Download or read book Understanding Statistics and Experimental Design written by Michael H. Herzog and published by Springer. This book was released on 2019-08-13 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook provides the background needed to correctly use, interpret and understand statistics and statistical data in diverse settings. Part I makes key concepts in statistics readily clear. Parts I and II give an overview of the most common tests (t-test, ANOVA, correlations) and work out their statistical principles. Part III provides insight into meta-statistics (statistics of statistics) and demonstrates why experiments often do not replicate. Finally, the textbook shows how complex statistics can be avoided by using clever experimental design. Both non-scientists and students in Biology, Biomedicine and Engineering will benefit from the book by learning the statistical basis of scientific claims and by discovering ways to evaluate the quality of scientific reports in academic journals and news outlets.
Download or read book Encyclopedia of Systems Biology written by Werner Dubitzky and published by Springer. This book was released on 2013-06-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology refers to the quantitative analysis of the dynamic interactions among several components of a biological system and aims to understand the behavior of the system as a whole. Systems biology involves the development and application of systems theory concepts for the study of complex biological systems through iteration over mathematical modeling, computational simulation and biological experimentation. Systems biology could be viewed as a tool to increase our understanding of biological systems, to develop more directed experiments, and to allow accurate predictions. The Encyclopedia of Systems Biology is conceived as a comprehensive reference work covering all aspects of systems biology, in particular the investigation of living matter involving a tight coupling of biological experimentation, mathematical modeling and computational analysis and simulation. The main goal of the Encyclopedia is to provide a complete reference of established knowledge in systems biology – a ‘one-stop shop’ for someone seeking information on key concepts of systems biology. As a result, the Encyclopedia comprises a broad range of topics relevant in the context of systems biology. The audience targeted by the Encyclopedia includes researchers, developers, teachers, students and practitioners who are interested or working in the field of systems biology. Keeping in mind the varying needs of the potential readership, we have structured and presented the content in a way that is accessible to readers from wide range of backgrounds. In contrast to encyclopedic online resources, which often rely on the general public to author their content, a key consideration in the development of the Encyclopedia of Systems Biology was to have subject matter experts define the concepts and subjects of systems biology.
Download or read book Large Scale Inference written by Bradley Efron and published by Cambridge University Press. This book was released on 2012-11-29 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.
Download or read book Multiple Testing Problems in Pharmaceutical Statistics written by Alex Dmitrienko and published by CRC Press. This book was released on 2009-12-08 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c
Download or read book Multiple Testing Procedures with Applications to Genomics written by Sandrine Dudoit and published by Springer Science & Business Media. This book was released on 2007-12-18 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
Download or read book Resampling Based Multiple Testing written by Peter H. Westfall and published by John Wiley & Sons. This book was released on 1993-01-12 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combines recent developments in resampling technology (including the bootstrap) with new methods for multiple testing that are easy to use, convenient to report and widely applicable. Software from SAS Institute is available to execute many of the methods and programming is straightforward for other applications. Explains how to summarize results using adjusted p-values which do not necessitate cumbersome table look-ups. Demonstrates how to incorporate logical constraints among hypotheses, further improving power.
Download or read book Multiple Comparison Procedures written by Yosef Hochberg and published by . This book was released on 1987-10-05 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a balanced, up-to-date view of multiple comparison procedures, this book refutes the belief held by some statisticians that such procedures have no place in data analysis. With equal emphasis on theory and applications, it establishes the advantages of multiple comparison techniques in reducing error rates and in ensuring the validity of statistical inferences. Provides detailed descriptions of the derivation and implementation of a variety of procedures, paying particular attention to classical approaches and confidence estimation procedures. Also discusses the benefits and drawbacks of other methods. Numerous examples and tables for implementing procedures are included, making this work both practical and informative.
Download or read book The Method of Multiple Hypotheses written by Charles S. Reichardt and published by Routledge. This book was released on 2021-10-20 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the method of multiple hypotheses with detailed examples and describes the limitations facing all methods (including the method of multiple hypotheses) as the means for constructing knowledge about nature. Author Charles Reichardt explains the method of multiple hypotheses using a range of real-world applications involving the causes of crime, traffic fatalities, and home field advantage in sports. The book describes the benefits of utilizing multiple hypotheses and the inherent limitations within which all methods must operate because all conclusions about nature must remain tentative and forever subject to revision. Nonetheless, the book reveals how the method of multiple hypotheses can produce strong inferences even in the face of the inevitable uncertainties of knowledge. The author also explicates some of the most foundational ideas in philosophy of science including the notions of the underdetermination of theory by data, the Duhem-Quine thesis, and the theory-ladenness of observation. This book will be important reading for advanced undergraduates, graduates, and professional researchers across the social, behavioral, and natural sciences wanting to understand this method and how to apply it to their field of interest.
Download or read book The Mathematics of the Uncertain written by Eduardo Gil and published by Springer. This book was released on 2018-02-28 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a tribute to Professor Pedro Gil, who created the Department of Statistics, OR and TM at the University of Oviedo, and a former President of the Spanish Society of Statistics and OR (SEIO). In more than eighty original contributions, it illustrates the extent to which Mathematics can help manage uncertainty, a factor that is inherent to real life. Today it goes without saying that, in order to model experiments and systems and to analyze related outcomes and data, it is necessary to consider formal ideas and develop scientific approaches and techniques for dealing with uncertainty. Mathematics is crucial in this endeavor, as this book demonstrates. As Professor Pedro Gil highlighted twenty years ago, there are several well-known mathematical branches for this purpose, including Mathematics of chance (Probability and Statistics), Mathematics of communication (Information Theory), and Mathematics of imprecision (Fuzzy Sets Theory and others). These branches often intertwine, since different sources of uncertainty can coexist, and they are not exhaustive. While most of the papers presented here address the three aforementioned fields, some hail from other Mathematical disciplines such as Operations Research; others, in turn, put the spotlight on real-world studies and applications. The intended audience of this book is mainly statisticians, mathematicians and computer scientists, but practitioners in these areas will certainly also find the book a very interesting read.
Download or read book Exact and Approximate Stepdown Methods for Multiple Hypothesis Testing written by Joseph P. Romano and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consider the problem of testing k hypotheses simultaneously. In this paper, we discuss finite and large sample theory of stepdown methods that provide control of the familywise error rate (FWE). To improve upon the Bonferroni method or Holm's stepdown method, Westfall and Young (1993) make use of resampling to construct stepdown methods that implicitly estimate the dependence structure of the test statistics. However, their methods depend on the assumption of subset pivotality. Our goal is to construct general stepdown methods that do not require such an assumption. It turns out that a key component for the validity of stepdown methods is a monotonicity requirement of critical values. By imposing such monotonicity on estimated critical values, we show that the problem of constructing a valid multiple test procedure controling the FWE can be reduced to the problem of contructing a single test controling the usual probability of a Type 1 error.
Download or read book Multiple Comparisons Using R written by Frank Bretz and published by CRC Press. This book was released on 2016-04-19 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, which offers a convenient interface to perform multiple comparisons in a general context. Following this theoretical framework, the book explores applications involving the Dunnett test, Tukey’s all pairwise comparisons, and general multiple contrast tests for standard regression models, mixed-effects models, and parametric survival models. The last chapter reviews other multiple comparison procedures, such as resampling-based procedures, methods for group sequential or adaptive designs, and the combination of multiple comparison procedures with modeling techniques. Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. A self-contained introduction to multiple comparison procedures, this book offers strategies for constructing the procedures and illustrates the framework for multiple hypotheses testing in general parametric models. It is suitable for readers with R experience but limited knowledge of multiple comparison procedures and vice versa. See Dr. Bretz discuss the book.
Download or read book A Manual of the History of Dogmas written by Bernard John Otten and published by . This book was released on 1917 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiple Hypothesis Testing written by Stanford University. Institute for Mathematical Studies in the Social Sciences and published by . This book was released on 1982 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiple Hypothesis Testing written by Juliet Popper Shaffer and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiple Comparisons written by Alan J. Klockars and published by SAGE. This book was released on 1986-09 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the most important methods used to investigate differences between levels of an independent variable within an experimental design. Readers will learn not only how to conduct multiple comparisons in experimental designs but also how to better understand and evaluate published research. "A highly readable introduction to multiple comparison methods, which demands little from its reader in the way of background other than some familiarity with analysis of variance." --The Statistician
Download or read book Bootstrap Methods and Their Application written by A. C. Davison and published by Cambridge University Press. This book was released on 1997-10-28 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disk contains the library functions and documentation for use with Splus for Windows.
Download or read book Multiple Hypothesis Testing written by Houston Nash Gilbert and published by . This book was released on 2009 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
