Download or read book Multi template Analysis of Human Perirhinal Cortex in Brain MRI written by Long Xie and published by . This book was released on 2018 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain is highly variable in terms of its folding pattern and the distribution of underlining cytoarchitecture. Current leading paradigms in brain structural MRI analysis have been almost completely based on methods that use a single template to capture variability between all subjects in a population, even when the underlying assumptions of these methods are not consistent with the actual anatomy. Failure to account for the anatomical variability in the analysis degrades the ability to reliably localize and accurately quantify brain regions in individual subjects. Although characterizing anatomical variability of the brain "on a whole" is desirable, it might not be feasible given an almost infinite number of anatomical configurations. However, when focusing on specific local brain regions, regional anatomical variability can often be described by discrete anatomical variants and thus can be characterized and modeled by multi-template analysis. This dissertation focuses on the human perirhinal cortex (PRC) in brain MRI. PRC is located in the medial temporal lobe (MTL) and plays important roles in semantic memory, episodic memory and visual processing systems. In addition, pathology studies have found that the PRC is the first site in the cortex that is affected by neurofibrillary tangle (NFT) pathology, the hallmark of Alzheimer's disease (AD) that is more directly linked to neurodegeneration. Thus, accurate quantification of morphometry features of the PRC may have important utility in diagnosis and monitoring of early AD, as well as brain-behavior studies in the MTL. Probably due to its large anatomical variability, PRC is surprisingly overlooked by the biomedical image analysis literature. What makes PRC an ideal structure for multi-template analysis is that 97% of its anatomical variability can be accounted by three discrete anatomical variants, defined by the depth and the branching pattern of the anterior portion of the collateral sulcus (CS) adjacent to the PRC.In this dissertation, I introduced a novel multi-template analysis pipeline for the PRC in structural brain MRI. Anatomical variants of the PRC are identified automatically from structural MRI scans. Then, we explicitly construct a template and model anatomical variability for each anatomical variant. Experimental results show that the proposed technique is able to generate templates that recover the dominant discrete variants of the PRC and establish more meaningful correspondences between subjects than a single-template approach. In the application of discriminating AD patients from cognitively normal adults, the proposed pipeline generates measurements that are more sensitive to disease status and yields results that are consistent with the patterns of NFT pathology distribution.In addition, since the cortex is organized like a sheet, it is likely that the location of the earliest NFT pathology within the PRC is itself variable across different anatomical subtypes. By applying the proposed multi-template analysis pipeline to a large dataset with subjects at different stages of the AD spectrum, we find, for the first time, discrete patterns of spatial distribution of cortical thinning between anatomical variants. Incorporating this variability in future studies will likely further improve the sensitivity of MRI-derived measures of the PRC to early detection and monitoring of AD.
Download or read book Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support written by M. Jorge Cardoso and published by Springer. This book was released on 2017-09-07 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed joint proceedings of the Third International Workshop on Deep Learning in Medical Image Analysis, DLMIA 2017, and the 6th International Workshop on Multimodal Learning for Clinical Decision Support, ML-CDS 2017, held in conjunction with the 20th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2017, in Québec City, QC, Canada, in September 2017. The 38 full papers presented at DLMIA 2017 and the 5 full papers presented at ML-CDS 2017 were carefully reviewed and selected. The DLMIA papers focus on the design and use of deep learning methods in medical imaging. The ML-CDS papers discuss new techniques of multimodal mining/retrieval and their use in clinical decision support.
Download or read book Shape in Medical Imaging written by Martin Reuter and published by Springer. This book was released on 2018-11-22 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the proceedings of the Workshop on Shape in Medical Imaging, ShapeMI 2018, held in conjunction with the 21st International Conference on Medical Image Computing, MICCAI 2018, in Granada, Spain, in September 2018. The 26 full papers and 2 short papers presented were carefully reviewed and selected for inclusion in this volume. The papers discuss novel approaches and applications in shape and geometry processing and their use in research and clinical studies and explore novel, cutting-edge theoretical methods and their usefulness for medical applications, e.g., from the fields of geometric learning or spectral shape analysis.
Download or read book Deciphering the biomarkers of Alzheimer s disease written by Yu Chen and published by Frontiers Media SA. This book was released on 2022-02-11 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Space Time and Memory in the Hippocampal Formation written by Dori Derdikman and published by Springer. This book was released on 2014-07-08 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of new cell types, such as grid and time cells, in the hippocampus has been accompanied by major anatomical and theoretical insights in the recent years. This book provides comprehensive, up-to-date information about the hippocampal formation and especially the neural basis of episodic memory, spatial location (the formation of the cognitive map) and temporal representation. The first part of the book describes the information flow from pre-hippocampal areas into the hippocampus, the second part discusses the different types of hippocampal processing and finally, the third part depicts the influence that the hippocampal processing has on other brain structures that are perhaps more closely tied to explicit cognitive or behavioral output. This book is intended for neuroscientists, especially for those who are involved in research on the hippocampus, as well as for behavioral scientists and neurologists.
Download or read book fMRI written by Stephan Ulmer and published by Springer Science & Business Media. This book was released on 2013-06-12 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades, fMRI has evolved into an invaluable clinical tool for routine brain imaging. This book provides a state of the art overview of fMRI and its use in clinical practice. Experts in the field share their knowledge and explain how to overcome diverse potential technical barriers and problems. Starting from the very basics on the origin of the BOLD signal, the book covers technical issues, anatomical landmarks, the full range of clinical applications, methods of statistical analysis, and special issues in various clinical fields. Comparisons are made with other brain mapping techniques, such as DTI, PET, TMS, EEG, and MEG, and their combined use with fMRI is also discussed. Since the first edition, original chapters have been updated and new chapters added, covering both novel aspects of analysis and further important clinical applications.
Download or read book Collaborative Efforts for Understanding the Human Brain written by Sook-Lei Liew and published by Frontiers Media SA. This book was released on 2019-10-10 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human brain is incredibly complex, and the more we learn about it, the more we realize how much we need a truly interdisciplinary team to make sense of its intricacies. This eBook presents the latest efforts in collaborative team science from around the world, all aimed at understanding the human brain.
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Download or read book The Superficial Veins of the Human Brain written by Henri M. Duvernoy and published by Springer. This book was released on 1975 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Parahippocampal Region written by Menno P. Witter and published by Oxford University Press, USA. This book was released on 2002 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent dramatic advances in imaging technologies have enabled researchers to build on the evidence obtained from lesion and behavioural studies to propose a new range of functions for the parahippocampal region. It is now possible to image the region in healthy human subjects and todefine the pathological changes occurring during the early phases of a range of neurologic and psychiatric conditions.The results have uncovered evidence suggesting that the region plays an important role in the higher cognitive processes of learning and memory, and in specific brain diseases, including Alzheimer's disease, schizophrenia and epilepsy, as well as in the aging process itself.The Parahippocampal Region: Organization and Role in Cognitive Functions examines the architecture and activity of this section of the temporal lobe, describes the systems active in memory, perception and behaviour, and outlines the significance of its involvement in the progress of a range ofdisease states. It provides an overview of our current basic and clinical knowledge and a baseline for further expansion of the functional understanding of the region.With contributions from an international team of authors this book will be of interest to neuroscientists, researchers and practitioners from the fields of neuropsychology, neurology and psychiatry, as well as to students from these disciplines.
Download or read book Neuroimaging Part II written by and published by Newnes. This book was released on 2016-07-12 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimaging, Part Two, a volume in The Handbook of Clinical Neurology series, illustrates how neuroimaging is rapidly expanding its reach and applications in clinical neurology. It is an ideal resource for anyone interested in the study of the nervous system, and is useful to both beginners in various related fields and to specialists who want to update or refresh their knowledge base on neuroimaging. This second volume covers imaging of the adult spine and peripheral nervous system, as well as pediatric neuroimaging. In addition, it provides an overview of the differential diagnosis of the most common imaging findings, such as ring enhancement on MRI, and a review of the indications for imaging in the most frequent neurological syndromes. The volume concludes with a review of neuroimaging in experimental animals and how it relates to neuropathology. It brings broad coverage of the topic using many color images to illustrate key points. Contributions from leading global experts are collated, providing the broadest view of neuroimaging as it currently stands. For a number of neurological disorders, imaging is not only critical for diagnosis, but also for monitoring the effect of therapies, with the entire field moving from curing diseases to preventing them. Most of the information contained in this volume reflects the newness of this approach, pointing to the new horizon in the study of neurological disorders. Provides a relevant description of the technologies used in neuroimaging, such as computed tomography, magnetic resonance imaging, positron emission tomography, and several others Discusses the application of these techniques to the study of brain and spinal cord disease Explores the indications for the use of these techniques in various syndromes
Download or read book A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates written by Kadharbatcha S. Saleem and published by Academic Press. This book was released on 2012-04-23 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, Second Edition maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This edition of the atlas is unlike anything else available as it includes the detailed cyto- and chemoarchitectonic delineations of the brain areas in all three planes of sections (horizontal, coronal, and sagittal) that are derived from the same animal. This is a significant progress because in functional imaging studies, such as fMRI, both the horizontal and sagittal planes of sections are often the preferred planes given that multiple functionally active regions can be visualized simultaneously in a single horizontal or sagittal section. This combined MRI and histology atlas is designed to provide an easy-to-use reference for anatomical and physiological studies in macaque monkeys, and in functional-imaging studies in human and non-human primates using fMRI and PET. The first rhesus monkey brain atlas with horizontal, coronal, and sagittal planes of sections, derived from the same animal Shows the first detailed delineations of the cortical and subcortical areas in horizontal, coronal, and sagittal plane of sections in the same animal using different staining methods Horizonal series illustrates the dorsoventral extent of the left hemisphere in 47 horizontal MRI and photomicrographic sections matched with 47 detailed diagrams (Chapter 3) Coronal series presents the full rostrocaudal extent of the right hemisphere in 76 coronal MRI and photomicrographic sections, with 76 corresponding drawings (Chapter 4) Sagittal series shows the complete mediolateral extent of the left hemisphere in 30 sagittal MRI sections, with 30 corresponding drawings (Chapter 5). The sagittal series also illustrates the location of different fiber tracts in the white matter Individual variability - provides selected cortical and subcortical areas in three-dimensional MRI (horizontal, coronal, and sagittal MRI planes). For comparison, it also provides similar areas in coronal MRI section in six other monkeys. (Chapter 6) Vasculature - indicates the corresponding location of all major blood vessels in horizontal, coronal, and sagittal series of sections Provides updated information on the cortical and subcortical areas, such as architectonic areas and nomenclature, with references, in chapter 2 Provides the sterotaxic grid derived from the in-vivo MR image
Download or read book Oxford Textbook of Cognitive Neurology and Dementia written by Masud Husain and published by Oxford University Press. This book was released on 2018-10-29 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. It is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.
Download or read book Imaging Biomarkers in Epilepsy written by Andrea Bernasconi and published by Cambridge University Press. This book was released on 2019-01-10 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.
Download or read book Medical Image Computing and Computer Assisted Intervention MICCAI 2014 written by Polina Golland and published by Springer. This book was released on 2014-08-31 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three-volume set LNCS 8673, 8674, and 8675 constitutes the refereed proceedings of the 17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, held in Boston, MA, USA, in September 2014. Based on rigorous peer reviews, the program committee carefully selected 253 revised papers from 862 submissions for presentation in three volumes. The 53 papers included in the third volume have been organized in the following topical sections: shape and population analysis; brain; diffusion MRI; and machine learning.
Download or read book The Temporal Lobe and Limbic System written by Pierre Gloor and published by . This book was released on 1997 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the detailed anatomy, physiology, and clinical aspects of the temporal lobe and the limbic system, this monograph makes a timely appearance because of the widespread interest in this subject in relation to epilepsy, Alzheimer's disease, and schizophrenia. The structural and functional information serves as an important foundation for the detailed anatomical knowledge necessary for the interpretation of imaging. The components of the temporal lobe are characterized. The temporal isocortex is considered from the point of view of its principal cellular constituents, connectivity, columnar organization, and how the cortex embodies experience. The cortical association areas for vision, audition, degustation, visceral sensory function, and olfaction are treated in detail, and the cortical area of the temporal lobe relating to speech is discussed. The structure of the insula, the temporal cortex, and its connectivity to the thalamus, pulvinar, striatum, and claustrum are described thoroughly. A chapter reviews the structure, connections and functions of the olfactory system, as well as its social aspects and pathological conditions. The largest chapter deals with the hippocampus--its anatomy and connections, its cellular architectonics, its relation to memory, and its varied functions. The final chapter details the amygdala, its connections, and its significant role in temporal lobe seizures.
Download or read book Microstructural Parcellation of the Human Cerebral Cortex written by Stefan Geyer and published by Springer Science & Business Media. This book was released on 2013-07-04 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unraveling the functional properties of structural elements in the brain is one of the fundamental goals of neuroscientific research. In the cerebral cortex this is no mean feat, since cortical areas are defined microstructurally in post-mortem brains but functionally in living brains with electrophysiological or neuroimaging techniques – and cortical areas vary in their topographical properties across individual brains. Being able to map both microstructure and function in the same brains noninvasively in vivo would represent a huge leap forward. In recent years, high-field magnetic resonance imaging (MRI) technologies with spatial resolution below 0.5 mm have set the stage for this by detecting structural differences within the human cerebral cortex, beyond the Stria of Gennari. This provides the basis for an in vivo microanatomical brain map, with the enormous potential to make direct correlations between microstructure and function in living human brains. This book starts with Brodmann’s post-mortem map published in the early 20th century, moves on to the almost forgotten microstructural maps of von Economo and Koskinas and the Vogt-Vogt school, sheds some light on more recent approaches that aim at mapping cortical areas noninvasively in living human brains, and culminates with the concept of “in vivo Brodmann mapping” using high-field MRI, which was introduced in the early 21st century.
