation). Myogenic progenitors were prepared from human iPSCs using free-floating spherical culture and then differentiated into myotubes. The ultrastructure of iPSC-derived myotubes revealed well-organized sarcomere structures after a long differentiation period over 6 weeks. Next, we used patient-derived iPSCs with Pompe disease and evaluated the ability of these skeletal myocytes to act as [in vitro] disease models for studying disease mechanisms and testing drug candidates. Pompe iPSC-derived myotubes exhibited specific disease phenotypes, including reduction of acid alpha-glucosidase enzyme activity and abnormal accumulation of glycogen in enlarged lysosomes. We also attempted to repair cellular pathology in Pompe iPSC-derived myotubes by using specific compounds that could potentially modulate transcription factor EB signaling or glycogen metabolism. Lastly, we applied bioengineering approaches to improve alignment, sarcomere formation, and spontaneous contractions of human iPSC-derived myotubes. The micropatterned substrate with controlled stiffness significantly promoted fusion and differentiation of iPSC-derived myocytes, leading to the formation of well-aligned and multi-nucleated myotubes. Notably, these aligned myotubes exhibited spontaneous contractions specifically along the long axis of the pattern. On the bioengineered culture platform, bundle-like myotubes were created from patient-derived iPSCs with Pompe disease, which showed specific pathology such as abnormal accumulations of enlarged lysosomes. Using healthy- and patient-derived iPSC lines with a neuromuscular disorder, we successfully created matured skeletal myotubes in culture. These myotubes morphologically and functionally resemble myotubes found in adult skeletal muscles. This matured muscle model would be enormously valuable to study skeletal muscle development, disease mechanisms, and would aid in pharmacological studies.

Download or read book The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment written by Joerg Bluemel and published by Academic Press. This book was released on 2015-03-13 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Download or read book Biology of Drosophila written by Milislav Demerec and published by CSHL Press. This book was released on 1994 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference.

Download or read book Current Topics in Membranes written by and published by Academic Press. This book was released on 1992-01-08 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes

Download or read book The Laboratory Mouse written by Hans Hedrich and published by Academic Press. This book was released on 2012-06-14 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries