Download or read book Multiscale and Multimodal Structure Function Analysis of Intervertebral Disc Degeneration and Regeneration written by Beth Gayle Ashinsky and published by . This book was released on 2020 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intervertebral disc (IVD) degeneration and associated back pain place a significant burden on the population. IVD degeneration is a progressive cascade of cellular, compositional and structural changes, which results in a loss of disc height, disorganization of extracellular matrix architecture, herniation of the nucleus pulposus (NP), tears in the annulus fibrosus (AF), and remodeling of the boney and cartilaginous endplates. These changes often occur concomitantly, making it difficult to determine which factor initiates degeneration. Furthermore, assessment of the subcomponents and interfacial regions of the IVD have been largely qualitative to date, and the changes that occur at this length scale with degeneration are not yet well understood. This poor understanding of disease etiology hinders the development of therapies to restore native structure and function of the IVD, and so, current clinical treatments are focused on alleviation of symptoms rather than focused regeneration. As such, tissue engineering provides a promising treatment option and has the potential to restore both the structure and function of the native disc. The overall goal of this thesis is to establish quantitative microscale and macroscale outcomes that define the spectrum of degeneration and to inform regeneration. In Aim 1, we developed a quantitative dataset of the structural and functional features of degeneration over time in an in vivo rabbit model and identified the primary contributors to disc degeneration using a machine learning approach. We found that puncture acutely compromised disc macro and microscale mechanics, followed by progressive AF stiffening and remodeling. These dynamic changes were accompanied by increases in endplate bone volume fraction, increases in microscale stiffness of the soft tissue interfaces between the disc and vertebral bone, and reductions in endplate vascularity and small molecule transport into the disc as a function of degenerative state. Notably, our neural network model identified changes in diffusion into the disc (a measurement of disc nutrition) as the most significant predictor of disc degeneration. In order to extend the translatability of this animal model, we employed similar multimodal analyses in Aim 2, using human cadaveric spines of differing degenerative states. We observed widespread multiscale alterations to the IVD, endplates, bone, and whole motion segment. Interestingly, and in contrast to the rabbit model, we observed motion segment softening and endplate resorption with degeneration. We discerned several correlations between the quantitative variables, particularly between IVD and endplate measurements, suggesting crosstalk between these tissues during degeneration. To address a potential treatment strategy for end-stage degeneration, we sought to advance and optimize the composition and mechanics of a tissue-engineered whole disc replacement (DAPS). Our findings from Aims 1 & 2 indicated that AF structural integrity and micromechanical properties are severely affected during degeneration, and as such, in Aim 3, we included a soluble polymer into the AF region of the DAPS to promote cell ingress and improve matrix distribution. This modification better approximated native micro- and macro-mechanical properties of the DAPS, cellular colonization, and matrix elaboration, in the in vitro and vivo environments. Overall, the results from this Thesis identify the most significant contributors to disc degeneration, and advance new treatment strategies towards clinical use.

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Download or read book Computational Biomechanics written by Kozaburo Hayashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combination of readily available computing power and progress in numerical techniques has made nonlinear systems - the kind that only a few years ago were ignored as too complex - open to analysis for the first time. Now realistic models of living systems incorporating the nonlinear variation and anisotropic nature of physical properties can be solved numerically on modern computers to give realistically usable results. This has opened up new and exciting possibilities for the fusing of ideas from physiology and engineering in the burgeoning new field that is biomechanics. Computational Biomechanics presents pioneering work focusing on the areas of orthopedic and circulatory mechanics, using experimental results to confirm or improve the relevant mathematical models and parameters. Together with two companion volumes, Biomechanics: Functional Adaptation and Remodeling and the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.

Download or read book In Situ Tissue Regeneration written by Sang Jin Lee and published by Academic Press. This book was released on 2016-07-17 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. - Explores the body's ability to mobilize endogenous stem cells to the site of injury - Details the latest strategies developed for inducing and supporting the body's own regenerating capacity - Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume - Features chapter authors and editors who are authorities in this emerging field - Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

Download or read book Spinal Anatomy written by Jean Marc Vital and published by Springer Nature. This book was released on 2019-12-16 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated and comprehensive book covers a broad range of normal and pathologic conditions of the vertebral column, from its embryology to its development, its pathology, its dynamism and its degeneration. The dynamic anatomy of the living subject is viewed using the latest technologies, opening new perspectives to elucidate the pathology of the spine and improve spinal surgery. The respective chapters review in depth all sections of the vertebral column and offer new insights, e.g. the 3D study of vertebral movements using the “EOS system,” which makes it possible to define an equilibrium of posture and its limits. New histological and chemical findings on the intervertebral disc, as well as detailed descriptions of the aponeuroses and fasciae, are also provided. Bringing together the experience of several experts from the well-known French school, this book offers a valuable companion for skilled experts and postgraduate students in various fields: orthopedic surgery, neurosurgery, physiotherapy, rheumatology, musculoskeletal therapy, rehabilitation, and kinesiology.

Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers

Download or read book Spine Surgery written by Alexander R. Vaccaro and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides guidance on how to perform a wide-variety of techniques in spine surgery. Topics covered include immobilization techniques, anterior and posterior approaches, and thoracic spine surgery.

Download or read book Sciatica Foundations of diagnosis and conservative treatment written by Robert James Trager and published by Integrated Clinics, LLC. This book was released on 2019-11-09 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes research about sciatica for clinicians such as chiropractors, physical therapists, primary care providers, osteopaths, and physiatrists. Well-informed patients will also benefit from reading this book. This book uses thousands of references, hundreds of images, original illustrations, and case studies to review mechanisms of pain, examination techniques, and treatment of sciatica. While the focus is on non-pharmaceutical and minimally invasive treatments, this book also reviews the indications for more invasive procedures. Each chapter also includes a historical review dating back decades or centuries, which puts the newer treatments in perspective.In this book you will learn: What is sciatica and does it always relate to the spine? What common features occur in most cases of sciatica? Has our concept of what causes sciatica changed over time? What does it mean when symptoms are above the knee or below the knee? Can imaging help determine if disc lesions are causing symptoms? Does sciatica mean you are just getting old? What mechanisms allow disc herniations to heal? What percentage of cases of sciatica typically require surgery? What are the most effective non-pharmaceutical treatments for sciatica? What vitamins and natural substances are beneficial for sciatica?

Download or read book Model Selection and Multimodel Inference written by Kenneth P. Burnham and published by Springer Science & Business Media. This book was released on 2007-05-28 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique and comprehensive text on the philosophy of model-based data analysis and strategy for the analysis of empirical data. The book introduces information theoretic approaches and focuses critical attention on a priori modeling and the selection of a good approximating model that best represents the inference supported by the data. It contains several new approaches to estimating model selection uncertainty and incorporating selection uncertainty into estimates of precision. An array of examples is given to illustrate various technical issues. The text has been written for biologists and statisticians using models for making inferences from empirical data.

Download or read book Cutting Edge Enabling Technologies for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.

Download or read book Bio Inspired Innovation and National Security written by National Defense University and published by NDU Press. This book was released on 2010-10 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.

Download or read book Biomaterials for Implants and Scaffolds written by Qing Li and published by Springer. This book was released on 2016-11-30 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the latest, cutting-edge advances in implantable biomaterials. It brings together a class of advanced biomaterials in two highly active research areas, namely implants and tissue scaffolds, to underline their respective functional requirements for further development. It is unique in providing a full range of methodological procedures, including materials syntheses, characterisation, cellular tests and mathematical modelling. Covering metallic, ceramic, polymeric and composite materials commonly used in biological applications and clinical therapeutics, it is a valuable resource for anyone wanting to further their understanding of the latest developments in implantable biomaterials. Focusing on biomedical applications in implants and scaffolds, it provides methodological guides to this rapidly growing field. Qing Li and Yiu-Wing Mai are both professors at the University of Sydney, School of Aerospace, Mechanical and Mechatronic Engineering.

Download or read book Reverse Shoulder Arthroplasty written by David M. Dines and published by Thieme. This book was released on 2017-09-27 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This masterful book from top experts provides clinical insights on reverse shoulder arthroplasty gleaned from hands-on refinement of shoulder replacement techniques. Years of significant biomechanical and clinical research yielded invaluable knowledge that led to important improvements in functional outcome and implant durability. Among these refinements were stronger polyethylene derivatives, better ingrowth technology, and improved connection devices. As the durability and longevity of implant technology increased, younger active patients became suitable candidates for this procedure. In fact, RSA has played a pivotal role in making shoulder arthroplasty the fastest growing implant technology. In the first two sections, the authors take the reader through the history and evolution of RSA, followed by step-by-step surgical techniques for specific injuries and conditions. The next three sections discuss past and recent outcomes, complications, and rehabilitation. The last section covers special considerations including patient specific instrumentation, convertible humeral and glenoid components, and the future potential of stemless humeral technology. Key Features The latest trends in patient-specific components, guide systems, and instrument design The use of RSA for rotator cuff repair, shoulder arthritis, and acute and complex fractures In-depth discussion of techniques to improve deltoid function, avoid impingement, and increase implant longevity Clinical pearls on how to recognize and handle complications that occur: instability, infection, scapular notching, component loosening, glenoid and humeral bone loss, and RSA failure High quality videos and 300 superb illustrations further delineate techniques This book is a practical resource that enables learning complex procedures, putting them into practice, and handling complications should they arise. It is an essential tool for all orthopaedic surgeons who treat shoulder conditions.

Download or read book 5th International Conference on Biomedical Engineering in Vietnam written by Vo Van Toi and published by Springer. This book was released on 2014-11-18 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of the Fifth International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 16-18, 2014 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. I aims identifying new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.

Download or read book Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy written by Challa S.S.R. Kumar and published by Springer Nature. This book was released on 2019-11-22 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ninth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.

Download or read book Biophysics and Neurophysiology of the Sixth Sense written by Nima Rezaei and published by Springer. This book was released on 2019-04-26 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple senses, like multiple intelligences, are a key to brain variability and therefore human evolution. Besides the traditional five senses (vision, olfaction, gustation, audition, and somatosensory), humans can also perceive the body’s own position (the sense of proprioception) and movement (the vestibular sense). Interoception is the feeling one has about the internal physiological conditions of the entire body. Additionally there is a sense of intuition, also known as the sixth sense. Despite their best efforts, researchers are still unable to concur in specifying the nature of the sixth sense; some consider the sense of proprioception as the sixth sense, whereas others prefer to consider that as a part of interoception. This book will provide a scientific system for the human sixth sense using relevant biophysical and neurophysiological evidence. The power of “sixth sense” seems to be underestimated, due to difficulties in defining the concept clearly. According to socioeconomics and neural physics, the sixth sense is that which permits humans to create perception or to enhance the quality of their perception of events. Roughly speaking, the sixth sense engages a metacognitive process through which prior knowledge and the information received from other sensory modalities are synergized. It is not restricted to specific arrow of time and type of mind or to the observer’s body, but it considers all arrows of time (past, present, future), types of mind (conscious and unconscious), and physical bodies (self and other). However it is expected that the observer has specific biases towards what happens now or would happen in the future and its relation to himself. Particularly, humans appeal to the sixth sense on the road to achieving success in social competitions and to reduce uncertainty in complex decision making processes. In addition to evidence linking genetic components to the sixth sense submodalities, there have been developed strategies for increasing the quality of perceptions provided by the sixth sense. Meditation, through which individuals try to be detached from the world, increases gamma-band activity and that increased gamma-band activity is found following top-down processing. Therefore it can be inferred that the detachment from the environment may enhance synchronization of the wave functions in favor of strengthening the sixth sense. It can serve as the mechanism of enhancement of the sixth sense in those whose sensory systems are intact, it can also serve as the mechanism of compensation in those who have sensory deficiencies. In the latter case, it in fact encourages creativity in the use of relatively strong senses. This justifies Beethoven's deafness and his great musical creativity or Bramblitt's blindness and his enormous capability to paint and many other similar examples. In summary, the present book is divided into five parts. Part 1 (chapters 1-6) provides information about the system of proprioception and its neurophysiology and biophysics. Part 2 (chapters 7-10) examines the system of interoception. The information provided in these two parts would enable us to move towards the next three parts of the story, aimed at developing a scientific system of the sixth sense. The first chapter of part 3 begins with concepts and uses them to arrive at reasonable conclusion that there must be a sense that requires multistep information processing and that is separate from the sense of proprioception and the sense of interoception. Such sense is commonly known as the sixth sense. However it should be re-numbered because the sense of proprioception is already known as the sixth sense. The second chapter of this part is to draw neurocircuitry that innervates the sixth sense in the mind of a man, while the third chapter would address the questions whether the sixth sense system requires an optimal competence or consciousness of mind to function properly and if so which is the optimal state: conscious or unconscious and competence or incompetence. In the fourth chapter of this part, we will focus on the self-other mergence as a pivotal step of the sixth sense system. The next chapter would be of great interest to neurobiologists. It talks about that the human sixth sense of the unseen world, either the unseen arrow of time or the unseen events, requires creativity and therefore the human sixth sense should be considered a source of creativity, variability and thus evolution. In the sixth chapter, the sixth sense is viewed as an economic activity stimulated by social environments. This chapter arisen from the fact that humans are full of enthusiasm to heighten their sixth sense and its accuracy and that they owe their enthusiasm largely to achieving the best possible profit and in other words to wining intense competitions in their life holds mainly on the concept of elasticity. Finally this part is finished by an amazing discussion on the art of the sixth sense. The first chapter of part 4 discusses physical theories that support the existence of sixth sense in the universe. The next chapter is to apply the Bayes’ theory to the sixth sense, leading to the conclusion that the sixth sense improves multisensory integration through optimizing uncertainty of information received from other sensory modalities. Chapter three in this part would address whether relative timing is applicable to the sixth sense like other senses. The last part of book aimed at directly discussing the sixth sense into the context of human health and behavior is organized into four chapters. The first chapter is to discuss neurodevelopmental changes in the sixth sense, while the second and third ones will discuss that in relation to psychiatric and neurological disorders. The most striking question how much power the sixth sense the sixth sense have over human health and behavior is addressed in the fourth chapter of this part and final chapter of book, which will be prepared using neural network models and sophisticated portraits possible for the system of sixth sense.

Download or read book Tumor Microenvironments in Organs written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.