Download or read book Multi dimensional characterization of neuropsychiatric disorders written by Peng Wang and published by Frontiers Media SA. This book was released on 2023-01-03 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Statistical Methods for Evaluating Relational Structures in Multi dimensional Phenotypic Data for Neuropsychiatric Disorders written by Hung-Hsiu Vivian Shih and published by . This book was released on 2013 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: While awareness and detection of neuropsychiatric disorders have been on the rise since the mid-twentieth century, current diagnostic approaches lack laboratory-based support from genetic, neuroscientific, and behavioral research. The emerging field of phenomics increases the pace of discoveries in neuropsychiatry by examining physical and biochemical traits (i.e., phenotypes) of mental health disorders. Often the phenotypes measured in psychiatry include a multiplicity of data types such as clinical symptoms, behaviors, neurocognitive performance, or imaging data. However, the high-dimensionality problem often occurs in the test batteries and hinders simple interpretations of the characterizing patterns of phenotypic data. In this dissertation, I describe, develop, and implement a collection of statistical methods to evaluate relational structures in multi-dimensional phenotypic data for neuropsychiatric disorders. Complexities in high-dimensional data require sophisticated statistical tools to disentangle and extract the true underlying structures effectively. Adaptive shrinkage techniques and sparse covariance estimation reduce the effective dimensionality of the data, producing more stable or parsimonious final models. Graphical models provide visual representations of the sparse structures in the data using conditional relationships among the variables. Joint graphical models have the additional advantage of revealing common as well as distinct patterns within and across multiple groups (e.g., diagnoses, treatments, symptom severity, or time points). The analytical methods in this dissertation were motivated by the large p, small n problem often encountered in psychiatric data. The goal of phenomics is to establish sets of characterizing features that may be shared among multiple neuropsychiatric disorders. This is particularly important as comorbidity is now being recognized as the norm rather than the exception in the mental health field. However, the large number of interrelated measurements makes it difficult to interpret mutual and distinct characteristics across disorders. This dissertation evaluates high-dimensional relational structures of phenotypic data through two projects conducted in the UCLA Semel Institute of Neuroscience and Human Behavior. The Time Reproduction in Neurodevelopmental Disorders (TRIND) project concentrates on a single construct called temporal processing. I applied a range of statistical methods to these data including repeated measures mixed effects models, joint graphical models, cluster analysis, and functional data analysis. Collectively, these approaches suggest that temporal processing abilities are multi-dimensional rather than a single latent construct. The Centers for Intervention Development and Applied Research: Translational Research to Enhance Cognitive Control (CIDAR-TRECC) is a much broader study assessing a multitude of neurocognitive constructs. Adaptive shrinkage techniques as well as joint graphical models help extract similarities and differences in the relational structures of neurocognition for children with neurodevelopmental disorders. I further extended the conventional joint graphical models algorithm to handle multiple groups over time. In many ways, the taxonomic versus dimensional controversy in psychiatry is analogous to categorical versus continuous variables in statistics. There is no universal solution. In some situations, a continuous variable may describe a relationship more accurately, whereas other situations require a categorical viewpoint. Similarly, factor analysis may be preferred over Gaussian graphical models under one setting (e.g., to create a summary score) but fail in another (e.g., as a discriminatory tool). Simulations at the end of this dissertation show that there is no single answer. The optimal method depends not only on the pattern of the data, but also the objective of the study. The future of characterizing and treating neuropsychiatric disorders ought to be one which supports a comprehensive, synergistic viewpoint across both taxonomic and dimensional analyses using the appropriate data- and objective-driven statistical methods which successively disentangles the multi-dimensional constructs in phenotypic data.
Download or read book Pattern Analysis of the Human Connectome written by Dewen Hu and published by Springer. This book was released on 2020-11-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent advances in pattern analysis of the human connectome. The human connectome, measured by magnetic resonance imaging at the macroscale, provides a comprehensive description of how brain regions are connected. Based on machine learning methods, multiviarate pattern analysis can directly decode psychological or cognitive states from brain connectivity patterns. Although there are a number of works with chapters on conventional human connectome encoding (brain-mapping), there are few resources on human connectome decoding (brain-reading). Focusing mainly on advances made over the past decade in the field of manifold learning, sparse coding, multi-task learning, and deep learning of the human connectome and applications, this book helps students and researchers gain an overall picture of pattern analysis of the human connectome. It also offers valuable insights for clinicians involved in the clinical diagnosis and treatment evaluation of neuropsychiatric disorders.
Download or read book Mental Disorders and Disabilities Among Low Income Children written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2015-10-28 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Children living in poverty are more likely to have mental health problems, and their conditions are more likely to be severe. Of the approximately 1.3 million children who were recipients of Supplemental Security Income (SSI) disability benefits in 2013, about 50% were disabled primarily due to a mental disorder. An increase in the number of children who are recipients of SSI benefits due to mental disorders has been observed through several decades of the program beginning in 1985 and continuing through 2010. Nevertheless, less than 1% of children in the United States are recipients of SSI disability benefits for a mental disorder. At the request of the Social Security Administration, Mental Disorders and Disability Among Low-Income Children compares national trends in the number of children with mental disorders with the trends in the number of children receiving benefits from the SSI program, and describes the possible factors that may contribute to any differences between the two groups. This report provides an overview of the current status of the diagnosis and treatment of mental disorders, and the levels of impairment in the U.S. population under age 18. The report focuses on 6 mental disorders, chosen due to their prevalence and the severity of disability attributed to those disorders within the SSI disability program: attention-deficit/hyperactivity disorder, oppositional defiant disorder/conduct disorder, autism spectrum disorder, intellectual disability, learning disabilities, and mood disorders. While this report is not a comprehensive discussion of these disorders, Mental Disorders and Disability Among Low-Income Children provides the best currently available information regarding demographics, diagnosis, treatment, and expectations for the disorder time course - both the natural course and under treatment.
Download or read book Complex Systems Science in Biomedicine written by Thomas Deisboeck and published by Springer Science & Business Media. This book was released on 2007-06-13 with total page 857 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
Download or read book Re Visioning Psychiatry written by Laurence J. Kirmayer and published by Cambridge University Press. This book was released on 2015-07-29 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revisioning Psychiatry brings together new perspectives on the causes and treatment of mental health problems. The contributors emphasize the importance of understanding experience and explore how the brain, the person, and the social world interact to give rise to mental health problems as well as resilience and recovery.
Download or read book The Boundaries of Consciousness Neurobiology and Neuropathology written by Steven Laureys and published by Elsevier. This book was released on 2006-06-09 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consciousness is one of the most significant scientific problems today. Renewed interest in the nature of consciousness - a phenomenon long considered not to be scientifically explorable, as well as increasingly widespread availability of multimodal functional brain imaging techniques (EEG, ERP, MEG, fMRI and PET), now offer the possibility of detailed, integrated exploration of the neural, behavioral, and computational correlates of consciousness. The present volume aims to confront the latest theoretical insights in the scientific study of human consciousness with the most recent behavioral, neuroimaging, electrophysiological, pharmacological and neuropathological data on brain function in altered states of consciousness such as: brain death, coma, vegetative state, minimally conscious state, locked-in syndrome, dementia, epilepsy, schizophrenia, hysteria, general anesthesia, sleep, hypnosis, and hallucinations. The interest of this is threefold. First, patients with altered states of consciousness continue to represent a major clinical problem in terms of clinical assessment of consciousness and daily management. Second, the exploration of brain function in altered states of consciousness represents a unique lesional approach to the scientific study of consciousness and adds to the worldwide effort to identify the "neural correlate of consciousness". Third, new scientific insights in this field have major ethical and social implications regarding our care for these patients.
Download or read book Understanding Neuropsychiatric Disorders written by Martha E. Shenton and published by Cambridge University Press. This book was released on 2010-12-09 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: An informative and comprehensive review from the leading researchers in the field, this book provides a complete one-stop guide to neuroimaging techniques and their application to a wide range of neuropsychiatric disorders. For each disorder or group of disorders, separate chapters review the most up-to-date findings from structural imaging, functional imaging and/or molecular imaging. Each section ends with an overview from a internationally-renowned luminary in the field, addressing the question of 'What do we know and where are we going?' Richly illustrated throughout, each chapter includes a 'summary box', providing readers with explicit take-home messages. This is an essential resource for clinicians, researchers and trainees who want to learn how neuroimaging tools lead to new discoveries about brain and behaviour associations in neuropsychiatric disorders.
Download or read book Molecular Neuropathology written by Gareth W. Roberts and published by Cambridge University Press. This book was released on 1995-06-08 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.
Download or read book Psychiatric Neuroimaging written by Virginia Ng and published by IOS Press. This book was released on 2003 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropsychological Assessment of Neuropsychiatric Disorders written by Igor Grant and published by Oxford University Press, USA. This book was released on 1996 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 1996 survey of the members of the American Board of Professional Psychology Diplomates, published by The Clinical Neuropsychologist journal, selected the first edition of this book as one of the "Essential Books and Journals in North American Clinical Neuropsychology"--a list which included only 10 other titles! The Second Edition has improved further on this high standard. While the authors have retained the same general structure--with the addition of a set of three chapters on psychosocial outcomes--virtually the entire book has been rewritten and thoroughly updated to reflect recent developments in this area of knowledge. Part I features new chapters on the Iowa-Benton approach, on cognitive screening methods, and on computers and memory. Part II has been expanded with new chapters on Tourette's syndrome, acute and chronic hypoxemia, HIV infection, schizophrenia, Huntington's disease, and an expanded chapter on Parkinson's disease. Part III is entirely new, and it focuses on life quality outcome in head injury and pulmonary disease. Considerably enlarged in size, this book will remain the basic reference on the neuropsychological aspects of diseases affecting brain and behavior.
Download or read book Drug Repurposing in Neurodegenerative and Neuropsychiatric Disorders written by Anna R. Carta and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mapping the connectome Multi level analysis of brain connectivity written by Trygve B. Leergaard and published by Frontiers E-books. This book was released on with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rapid Eye Movement Sleep written by MallIck/Inoue and published by CRC Press. This book was released on 1999-06-29 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference also includes nine color plates. Written by leading international scientists in the field, this comprehensive and up-to-date reference provides detailed coverage of various aspects of rapid eye movement sleep (REMS)-including phylogeny and evolution, ontogeny, neurophysiological and neurochemical phenomena, molecular processes, behavioral and physiological changes due to deprivation, and hypotheses on the neurodynamics of REMS. Examining the relationship between the neocortex in mammals and birds in the evolution of REM sleep, Rapid Eye Movement Sleep considers the roles of REMS in the maturation of the brain reveals a new theory that challenges the assumption that REM is solely initiated by bulbar mechanisms in intact animals explores experimental studies of REMS atonia and the mechanisms underlying tonic and phasic muscle atonia describes the cellular and molecular mechanisms and function of pontine ponto-geniculo-occipatal waves during REMS details the role of nitric oxide in the regulation of REMS summarizes new evidence on which neurotransmitters are responsible for the REMS generating mechanism presents an overview of several endogenous sleep substances that may positively or negatively regulate REMS and more. Rapid Eye Movement Sleep serves as essential reading for all researchers and clinicians in the study of sleep science, particularly physiologists and biologists; neurologists, neuropsychiatrists, psychiatrists, and psychologists; anesethiologists; and pharmacologists.
Download or read book MultiMedia Modeling written by Ioannis Kompatsiaris and published by Springer. This book was released on 2018-12-20 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set LNCS 11295 and 11296 constitutes the thoroughly refereed proceedings of the 25th International Conference on MultiMedia Modeling, MMM 2019, held in Thessaloniki, Greece, in January 2019. Of the 172 submitted full papers, 49 were selected for oral presentation and 47 for poster presentation; in addition, 6 demonstration papers, 5 industry papers, 6 workshop papers, and 6 papers for the Video Browser Showdown 2019 were accepted. All papers presented were carefully reviewed and selected from 204 submissions.
Download or read book Bioinformatics and Biomarker Discovery written by Francisco Azuaje and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of "omic" data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations
Download or read book The heterogeneity of neuropsychiatric disorders written by Lu Liu and published by Frontiers Media SA. This book was released on 2023-02-10 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
