Download or read book Molecular Pathology of HTLV 1 written by Umberto Bertazzoni and published by Frontiers Media SA. This book was released on 2019-03-25 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered, in 1980, by Gallo and co-workers. About 5-10% of HTLV-1-infected individuals are at risk of developing either a fatal malignancy, adult T-cell leukemia (ATL), or a chronic neuroinflammatory syndrome, HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Both diseases are incurable at present. Many issues concerning HTLV-1’s life cycle and pathobiology are still unsolved or controversial, and new approaches for prognostic stratification of patients and eradication of HTLV-1 infection are in high demand. In this Research Topic, the focus has been centered on discussing two main themes: the functional analysis and oncogenic potential of HTLV-1 regulatory proteins and the control of HTLV-1-associated diseases. The 22 articles in this eBook cover many different aspects of HTLV-1 infection and pathogenesis, providing new perspectives and groundwork for future studies.
Download or read book Molecular Pathogenesis of HTLV 1 written by O. John Semmes and published by Abi Professional Publications. This book was released on 1999 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been almost two decades since the discovery of Human T-cell Leukemia Virus as the first human retrovirus linked to disease. The virus was first isolated from an individual suffering from an aggressive lymphoma and has since been conclusively linked to the development of Adult T-cell Leukemia (ATL). HTLV-1 infection has also been identified as the main etiological agent for a progressive neurodegenerative condition known as HTLV-1-associated myelopathy in Japan, and tropical spastic paraparesis in the Caribbean (HAM/TSP). In addition to ATL and HAM/TSP, the virus has also been associated with inflammatory disease, resulting in a cumulative lifetime risk of disease of about 10%. Given the widespread infections in areas of Japan, the Caribbean, and Africa, as well as the increasing incidence of infection in the United States and elsewhere, this virus warrants worldwide attention. Molecular Pathogenesis of HTLV-1 presents an updated perspective of our current knowledge of molecular events contributing to pathogenesis associated with HTLV-1. The book is divided into 5 sections with each section composed of multiple original research articles. Each article is written by a leading authority in the field. Issues addressed include progression to disease state, current disease models, and molecular events leading to pathogenesis. There are also two articles that provide a more general "layman's" perspective.
Download or read book Molecular Mimicry Infection Inducing Autoimmune Disease written by Michael B. A. Oldstone and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Text will follow)
Download or read book Comparative Studies on Molecular Mechanisms Utilized by HTLV 1 and HTLV 2 in Viral Replication and Induction of T cell Transformation written by Li Xie and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Human T-cell leukemia virus (HTLV)-1 and HTLV-2 are closely related human retroviruses that have similar genetic organization and biological properties. However, they display distinct pathogenicity. HTLV-1 has been identified as a causal agent for two human diseases, adult T-cell leukemia (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP), whereas HTLV-2 appears much less pathogenic without conclusive disease association. In order to understand the distinct pathogenicity between HTLV-1 and HTLV-2, studies in this dissertation manipulate viral elements in the context of full-length proviral clones, analyze their function and mechanism of action in a system closely mimicking in vivo HTLV infection, and focus on the unique strategies employed by HTLV-1 and/or HTLV-2 to replicate and induce cellular transformation, the initial stage of HTLV oncogenesis. First, our results indicate that the PDZ domain binding motif (PBM) uniquely present in HTLV-1 viral oncoprotein Tax, but absent in HTLV-2 Tax, plays a key role in HTLV-1-induced cell proliferation and genetic instability in vitro and facilitate viral spread and persistence in vivo. Next, we identified a major viral determinant of HTLV T-cell transformation tropism, the envelope, using recombinant proviral clones between HTLV-1 and HTLV-2. Lastly, viral trans-regulatory protein Rex facilitates efficient viral replication and its functional activity is regulated by phosphorylation events. A c-terminal phosphorylation domain (CTPD) has been previously described in HTLV-2 Rex. Here mutational analyses indicate that either introducing phosphomimetic amino acids into the CTPD or deletion of the CTPD can lock Rex in active state. However, HTLV-2 with Rex phosphomimetic mutants, but not HTLV-2 with Rex CTPD deletion mutants, can efficiently infect and stimulate cellular proliferation and immortalization of human primary T-cell, implying the critical role of the Rex CTPD in HTLV-2 life cycle. Overall, our studies provide important insight into the distinct molecular pathogenesis of HTLV-1 and HTLV-2.
Download or read book Human Retroviruses written by Bryan Cullen and published by Oxford University Press. This book was released on 1993 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Download or read book Retroviruses written by Reinhard Kurth and published by Caister Academic Press Limited. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scientists in the field review the genomics, molecular biology and pathogenesis of these important viruses, comprehensively covering all the recent advances.
Download or read book Human T Cell Lymphotropic Virus Type I written by Per Höllsberg and published by John Wiley & Sons. This book was released on 1996-12-02 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: HTLV is made up of any of several retroviruses including the retrovirus known as AIDS. Devoted to the rapidly growing field of HTLV, this book explores the many different aspects of the virus.
Download or read book Infections of the Central Nervous System written by Fabrice Chretien and published by John Wiley & Sons. This book was released on 2020-01-08 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Der neue Band aus der Reihe International Society of Neuropathology wurde anlässlich der British Medical Association (BMA) Awards 2019 wärmstens empfohlen. Die Herausgeber sind Experten des Fachgebiets und beschreiben Infektionen des Nervensystems mit ihren klinischen, pathologischen und genetischen Eigenheiten. Auch seltene Erkrankungen werden in übersichtlichen Kapiteln erläutert, zusammen mit Definitionen, mikrobiologischen Eigenschaften, Epidemiologie, klinischen Ausprägungen, Labortests, Pathologie, Genetik und Behandlungsoptionen.
Download or read book Two Decades of Adult T cell Leukemia and HTLV I Research written by Kazuo Sugamura and published by . This book was released on 2003 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mostly drawn from the April 2001 symposium titled "Two Decades since the Discovery of the Viral Pathogenesis of ATL" and hosted by the Japanese Cancer Association, 30 papers present recent research results on adult T-cell leukemia (ATL) and its etiological, virus human T-cell leukemia virus type I (HTLV-I). After a number of medico-historical contributions, papers discuss aspects of molecular pathogenesis, mechanisms of disease development, animal disease models, prevention and therapy, and epidemiology. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Download or read book Human Oncogenic Viruses written by Jing-hsiung James Ou and published by World Scientific. This book was released on 2010 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and The cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epsteinndash;Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers.
Download or read book HTLV Molecular Biology and Pathogenesis written by Zwi N Berneman and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Aggressive Lymphomas written by Georg Lenz and published by Springer. This book was released on 2018-12-27 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes current knowledge of the biology and molecular pathogenesis of aggressive lymphomas and reviews the state of the art in diagnostic and therapeutic strategies. The aim is both to provide the reader with a sound understanding of the very significant progress that has been achieved in the understanding and management of these malignancies over recent years and to facilitate appropriate choice of the therapeutic strategy in individual cases. The assessment of different prognostic parameters are clearly presented in order to permits effective risk stratification that impacts on treatment choice. Recent insights into lymphomagenesis are exemplified and may assist in identifying emerging therapeutic targets. The comprehensive and up-to-date nature of the book will make it an ideal reference for all physicians and researchers interested in lymphoma, including clinicians from various medical specialties, biologists, pathologists, radiologists and nuclear medicine specialist, as well as students.
Download or read book Viruses and Human Cancer written by Mei Hwei Chang and published by Springer Science & Business Media. This book was released on 2013-09-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on oncogenic viruses and related human cancers has advanced rapidly in the past decade. Most articles, however, focus on a specific oncogenic virus and cancer. There is consequently a need for a comprehensive, up-to-date monograph that offers broad and integrated knowledge. Viruses and Human Cancer – From Basic Science to Clinical Prevention is designed to meet this need by providing an advanced overview on the basic and clinical aspects of oncogenic viruses and the human cancers that they cause. Virology, virus-induced inflammation and tissue injuries, oncogenic mechanisms, epidemiology, and current and emerging preventive and therapeutic strategies are all discussed in detail. In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.
Download or read book Viral Oncology written by George Klein and published by . This book was released on 1980 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV 1 Latency written by Guido Silvestri and published by Springer. This book was released on 2018-10-11 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
Download or read book Principles of Molecular Virology written by Alan Cann and published by Elsevier. This book was released on 2005-07-26 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Principles of Molecular Virology, Fourth Edition" provides an essential introduction to modern virology in a clear and concise manner. It is a highly enjoyable and readable text with numerous illustrations that enhance the reader's understanding of important principles. It contains new material on virus structure, virus evolution, zoonoses, bushmeat, SARS and bioterrorism. The standard version includes a CD-ROM with Flash animations, virtual interactive tutorials and experiments, self-assessment questions, useful online resources, along with the glossary, classification of subcellular infectious agents and history of virology.
Download or read book HTLV Molecular Biology and Pathogenesis written by Zwi N Berneman and published by . This book was released on 2000 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt:
