Download or read book Monitoring and Evaluation of Biomaterials and their Performance In Vivo written by Roger Narayan and published by Woodhead Publishing. This book was released on 2016-11-11 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monitoring and Evaluation of Biomaterials and Their Performance In Vivo provides essential information for scientists and researchers who need to assess and evaluate performance, monitor biological responses, gauge efficacy, and observe changes over time. Crucially, it also enables the optimization of design for future biomaterials and implants. This book presents readers with comprehensive coverage of the topic of in vivo monitoring of medical implants and biomaterials. - Contains a specific focus on monitoring and evaluation of biomaterials in vivo - Multi-faceted coverage of materials function and performance - Focuses on a range of implants and subsequent bodily reactions

Download or read book Biocompatibility and Performance of Medical Devices written by Jean-Pierre Boutrand and published by Elsevier. This book was released on 2012-10-26 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implant and device manufacturers are increasingly facing the challenge of proving that their products are safe and biocompatible, and that they will perform as expected. Biocompatibility and performance of medical devices provides an essential guide to the performance analysis of these vital devices.Part one introduces the key concepts and challenges faced in relation to biocompatibility in medical devices, with consideration of biological safety evaluation planning and biomechanical and biochemical compatibility in innovative biomaterials. Part two goes on to discuss the evaluation and characterisation of biocompatibility in medical devices. Topics covered include material and chemical characterisation, allowable limits for toxic leachables, in vivo and in vitro testing and blood compatibility assessment. Testing and interpreting medical device performance is the focus of part three, with chapters describing preclinical performance studies for bone, dental and soft tissue implants, and mechanical testing of soft and hard tissue implants. Part four provides information on the regulation of medical devices in the European Union, Japan and China, and the book concludes with part five, a review of histopathology principles for biocompatibility and performance studies.With its distinguished editor and international team of expert contributors, Biocompatibility and performance of medical devices is a vital tool for all those involved in the research, design, production and application of medical devices, including research directors, production companies and medical regulatory agencies, as well as industry professionals and academics. - Examines the key concepts and challenges faced in relation to biocompatibility in medical devices - Discusses evaluation and characterisation issues, including material and chemical characterization, allowable limits for toxic leachables, in vivo and in vitro testing, and blood compatibility assessment - Delivers a comprehensive overview of testing and interpreting medical device performance

Download or read book Biomaterials and Implant Biocompatibility written by Anişoara Cîmpean and published by MDPI. This book was released on 2020-03-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific advances in life sciences and engineering are constantly challenging, expanding, and redefining concepts related to the biocompatibility and safety of medical devices. New biomaterials, new products, and new testing regimes are being introduced to scientific research practices. In order to provide clinically predictive results and to ensure a high benefit–risk ratio for patients, we need to optimize material and implant characteristics, and to adapt performance and safety evaluation practices for these innovative medical devices. Various characteristics related to materials and implant development such as raw materials composition, implant surface morphology, design, geometry, porosity, and mechanical properties need to be thoroughly characterized before evaluating the biological performance of implants. Furthermore, with the increase of regulatory demands, biological evaluation needs to ensure appropriate models and methods for each implant development stage. This book is a result of the Special Issue of Materials on "Biomaterials and Implant Biocompatibility”, which focused on the recent progress in development, material testing, and the biocompatibility and bioactivity evaluation of various materials including, but not limited to, bioceramics, biopolymers, biometals, composite materials, biomimetic materials, hybrid biomaterials, and drug/device combinations for implants and prostheses with medical applications spanning from soft to hard tissue regeneration. The book covers aspects ranging from investigations into material characterization to in vitro and in vivo testing for the assessment of biological performance of advanced, novel biomaterials and implants.

Download or read book Handbook Of Biomaterials Evaluation written by Andreas F von Recum and published by CRC Press. This book was released on 1998-12-18 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook addresses the needs of those who are involved in inventing, developing, and testing implants and are concerned about the interactions between biomaterial and body tissue. The authors explore the physical, chemical, mechanical and regulatory considerations of synthetic materials used in surgical and implant procedures, and how these factors impact the latest developments and new approaches. This updated edition provides the biomaterials professional with necessary information on a range of issues, including bulk characterization, surface evaluations, toxicological evaluations, in vitro methods for safety evaluation, methods for evaluating materials in special applications, surgical considerations, systems implantology, soft and hard tissue history, regulatory aspects, and clinical trials.

Download or read book Adverse Reactions to Biomaterials State of the Art in Biomaterial Risk Assessment Immunomodulation and In Vitro Models for Biomaterial Testing written by Nihal Engin Vrana and published by Frontiers Media SA. This book was released on 2019-05-15 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adverse immune reactions to biomaterials are important bottlenecks for translation of novel biomaterials for clinical use. Moreover, recent advances in highthrough-put biomaterial discovery and synthetic biology, while providing exciting new veues, also significantly increases potential risks related to the in vivo reactions to these new materials. For example, the novel materials might have unintended biological activities due to their natural building blocks. In this perspective, biomaterial field needs i) better understanding of cell/biomaterial interactions at systems level; ii) development of new analysis and testing tools for advanced risk assessment iii) tools and technologies for modulating reactions to biomaterials and iv) advanced in vitro models for understanding and testing of reactions to biomaterials. In the following collection of articles you will find examples of such systems,together with comprehensive reviews of current developments in in vitro model systems. The collection also contains articles that elucidate the immune reaction to biomaterials in vitro and in vitro.

Download or read book Biomaterials Medical Devices and Combination Products written by Shayne Cox Gad and published by CRC Press. This book was released on 2015-12-01 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials, Medical Devices, and Combination Products is a single-volume guide for those responsible for-or concerned with-developing and ensuring patient safety in the use and manufacture of medical devices.The book provides a clear presentation of the global regulatory requirements and challenges in evaluating the biocompatibility and clinical

Download or read book Biomaterials in the Design and Reliability of Medical Devices written by Michael N. Helmus and published by Springer Science & Business Media. This book was released on 2003-01-31 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the responsibility of medical device designers and engineers to eliminate sites of failure and to test devices to demonstrate their ultimate safety and efficacy. It also evaluates biomaterials and their properties as related to the design and reliability of medical devices. The principles that are described are readily applicable to the biomaterial scaffolds used for generating tissue-engineered constructs.

Download or read book Biomedical Product and Materials Evaluation written by P.V. Mohanan and published by Woodhead Publishing. This book was released on 2022-01-22 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Product and Materials Evaluation: Standards and Ethics provides a much-needed overview of the procedures, issues, standards and ethical issues in the early development of biomedical products. The book covers a range of key biomedical products, from 3D printed organs and blood derived products, to stem calls and decellularized tissue products. Each chapter reviews a single product type, associated materials, biomedical applications, proven development strategies, and potential challenges. The core focus of the book is on the standardization and ethical aspects of biomedical product development, with these elements addressed and discussed in chapters dedicated to product evaluation. This is a useful reference for academics, researchers and industry professionals in R&D groups with an interest in biomaterial research and production, as well as those working in the fields of biomedical engineering, biotechnology and toxicology. - Covers a variety of biomedical products, including specific biomaterials, organs-on-chips, wound care products, combinational products, and more - Delves into strategies and considerations for product evaluation, including cytotoxicity assays, microbial and blood compatibility studies - Discusses standardization and ethical hurdles in biomedical product development and how to overcome them

Download or read book Biological Performance of Materials written by Jonathan Black and published by CRC Press. This book was released on 1999-07-21 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A balanced approach to understanding the response of living tissues and systems to manufactured biomaterials and the effect of life processes on the properties and behaviour of successful and unsuccessful biomaterials. This third edition contains a glossary of specialized terms; discussion of the emerging area of tissue engineering; more sources; and more tables to additional generic biomaterials properties.

Download or read book Evaluation of Biomaterials written by George D. Winter and published by John Wiley & Sons. This book was released on 1980 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of Biomaterials written by Samit K. Nandi and published by Elsevier Inc. Chapters. This book was released on 2013-03-12 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of biomaterials has become indispensable in modern medicine that includes primarily for the restoration of function as well as drug carriers. Biomaterials developed for bone, cartilage, ligament, tendon, skeletal muscle, dental, and other musculoskeletal applications almost always necessitate mechanical properties characterization to guarantee that they are robust enough for their in vivo functionality. In addition, mechanical conditioning often has a direct consequence on cellular behaviors such as differentiation, extracellular matrix production, migration, and proliferation. There is imperative necessity to get real-time data of tissue development in vivo in response to various biomechanical stimuli such as tension/compression, bending, torsion, and steady or dynamic fluid flow of construct that allows experimental protocol changes to be made early. In vitro characterization is unable to exhibit the tissue response to materials, instead being limited to the response of individual cell lines or primary cells taken from animals. Considering the wide and ever-increasing use of biomaterials in different fields of veterinary and medical sciences with its effective use in emerging fields, the characterization in respect to cellular response in the living system and its effect thereafter for leading a physiologic life, a comprehensive understanding have to be developed in totality. Further, implant safety such as avoidance of adverse tissue reaction and resistance to wear and corrosion are of high clinical significance for implants used in long-term clinical situations. The characterization along with related factors like histological, histomorphological, biochemical, radiological, scanning and transmission electron microscopic, fluorochrome labelling, biomechanical, micro-CT analysis, immunohistochemistry in orthopaedic and soft tissue surgery have been tried to elucidate with emphasis on in vivo applications of biomaterials. Amid various characterization parameters, histology is one of the most important tools to assess cellular reactions in the implant–tissue interface that can be carried out by both undecalcified and decalcified bone specimens. Histomorphometry can directly help in quantitative measurement (percentage) of newly formed bone in the implanted scaffold using semiautomatic image analysis software and also sometimes determines the host's vascularization. Histochemistry can be used to observe connective tissue ingrowth within the scaffold. The morphology and the proliferating cells can be evaluated by immunohistochemical technique. Biochemical markers like serum calcium, phosphorus, alkaline phosphatase, and osteocalcin help in evaluating the progress of healing and tartrate-resistant acid phosphatase for determining the osteoclasts activity. To understand the mechanisms of unusual bone remodelling, a number of different fluorescent stains like calcein green, tetracycline, alizarin red derivatives and xylenol orange have been developed to detect and quantify bone mineralization. Angiogenesis within the scaffold can be observed and quantified by angiography, osteomedullography, micro-CT, immunostaining with von Willebrand factor stain and intravital microscopy. Biomechanical testing is essential for quantitative assessment of implant integration and contact percentage between implant materials with the host tissue and can be performed by pull-out or push-out tests. Surface analysis and the interaction with bone tissue can be best detected by scanning electron microscopy. Non-invasive techniques include radiological, micro-CT analysis, densitometry study and ultrasound elasticity imaging (UEI). Radiological study helps to assess the union at the host bone–implant interfaces during the follow-up period and should be carried out at regular and calculated interval. Micro-CT is also a non-invasive technique and has great potential in characterization of biomaterials in regard to pore size and spatial distribution of newly formed bone together with quantitative information. Densitometric evaluation is helpful for estimating bone mineral content and density. UEI provides more information of scaffold degradation and tissue development. Finally, targeted delivery system needs quantitative measurements of biodistributable materials which can be best accomplished by computed tomography (CT), fluorescence imaging, inductively coupled atomic emission spectroscopy, inductively coupled plasma-mass spectrometry, micro-positron emission tomography, MRI imaging, and radiography. This chapter is primarily on hands-on experience in surgical manipulation of different biomaterials like hydroxyapatite, tricalcium phosphate, bioactive glass, metals, chitosan, as well as natural coralline hydroxyapatite. Different characterization techniques elaborated in this chapter can show a road map to the researchers, scientists, teachers and readers in this field of biomaterials to understand fundamental aspects of materials and related tissue response to the system in vivo. It can also provide clues for further research in the future towards this emerging field.

Download or read book Handbook of Biomaterials for Medical Applications Volume 2 written by Deepa Suhag and published by Springer Nature. This book was released on with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nanohybrids written by Gaurav Sharma and published by Materials Research Forum LLC. This book was released on 2021-01-20 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers preparation, designing and utilization of nanohybrid materials for biomedical applications. These materials can improve the effectiveness of drugs, promote high cell growth in new scaffolds, and lead to biodegradable surgical sutures. The use of hybrid magneto-plasmonic nanoparticles may lead to non-invasive therapies. The most promising materials are based on silica nanostructures, polymers, bioresorbable metals, liposomes, biopolymeric electrospun nanofibers, graphene, and gelatin. Much research focuses on the development of biomaterials for cell regeneration and wound healing applications. Keywords: Biomedical Materials, Cell Growth, Cell Regeneration, Wound Healing, Surgical Sutures, Non-invasive Therapies , Drug Transport, Tissue Engineering, Cardiovascular Implants, Fracture Repair Implants, Biodegradable Materials, Hybrid Magneto-plasmonic Nanoparticles, Silica Nanostructures, Polymers, Bioresorbable Metals, Liposomes, Biopolymeric Electrospun Nanofibers, Graphene, Gelatin-based Hydrogels.

Download or read book High Performance Biomaterials written by Michael Szycher and published by Routledge. This book was released on 2017-11-22 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedic presentation of the clinical applications of biomaterials from markets and advanced concepts to pharmaceutical applications and blood compatibility.

Download or read book Foundations of Biomaterials Engineering written by Maria Cristina Tanzi and published by Academic Press. This book was released on 2019-03-16 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foundations of Biomaterials Engineering provides readers with an introduction to biomaterials engineering. With a strong focus on the essentials of materials science, the book also examines the physiological mechanisms of defense and repair, tissue engineering and the basics of biotechnology. An introductory section covers materials, their properties, processing and engineering methods. The second section, dedicated to Biomaterials and Biocompatibility, deals with issues related to the use and application of the various classes of materials in the biomedical field, particularly within the human body, the mechanisms underlying the physiological processes of defense and repair, and the phenomenology of the interaction between the biological environment and biomaterials. The last part of the book addresses two areas of growing importance: Tissue Engineering and Biotechnology. This book is a valuable resource for researchers, students and all those looking for a comprehensive and concise introduction to biomaterials engineering. - Offers a one-stop source for information on the essentials of biomaterials and engineering - Useful as an introduction or advanced reference on recent advances in the biomaterials field - Developed by experienced international authors, incorporating feedback and input from existing customers

Download or read book Nanocarriers for Drug Targeting Brain Tumors written by Lalit Kumar and published by Elsevier. This book was released on 2022-06-21 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting. - Provides information on the design and development of nanocarriers for targeting brain tumors - Outlines the working principles of different nanocarriers for targeting brain tumors - Includes case studies of different nanocarriers for targeting brain tumors

Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications