Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Molecular Glycobiology written by Minoru Fukuda and published by . This book was released on 1994 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-surface carbohydrates play critical roles in cell-cell interactions. This well-written book brings together leading researchers to detail major recent advances regarding our understanding of the molecular mechanisms underlying such processes. Emphasis is given to cell type, specific carbohydrate expression, and the carbohydrates and proteins involved in cell recognition. Topics include the molecular structure of animal lectins, carbohydrate recognition in cell-cell interaction, chemical synthesis of oligosaccharides, conformational studies on oligosaccharides, and cell-surface carbohydrates, among others. Also included is a full discussion of key experimental approaches such as chemical synthesis and the three-dimensional structural analysis of carbohydrates. Providing both an up-to-date description of the subject and a forecast of likely future developments, Molecular Glycobiology is a much-needed synopsis of an exciting and rapidly expanding field. It will be welcomed by students and researchers in molecular biology, biochemistry, cell biology, and glycobiology.
Download or read book Functional and Molecular Glycobiology written by Dr Susan Brooks and published by Taylor & Francis. This book was released on 2023-06-14 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional and Molecular Glycobiology explains the chemistry of carbohydrates, and the biosynthesis and diversity of different types of glycans. It looks at the functional role of glycoconjugate compounds in normal cellular processes, in both disease and development. The book also describes how these compounds can be studied, analysed and manipulated for use in biotechnology. Functional and Molecular Glycobiology is a unique introduction to the field bridging the gap between introductory books and current research.
Download or read book Structural Glycobiology written by Elizabeth Yuriev and published by CRC Press. This book was released on 2012-09-27 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on: X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking Alternative techniques for yielding structural information on carbohydrates from complex biological samples Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection
Download or read book Introduction to Glycobiology written by Maureen E. Taylor and published by Oxford University Press, USA. This book was released on 2011-04-21 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level and their clinical relevance.
Download or read book Glycobiology written by Minoru Fukuda and published by Elsevier. This book was released on 2006-11-14 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, there has been an explosion of progress in understanding the roles of carbohydrates in biological systems. This explosive progress was made with the efforts in determining the roles of carbohydrates in immunology, neurobiology and many other disciplines, examining each unique system and employing new technology. This volume represents the first of three in the Methods in Enzymology series, including Glycomics (vol. 416) and Functional Glycomics (vol. 417), dedicated to disseminating information on methods in determining the biological roles of carbohydrates. These books are designed to provide an introduction of new methods to a large variety of readers who would like to participate in and contribute to the advancement of glycobiology. The methods covered include structural analysis of carbohydrates, biological and chemical synthesis of carbohydrates, expression and determination of ligands for carbohydrate-binding proteins, gene expression profiling including micro array, and generation of gene knockout mice and their phenotype analyses.
Download or read book Functional and Molecular Glycobiology written by Susan A. Brooks and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional and Molecular Glycobiology explains the chemistry of carbohydrates, and the biosynthesis and diversity of different types of glycans. It looks at the functional role of glycoconjugate compounds in normal cellular processes, in both disease and development. The book also describes how these compounds can be studied, analysed and manipulated for use in biotechnology. Functional and Molecular Glycobiology is a unique introduction to the field bridging the gap between introductory books and current research.
Download or read book I written by and published by Academic Press. This book was released on 2017-09-18 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Glycobiology, Volume 597, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume, the first on chemical glycobiology, contains comprehensive chapters on the Discovery of New Glycosidases from Metagenomic Libraries, Structure-guided directed evolution of glycosidases: A case study in engineering a blood group antigen-cleaving enzyme, A Pipeline for Studying and Engineering Single-Subunit Oligosaccharyltransferases, Directed evolution of glycopeptides using mRNA display, Chemoenzymatic Synthesis and Applications of Prokaryote-Specific UDP-Sugars, and Biosynthesis of Legionaminic Acid and its Incorporation into Glycoconjugates. Readers will find the latest information on this developing area of research, as reported by leaders in the field. Presents an updated volume in this regular series Covers research on chemical glycobiology
Download or read book Glycobiology Protocols written by Inka Brockhausen and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the different carbohydrate structures and the enzymes synthesizing them, the field has now moved toward identifying the functions of carbohydrates. The pro- cols described in Glycobiology Protocols form a solid basis for investigations of glycan functions in health and disease. The cloning of many of the genes participating in glycosylation processes has helped to enhance our knowledge of how glycosylation is controlled, but has also added another dimension of complexity to the great heterogeneous variety of the structures of the oligos- charides of glycoproteins, proteoglycans, and glycolipids. A family of similar enzyme proteins exists for each glycosylation step. Glycosyltransferases are extremely specific for both the nucleotide sugar donor and the acceptor s- strate, but many other factors control sugar transfer, including the locali- tion and topology of enzymes, cofactors, possible chaperone proteins, and the availability of sugar acceptor substrates. The analysis of the intracellular organization of glycosylation and of the factors controlling the activities of the participating enzymes in the cell are important areas that need more research efforts. Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell.
Download or read book Bioinformatics for Glycobiology and Glycomics written by Claus-Wilhelm von der Lieth and published by John Wiley & Sons. This book was released on 2009-10-01 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.
Download or read book Functional and Molecular Glycobiology written by Susan A. Brooks and published by Garland Pub. This book was released on 2002 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional and Molecular Glycobiology explains the chemistry of carbohydrates, and the biosynthesis and diversity of different types of glycans. It looks at the functional role of glycoconjugate compounds in normal cellular processes, in both disease and development. The book also describes how these compounds can be studied, analysed and manipulated for use in biotechnology. Functional and Molecular Glycobiology is a unique introduction to the field bridging the gap between introductory books and current research.
Download or read book Chemical Glycobiology Monitoring Glycans and Their Interactions written by and published by Academic Press. This book was released on 2018-01-03 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Glycobiology, Part B, Volume 598, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume is the second release on chemical glycobiology. Presents an updated volume in this regular series Covers research on chemical glycobiology
Download or read book Essentials of Glycobiology written by Ajit Varki and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular and Cellular Glycobiology written by Minoru Fukuda and published by Oxford University Press on Demand. This book was released on 2000 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Glycobiology covers the recent progress in understanding the biological roles of carbohydrates and includes basic knowledge of carbohydrates in mammals. Emphasis is on structure, biosynthesis and function of carbohydrates in development and disease. In particular,biological significance in immune cells, neural cells and cytoplasmic and nuclear proteins are thoroughly described. In addition, Molecular and Cellular Glycobiology updates the knowledge of diseases caused by anomalies of carbohydrate biosynthesis and the animal models used to investigate thephysiological roles of carbohydrates including carbohydrates attached to lipids. Various attempts to develop therapeutic agents based on carbohydrates are also described. Molecular and Cellular Glycobiology covers recent developments in a comprehensive yet focused manner and will be of interest toanyone with a basic knowledge of carbohydrates.
Download or read book Chemical Biology of Glycoproteins written by Zhongping Tan and published by Royal Society of Chemistry. This book was released on 2017-03-27 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.
Download or read book Lectins and Glycobiology written by Hans-Joachim Gabius and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intriguing complexity, precision, and regulation of the wide range of biologi cal processes is determined by intricate mechanisms of molecular recognition. Their nature is under intense scrutiny. In addition to the well-appreciated interac tion of proteins either with amino acid or nucleotide sequences, the investigation of their interplay with carbohydrate elements of cellular glycoconjugates current ly exerts increasing attraction. In the group of carbohydrate-binding proteins, lec tins are distinguished from antibodies or ligand-affecting enzymes, according to the most recent definition. The thorough analysis of their structure and function is considered as a focus to collect a critical mass of information for delineating details of a further array of biochemical processes with pivotal physiological im pact. Following an already century-long history of scientific description, reflected by subjectively chosen highlights (see the Brief History of Lectin Research at page VI), the excitement in glycobiological research that prevails today can easily be ex plained by our growing awareness of the multifarious significance of a sugar-code system of biological information. This present notion unmistakably has an im pact on lines of research in diverse disciplines like cell and molecular biology, histochemistry, or clinical sciences. It also prompts inherent practical questions such as how to obtain lectins, or how to employ them as instruments in various assay systems with the best possible results. Thus, this book is devoted intentionally to cover the techniques in different research fields that deal with lectins.
Download or read book Experimental Glycoscience written by Naoyuki Taniguchi and published by Springer Science & Business Media. This book was released on 2009-03-05 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure. In the post-genomic era, glycobiology is coming of age because more than half of proteins are glycosylated and the importance of sugar chains in various fields of life science research cannot be disregarded. Many scientists had not entered this area because glycobiology and glycoscience used to be considered difficult fields. This book, therefore, is presented much like a cookbook which can help scientists in fields other than glycobiology and glycoscience carry out research more easily.
