Download or read book Membrane Transporters in Drug Discovery and Development written by Qing Yan and published by Methods in Molecular Biology. This book was released on 2010-04-26 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.

Download or read book The Blood brain Barrier written by William M. Pardridge and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The characterization of the blood-brain barrier (BBB) is undergoing a paradigm shift as the century-old concept of a passive, impermeable barrier that segregates blood and brain interstitial fluid is giving way to the idea that the BBB is a dynamic conduit for the transport between blood and brain of those nutrients, peptides, proteins, or immune cells that have access to certain transport systems localized within the BBB membranes. This volume contains 20 contributed chapters organized in four parts: cell-cell interactions, subcellular organelle function, signal transduction mechanisms, and gene expression. There is also a foreword by the late W.H. Oldendorf (1925-1992) on the teleology of the blood-brain barrier and the survival advantage conferred upon the organism by its presence in the vertebrate brain. Annotation copyright by Book News, Inc., Portland, OR

Download or read book Transport and Trafficking in the Malaria Infected Erythrocyte written by Novartis Foundation and published by Wiley-Blackwell. This book was released on 1999 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an urgent need to uncover new therapies that will protect against malaria, as the parasite becomes increasingly resistant to available drugs and this book offers insights into three interrelated aspects of the malaria-infected erythrocyte: * The transport of solutes into and out of the infected cell and the use of specific trafficking pathways in drug targeting * The traffic of proteins produced by the intracellular parasite as an essential process for the biogenesis of transport systems. * The relationship between the transport of drugs into the infected cell and the mode of drug action and drug resistance.