Download or read book Molecular Biomarkers In Cardiology written by Pietro Scicchitano and published by MDPI. This book was released on 2021-04-28 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: ear Colleagues, The approach to diseases is facing novel frontiers: targeting gene and improving person-centered medicine able to easily and specifically detect early stages of pathologies. The present book includes the most futuristic approaches to the identification of cardiac diseases by means of the most recent discoveries in molecular and genetic diagnosis. The articles will give you the opportunity to think of cardiac diseases as adverse conditions which can be more easily detected by means of technologies and the research spirit of us, physicians dedicated to humans’ care. Please enjoy this reading.
Download or read book Novel Biomarkers for Heart Disease written by Michael Lichtenauer and published by MDPI. This book was released on 2020-12-28 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.
Download or read book Cardiovascular Risk Factors Related Vascular Injury and New Molecular Biomarkers written by Yuli Huang and published by Frontiers Media SA. This book was released on 2022-10-21 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Markers An Issue of Clinics in Laboratory Medicine written by Kent Balanis Lewandrowski and published by Elsevier Health Sciences. This book was released on 2014-03-28 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in this clinically focused publication devoted to Cardiac Markers include: Overview of cardiac markers in heart disease; Methodologies for measurement of cardiac markers; Natriuretic peptides in HF and ACS; Tropoinins and high sensitivity troponins; Point-of-care testing for cardiac markers; ST-2 and galectin 3 in patients with heart failure; Cardiac markers following heart surgery and percutaneous coronary intervention; Cholesterol, lipoproteins, high sensitivity CRP and other risk factors for atherosclerosis; Myocarditis and cardiac transplant and rejection; New molecular genetic tests in the diagnosis of heart disease; Biomarkers for cholesterol balance.
Download or read book Biomarkers in Cardiovascular Disease written by Vijay Nambi and published by Elsevier Health Sciences. This book was released on 2018-11-27 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today’s available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Download or read book Molecular biomarkers of cardiometabolic disease written by Mirjana Macvanin and published by Frontiers Media SA. This book was released on 2024-08-22 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiometabolic disease (CMD) represents the major cause of mortality, accounting for one-third of all global deaths, 75% of which occur in middle- and low-income countries. CMD encompasses a broad spectrum of conditions characterized by limited prediction, based mainly on classical risk factors due to a lack of accurate molecular CMD predictors. Thus, there is an urgent need for improved diagnostics solutions to support early intervention and improve outcomes. Early detection and adequate intervention are crucial to prevent CMD-associated complications, encouraging the quest for appropriate biomarkers with diverse applications ranging from risk assessment and screening to diagnosis and prognosis. Different circulating biomarkers for quantifying the CMD risk have been reported in the literature, such as C-reactive protein (CRP), leptin, and adiponectin. In addition, accumulating evidence in the literature points to the emergence of novel CMD biomarkers, such as cytokines, various metabolites, apelin, microRNAs, inflammasome molecules, and cardiac fibrosis markers. However, large meta-analyses have not sufficiently investigated and confirmed their biological roles in CMD diagnosis, prognosis, and/or potential reduction.
Download or read book Cardiovascular Biomarkers written by David A. Morrow and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison’s Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients. Thirty years later, when the first edition of Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine was published, 2 out of the 1943 pages in the text contained a discussion of the laboratory examinations in acute myocardial infarction. Our knowledge base of the multitude of ways that physicians can and should use the clinical chemistry laboratory has expanded dramatically since these classic texts were published. The nomenclature has changed: terms such as “cardiac enzymes” have given way to “cardiac biomarkers. ” The number of assays has multiplied, and the operating characteristics of available assays are impr- ing at a gratifying but dizzying rate. We now use biomarkers to diagnose cardiovascular diseases and also to frame our treatment strategies. Thus, there is a clear need for a scholarly compilation of the state of the art of cardiac biomarkers. Dr. David Morrow has expertly edited an authoritative book that answers this need. The 34 chapters in Cardiovascular Biomarkers: Pathophysiology and Disease Mana- ment were written by a group of individuals who are internationally recognized thought leaders and experts in clinical and laboratory medicine.
Download or read book Biomarkers in Cardiovascular Diseases written by Dimitris Tousoulis and published by CRC Press. This book was released on 2013-07-29 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The establishment of precise and reliable biomarker tests for the early stages of cardiovascular disease is of great importance and can be the cornerstone in the prevention of future cardiovascular disease (CVD). Furthermore, some biomarkers may provide important information concerning the pathogenesis of CVD or appear to be useful in risk stratification, in CVD diagnosis, or in monitoring therapy; many others may be risk factors themselves, representing therefore potential targets of therapy. The ideal biomarker should have the following characteristics: highly sensitive, specific, reliable, accessible, standardized, dependable, cost effective, and easily interpretable by clinicians. The present book focuses on the presentation and evaluation of the most promising classical and novel biochemical markers used in CVD (coronary artery disease, hypertension, heart failure, hyperlipidemia, peripheral arterial disease). The underlying pathophysiological characteristics of each biomarker, as well as potential clinical implications in daily practice are reviewed in this book.
Download or read book Novel Biomarkers for Heart Disease written by Michael Lichtenauer and published by . This book was released on 2020 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.
Download or read book Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease written by Institute of Medicine and published by National Academies Press. This book was released on 2010-06-25 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Download or read book The Detection of Biomarkers written by Sibel A. Ozkan and published by Academic Press. This book was released on 2021-12-05 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods
Download or read book Circulating MicroRNAs written by Takahiro Ochiya and published by Humana Press. This book was released on 2013-05-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.
Download or read book Cardiac Markers written by Alan H. B. Wu and published by Springer Science & Business Media. This book was released on 2003-06-12 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and-for the first time-on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. Comprehensive and cutting-edge, Cardiac Markers, Second Edition offers physicians a complete guide to the use of cardiac markers in clinical practice and clinical laboratorians a close-up view of the new markers now becoming standard.
Download or read book Accelerating the Development of Biomarkers for Drug Safety written by Institute of Medicine and published by National Academies Press. This book was released on 2009-07-20 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held "Assessing and Accelerating Development of Biomarkers for Drug Safety," a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development.
Download or read book Cardiac Biomarkers written by Alan S. Maisel and published by Springer. This book was released on 2016-10-24 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know. The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.
Download or read book ROLE OF MOLECULAR BIOMARKERS IN PREDICTING OCCURRENCE OF PAROXYSMAL ATRIAL FIBRILLATION AFTER AN ISCHAEMIC STROKE OR TRANSIENT ISCHAEMIC ATTACK A SYSTEMATIC REVIEW written by Kirsty Ward and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of molecular biomarkers in predicting occurrence of paroxysmal atrial fibrillation after an ischaemic stroke or transient ischaemic attack: a systematic reviewKirsty Ward 1, Andy Vail 2, Craig J. Smith 1,3, Amit Kishore 1,31Greater Manchester Comprehensive Stroke Centre, Salford Royal Foundation Trust, UK; 2Centre for Biostatistics, University of Manchester, Salford Royal Foundation Trust, UK; 3Division of Cardiovascular Sciences, University of Manchester, Manchester Academic Health Science Centre, UKBackgroundParoxysmal atrial fibrillation (PAF) is difficult to detect using currently available methods of cardiac monitoring. We sought to identify molecular biomarkers used to predict PAF after ischaemic stroke (IS) or transient ischaemic attack (TIA), and evaluate their performance.MethodsA systematic literature review was undertaken in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies of patients with IS, TIA, or both, who underwent any cardiac monitoring for a minimum of 12 hours, were included after electronic searches of multiple databases. We pre-specified subgroup analysis of selected (pre-screened or cryptogenic) versus unselected stroke patients and according to duration of monitoring.Results21 studies (67% IS, 33% IS and TIA) involving 6327 patients were included. Twelve biomarkers (BNP, NT- ProBNP, NT-ProANP, MR-ProANP, Troponin I, Troponin T, CRP, ESR, D-Dimer, HbA1c, eGFR, creatinine) were investigated, with cardiac biomarkers utilised in 77% of patients. Among selected cohorts (9 studies), the most commonly used biomarker was NT-ProBNP (5 studies; C-statistic of 0.65 to 0.91). Among unselected cohorts (12 studies), the most common biomarker was BNP (7 studies; C-statistic 0.63 to 0.88). Only BNP was externally validated with varying biomarker thresholds reported among studies (65-134pg/ml).ConclusiontAnalysis was limited due to small, heterogenous study populations and varying methods of patient selection, definitions of PAF and cardiac monitoring strategies. Cardiac biomarkers appear to have modest to good discrimination for predicting PAF. This review supports the need to assess role of biomarkers in larger studies with standardised selection criteria, definition of PAF and laboratory assays.
Download or read book Cardiovascular Disease written by Gaetano Santulli and published by MDPI. This book was released on 2021-04-30 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the most updated epidemiological studies, cardiovascular disease remains a leading cause of death; in fact, despite substantial advances in the care of patients, the incidence of cardiovascular disorders continues to increase. Therefore, the search for novel mechanisms and therapeutics is desperately needed, and translational studies represent the best strategy to uncover novel therapeutic targets, reduce mortality, and improve the quality of life. This book gathers original articles and systematic reviews that have both a strong basic research background and clear translational potential. All the studies have been peer reviewed by at least two experts in the field. These contributions provide an updated systematic overview that examines, in detail, the mechanisms of the main cardiovascular and metabolic disorders, including ischemic and non-ischemic heart failure, hypertension, thromboembolism, atherosclerosis, stroke, diabetes mellitus, dyslipidemia, metabolic syndrome, valvulopathies, peripheral artery disease. In the final chapter, the functional role of the endothelium in the systemic manifestations of COVID-19 is described.
