Download or read book Monoclonality and Genetic Instability in Premalignant Breast Tissue written by Carol L. Rosenberg and published by . This book was released on 2002 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: By the time a cancer is detected, its tumor cells already exhibit myriad genetic abnormalities. To gain a better understanding of genetic events that occur early in breast carcinogenesis, this research examined genetic abnormalities 1) in histologically normal tissue from women at low, medium or high degrees of breast cancer risk, using archival specimens of reduction mammoplasties, and of diagnoses of atypical hyperplasia and breast cancers, respectively; and 2) in synchronously occurring putative precursor lesions, including normal-appearing epithelium, simple and atypical proliferative (hyperplastic) lesions and carcinomas themselves. Each specimen is microdissected, its DNA examined using a panel of selected microsatellite markers, and evidence of clonal abnormalities sought, in particular loss of heterozygosity (LOH) and microsatellite instability (MI). Investigation of the project's first goal generated data regarding the timing and sites of early genetic abnormalities. These data raise the possibility that a field defect exists in certain breast tissue. Investigation of the second goal is uncovering the nature of the clonal relationships existing between multiple synchronous putative precursors. These studies are identifying important sites of genetic abnormalities in early breast cancer precursors, and beginning to outline a sequence of acquired genetic abnormalities necessary for precursor lesions to evolve into full-blown malignancies.
Download or read book Monoclonality and Genetic Instability in Premalignant Breast Cancer written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer probably develops as multiple genetic abnormalities accumulate, but the timing and nature of the earliest steps in this progression remain unknown. Proliferative breast lesions, considered benign but associated with increased breast cancer risk, were recently shown to contain clona 1 genetic abnormalities. Therefore, we hypothesized that clonal genetic abnormalities might be detectable before any phenotypic abnormalities develop: i.e., in microscopically normal breast tissue. We examined DNA from 95 normal-appearing ducts or terminalductal-lobular units (TDLU) from 20 individuals with varying breast cancer risk: those undergoing reduction mammoplasty, those with proliferative lesions, and those already with breast cancer. Using 9 microsatellite markers, we looked for genetic instability, 0 allele imbalance, most likely loss of heterozygosity (LOH). We found genetically abnormal clones in 21/95 (22%) of seemingly normal samples from 10/20 (50%) women from all 3 risk groups. In women under age 50, trends towards increased rates of abnormalities were noted with increased cancer risk. Abnormalities were more likely to be at sites of known or postulated tumor suppressor genes than at random or neutral loci.
Download or read book Genomic Instability at Premalignant and Early Stages of Breast Cancer Development written by C. Aldaz and published by . This book was released on 1997 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allelic imbalances and losses affecting the chromosome 16q arm appear to be early abnormalities in breast carcinogenesis since they were observed in a significant number of preinvasive lesions. The most common region of overlapping allelic losses spans the region 16q23.3 - q24.1, observed affected in 60 - 70% of in situ breast lesions. Positional cloning strategies are currently being employed to clone the putative tumor suppressor gene. We have defined approximately 300 kb of a homozygous deletion within the region q23.3 - q24. 1 of chromosome 16 in a breast cancer cell line. A total of 29 previously reported ESTs were mapped to this region. Five new cDNA clones were isolated and mapped. The analysis of 150 kb of the genomic sequence from this deletion showed 22 putative exons. The identification of this gene as well as the use of molecular markers from this chromosome region will provide tools of potential diagnostic-prognostic significance.
Download or read book Molecular Genetic Pathology written by Liang Cheng and published by Springer. This book was released on 2013-03-05 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Genetic Pathology, Second Edition presents up-to-date material containing fundamental information relevant to the clinical practice of molecular genetic pathology. Fully updated in each area and expanded to include identification of new infectious agents (H1N1), new diagnostic biomarkers and biomarkers for targeted cancer therapy. This edition is also expanded to include the many new technologies that have become available in the past few years such as microarray (AmpliChip) and high throughput deep sequencing, which will certainly change the clinical practice of molecular genetic pathology. Part I examines the clinical aspects of molecular biology and technology, genomics. Poharmacogenomics and proteomics, while Part II covers the clinically relevant information of medical genetics, hematology, transfusion medicine, oncology, and forensic pathology. Supplemented with many useful figures and presented in a helpful bullet-point format, Molecular Genetic Pathology, Second Edition provides a unique reference for practicing pathologists, oncologists, internists, and medical genetisists. Furthermore, a book with concise overview of the field and highlights of clinical applications will certainly help those trainees, including pathology residents, genetics residents, molecular pathology fellows, internists, hematology/oncology fellows, and medical technologists in preparing for their board examination/certification.
Download or read book Prognostic variables in node negative and node positive breast cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Pathology of Early Cancer written by Sudhir Srivastava and published by IOS Press. This book was released on 1999 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the principles and the application of the existing molecular methodology for the detection of early cancer. Discussion focuses on the molecular changes characterizing preneoplastic lesions; molecular targets for early detection; validation of molecular targets; and new diagnostic technology for early detection. The advantages of molecular detection over current methods are examined, as well as the importance of identifying and characterizing preneoplastic lesions. In addition to the uses of highly specific molecular probes to detect early cancer, this book demonstrates the many ways in which molecular markers serve oncology. While meeting pressing needs in the practice of medicine, molecular detection of early cancer scientifically necessitates a confrontation with the biology of cancer, such as the genetic determinants of progression, regression, dormancy, and invasion. This work not only discusses the diagnostic value of these molecular methods but views their practical benefits against a background of conventional morphology.
Download or read book AJCC Cancer Staging Manual written by Frederick L, Greene and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.
Download or read book Growth Factors and Oncogenes written by M. Bolla and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major objective of this book is to bring together specialists well-known for their contribution to the basic knowledge of growth factors and oncogenes and experts engaged in clinical research and prospective in cancer therapy."
Download or read book Contemporary Oral Oncology written by Moni Abraham Kuriakose and published by Springer. This book was released on 2016-12-08 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first of four volumes that together offer an authoritative, in-depth reference guide covering all aspects of the management of oral cancer from a multidisciplinary perspective and on the basis of a strong scientific foundation. This volume, on tumor biology, epidemiology, etiology, emerging role of cancer stem cells and prevention of oral cancer, opens by discussing oral carcinogenesis in general and the role of particular carcinogens and human papillomavirus. Global epidemiology and changes in disease prevalence are then addressed. Up-to-date information is provided on emerging cancer biomarkers, and the biologic basis of personalized therapy is explained. Histopathological features of malignant and premalignant neoplasms and their relevance to management are described. Further chapters focus on the current status of chemoprevention, the management of oral submucous fibrosis, and the value of various diagnostic adjuncts. The volume concludes by critically evaluating the efficacy of oral screening methods. Volume 1: Biology, Epidemiology, Etiology, and Prevention Volume 2: Diagnosis and Management Volume 3: Oral and Maxillofacial Reconstructive Surgery Volume 4: Rehabilitation and Supportive Care
Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1998-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Oncology of Breast Cancer written by Jeffrey Stuart Ross and published by Jones & Bartlett Learning. This book was released on 2005 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this ground-breaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up-to-date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.
Download or read book Molecular Basis of Breast Cancer written by Jose Russo and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly-illustrated atlas-like book provides a foundation for the biological and molecular understanding of how the mammary gland develops and how breast cancer originates. The main goal is to comprehensively review in ten chapters fundamental knowledge in breast cancer. New paradigms are described in which induction of differentiation in the mammary gland can promote prevention and cure of breast cancer. The text is extremely helpful both for clinicians treating patients and researchers looking for new avenues of development.
Download or read book Tertiary Lymphoid Structures written by Marie-Caroline Dieu-Nosjean and published by Humana Press. This book was released on 2018-09-05 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2005 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Summaries of papers" contained in the journal accompany each issue, 19--
