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Book Molecular Mechanisms of Membrane Traffic

Download or read book Molecular Mechanisms of Membrane Traffic written by D. James Morre and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of membrane traffic in reconstituted cell-free systems has generated an unprecedented amount of new information on the biochemistry, molecular biology and genetics of membrane-based molecular events that underly normal and abnormal cellular function. Many of the individual steps have now been isolated and dissected in simple systems that permit detailed molecular analyses of transport mechanisms and their regulation. Reconstituted events of intercompartment transport include inter-membrane recognition, and controlled membrane fusion-fission reactions. Among the many advances is the growi ng awareness of a remarkabl e evolutionary conservation of many of the components involved in the many steps of membrane traffic, this realization has accelerated greatly the pace of progress in the field. This book provides a collection of participant contributions from the 1992 Summer Research Conference, "Mol ecul ar Mechani sms of Membrane Traffi c, " jointly sponsored with NATO by the American Society of Cell Biology. The conference was held May 9-13, at the Airlie Conference Center in the Virginia countryside, near Warrenton. The conference was attended by 158 scientists. A unique feature was the high proportion of young scientists among the participants. Approximately 65% were students, postdoctoral fe 11 ows and young investigators. Each attendee contri buted to the conference with either a pl atform or poster presentation.

Book Molecular Biology of the Cell

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Lipid and Protein Traffic

    Book Details:
  • Author : Jos A.F. Op den Kamp
  • Publisher : Springer Science & Business Media
  • Release : 2013-06-29
  • ISBN : 3642514634
  • Pages : 364 pages

Download or read book Lipid and Protein Traffic written by Jos A.F. Op den Kamp and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: The meeting on "Molecular Mechanisms of Lipid and Protein Traffic", sponsored by NATO Scientific Affairs Division as an Advanced Study Institute and by the Federation of European Biochemical Societies as a Lecture Course was held in Cargese, France, in June 1997. The program included introductory lectures, specialized up-to-date contributions, poster sessions, tutorials and workshops. Emphasis was laid on the new developments in the field of membrane dynamics, in particular on the insertion and translocation of proteins; on intracellular protein, lipid and membrane traffic and sorting and on the mutual interactions between the various events occurring during membrane biogenesis. Mitochondrial biogenesis, chloroplast assembly and the insertion of proteins into peroxisomes were highlighted. Much progress in these research areas has been made in recent years and the ASI provided an excellent opportunity to illustrate this progress in comparison with previous meetings on a similar topic. Not only graduate students and postdocs took advantage from this program but also experienced scientists were given the opportunity to obtain a complete overview of recent progress and the remodeling of ideas and concepts.

Book Regulatory Mechanisms of Intracellular Membrane Transport

Download or read book Regulatory Mechanisms of Intracellular Membrane Transport written by Sirkka Keränen and published by Springer Science & Business Media. This book was released on 2004-08-27 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.

Book Protein  Lipid and Membrane Traffic

Download or read book Protein Lipid and Membrane Traffic written by North Atlantic Treaty Organization. Scientific Affairs Division and published by IOS Press. This book was released on 2000 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text concentrates on the following specific topics: the dynamic character of lipids and proteins in biological membranes; the existence of specific domains in membranes including their visualisation; the molecular mechanisms of intracellular transport of membrane constituents and the involvement of lipid-protein interactions in these processes; protein assembly; structure and folding and transport through membranes; and the intracellular sorting and targeting of individual membrane components as well as different organelles."

Book Trafficking Inside Cells

    Book Details:
  • Author : Nava Segev
  • Publisher : Springer Science & Business Media
  • Release : 2010-05-30
  • ISBN : 038793877X
  • Pages : 459 pages

Download or read book Trafficking Inside Cells written by Nava Segev and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Book ARF Family GTPases

    Book Details:
  • Author : Richard A. Kahn
  • Publisher : Springer Science & Business Media
  • Release : 2004-02-29
  • ISBN : 1402017197
  • Pages : 368 pages

Download or read book ARF Family GTPases written by Richard A. Kahn and published by Springer Science & Business Media. This book was released on 2004-02-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.

Book Molecular Mechanisms of Water Transport Across Biological Membranes

Download or read book Molecular Mechanisms of Water Transport Across Biological Membranes written by Wilfred D. Stein and published by Gulf Professional Publishing. This book was released on 2002-04-02 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology--both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. This volume looks at water movements from a wide range of levels. It examines how water interacts with the major components of the cell, including proteins and lipids. It discusses how water moves across cell membranes by diffusion, how it is chanelled across these membranes or, in certain cases, pumped across, and how water movements are controlled. This book demonstrates how water and ion movements are closely linked in order to provide a better understanding of their behavior. *Essential Physical chemistry of water at biological interfaces *Up-to-date reviews of water behavior in cells *Water in integrated systems *Current information on water channels across membranes

Book Regulatory Mechanisms of Intracellular Membrane Transport

Download or read book Regulatory Mechanisms of Intracellular Membrane Transport written by Sirkka Keränen and published by Springer. This book was released on 2014-10-08 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the molecular mechanisms of membrane trafficking, a central eukaryotic cell biological process. In the post-genomic era many essential molecules involved in intracellular membrane/protein transport are emerging. A huge task now is to compile the molecular networks that govern these processes. Understanding of regulatory processes and participating molecules are likely to reveal global cellular regulatory circuits that couple membrane trafficking with other cellular functions. Such cell biological features are only starting to emerge. This book puts special emphasis on such mechanisms and processes. The contents discusses the role of coat proteins, tethering complexes, small rab GTPases, Sec1-family proteins and SNARE molecule phosphorylation in exocytosis, endocytosis and membrane fusion. In addition, the role of lipids in vesicle formation and membrane fusion, and some specialized cell biological denovo membrane generation processes are discussed.

Book Overview of Membrane Trafficking Pathways

Download or read book Overview of Membrane Trafficking Pathways written by Jill Lynch and published by . This book was released on 2015-03-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of membrane trafficking pathways has been provided in this all-inclusive book. Membrane traffic is a wide domain that deals with complex exchange of membranes that occurs inside a cell. Protein, lipids and other molecules travel among intracellular organelles, are delivered to or transferred from the cell surface by virtue of membranous carriers known as "transport intermediates." These carriers have distinct shapes and sizes; and their biogenesis, mode of transport and delivery to the final destination are monitored by a multitude of very intricate molecular mechanisms. The concept that every membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways has emerged in past few years. This book intends to present a general overview of the degree of this crosstalk.

Book Membrane Trafficking in Viral Replication

Download or read book Membrane Trafficking in Viral Replication written by and published by Springer Science & Business Media. This book was released on 2004-10-05 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.

Book Insight Into the Molecular Mechanisms of Membrane Geometry Generation and Recognition

Download or read book Insight Into the Molecular Mechanisms of Membrane Geometry Generation and Recognition written by Richard Gill and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane remodeling is an essential process in cell growth, division, intracellular vesicle transport, and many other essential biological phenomena. Furthermore, membrane geometry has recently been shown to regulate biological activity and determines the final cellular localization of some proteins. The aim of this thesis is to provide structural and molecular insights into the mechanism governing membrane geometry induction and recognition. SpoVM is a small peptide that was recently found to recognize and preferentially localize to the slightly curved outer surface of the forespore (diameter of curvature, R, ~1 [mu]m) during Bacillus subtilis spore development. However, little was known about how this was accomplished. We determined that the SpoVM molecule adopted an atypical amphipathic helical structure in bilayer-like bicelles and that the helix is deeply embedded into the membrane. Our study challenges the current accepted model, which is based on circular dichroism and biochemical data, and provides structural support that SpoVM uses a new molecular mechanism to sense small membrane curvature. Recent studies have linked protein intracellular trafficking to human diseases. In Alzheimer's Disease (AD), a type I membrane protein referred to as LR11 (SorLA) is a key regulator of the amyloid precursor protein (APP) trafficking. LR11 diverts APP away from amyloidogenic processing to A[beta] peptides. The accumulation of A[beta] in the brain is generally accepted as the primary cause of AD. We discovered a membrane proximal amphipathic [alpha]-helix in LR11 C-terminal domain and, moreover, this helix deforms the membrane mimic liposomes. Since changes in membraneivgeometry are inherent to trafficking events, we postulate that this helix may sense and/or induce the bending of the membrane during vesicle biogenesis to facilitate LR11 intracellular transport. Amphipathic helices play a myriad of functions in mediating protein-lipid interactions. Despite their structural simplicity, several key properties including charge, the physiochemical characteristics of the hydrophobic vs. hydrophilic face, hydrophobicity, helical length, membrane orientation, and insertion depth, can be fine-tuned for their biological functions. Our study highlights the importance to quantitatively dissect these parameters in order to mechanistically understand their functions in membrane remodeling and ultimately to be able to manipulate these properties for therapeutic uses such as in designing antimicrobial and cell penetrating peptides.

Book Trafficking of Intracellular Membranes

Download or read book Trafficking of Intracellular Membranes written by Maria C. Pedroso De Lima and published by Springer. This book was released on 1995-03-22 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Study Institute "Traficking of Intracellular Membranes: From Molecular Sorting to Membrane Fusion", held at Espinho, Portugal, June 19 - 30, 1994

Book Cells  Molecules and Mechanisms

Download or read book Cells Molecules and Mechanisms written by Eric Wong and published by Axolotl Academic Publishing. This book was released on 2009 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.

Book Plant Endocytosis

    Book Details:
  • Author : Jozef Šamaj
  • Publisher : Springer
  • Release : 2014-12-03
  • ISBN : 9783642425356
  • Pages : 0 pages

Download or read book Plant Endocytosis written by Jozef Šamaj and published by Springer. This book was released on 2014-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocytosis is a fundamental biological process, which is conserved among all eukaryotes. It is essential not only for many physiological and signalling processes but also for interactions between eukaryotic cells and pathogens or symbionts. This book covers all aspects of endocytosis in both lower and higher plants, including basic types of endocytosis, endocytic compartments, and molecules involved in endocytic internalization and recycling in diverse plant cell types. It provides a comparison with endocytosis in animals and yeast and discusses future prospects in this new and rapidly evolving plant research field. Readers will find an overview of the state-of-the-art methods and techniques applied in plant endocytosis research.

Book Cell Boundaries

    Book Details:
  • Author : Stephen H White
  • Publisher : Garland Science
  • Release : 2021-12-31
  • ISBN : 1000508536
  • Pages : 565 pages

Download or read book Cell Boundaries written by Stephen H White and published by Garland Science. This book was released on 2021-12-31 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central themes of Cell Boundaries concern the structural and organizational principles underlying cell membranes, and how these principles enable function. By building a biological and biophysical foundation for understanding the organization of lipids in bilayers and the folding, assembly, stability, and function of membrane proteins, the book aims to broaden the knowledge of bioscience students to include the basic physics and physical chemistry that inform us about membranes. In doing so, it is hoped that physics students will find familiar territory that will lead them to an interest in biology. Our progress toward understanding membranes and membrane proteins depends strongly upon the concerted use of both biology and physics. It is important for students to know not only what we know, but how we have come to know it, so Cell Boundaries endeavours to bring out the history behind the central discoveries, especially in the early chapters, where the foundation is laid for later chapters. Science is far more interesting if, as students, we can appreciate and share in the adventures—and misadventures—of discovering new scientific knowledge. Cell Boundaries was written with advanced undergraduates and beginning graduate students in the biological and physical sciences in mind, though this textbook will likely have appeal to researchers and other academics as well. Highlights the history of important central discoveries Early chapters lay the foundation for later chapters to build on, so knowledge is amassed High-quality line diagrams illustrate key concepts and illuminate molecular mechanisms Box features and spreads expand on topics in main text, including histories of discoveries, special techniques, and applications

Book Exocytosis and Endocytosis

    Book Details:
  • Author : Andrei I. Ivanov
  • Publisher : Springer Science & Business Media
  • Release : 2008
  • ISBN : 1588298655
  • Pages : 407 pages

Download or read book Exocytosis and Endocytosis written by Andrei I. Ivanov and published by Springer Science & Business Media. This book was released on 2008 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.