Download or read book Molecular genetic analysis of the Klarsicht gene in Drosophila eye development written by Kathleen Laverne Mosley-Bishop and published by . This book was released on 1998 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Genetics of Axial Patterning Growth and Disease in Drosophila Eye written by Amit Singh and published by Springer Nature. This book was released on 2020-05-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.
Download or read book Molecular Genetics of Axial Patterning Growth and Disease in the Drosophila Eye written by Amit Singh and published by Springer Science & Business Media. This book was released on 2013-09-14 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on how does a multi-cellular organism develop from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question, and led to other questions, such as the role of various genetics and cell biological pathways in regulating the crucial process of pattern formation and growth during organogenesis. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more. There have been no titles in the past ten years covering this topic, thus an update is urgently needed.
Download or read book Molecular Genetic Analysis of Drosophila Eye Development written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drosophila Eye Development written by Kevin Moses and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Kevin Moses It is now 25 years since the study of the development of the compound eye in Drosophila really began with a classic paper (Ready et al. 1976). In 1864, August Weismann published a monograph on the development of Diptera and included some beautiful drawings of the developing imaginal discs (Weismann 1864). One of these is the first description of the third instar eye disc in which Weismann drew a vertical line separating a posterior domain that included a regular pattern of clustered cells from an anterior domain without such a pattern. Weismann suggested that these clusters were the precursors of the adult ommatidia and that the line marks the anterior edge of the eye. In his first suggestion he was absolutely correct - in his second he was wrong. The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow". While it is too late to hear from August Weismann, it is a particular pleasure to be able to include a chapter in this Volume from the first author of that 1976 paper: Don Ready! These past 25 years have seen an astonishing explosion in the study of the fly eye (see Fig.
Download or read book Molecular Dynamics in the Developing Drosophila Eye written by Daisuke Yamamoto and published by Landes Bioscience. This book was released on 1996 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Genetic Analysis of Retinal Development in Drosophila Melanogaster written by David Landreth Van Vactor and published by . This book was released on 1991 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Molecular and Genetic Analysis of the Developing Visual System in Drosophila Melanogaster written by Allen James Ebens (Jr.) and published by . This book was released on 1995 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Cellular and Molecular Genetic Analysis of Star and Asteroid Mutations which Disrupt Eye Development in Drosophila Melanogaster written by Theodore S. Higson and published by . This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular and Genetic Analysis of Disconnected a Gene Required for Proper Visual System Development in Drosophila written by Kevin John Lee and published by . This book was released on 1994 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Drosophila Eye Development by the Transcription Factors written by Jennifer Colleen Jemc and published by . This book was released on 2007 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) First, we characterized the eye phenotypes arising from overexpression of nito. Overexpression of nito perturbs eye development and in contrast to spen, which has been shown to act as a positive effector of EGFR signaling, appears to be a negative effector of EGFR signaling during eye development. Further genetic analysis of the relationship between spen and nito in the eye suggests they function antagonistically, possibly by targeting a common set of genes for transcriptional regulation. Further analysis of SPOC family mutants and study of the functions of these proteins at a molecular level will be necessary to understand the relationship of small and large SPOC proteins and the roles of the proteins in development and disease.
Download or read book Molecular Genetic Analysis of Larval Visual System Development and Programmed Cell Death in Drosophila written by Megan Elizabeth Grether and published by . This book was released on 1994 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Molecular Genetic Analysis of Head Development in the Fruitfly Drosophila Melanogaster written by Amelia L. Gallitano-Mendel and published by . This book was released on 1997 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Mechanisms Involved in Axial Patterning and Neurodegeneration in Drosophila Eye written by Meghana Tare and published by . This book was released on 2013 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex network of genetic and molecular mechanisms governing the process of organogenesis have an important bearing on development of organisms. We are using an established model of Drosophila melanogaster commonly referred to as fruit fly in order to understand these mechanisms. We have used Drosophila eye to discern genetic hierarchy controlling the (i) event of axial patterning, and (ii) to study neurodegeneration in the developing eye. Axial patterning involves generation of dorsal-ventral (DV), anterior-posterior (AP) and proximal-distal (PD) axes in the organ primordium and is considered crucial for transformation of monolayer epithelium into a three dimensional organ. Any abnormalities in expression patterns of axial patterning genes may result in complete loss of organ. Drosophila eye develops from a default ventral state conferred by expression of genes Lobe (L) and Serrate (Ser). It has been found that antagonistic interaction of dorsal and ventral genes helps generation of midline or the equator which is essential for growth and differentiation of the eye field. Loss-of-function of L/Ser results in complete or loss-of-ventral eye depending on time axis involved. In a genetic modifier screen performed for search for modifiers of L mutant phenotypes, an E3 ubiquitin ligase, Cullin-4 (Cul-4) and GATA-1 transcription factor Pannier (Pnr) were identified. In the current study, we have characterized Cul-4, in promoting cell survival in the ventral domain of developing eye via downregulation of Wingless (Wg) signaling. Cul-4 also regulates JNK signaling to prevent cell death in the developing eye. We thus place the Cul-4 in the hierarchy of ventral genes involved in eye development.We also present the role of GATA-1 transcription factor Pnr in defining the dorsal eye margin boundary by suppressing the eye fate. Pnr downregulates retinal determination gene machinery via zinc finger transcription factor teashirt (tsh). We thus provide a novel mechanism involved in defining dorsal margins of the eye during early stages of organogenesis and an eye suppression function, as a late role of pnr in the developing eye. Identification and characterization of these genes in the dorsal and ventral domains of the eye may help enrich our understanding of the genetic hierarchy and the complex interactions of genes involved in axial patterning in the eye during organogenesis. Since the genetic machinery is highly conserved from flies to humans, these studies will have direct implications on higher vertebrates as well. Other than patterning and growth studies, Drosophila eye has been widely used to study genetic and molecular basis of neurodegeneration. A part of current study is to test the mechanisms involved in the neuronal cell death caused during the course of Alzheimer's disease (AD). AD is caused due to accumulation of Aß-42 peptide which is a product formed because of incorrect cleavage of Amyloid Precursor Protein (APP). Accumulation of Aß-42 results in formation of amyloid plaques which eventually results into stress and the neuronal cell death. We have found that JNK signaling pathway is induced upon Aß-42 accumulation and causes cell death of the neurons in the brain. Our study provides a new mechanistic insight from the perspective of identifying the new targets of AD neuropathy.
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2005 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Migration and Formation of Neuronal Connections written by and published by Academic Press. This book was released on 2013-05-06 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
