Download or read book MTT written by Richard Jameson and published by Xlibris Corporation. This book was released on 2014-08-05 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Four new candidates for positions as Observers in the Metaphysical Time Travel (MTT) Organization arrive at the organizations principal facility. They come under the influence of the primary management team at the facility and begin their training. This novel is about the people involved in the facility and its satellite organizations. As the candidates progress through the learning process their development reflects the paths being carved by their linear choices. These choices are impacted by a mixture of rational and irrational decisions and the resultant interactions with each other and the existing facility staff. Everyone has a past, a present and a future. The facility staff includes, Dr. Anne Cleary, the founder of the MTT organization. Her life is extensively intertwined with the other staff members and the novel allows us to examine some of the key moments in the life of Dr. Cleary and her staff. A crucial time in the future is discovered. It changes everything about how the MTT organization will have to function. It also impacts each of the individuals by forcing them to consider their own mortality. These are mostly good people in a challenging environment. Humor is their salvation in most cases. Anne Cleary has created an organization of caring and committed individuals. This novel lets you meet the key players and a selection of the more individual walk on parts.

Download or read book Cancer Cell Culture written by Ian A. Cree and published by Humana Press. This book was released on 2016-08-23 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: With many recent advances, cancer cell culture research is more important than ever before. This timely edition of Cancer Cell Culture: Methods and Protocols covers the basic concepts of cancer cell biology and culture while expanding upon the recent shift in cell culture methods from the generation of new cell lines to the use of primary cells. There are methods to characterize and authenticate cell lines, to isolate and develop specific types of cancer cells, and to develop new cell line models. Functional assays are provided for the evaluation of clonogenicity, cell proliferation, apoptosis, adhesion, migration, invasion, senescence, angiogenesis, and cell cycle parameters. Other methods permit the modification of cells for transfection, drug resistance, immortalization, and transfer in vivo, the co-culture of different cell types, and the detection and treatment of contamination. In this new edition, specific emphasis is placed on safe working practice for both cells and laboratory researchers. These chapters contain the information critical to success – only by good practice and quality control will the results of cancer cell culture improve. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Cancer Cell Culture: Methods and Protocols serves as a practical guide for scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this research field.

Download or read book Chemosensitivity Testing in Oncology written by Uwe Reinhold and published by Springer Science & Business Media. This book was released on 2002-10-31 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

Download or read book Advances and Applications of DSmT for Information Fusion Collected Works Volume 5 written by Florentin Smarandache and published by Infinite Study. This book was released on 2023-12-27 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth volume on Advances and Applications of DSmT for Information Fusion collects theoretical and applied contributions of researchers working in different fields of applications and in mathematics, and is available in open-access. The collected contributions of this volume have either been published or presented after disseminating the fourth volume in 2015 (available at fs.unm.edu/DSmT-book4.pdf or www.onera.fr/sites/default/files/297/2015-DSmT-Book4.pdf) in international conferences, seminars, workshops and journals, or they are new. The contributions of each part of this volume are chronologically ordered. First Part of this book presents some theoretical advances on DSmT, dealing mainly with modified Proportional Conflict Redistribution Rules (PCR) of combination with degree of intersection, coarsening techniques, interval calculus for PCR thanks to set inversion via interval analysis (SIVIA), rough set classifiers, canonical decomposition of dichotomous belief functions, fast PCR fusion, fast inter-criteria analysis with PCR, and improved PCR5 and PCR6 rules preserving the (quasi-)neutrality of (quasi-)vacuous belief assignment in the fusion of sources of evidence with their Matlab codes. Because more applications of DSmT have emerged in the past years since the apparition of the fourth book of DSmT in 2015, the second part of this volume is about selected applications of DSmT mainly in building change detection, object recognition, quality of data association in tracking, perception in robotics, risk assessment for torrent protection and multi-criteria decision-making, multi-modal image fusion, coarsening techniques, recommender system, levee characterization and assessment, human heading perception, trust assessment, robotics, biometrics, failure detection, GPS systems, inter-criteria analysis, group decision, human activity recognition, storm prediction, data association for autonomous vehicles, identification of maritime vessels, fusion of support vector machines (SVM), Silx-Furtif RUST code library for information fusion including PCR rules, and network for ship classification. Finally, the third part presents interesting contributions related to belief functions in general published or presented along the years since 2015. These contributions are related with decision-making under uncertainty, belief approximations, probability transformations, new distances between belief functions, non-classical multi-criteria decision-making problems with belief functions, generalization of Bayes theorem, image processing, data association, entropy and cross-entropy measures, fuzzy evidence numbers, negator of belief mass, human activity recognition, information fusion for breast cancer therapy, imbalanced data classification, and hybrid techniques mixing deep learning with belief functions as well. We want to thank all the contributors of this fifth volume for their research works and their interests in the development of DSmT, and the belief functions. We are grateful as well to other colleagues for encouraging us to edit this fifth volume, and for sharing with us several ideas and for their questions and comments on DSmT through the years. We thank the International Society of Information Fusion (www.isif.org) for diffusing main research works related to information fusion (including DSmT) in the international fusion conferences series over the years. Florentin Smarandache is grateful to The University of New Mexico, U.S.A., that many times partially sponsored him to attend international conferences, workshops and seminars on Information Fusion. Jean Dezert is grateful to the Department of Information Processing and Systems (DTIS) of the French Aerospace Lab (Office National d’E´tudes et de Recherches Ae´rospatiales), Palaiseau, France, for encouraging him to carry on this research and for its financial support. Albena Tchamova is first of all grateful to Dr. Jean Dezert for the opportunity to be involved during more than 20 years to follow and share his smart and beautiful visions and ideas in the development of the powerful Dezert-Smarandache Theory for data fusion. She is also grateful to the Institute of Information and Communication Technologies, Bulgarian Academy of Sciences, for sponsoring her to attend international conferences on Information Fusion.

Download or read book Modern Alkaloids written by Ernesto Fattorusso and published by John Wiley & Sons. This book was released on 2007-12-03 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis. A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.

Download or read book The Wiley Blackwell Handbook of Group Psychotherapy written by Jeffrey L. Kleinberg and published by John Wiley & Sons. This book was released on 2015-06-22 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group Psychotheraphy “Finally, we have a book about group therapy that answers the question, ‘Is there one book that covers the waterfront but is deep enough to provide more than just an overview of models, and can actually help me become a better group therapist?’ This is such a book.” International Journal of Group Psychotherapy “This volume reflects the expansion in the field of psychodynamic group psychotherapy that today incorporates a variety of theoretical perspectives. Leading experts from various countries provide the reader with a clear overview of the different approaches. In addition, there are chapters in this volume that deal with special populations and conditions of treatment. While providing a straightforward introduction to the plethora of material in the field, the volume will also serve as a comprehensive resource for any seasoned group psychotherapist.” Howard D. Kibel, Professor of Psychiatry, New York Medical College and past President of the American Group Psychotherapy Association, USA The Handbook of Group Psychotherapy is a user-friendly guide to conducting group psychotherapy in various settings and with different populations. It has been designed as a resource for new professionals, including graduate students in mental health, as well as more seasoned clinicians planning to integrate group psychotherapy into their work. Bringing together pre-eminent group psychotherapists from different theoretical perspectives and countries, the articles in this volume present their approaches to conducting groups with diverse populations in different settings. Written in straight-forward, jargon-free language, the articles directly speak to the needs of the mental health professional planning to begin a group or to strengthen an existing group. Whether combined with a formal class in group techniques, human relations, or group dynamics, or in an institute training group practitioners, or read as part of one’s own professional development, this work is likely to advance the reader’s clinical competency and strengthen their self-confidence as a leader. Using a personal style and speaking from years of experience, the contributors provide hands-on suggestions as to how a group leader really works. From determining patient or client needs, developing treatment goals, and constructing a group, to handling emergencies, the contributors address the needs of the new group leader. The articles also address issues of diversity and globalism, as well as trauma and resiliency, making this a truly post-9/11 contribution.

Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.

Download or read book 1984 IEEE MTT S International Microwave Symposium Digest written by and published by . This book was released on 1984 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Monument Reporter written by and published by . This book was released on 1898 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protocols for Neural Cell Culture written by Sergey Fedoroff and published by Springer Science & Business Media. This book was released on 2001 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sergey Fedoroff and Arleen Richardson extensively revise, update, and expand their best-selling and highly praised collection of readily reproducible neural tissue culture protocols. This 3rd edition adds 11 new chapters describing important new procedures for the isolation, growth, and characterization of neural stem cells and for the manipulation of glial progenitor cells, as well as are essential procedures for hippocampal and microglial slice cultures. Protocols for Neural Cell Culture: Third Edition is a richly augmented updating of the tried and tested laboratory procedures that have made earlier editions an indispensable reference and guide to neural cell culture and its disorders.

Download or read book The 4 Disciplines of Execution written by Chris McChesney and published by Simon and Schuster. This book was released on 2016-04-12 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: BUSINESS STRATEGY. "The 4 Disciplines of Execution "offers the what but also how effective execution is achieved. They share numerous examples of companies that have done just that, not once, but over and over again. This is a book that every leader should read! (Clayton Christensen, Professor, Harvard Business School, and author of "The Innovator s Dilemma)." Do you remember the last major initiative you watched die in your organization? Did it go down with a loud crash? Or was it slowly and quietly suffocated by other competing priorities? By the time it finally disappeared, it s likely no one even noticed. What happened? The whirlwind of urgent activity required to keep things running day-to-day devoured all the time and energy you needed to invest in executing your strategy for tomorrow. "The 4 Disciplines of Execution" can change all that forever.

Download or read book 1988 IEEE MTT International Microwave Symposium Digest written by and published by . This book was released on 1988 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 1987 IEEE MTT S International Microwave Symposium Digest written by and published by . This book was released on 1987 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alternatives for Dermal Toxicity Testing written by Chantra Eskes and published by Springer. This book was released on 2017-11-21 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.

Download or read book In Vitro Methods in Pharmaceutical Research written by Jose V. Castell and published by Elsevier. This book was released on 1996-10-04 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. - Meets the continuing demand for information in this field - Compares In Vitro techniques with other methods - Describes cell-culture methods used to investigate toxicity in cells derived from different organs - Includes contributions by leading experts in the field

Download or read book Holy Bible NIV written by Various Authors, and published by Zondervan. This book was released on 2008-09-02 with total page 6793 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NIV is the world's best-selling modern translation, with over 150 million copies in print since its first full publication in 1978. This highly accurate and smooth-reading version of the Bible in modern English has the largest library of printed and electronic support material of any modern translation.