Download or read book Molecular Interactions in Human Atherosclerotic Plaques written by Elspeth B. Smith and published by . This book was released on 1983* with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Atherosclerosis written by Sergey Fedoroff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the papers which were presented at the First Altschul Symposium, Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall. The symposium was held in Saskatoon, at the University of Saskatchewan in May 1990 in memory of Dr. Rudolph Altschul, a pioneer in the field of vascular biology and the prevention of atherosclerosis. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The challenge for biomedical scientists is to unravel the multifactorial etiology of atherosclerosis. For the last hundred and sixty years, anatomical pathologists have carefully studied the morphological changes of the human vascular wall during the initiation and evolution of the fibrofatty atherosclerotic plaque. Based on these elegant morphological observations, theories on atherogenesis were put forth by pathologists in the 1840's. Rudolf Virchow suggested that the movement of substances from the blood into the vessel wall was important for atherogenesis while Carl von Rokitansky felt that the deposition of substances on the lumenal surface of the artery resulted in the formation of atherosclerotic plaque. Since these original theories, it has become apparent that the pathogenesis of atherosclerosis is multifactorial and the disease evolves in stages. It is also likely that not all plaques arise through the same sequence of events and that many steps are involved in the development of each plaque. Today, our understanding of the complicated processes of atherogenesis is still incomplete.
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book Pathobiology of the Human Atherosclerotic Plaque written by Seymour Glagov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study of blood vessels at that time, so that details of the infrastructure and cellular composition of the artery wall and of atherosclerotic lesions were presented in some detail. There was, as one result of these explorations, considerable discussion of morphologic evidence suggesting that the principal cell involved in the atherogenic process was neither the fibroblast nor the macrophage, as had been supposed, but the smooth muscle cell. In particular, the findings indicated that this cell could incorporate lipid and become a foam cell.
Download or read book Biology of Platelet derived Growth Factor written by Bengt Westermark and published by S. Karger AG (Switzerland). This book was released on 1993 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inflammation and Atherosclerosis written by Georg Wick and published by Springer Science & Business Media. This book was released on 2011-12-03 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.
Download or read book Fundamentals of Vascular Biology written by Margarethe Geiger and published by Springer. This book was released on 2019-05-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-structured textbook offers essential knowledge on the vascular system. The reader will learn the properties, basic cellular mechanisms and development of the different parts of the vascular system (including the heart), gain knowledge on vascular and related diseases, and will be made familiar with common and most current methods and techniques applied to analyze the vascular system in patients, in animal models, and ex vivo. This book is based on a PhD Course for students from various bioscientific backgrounds given at the Medical University of Vienna, and it will be a valuable resource for Master ́s Students in vascular biology and biomedicine in general and a helpful tool for young researchers world-wide wishing to gain or refresh their knowledge in this field.
Download or read book Coronary Magnetic Resonance Angiography written by Andre J. Duerinckx and published by Springer Science & Business Media. This book was released on 2002 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there has been increasing interest in the clinical applications of coronary angiography techniques. Coronary MRA can be instrumental in the evaluation of congenital coronary artery anomalies, however, the complexity of advanced MR pulse sequences and strategies may be overwhelming to many. Coronary MR Angiography demystifies the art of coronary MRA by providing a text in plain language with clearly illustrated imaging steps and protocols. Designed to bridge the gap between radiology and cardiology, it is written for physicians and scientists planning to incorporate this technique into their research or practice.
Download or read book Cardiovascular Medicine written by James T. Willerson and published by Springer Science & Business Media. This book was released on 2007-12-06 with total page 2877 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease. The book and DVD package is designed to provide comprehensive coverage of every aspect of cardiovascular medicine. The book has consistent chapter organization relevant to modern cardiovascular practice, clear design and engaging text. The reader will have all the guidance to diagnose and manage the full range of cardiovascular conditions in one textbook resource, while also benefiting from access to additional video material from the integral DVD-ROM. This includes over 100 individual heart sounds.
Download or read book Lower Extremity Arterial Disease written by Dennis G. Caralis and published by Springer Science & Business Media. This book was released on 2007-11-15 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review the state-of-the-art in atherosclerosis of the arteries of the legs and feet. The authors discuss in detail the primary symptom-claudication-an intermittent pain in the leg or foot while walking, its predisposing factors, the current diagnostic methodologies, the impressive advances in the therapeutic armamentarium, and the need to screen for co-existing coronary artery disease. Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug eluting stents for peripheral arterial disease. The authors also examine the epidemiology of LEAD, the effects of smoking and effective smoking cessation programs, its pathogenesis and its association with lipid abnormalities and hypertension, aggressive risk factor modification, and the need to measure the ankle brachial index of every patient over 45.
Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Download or read book Coronary Angioscopy written by Kyoichi Mizuno and published by Springer. This book was released on 2015-07-03 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough review of coronary angioscopy, ranging from instructions on its use to the latest advances. Starting with the structure and fundamental principles of angioscopy, it shows readers how to apply the image to comprehensive care of coronary-artery patients. Plentiful color photos and illustrations will enable readers to investigate and classify plaques and thrombi and to evaluate coronary stent- and drug-based therapies. The authors are leading researchers on angioscopy. This book offers the perfect guide not only for new clinicians but also for cardiologists who have already adopted this technique for medical examination and treatment. Angioscopy is a unique medical technique for visualizing the interior of blood vessels and helps physicians not only to diagnose the pathology but also to measure the effectiveness of Percutaneous coronary intervention (PCI) or antiarteriosclerotic drugs. Furthermore, the recently developed molecular angioscopy approach allows us to observe Low-density lipoprotein (LDL) oxide, collagen, and macrophages, and is rapidly growing in importance.
Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tissue Proteomics written by Minnie M. Sarwal and published by Humana. This book was released on 2019-09-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a compilation of methods that detail improved protein and peptide sample preparation and identification. Chapters guide readers through methods for depletion of myofibril-associated proteins, peptide sample preparation in urinary proteomics, purification of targeted proteins from native tissues, fractionation strategies for protein analysis, and GeLC-MS as a sample preparation method for sample preparation for proteomics using minimal amount of tissue. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Tissue Proteomics: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.
Download or read book Biomechanics of Coronary Atherosclerotic Plaque written by and published by Academic Press. This book was released on 2020-03-15 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics of Coronary Atherosclerotic Plaque: From Model to Patient, First Edition, is the first comprehensive text to focus on important biomechanical studies conducted in the last decade that have increased our understanding of coronary atherosclerotic plaque initiation, growth, and rupture, as well as improving the design of medical devices and clinical interventions, including surgical procedures. The book provides students, researchers, engineers, clinicians, and interventional cardiologists with an overview of the main topics related to the biomechanics of atherosclerosis, in a single volume written by several experts in the field. This volume is part of the Biomechanics of Living Organs book series. The biomechanics of human soft tissues and organs has been an emerging research field since the publication of Y.C. Fung’s original book series in the 1990s. The publication of such books entirely dedicated to a specific biomechanical subject is necessary to advance scientific research in the field of biomechanics and to transfer important knowledge to future generations. Therefore, this series of volumes on the biomechanics of living organs has been created. This series began in July 2017 with the publication of a first volume on the fundamentals of Hyperelastic Constitutive Laws for Finite Element Modeling of Living Organs. The current volume on the Biomechanics of Coronary Atherosclerotic Plaque, is the latest in this new series. Presents the main computational fluid dynamic studies performed, describing blood flow in healthy and pathological artery branches, including in coronary bifurcations Highlights the correlation between plaque initiation regions and blood shear stress amplitude Discusses the main biomechanical and mechanobiological models to highlight the importance of quantifying the residual and peak cap stresses and the presence of μ-calcifications to evaluate the risk of plaque rupture Introduces the most recent intravascular imaging biomarker techniques (elastography, palpography and modulography)
Download or read book Oxidative Stress and Vascular Disease written by John F. Keaney Jr. and published by Springer Science & Business Media. This book was released on 1999-12-31 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
