Download or read book Mussel inspired Mucoadhesive Hydrogels for Drug Delivery written by Jinke Xu and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "A controlled drug delivery system can deliver a drug with the right dose, control its release rate and time, and target the site of action in the body. Chitosan (CS) and its derivatives have been extensively used in drug delivery. Additionally, CS is mildly mucoadhesive, i.e. it can stick to mucus. Many drug delivery routes such as oral, buccal, and rectal delivery exploit the presence of a mucosa to deliver the drug. Drug delivery systems made from mucoadhesive materials can stick to the mucosa, thus prolonging the retention of drugs on site and allowing a sustained release of the loaded drugs. CS-based mucoadhesive drug delivery systems have shown improved therapeutic effects in many applications.Recently, the strong adhesion of marine mussels under the sea inspired the development of several water-resistant adhesives. The catechol groups present in large amount in the mussel adhesive proteins contribute to the outstanding adhesion of mussels on many different surfaces. Catechols also interact with biological surfaces, including mucus. These findings inspired us to use catechol-CS mucoadhesive systems to facilitate drug delivery. This was the first time that catechol groups were used to improve the mucoadhesion and thus the efficacy of a drug delivery system.In this work, we developed three types of catechol-containing CS hydrogels as mucoadhesive drug delivery systems for oral, buccal and rectal drug delivery. We introduced catechols into CS hydrogels by simple physical mixing or covalent conjugation. We assessed the efficacy of catechol-containing hydrogels as drug delivery systems and their mucoadhesion both in vitro and in vivo.Our first study showed that simple physical mixing of hydrocaffeic acid in CS-based hydrogels enhanced the mucoadhesion of the gels. The electrostatic interaction between hydrocaffeic acid and CS caused a slow release of this molecule from the CS hydrogel, and enhanced the adhesion of CS on mucus. The mucoadhesion of this hydrogel can be further increased in the presence of oxidizing agents during the contact with mucin. However, if the gel is oxidized before contacting mucin, there is no mucoadhesion enhancement. In our second study we developed a chemically conjugated catechol-CS (Cat-CS) hydrogel crosslinked by genipin. In this case, the immobilized catechols were not released from the gel. This system showed good mechanical properties and great mucoadhesion both in vitro and in vivo. Using this mucoadhesive hydrogel, we succeeded in delivering lidocaine to rabbits through the buccal mucosa. Differently from gels made with unmodified CS, this system established an intimate contact with the rabbit buccal mucosa, achieved a sustained release of the drug, and maintained the drug concentration in the blood at a relatively high level during the 2 h experiment.In our third study we developed an injectable sulfasalazine (SSZ) loaded Cat-CS hydrogel formulation for rectal treatment of ulcerative colitis (UC). In UC mice, rectal SSZ/Cat-CS formulation showed better therapeutic effects with only 50% of the normal oral dose. Most importantly, this formulation reduced the plasma levels of the SSZ metabolite sulfapyridine, which is associated with many side effects of SSZ and toxicity. Thus, these results proved the great potential of mucoadhesive SSZ/Cat-CS rectal formulation in UC treatment. Overall, we developed mussel-inspired catechol-containing CS hydrogels that improved the mucoadhesion and thus the drug efficacy and therapeutic effects in drug delivery." --

Download or read book Bioadhesives in Drug Delivery written by K. L. Mittal and published by John Wiley & Sons. This book was released on 2020-05-12 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; and bioadhesive hydrogels and applications ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems ; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Download or read book Mucoadhesive Drug Delivery Systems written by Pranshu Tangri and published by LAP Lambert Academic Publishing. This book was released on 2012-08 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on defining the principles of bioadhesive delivery systems based on hydrogels to biological surfaces that are covered by mucus. An overview of the last decade's discoveries on mucoadhesion and applications of mucoadhesive hydrogels as drug carriers is given. Techniques that are frequently used to study the adhesion forces and physicochemical linteractions between hydrogel, mucus, and the underlying mucosa are reviewed. Typical examples of applications of mucoadhesive hydrogels to mucosal routes of delivery are given. Finally, the perspectives of the application of these polymers in drug delivery are discussed.

Download or read book Bioadhesives in Drug Delivery written by K. L. Mittal and published by John Wiley & Sons. This book was released on 2020-06-16 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications. Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; bioadhesive hydrogels and applications; ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.

Download or read book Synthesis Characterization and Applications of Injectable Citrate based Mussel inspired Biodegradable Adhesive iCMBA Polymers and Hydrogels written by Mohammadreza Mehdizadeh and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue adhesives are increasingly gaining more popularity in various areas of biomedical applications. They are utilized as surgical adhesives, as a replacement or adjunct to conventional wound closure and bleeding control techniques such as suturing, as well as in other applications such as tissue engineering and drug delivery. Unfortunately, the existing surgical adhesives are not ideal for wet tissue adhesion required in many surgeries such as those for internal organs. Developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility has been a significant challenge. Herein, learning from nature, we report a one-step synthesis of a novel family of injectable citrate-based mussel-inspired bioadhesives (iCMBAs) for surgical use. Within the formulations investigated, iCMBAs showed 2.5-8.0 folds stronger wet tissue adhesion strength over the clinically used fibrin glue (39 to 123 kPa for iCMBAs vs.15 kPa for fibrin glue), demonstrated controlled degradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility both in vitro and in vivo. iCMBAs were able to stop bleeding instantly and suturelessly, and close wounds (2 cm long x 0.5 cm deep) created on the back of Sprague-Dawley rats. Equally important, the new bioadhesives facilitated wound healing, and were completely degraded and absorbed without eliciting significant inflammatory response. Our results support that iCMBA technology is highly translational and could have broad impact on surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used. In the second part of this work, iCMBAs application in tissue engineering was also investigated by developing a new injectable in-situ crosslinkable bone composite based on iCMBA-hydroxyapatite (HA) with tunable set time, biodegradability, and excellent in vitro cytocompatibility. The iCMBA-HA composites induced invitro mineralization and differentiation of preosteoblast cells to osteobalsts. In vivo test showed that iCMBA-HA composite accelerated the bone repair and new bone tissue formation when injected to the region of a comminuted fracture in a New Zealand rabbit model. iCMBAs were also found to be pH sensitive polymers, from which we developed a new pH-responsive hydrogel for application in stimuli-responsive controlled drug delivery systems (CDDS). The controllable swelling ratio and degradation of pH-sensitive iCMBA hydrogels render them suitable for applications such as delivery of drugs and biological molecules to lower gastrointestinal tract through oral administration. In addition, iCMBA can be used to not only close wounds, but also prepare drug-eluting hydrogels, which can sense and release drugs, e.g. anti-infectives, upon an increase in local pH due to worsening wound condition. iCMBA's tunable swelling and degradation, and cyto/tissue-compatibility make them a suitable candidate for this type of applications. In addition, we successfully fabricated iCMBA nanoparticles through a facile and safe technique, which can earn additional advantage for iCMBA nanogels as a novel pH-responsive drug delivery system.

Download or read book Emerging Areas in Bioengineering written by Ho Nam Chang and published by John Wiley & Sons. This book was released on 2018-03-12 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: With more than 40 contributions from expert authors, this is an extensive overview of all important research topics in the field of bioengineering, including metabolic engineering, biotransformations and biomedical applications. Alongside several chapters dealing with biotransformations and biocatalysis, a whole section is devoted to biofuels and the utilization of biomass. Current perspectives on synthetic biology and metabolic engineering approaches are presented, involving such example organisms as Escherichia coli and Corynebacterium glutamicum, while a further section covers topics in biomedical engineering including drug delivery systems and biopharmaceuticals. The book concludes with chapters on computer-aided bioprocess engineering and systems biology. This is a part of the Advanced Biotechnology book series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question. Invaluable reading for biotechnologists and bioengineers, as well as those working in the chemical and pharmaceutical industries. Advanced Biotechnology Biotechnology is a broad, interdisciplinary field of science, combining biological sciences and relevant engineering disciplines, that is becoming increasingly important as it benefits the environment and society as a whole. Recent years have seen substantial advances in all areas of biotechnology, resulting in the emergence of brand new fields. To reflect this progress, Sang-Yup Lee (KAIST, South Korea), Jens Nielsen (Chalmers University, Sweden), and Gregory Stephanopoulos (MIT, USA) have joined forces as the editors of a new Wiley-VCH book series. Advanced Biotechnology will cover all pertinent aspects of the field and each volume will be prepared by eminent scientists who are experts on the topic in question.

Download or read book Mucoadhesive Materials and Drug Delivery Systems written by Vitaliy V. Khutoryanskiy and published by John Wiley & Sons. This book was released on 2014-06-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). This is followed by chapters on the various methods used to study mucoadhesion and to characterise mucoadhesive properties of various dosage forms. The final section will summarise information on traditional and novel types of mucoadhesive materials, such as chitosan, thiomers, and liposome-based formulations. This book is unique as there is currently no modern book considering mucoadhesion - all other existing books on the topic are either narrowly focused or more than 10 years old. Furthermore, each contributor offers specialist perspectives from a variety of global locations in both industrial and academic research centres.

Download or read book Green Adhesives written by Inamuddin and published by John Wiley & Sons. This book was released on 2020-06-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Adhesives: Preparation, Properties and Applications deals with the fabrication methods, characterization, and applications of green adhesives. It also includes the collective properties of waterborne, bio, and wound-healing green adhesives. Exclusive attention is devoted to discussing the applications of green adhesives in biomedical coatings, food, and industrial applications.

Download or read book Adhesives in Biomedical Applications written by K. L. Mittal and published by John Wiley & Sons. This book was released on 2023-10-17 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: ADHESIVES IN BIOMEDICAL APPLICATIONS Uniquely provides up-to-date and comprehensive information on adhesives in biomedical applications in an easily accessible form. Adhesives are gaining popularity in many and varied biomedical applications as they are being used as a replacement for sutures and staples, which have the disadvantages such as scarring, infection, keloid formation, poor skin healing, or hernia in the case of abdominal sutures. On the other hand, adhesives dramatically reduce healthcare costs, significantly reduce time spent in surgery, curb the risks of bleeding, and are generally easy to use. Adhesives also find their use in diagnostic imaging, various biomedical devices, dental adhesives, dermal adhesives, etc. Adhesives in Biomedical Applications contains eleven chapters and is divided into two parts: Part 1: General Topics; and Part 2: Specific Adhesives, Characteristics, and Applications. Topics covered include: historical developments of various adhesives for biomedical applications; global industry development and analysis of adhesives for biomedical applications; biomedical adhesives; bioadhesion: fundamentals and mechanisms; fibrin glue; herbal bioactives-based mucoadhesive drug delivery systems; adhesive hydrogels; adhesives in dermal patches; medical adhesives from extracted mussel adhesive proteins; dental adhesives; and the role of adhesive-based systems for diagnostic imaging and theranostic applications. Audience The book will be used by adhesionists, adhesive technologists, polymer scientists, materials scientists, as well as those involved with biomedical devices and bioimplants such as medical doctors, surgeons, cosmetologists, as well as engineers in the pharmaceutical industry.

Download or read book A Holistic and Integrated Approach to Lifestyle Diseases written by Jesiya Susan George and published by CRC Press. This book was released on 2022-01-31 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an informative collection of peer-reviewed chapters on new and innovative holistic approaches to treat contemporary lifestyle diseases. The volume discusses the basics of holistic medicine along with detailed explanations of lifestyle diseases such as various types of cancers, health problems due to overnight mobile telephone usage, AIDS, arthritis, and asthma. The book also advocates several effective strategies that use a combination of nontraditional treatment approaches. The chapters discuss medicinal mushrooms in cancer therapy, employing Ayurveda to treat obesity, treating AIDS by using gene therapy and gene editing technology, and more. This volume will be of interest to open-minded and forward-thinking scientists, researchers, doctors, and other healthcare experts worldwide who endeavor to employ new holistic approaches for the treatment of contemporary lifestyle health issues.

Download or read book Biological Adhesive Systems written by Janek Byern and published by Springer Science & Business Media. This book was released on 2011-01-27 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: J. Herbert Waite Like many graduate students before and after me I was There are so many species about which nothing is known, mesmerized by a proposition expressed years earlier by and the curse of not knowing is apathy. Krogh (1929) – namely that “for many problems there is Bioadhesion is the adaptation featured in this book, an animal on which it can be most conveniently studied”. and biology has many adhesive practitioners. Indeed, This opinion became known as the August Krogh Prin- every living organism is adhesively assembled in the ciple and remains much discussed to this day, particu- most exquisite way. Clearly, speci? c adhesion needs to larly among comparative physiologists (Krebs, 1975). be distinguished from the opportunistic variety. I think The words “problems” and “animal” are key because of speci? c adhesion as the adhesion between cells in the they highlight the two fundamental and complementary same tissue, whereas opportunistic adhesion might be the foci of biological research: (1) expertise about an animal adhesion between pathogenic microbes and the urinary (zoo-centric), which is mostly observational and (2) a tract, or between a slug and the garden path. If oppor- mechanistic analysis of some problem in the animal’s life nistic bioadhesion is our theme, then there are still many history or physiology (problem-centric), which is usually practitioners but the subset is somewhat more select than a hypothesis-driven investigation. before.

Download or read book Functional Ingredients from Algae for Foods and Nutraceuticals written by Herminia Dominguez and published by Elsevier. This book was released on 2023-07-28 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Ingredients from Algae for Foods and Nutraceuticals, Second Edition presents an overview on the composition, properties and potential to develop novel ingredients and additives for functional foods and nutraceuticals. This revised edition includes recent data on the composition and biological properties of algae, along with examples of the development of novel algae products and their performance. It includes a new chapter on both conventional and green technologies for product development and will be of interest to nutrition researchers, food technologists and marine scientists, as well as those with an interest in natural product development. Addresses the chemical, nutritional and biological characterization of algae components Includes cases studies focused on bioactives and the development of novel food products Presents a new chapter on conventional and green technologies for product development

Download or read book Nanoparticles and Nanocarriers Based Pharmaceutical Formulations written by Akhlesh K. Jain and published by Bentham Science Publishers. This book was released on 2022-12-09 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicine is a rapidly expanding field because of its benefits over conventional drug delivery technology, as it offers site-specific and target-oriented delivery of therapeutic agents. Nanoparticles and Nanocarriers Based Pharmaceutical Preparations presents a structured summary of recent advances and discoveries in nanomedicine and nanocarrier-based drug delivery. The book covers several key topics in a very simple and easy to understand language. Readers will be familiarized with many types of nanocarriers that have been developed over the past decade, the pharmaceutical formulations composed of organic and inorganic materials as well as their clinical benefits. Chapters are written with the help of authoritative sources of knowledge with the goal of building a foundational understanding of novel drug delivery systems. Since the subject matter is interdisciplinary, it will be of interest to students, teachers and researchers in a broad range of fields, including pharmaceutical sciences, nanotechnology, biomedical engineering and material sciences.

Download or read book Marine Biomaterials written by Sougata Jana and published by Springer Nature. This book was released on 2022-02-14 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.

Download or read book Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials written by Munmaya Mishra and published by CRC Press. This book was released on 2017-08-16 with total page 1800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Download or read book Eco Friendly Adhesives for Wood and Natural Fiber Composites written by Mohammad Jawaid and published by Springer Nature. This book was released on 2021-01-21 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of eco-friendly resins and their composite materials covering their synthesis, sources, structures and properties for different industrial applications to support the ongoing research and development in eco-friendly and renewable commercial products. It provides comparative discussions on the properties of eco-friendly resins with other polymer composites. It is a useful reference on bio-based eco-friendly polymer resins, wood-based composites, natural fibers and biomass materials for the polymer scientists, engineers and material scientists.

Download or read book Tailor Made Polysaccharides in Drug Delivery written by Amit Kumar Nayak and published by Academic Press. This book was released on 2022-09-02 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tailor-Made Polysaccharides in Drug Delivery provides extensive details on all the vital precepts, basics and fundamental aspects of tailored polysaccharides in the pharmaceutical and biotechnological industry for understanding and developing high quality products. The book offers a comprehensive resource to understand the potential of the materials in forming new drug delivery methods. It will be useful to pharmaceutical scientists, chemical engineers, and regulatory scientists and students actively involved in pharmaceutical product and process development of tailored-made polysaccharides in drug delivery applications.The utilization of natural polymeric excipients in numerous healthcare applications demand the replacement of the synthetic polymers with the natural ones due to their biocompatibility, biodegradability, economic extraction and readily availability. The reality behind the rise in importance of these natural materials is that these sources are renewable if grown in a sustainable means and they can tender incessant supply of raw materials. Amongst these natural polymers, polysaccharides are considered as excellent excipients because of its non-toxic, stable, biodegradable properties. Several research innovations have been made on applications of polysaccharides in drug delivery. Provides methodologies for the design, development and selection of tailor-made, natural polysaccharides in drug delivery for particular therapeutic applications Includes illustrations that demonstrate the mechanism of biological interaction of tailor-made polysaccharides Discusses the regulatory aspects and demonstrates the clinical efficacy of tailor-made polysaccharides