Download or read book Neurological Disorders and Pregnancy written by Alireza Minagar and published by Elsevier. This book was released on 2010-12-08 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Timely diagnosis and management of neurological diseases during pregnancy poses major therapeutic challenges to neurologists and other non-neurologist health care providers. Pregnancy is a unique period in life associated with significant hormonal and other physiologic changes in female patients, which may trigger or alter the course of neurological and psychiatric disorders. In addition, many diagnostic procedures that can be performed in non-pregnant women are prohibited during pregnancy for safety reasons. Therapeutic decisions and management of a pregnant patient with neurological disorders heavily depends on the issue of the reasonable balance between the risks of no treatment versus active treatment for the mother and her fetus. This book provides a review of the latest findings in this field, giving the neurologist and non-neurologist the information they need to determine the best treatment. Neurological disorders covered include multiple sclerosis, stroke and epilepsy. Discusses how neurological disorders should be managed in a pregnant patient Includes contributions from leading authorities

Download or read book Multiple Sclerosis and Having a Baby written by Judy Graham and published by Simon and Schuster. This book was released on 1999-06-01 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for anyone with MS who is considering having a child. • Firsthand advice from a woman with multiple sclerosis who has successfully borne and raised a child. • Contains information that can change the lives of many of the 250,000 women in the United States suffering from MS. • Highly readable format puts the facts at your fingertips. Diagnosed with MS at twenty-eight, author Judy Graham gave birth for the first time at the age of thirty-eight. Her new book Multiple Sclerosis and Having a Baby provides other women who are considering starting a family with the kind of genuine and useful insight that comes only from firsthand experience. Multiple Sclerosis and Having a Baby makes available not only the medical answers prospective parents need, but also the practical suggestions and sound advice that will help them meet the many unique and sometimes difficult challenges that face couples living with MS. In this highly informative and readable book, Graham asks and provides answers for nearly every question a woman with multiple sclerosis might want to consider before having a baby. With the latest medical facts and valuable data culled from hundreds of interviews with women who have multiple sclerosis and are currently raising a child, Graham straightforwardly addresses such issues as the possibility of relapse, genetic predisposition to MS, sexuality and fertility, pregnancy, postnatal care, and breastfeeding as they relate to women with MS.

Download or read book Multiple Sclerosis and Pregnancy written by June R. Wyman and published by . This book was released on 1987 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fast Facts Multiple Sclerosis written by Mary Rensel and published by Karger Medical and Scientific Publishers. This book was released on 2016-08-29 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last edition of this book, 'no evidence of disease activity' (NEDA) has been proposed as a new treatment target, early data on the first pharmacological treatments for progressive MS have emerged, and the first remyelination trial has shown positive effects on nerve repair. It is with this sense of optimism that the authors of 'Fast Facts: Multiple Sclerosis' have detailed the latest developments for use in clinical practice by all members of the multidisciplinary team, including: • a concise overview of investigations and modern diagnostic criteria • a holistic approach to all signs and symptoms, and proactive relapse management • the latest disease-modifying drugs, including when to treat, choice of drug and risk versus benefit. With case histories that will help to guide treatment decisions, discussion of the special considerations for MS during pregnancy, and in children and the elderly, and a detailed outline of emerging therapies, this book will benefit all healthcare professionals involved in the care of patients with this complex disease.

Download or read book Effects of Pregnancy and Hormones on T cell Immune Regulation in Multiple Sclerosis written by Sandra Hellberg and published by Linköping University Electronic Press. This book was released on 2019-10-22 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place during pregnancy to accommodate the presence of the semi-allogenic fetus contribute to the observed disease improvement. The aim of this thesis was to characterize the dysregulated immune system in MS and define potential factors and mechanisms established during pregnancy that could be involved in the pregnancy-induced effects in MS, focusing on CD4+ T cells as one of the main drivers in immunity and in the MS pathogenesis. Using a network-based modular approach based on gene expression profiling, we could show that CD4+ T cells from patients with MS displayed an altered dynamic gene response to activation, in line with a dysregulated immune system in MS. The resulting gene module disclosed cell activation and chemotaxis as central components in the deviating response, results that form a basis for further studies on its modulation during pregnancy. Moreover, a combination of secreted proteins (OPN+CXCL1-3+CXCL10-CCL2), identified from the module, could be used to separate patients and controls, predict disease activity after 2 years and discriminate between high and low responders to treatment, highlighting their potential use as biomarkers for predicting disease activity and response to treatment. The pregnancy hormone progesterone (P4), a potential factor involved in the pregnancy-induced amelioration of MS, was found to significantly dampen CD4+ T cell activation. Further detailed transcriptomic profiling revealed that P4 almost exclusively down-regulated immune-related pathways in activated T cells, several related to or downstream of T cell activation such as JAKSTAT signaling, T cell receptor signaling and cytokine-cytokine receptor interaction. In particular, P4 significantly affected genes of relevance to diseases known to be modulated during pregnancy, where genes associated to MS were most significantly affected, supporting a role for P4 in the pregnancy-induced immunomodulation. By using another approach, the role of thymus in T cell regulation during pregnancy was assessed. Two established measures of thymic output, CD31 expression and TREC content, were used and showed that thymic output of T cells is maintained during human pregnancy, or even possibly increased in terms of regulatory T cells. This thesis further supports a pivotal role for CD4+ T cells and T cell activation in the MS pathogenesis and adds to the knowledge of how they could be involved in driving disease. We identified a novel strategy for capturing central aspects of the deviating response to T cell activation that could be translated into potentially clinically relevant biomarkers. Further, P4 is emerging as a promising candidate for the pregnancy-induced immunomodulation that could be of importance as a future treatment option. Lastly, maintained thymic output of T cells during human pregnancy challenges the rodent-based dogma of an inactive thymus during pregnancy. Thymic dysfunction has been reported not only in MS but also in rheumatoid arthritis, another inflammatory disease that improves during pregnancy, which highlights a potential role for thymus in immune regulation that could be involved in the pregnancy-induced amelioration.

Download or read book Multiple Sclerosis the Decision to Become Pregnant and Factors Associated with Perinatal Relapse written by Natalia Zelia Afonso and published by . This book was released on 2017 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Multiple sclerosis (MS) is one of the most common diseases of the nervous system, impacting more than two million people worldwide. Over 400,000 individuals in the United States are diagnosed with MS each year. MS diagnosis is more common (two to three times more) among women than men and it is most commonly diagnosed during the second and third decades of life, prime reproductive years for many women. While research has shown that a diagnosis of MS does not decrease a woman's ability to have children, the MS diagnosis and pregnancy experience after MS diagnosis may influence the decision to have children. Further, pregnancy may have an impact on the course of MS. Methods: The study was conducted in the setting of the Greater Washington Chapter of the National Multiple Sclerosis Society (NMSS). The current study was conducted among 391 women, community-dwelling participants with MS, who responded to survey questions related to pregnancy and MS. Study participant characteristics (e.g. socio-demographic characteristics), opinion on pregnancy-related decision making, and experience of MS relapse during the perinatal period were summarized using descriptive statistics. Differences in characteristics between women who experienced perinatal MS relapse and women who did not were compared using Student's T-test and Chi-square tests. Results: The mean age of participants was 52 years. Of the women who participated in the survey, 67 (17.1%) had at least one pregnancy after their MS diagnosis. Women who experienced pregnancy after MS diagnosis were younger at MS diagnosis (28 vs. 40 years) and of lower body mass index (25 vs. 27 kg/m2), compared with women who did not experience pregnancy after MS diagnosis (all p-value

Download or read book Infertility and Impaired Fecundity in the United States 1982 2010 written by Anjani Chandra and published by . This book was released on 2013 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Multiple Sclerosis and Pregnancy written by June R. Wyman and published by . This book was released on 1987 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Breastfeeding and Medication written by Wendy Jones and published by Routledge. This book was released on 2018-05-11 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sadly, women often feel they have no alternative but to give up breastfeeding, having been prescribed or purchased medication. In many cases, however, this is unnecessary. This book outlines the evidence base for the use of medication during breastfeeding. Breastfeeding and Medication presents a comprehensive A to Z guide to the most frequently prescribed drugs and their safety for breastfeeding mothers. Evaluating the evidence for interventions and using a simple format for quickly identifying medications that are safe or unsafe to use, it also highlights those drugs where there is inconclusive evidence. Additional contextual information makes this the most complete text for those practitioners who support and treat breastfeeding women. It: provides an overview of the anatomy and physiology of the breast together with hormonal influences to better understand how complications, such as mastitis, arise and inform the approach to their treatment; includes a section on conditions that affect women specifically when they are lactating where prescription of medication may be necessary; discusses the importance of breastfeeding and its advantages, as well as its disadvantages; and explores how to support breastfeeding mothers, and presents a counselling model approach. This new edition contains information on more drugs and a chapter on the management of some chronic conditions which may affect breastfeeding mothers. In most cases there are options to support the mother’s optimal care whilst allowing her to continue to breastfeed her baby as long as she wishes. This is a topic which raises many questions on social media, which informed the choice of conditions to consider. This is an invaluable reference for all health practitioners and volunteers who work with, support and treat breastfeeding women, including lactation consultants, breastfeeding support workers, health visitors, GPs, practice nurses, pharmacists and midwives.

Download or read book Health Issues in Women with Multiple Sclerosis written by Maria K. Houtchens and published by Springer. This book was released on 2017-03-15 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses specific concerns of females affected by multiple sclerosis, where women are disproportionally impacted by the disease. MS is an autoimmune disease of the central nervous system affecting young adults of reproductive age. This book presents the current understanding of genetic variables, hormonal influences, immunological milieu and neurological outcomes, discussing issues such as fertility, pregnancy management, and menopause, as well as end of life care and mortality in women with MS. With contributions by international experts, this interdisciplinary book will serve as a useful reference and guide for MS specialists, general neurologists, obstetricians/gynecologists, physicians in training, family practice doctors, clinical nurse specialists in multiple sclerosis, and all other healthcare professionals involved in the care and treatment of women affected by MS.​

Download or read book Multiple Sclerosis written by Jonathan Howard, MD and published by Springer Publishing Company. This book was released on 2018-09-28 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you or a loved one has been diagnosed with multiple sclerosis, this book should be your first stop. Written in easy-to-understand language by an MS specialist, this guide explores the questions that patients and their families typically ask—from disease basics, to treatment options, managing relapses, and lifestyle concerns, including diet and working. Whether newly diagnosed or coping with the unpredictable day-to-day, this valuable reference will arm you with the latest information. Designed to be a thorough, yet concise summary of all aspects of MS, the book simplifies complex medical topics and is based on the latest science. For patients at any stage and the people who support them, Multiple Sclerosis: Questions and Answers for Patients and Loved Ones provides the answers you need to understand this disease, its challenges, and the medical treatments and other tools now available for managing it successfully. Key Features: Complete guide with straightforward answers to the most frequently asked questions by MS patients Up-to-date information on treatment options, including the benefits and drawbacks of new MS medications and who should be taking them Addresses special topics, such as pregnancy in combination with MS treatments and working after diagnosis Presents an overview of symptoms with tips on how to combat them Offers useful advice about symptom management and lifestyle changes to meet the physical and emotional challenges MS brings

Download or read book Pregnancy and Multiple Sclerosis written by Andrew Lawrence Smith and published by . This book was released on 2017 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background; Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central nervous system that commonly affects young women of reproductive potential. As such, issues related to family planning are of critical importance. Objective; The objective of this study was to first determine both what are the risk factors of having an unplanned pregnancy and the risk factors of having a relapse while attempting to conceive. Secondly, we look at the rate of post-partum relapses as a function of labor anesthesia choice. Methods; A retrospective observational cohort study was created from a chart review. Multiple stepwise logistic regressions were used to determine the risk factors for a relapse while attempting, unplanned pregnancies, and DMT exposed pregnancies. Cox modeling was used to predict post-partum relapse. Results; 150 patients were identified as having MS and concomitant pregnancy. The medical records of these patients were reviewed and 45 patients had both obstetric and MS care within the Cleveland Clinic hospital system. There were a total of 63 pregnancies (20 unplanned and 43 planned). Risk factors for unplanned pregnancy were younger age (p

Download or read book Neuroimmune Diseases written by Hiroshi Mitoma and published by Springer. This book was released on 2019-08-13 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases

Download or read book Registries for Evaluating Patient Outcomes written by Agency for Healthcare Research and Quality/AHRQ and published by Government Printing Office. This book was released on 2014-04-01 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Download or read book MS and Pregnancy written by Alec Forti and published by . This book was released on 1989* with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neurology and Psychiatry of Women written by Mary Angela O’Neal and published by Springer. This book was released on 2019-02-14 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive resource covers a range of women’s health issues and their intersection with neurologic and psychiatric disease. Chapters feature high quality, integrated information based on leading-edge research on gender-specific care and are grouped by reproductive years, pregnancy and health, and aging. Emerging science regarding sex differences in neurological and psychiatric illnesses, including anxiety, reproductive health, conversion disorders, depression and ethical issues in pregnancy, stroke risk factors, and successful aging strategies are covered along with clinical application of this knowledge to the delivery of care. In addition, in those medical problems that afflict both men and women, authors will point out the different risks, prevalence, presentations, and responses to treatments or outcomes in women. Written by renowned experts in the field, this textbook will thoroughly address the educational needs of physicians, nurse practitioners, and physician assistants in the areas of neurology, psychiatry, internal medicine, and obstetrics and expanding their understanding of concerns unique to female patients.

Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.