Download or read book Multi organ Finite Element Modeling of the Human Heart with Ventricular arterial Interactions written by Sheikh Mohammad Shavik and published by . This book was released on 2019 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computer heart models with realistic description of cardiac geometry and muscle architecture have advanced significantly over the years. Despite these significant advancements, there are nevertheless, some unresolved issues and aspects that need improvements. The goal of this dissertation was to address some of those issues as well as to develop new computational modeling framework to understand the underlying mechanics in heart failure with preserved ejection fraction (HFpEF) and pulmonary arterial hypertension (PAH). Clinical studies have found that global longitudinal strain is reduced in HFpEF, suggesting that LV contractility is impaired in this syndrome. This finding is, however, contradicted and confounded, respectively, by findings that end-systolic elastance (Ees) and systolic blood pressure (SBP) are typically also increased in HFpEF. To reconcile these issues, we developed and validated a multiscale computational modeling framework consisting of detailed cell‐based descriptors of the cross‐bridge cycling against well‐established organ‐level physiological behaviors. This framework is then used to isolate the effects of HFpEF features in affecting systolic function metrics by quantifying the effects on Ees and myocardial strains due to 1) changes in LV geometry found in HFpEF patients, 2) active tension developed by the tissue (Tref), and 3) afterload. Our study suggests that it is likely that the LV contractility as indexed by the tissue's active tension is reduced in HFpEF patients. Right ventricular assist device (RVAD) has been considered as a treatment option for the end-stage pulmonary arterial hypertension (PAH) patients, but, its effects on biventricular mechanics are, however, largely unknown. To address this issue, we developed an image-based modeling framework consisting of a biventricular finite element (FE) model that is coupled to a lumped model describing the pulmonary and systemic circulations in a closed-loop system. Our results showed that RVAD unloads the RV, improves cardiac output and increases septum curvature, which are more pronounced in the PAH patient with severe RV remodeling. These improvements, however, are also accompanied by an adverse increase in the PA pressure, suggesting that the RVAD implantation may need to be optimized depending on disease progression. While it has long been recognized that bi-directional interaction between the heart and vasculature plays a critical role in the pathophysiological process of HFpEF and PAH, a comprehensive study of this interaction is hampered by a lack of modeling framework capable of simultaneously accommodating high-resolution models of the heart and vasculature. To address this issue, we developed a computational modeling framework that couples FE models of the LV and aorta to simulate ventricular-arterial coupling in the systemic circulation. We show that the model is able to capture the physiological behaviors in both the LV and aorta that are consistent with in vivo measurements. We also showed that the framework can reasonably predict the effects of changes in geometry and microstructural details the two compartments have on each other. The model is extended to accommodate a biventricular FE heart model together with FE models of the aorta and pulmonary artery to simulate the ventricular-vascular interactions in both systemic and pulmonary circulation.
Download or read book Patient Specific Finite Element Modeling of the Blood Flow in the Left Ventricle of a Human Heart written by Jeannette Hiromi Spühler and published by . This book was released on 2017 with total page 51 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mathematical Modeling of Cardiovascular Systems From Physiology to the Clinic written by Julius Guccione and published by Frontiers Media SA. This book was released on 2020-01-13 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modelling the Human Cardiac Fluid Mechanics written by Herbert Oertel (jr.) and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: We present a virtual heart model simulating the flow in the left human ventricle and in the aorta. Because of the lack of in vivo structure data of the human ventricle, the active ventricle movement is given by a time-dependent ventricle model that is derived from in vivo image data of a nuclear spin MRT tomograph of a healthy human heart. The passive part of the virtual heart model consists of a model aorta and vena cava, and of heart valves. As the movement is due to the flow in the inactive region of the heart, a coupling of flow and structure is necessary in the model to take into account the deviation of the aorta and the closing and opening of the heart valves. The flow calculation is performed with a finite volume method, while the structure of the aorta is calculated using the finite element method. The flow resistance of the time simulation in the body is taken into account with a circulation model. In the outlook of the article, we show how the virtual heart model can be used to predict flow losses due to pathological ventricle contraction defects in an unhealthy human heart.
Download or read book Finite Element Analysis of the Left Ventricle of the Human Heart written by Puja Lakshmi and published by . This book was released on 2003 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Hemodynamics for the Clinician written by George A. Stouffer and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular Hemodynamics for the Clinician, 2nd Edition, provides a useful, succinct and understandable guide to the practical application of hemodynamics in clinical medicine for all trainees and clinicians in the field. Concise handbook to help both practicing and prospective clinicians better understand and interpret the hemodynamic data used to make specific diagnoses and monitor ongoing therapy Numerous pressure tracings throughout the book reinforce the text by demonstrating what will be seen in daily practice Topics include coronary artery disease; cardiomyopathies; valvular heart disease; arrhythmias; hemodynamic support devices and pericardial disease New chapters on TAVR, ventricular assist devices, and pulmonic valve disease, expanded coverage of pulmonary hypertension, fractional flow reserve, heart failure with preserved ejection fraction and valvular heart disease Provides a basic overview of circulatory physiology and cardiac function followed by detailed discussion of pathophysiological changes in various disease states
Download or read book Snapshots of Hemodynamics written by Nico Westerhof and published by Springer Science & Business Media. This book was released on 2006-01-12 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemodynamics makes it possible to characterize in a quantitative way, the function of the heart and arterial system, thereby producing information about what genetic and molecular processes are of importance for cardiovascular function. Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education by Nico Westerhof, Nikos Stergiopulos and Mark I. M. Noble is a quick reference guide designed to help basic and clinical researchers as well as graduate students to understand hemodynamics. The layout of the book provides short and independent chapters that provide teaching diagrams as well as clear descriptions of the essentials of basic and applied principles of hemodynamics. References are provided at the end of each chapter for further reading and reference.
Download or read book Network physiology insights in systems interactions and organ networks 2021 written by Plamen Ch. Ivanov and published by Frontiers Media SA. This book was released on 2023-06-06 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Numerical Models for Differential Problems written by Alfio Quarteroni and published by Springer Science & Business. This book was released on 2014-04-25 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this text, we introduce the basic concepts for the numerical modelling of partial differential equations. We consider the classical elliptic, parabolic and hyperbolic linear equations, but also the diffusion, transport, and Navier-Stokes equations, as well as equations representing conservation laws, saddle-point problems and optimal control problems. Furthermore, we provide numerous physical examples which underline such equations. We then analyze numerical solution methods based on finite elements, finite differences, finite volumes, spectral methods and domain decomposition methods, and reduced basis methods. In particular, we discuss the algorithmic and computer implementation aspects and provide a number of easy-to-use programs. The text does not require any previous advanced mathematical knowledge of partial differential equations: the absolutely essential concepts are reported in a preliminary chapter. It is therefore suitable for students of bachelor and master courses in scientific disciplines, and recommendable to those researchers in the academic and extra-academic domain who want to approach this interesting branch of applied mathematics.
Download or read book Cardiac Mechano Electric Coupling and Arrhythmias written by Peter Kohl and published by OUP Oxford. This book was released on 2011-08-25 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.
Download or read book Patient Specific Modeling of the Cardiovascular System written by Roy C.P. Kerckhoffs and published by Springer Science & Business Media. This book was released on 2010-09-03 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.
Download or read book Cardiovascular Mathematics written by Luca Formaggia and published by Springer Science & Business Media. This book was released on 2010-06-27 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.
Download or read book Computational Methods in Cardiac Electrophysiology written by Matthijs Cluitmans and published by Frontiers Media SA. This book was released on 2023-07-06 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nonlinear Continuum Mechanics for Finite Element Analysis written by Javier Bonet and published by Cambridge University Press. This book was released on 1997-09-28 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unified treatment of nonlinear continuum analysis and finite element techniques.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Conduction System Of The Mammalian Heart The An Anatomico histological Study Of The Atrioventricular Bundle And The Purkinje Fibers written by Sunao Tawara and published by World Scientific. This book was released on 2000-05-25 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sunao Tawara's epoch-making work on the excitation conduction system of the mammalian heart paved the way for the advancement of modern cardiology in the 20th century. Even today, more than 90 years after the publication of the German monograph “Das Reizleitungssystem des Säugetierherzen”, his precise account of the conduction system from the atrioventricular node through the His-Purkinje system to the ordinary ventricular muscle fibers retains all of its original actuality.This English edition of Tawara's monograph will serve as an invaluable reference for both basic and clinical cardiological research in the years ahead.
Download or read book Applied Mechanics Reviews written by and published by . This book was released on 1994 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
