Download or read book Molecular Genetics of Pediatric Orthopaedic Disorders written by Carol A. Wise and published by Springer. This book was released on 2015-03-04 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades we have seen a surge forward in understanding the genetics and biochemistry underlying many pediatric orthopaedic disorders. A few projects have even progressed into the realm of clinical trials that are primarily aimed at controlling progressive disease. Meanwhile, genomic technology development has outpaced expectations and is enabling gene discovery for disorders that were previously intractable with traditional genetic methods. Included in this latter category are common disorders that display multigenic inheritance, sporadic disorders, and very rare conditions that are difficult to ascertain. Simultaneously, the study of pediatric orthopaedic disorders has been continuously refined and updated, highlighting a number of likely genetic conditions that are as yet unsolved. Molecular Genetics of Pediatric Orthopaedic Disorders updates researchers and clinicians of new developments of pediatric orthopaedic genetics. The chapters inform the audience on the revolution in new genomic methods and the impact this is having on potential study designs and the potential to discover genetic causes of many unsolved orthopaedic conditions. Recent examples have been included of pediatric orthopaedic conditions, both rare and common, that are being solved with these new methods. The book also educates pediatric orthopedic clinicians and geneticists on our understanding of the biology of “classic” genetic diseases that were derived from prior genetic studies. Chapters include biobanks and strategies for studying very rare disorders, genes and pathways causing primordial dwarfism, and notch signaling in congenital scoliosis, and more.
Download or read book Genetics for Orthopedic Surgeons written by Ian D. Young and published by Remedica. This book was released on 2002 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular biology is one of the fastest growing areas of medical research and now impinges on almost every medical discipline. This work provides an up-to-date overview of developments in molecular genetics as they relate to orthopedic practice.
Download or read book Pediatric Orthopedic Deformities Volume 1 written by Frederic Shapiro and published by Springer. This book was released on 2015-12-20 with total page 789 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental biology of normal bone and cartilage including histogenesis, molecular/gene and biomechanical aspects is updated and expanded. The book outlines the biology of: bone repair with differing mechanical environments; cartilage repair at articular and physeal sites; and distraction osteogenesis. The generously illustrated text provides an in-depth presentation of the interplay between normal developmental biology, abnormal pathologic states and the influence of operative and non-operative orthopedic interventions on childhood orthopedic deformity. Thirty-four principles underlying the development, progression and management of skeletal deformity in the growing child are defined. Orthopedic management including surgical treatment is discussed for: skeletal dysplasias; epiphyseal growth plate fracture-separations; lower extremity length discrepancies; and deformities of joints and epiphyses due to metabolic, inflammatory, infectious, hematologic, and neoplastic disorders. Treatments are related to extent of deformity, remodeling post-surgery and possible recurrence. This 2nd edition of Pediatric Orthopedic Deformities has been expanded to cover more regions and disorders and is being presented in 3 volumes.
Download or read book Pediatric Orthopedic Deformities written by Frederic Shapiro and published by Elsevier. This book was released on 2002-01-16 with total page 975 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific operative and nonoperative techniques and their results are stressed. The book is extensively illustrated with drawings, most of which were made for this book, microscopy photos, and serial radiographs. The reader learns of pediatric orthopedic deformity in relation to normal and abnormal developmental biology, the worsening of untreated disease with growth, and the diagnostic and treatment interventions required based on the stage of progression. * Treatments are correlated with the pathologic state of the disorder* Discusses disorders from earliest onset to the final state showing how the altered biology leads to progressively greater clinical deformity* Initial chapter focuses on development bone biology stressing a broad based approach involving histologic, gene and molecular, and biomechanical features* Subsequent chapters discuss the pathogenesis of the various deformities, natural history, radiographic and imaging findings and orthopaedic and surgical management
Download or read book Research Into Spinal Deformities 9 written by J.G. Thometz and published by IOS Press. This book was released on 2021-07 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is over 70 years since two orthopedic surgeons invented the Milwaukee brace for the treatment of children with scoliosis. Since then, clinicians and researchers have been inspired to design ever more effective braces to correct 3-D spinal deformities. This book presents papers from the bi-annual meeting of the International Research Society of Spinal Deformities (IRSSD), held as a virtual event on 22 and 23 January 2021. The IRSSD concentrates on research into spinal deformity with clinical applications. In addition to 3D assessment of the spine, researchers also explore spinal biomechanics, etiopathogenesis, and innovative conservative and surgical therapies with the goal of integrating science with clinical care to improve patient care. The 2021 meeting was originally scheduled to take place in Milwaukee, Wisconsin, USA, but was instead held in a virtual format due to the Covid 19 pandemic. Despite this change, the meeting still allowed valuable interaction and open discussion among practitioners from around the world, and keynote speakers and authors contributed the 44 short papers and 47 abstracts included here. The papers are grouped under 17 chapter headings, and cover a wide range of topics, including biologic and biomechanical benchmarks, clinical evaluation, conservative treatments and surgical approaches. Diagnostic assessments and non-surgical treatments of EOS are also emphasized and elucidated. The book will be of interest to all those whose work is related to the treatment and care of patients with spinal deformities.
Download or read book Tachdjian s Pediatric Orthopaedics E Book written by John A. Herring and published by Elsevier Health Sciences. This book was released on 2013-12-09 with total page 2662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing the tradition of excellence that began in 1972, this latest edition of Tachdjian?s Pediatric Orthopaedics offers the detailed visual guidance; and unmatched expertise you need to effectively diagnose and treat pediatric musculoskeletal disorders. Extensive updates offer you the latest knowledge on etiology, imaging, differential diagnosis, and non-operative and surgical techniques for a wide range of pediatric orthopaedic conditions. "... delivers the most comprehensive text on this subject." Reviewed by Dr. Neel Kamal on behalf of BACCH Newsletter, March 2015 Access expert guidance on difficult diagnostic and clinical management issues for your most challenging cases. Perfect your technique with the visual guidance of nearly 2,500 full-color illustrations and 60 videos of pediatric surgical procedures, including a number that highlight clinical examination and unusual clinical findings. Produce the best possible outcomes using today's most effective approaches for management of severe spinal deformities, hip impingement, early-onset scoliosis, and other pediatric musculoskeletal conditions. See exactly how to proceed step-by-step with instructional videos demonstrating repair of bilateral dislocated hips, triple arthrodesis for planovalgus foot, patellofemoral ligament reconstruction, elbow arthroscopy, and more. Access the full contents online at Expert Consult.
Download or read book Orthopaedic Knowledge Update Pediatrics 5 written by Jeffrey E. Martus, MD, MS and published by Lippincott Williams & Wilkins. This book was released on 2018-08-21 with total page 1311 pages. Available in PDF, EPUB and Kindle. Book excerpt: OKU: Pediatrics 5 reflects the substantial number of high-quality studies in pediatric orthopaedics, as well as the most recent clinical practice guidelines and appropriate use criteria. This comprehensive multispecialty resource explores the latest advances in pediatric trauma, sports-related injuries, and upper and lower extremity conditions, with a brand-new section on Neuromuscular, Metabolic, and Inflammatory Disorders.
Download or read book Genetics for Pediatricians written by Mohnish Suri and published by Remedica. This book was released on 2005 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Pediatricians, medical geneticists, genetics counselors. Genetic testing now plays an important role in the investigation of almost every child who presents with one of the many commonly inherited disorders that make a major contribution to pediatric morbidity and mortality throughout the world. It can be difficult for even the most conscientious practitioner to keep abreast of developments and to appreciate both the significance and relevance of some of the major discoveries of recent years. The number of conditions that have been mapped or in which the causative gene has been isolated is vast. In this book, coverage has been restricted to the more common single-gene disorders that are likely to be encountered in general pediatric practice, with particular attention focused on those in which molecular analysis can play an important role in the diagnosis or management of a child and his or her family.
Download or read book Disordered Vertebral and Rib Morphology in Pudgy Mice written by Frederic Shapiro and published by Springer. This book was released on 2016-09-21 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.
Download or read book Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine written by Johnny Huard and published by Springer Science & Business Media. This book was released on 2013-03-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been written in response to the many physicians and scien tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.
Download or read book Lovell and Winter s Pediatric Orthopaedics written by Stuart L. Weinstein and published by Lippincott Williams & Wilkins. This book was released on 2013-11-14 with total page 4072 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its updated Seventh Edition, Lovell and Winter’s Pediatric Orthopaedics remains a must-have for physicians and residents treating infants, children, and adolescents with orthopaedic problems. This classic, comprehensive reference covers the basic science, clinical manifestations, and management of orthopaedic problems in children. Now in full color, the foremost orthopaedists examine normal musculoskeletal development and the causes, diagnosis, and treatment of the entire range of abnormalities, with emphasis on evidence-based decision making in treatment selection. The clinical chapters include pearls and pitfalls and a description of the author's preferred approach. The book will now cover surgical techniques of management with step-by-step illustrations from the Atlas of Pediatric Orthopaedic Surgery.
Download or read book Pediatric Orthopedics An Issue of Pediatric Clinics of North America written by Paul Haynes and published by Elsevier Health Sciences. This book was released on 2019-12-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In collaboration with Consulting Editor, Dr. Bonita Stanton, Dr. Paul Haynes has assembled expert authors to bring current information to pediatricians on the topic of Pediatric Orthopedics. The issue provides a general overview of evaluation and treatment of the pediatric orthopedic patients. Specific articles are devoted to the following topics: Evaluation: Pediatric Orthopedic Exam; Genetic and Metabolic Conditions; Musculoskeletal Infections; Neuromuscular Conditions - Orthopedic Manifestations; Pediatric Anesthesia as Related To Orthopedic Procedures -Perioperative Management; The Limping Child; Pediatric Orthopedic Trauma; Hand and Upper Extremity; Hip and Pelvis; Knee and Lower Extremity; Foot and Ankle; Pediatric Spine; Pediatric Sports Injuries; Concussions and Chronic Overuse Injuries And Injury Prevention; and Tumors and Tumor-Like Conditions. Readers will come away with the most current information on this important topic.
Download or read book Lovell and Winter s Pediatric Orthopaedics written by Wood W. Lovell and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its updated Sixth Edition, this classic text remains a must-have for physicians and residents treating infants, children, or adolescents with orthopaedic problems. The foremost orthopaedists examine normal musculoskeletal development and the causes, diagnosis, and treatment of the entire range of abnormalities, with emphasis on evidence-based decision making in treatment selection. Many of this edition's clinical chapters include pearls and pitfalls and a description of the author's approach. This edition also has more clinical photographs. Discussions of surgical procedures are cross-referenced to the Atlas of Pediatric Orthopaedic Surgery, Fourth Edition, where readers can find step-by-step, illustrated technical instructions.
Download or read book Tachdjian s Pediatric Orthopaedics From the Texas Scottish Rite Hospital for Children written by John A. Herring and published by Elsevier Health Sciences. This book was released on 2020-11-27 with total page 2184 pages. Available in PDF, EPUB and Kindle. Book excerpt: With complete coverage appropriate for residents through experienced pediatric orthopaedic surgeons, Tachdjian's Pediatric Orthopaedics, 6th Edition, continues a 50-year tradition of excellence as the most comprehensive, authoritative guide to diagnosing and treating pediatric musculoskeletal disorders. Editor John Herring, MD, and experts from the Texas Scottish Rite Hospital for Children offer step-by-step instruction and detailed visual guidance on both surgical and non-surgical approaches. It’s everything the orthopaedic surgeon needs to know to accurately treat the full spectrum of pediatric orthopaedic conditions and injuries. Presents complete coverage of the latest knowledge on etiology, imaging, differential diagnosis, growth instrumentation, and non-operative and surgical techniques for a wide range of pediatric orthopaedic conditions. Provides expert guidance on difficult diagnostic and clinical management issues for your most challenging cases. Covers today’s most effective approaches for management of severe spinal deformities, early onset scoliosis, hip preservation methods, long-term follow-up of trauma conditions, and much more. Offers superb visual guidance with nearly 2,500 full-color illustrations and 70 videos (many are new!) of pediatric surgical procedures, including a number that highlight clinical examination and unusual clinical findings.
Download or read book Pediatric Orthopedics for Primary Care Physicians written by Dennis S. Weiner and published by Cambridge University Press. This book was released on 2004-03-25 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise account of common pediatric orthopaedic disorders for pediatricians and family physicians.
Download or read book Ca adell s Pediatric Bone Sarcomas written by Mikel San-Julian and published by Springer. This book was released on 2015-11-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this well-received book reflects the state of the art in surgery for malignant bone tumors in children, with a particular focus on epiphysiolysis before excision. With a thorough update, new chapters, a clear presentation of tips and tricks to address complications, as well as supplementary online videos and tutorials, this book addresses the challenges of limb preservation that are posed to the surgeon in this new era of cancer treatment characterized by higher survival rates and longer survival times. The authors are experienced practitioners of Cañadell's technique, but the book also explores, thanks to the focused contributions of experts from other fields of medicine, a range of topics from the molecular biology and histological aspects of bone tumors, to the use of imaging techniques and surgical options for epiphyseal preservation. Abundant illustrations and accounts of clinical results make this book an indispensable guide for orthopedic surgeons and pediatric oncologists and give the book an interdisciplinary appeal to practitioners in more general orthopedics, oncology, pediatrics and surgery.
Download or read book Molecular Genetics and Pathogenesis of Ehlers Danlos Syndrome and Related Connective Tissue Disorders written by Marina Colombi and published by MDPI. This book was released on 2020-12-14 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ehlers–Danlos syndromes (EDS) are a group of heritable connective tissue disorders (HCTDs) characterized by a variable degree of skin hyperextensibility, joint hypermobility and tissue fragility. The current EDS classification distinguishes 13 subtypes and 19 different causal genes mainly involved in collagen and extracellular matrix synthesis and maintenance. EDS need to be differentiated from other HCTDs with a variable clinical overlap, including Marfan syndrome and related disorders, some types of skeletal dysplasia and cutis laxa. The clinical recognition of EDS is not always straightforward, and, for a definite diagnosis, molecular testing can be of great assistance, especially in patients with an uncertain phenotype. Currently, the major challenging task in EDS is to unravel the molecular basis of the hypermobile EDS that is the most frequent form, and for which the diagnosis is only clinical in the absence of any definite laboratory test. This EDS subtype, as well as other EDS-reminiscent phenotypes, are currently investigated worldwide to unravel the primary genetic defect and related pathomechanisms. The research articles, case report, and reviews published in the Special Issue entitled “Molecular Genetics and Pathogenesis of Ehlers–Danlos Syndrome and Related Connective Tissue Disorders” focus on different clinical, genetic and molecular aspects of several EDS subtypes and some related disorders, offering novel findings and future research and nosological perspectives.
