Download or read book The Multileveled Regulation of the Human Cholinesterase Genes and Their Protein Products written by and published by . This book was released on 1993 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ACHE and BCHE genes encoding the acetylcholine hydrolyzing enzymes acetyl- and butyrylcholinesterase (AChE, BuChE) were molecularly cloned and their chromosomal positions determined to be 7q22 and 3q26, respectively. Several point mutations were found in these two genes and their frequency determined within ethnically distinct populations of Israeli residents. Xenopus oocyte expression studies revealed the BuChE mutations variably alter sensitivity to inhibitors, including organophosphorous poisons. The promoter controlling ACHE gene expression was characterized and shown to direct the expression of human AChE in developing myotomes from transiently transgenic Xenopus laevis embryos, where the transgenic enzyme faithfully accumulated in neuromuscular junctions. Alternative splicing in ACHEmRNA transcripts was found to lead to 3 distinct enzyme forms, 2 of which are abundant in tumors. Antisense phosphorothioate oligodeoxynucleotide-targetted destruction of ACHEmRNA in mice was found to cause transient hematopoietic alterations, notably reduced erythrocyte counts. Acetylcholinesterase, Butyrylcholinesterase, DNA sequencing, Alternative splicing, Natural variants, Xenopus expression, Site-directed mutagenesis.

Download or read book Multileveled Regulation of the Human Cholinesterase Genes and Their Protein Products written by Patrick A. Dreyfus and published by . This book was released on 1988 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinesterase Genes written by H. Soreq and published by . This book was released on 1990 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Cholinesterases and Anticholinesterases written by Hermona Soreq and published by Academic Press. This book was released on 2012-12-02 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesterase. Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable.

Download or read book Regulation and Expression of Human Cholinesterase Genes written by Patrick A. Dreyfus and published by . This book was released on 1989 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cytogenetics and Cell Genetics written by and published by . This book was released on 1990 with total page 1314 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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Download or read book Human Heredity written by and published by . This book was released on 1990 with total page 938 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biology of the Neonate written by and published by . This book was released on 1990-07 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fetal Therapy written by and published by . This book was released on 1989 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Gynecologic and Obstetric Investigation written by and published by . This book was released on 1990 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Government Reports Announcements Index written by and published by . This book was released on 1994 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Research written by and published by . This book was released on 1990 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Directory of Medical Research in Israel written by and published by . This book was released on 1996 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Government Reports Annual Index written by and published by . This book was released on 1995 with total page 1686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sections 1-2. Keyword Index.--Section 3. Personal author index.--Section 4. Corporate author index.-- Section 5. Contract/grant number index, NTIS order/report number index 1-E.--Section 6. NTIS order/report number index F-Z.

Download or read book Chemical Abstracts written by and published by . This book was released on 1991 with total page 2682 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt: