Download or read book Molecular Approaches to Optical Biosensors written by and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A carbonic anhydrase-based metal ion biosensor was optimized using molecular biology methods. CA variants were prepared that alter the metal ion specificity, the half-time for metal equilibration, the zinc dissociation constant, and the metal detection limit. Reagentless signal transduction methods and enhanced immobilization methods were also developed. These methods will be useful in the development of sensor arrays to determine the concentration of multiple metal ions in wastewater and the ocean.
Download or read book Optical Biosensors Present Future written by Frances S. Ligler and published by Gulf Professional Publishing. This book was released on 2002-04-16 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: PART I. Optical Biosensors: The Present -- Chapter 1. Optrode-based Fiber Optic Biosensors -- Israel Biran and David R. Walt -- Chapter 2. Evanescent Wave Fiber Optic Biosensors -- Chris Rowe Taitt and Frances S. Ligler -- Chapter 3. Planar Waveguides for Fluorescence Biosensors -- Kim Sapsford, Chris Rowe Taitt, and Frances S. Ligler -- Chapter 4. Flow Immnosensor -- Anne W. Kusterbeck -- Chapter 5. Time Resolved Fluorescence -- Richard Thompson -- Chapter 6. Electrochemiluminescence -- Mark M. Richter -- Chapter 7. Surface Plasmon Resonance Biosensors -- Jiri Homola, Sinclair Yee, and David Myszka -- Chapter 8. The Resonant Mirror Optical Biosensor -- Tim Kinning and Paul Edwards -- Chapter 9. Interferometric Biosensors -- Daniel P. Campbell and Candice J. McCloskey -- Part II. Optical Biosensors: The Future -- Chapter 10. Genetic Engineering of Signaling Molecules -- Agatha Feltus and Sylvia Daunert -- Chapter 11. Artificial Receptors for Chemosensors -- Thomas W. Bell and Nicholas ...
Download or read book Biosensor Design Combinatorial and Rational Approaches written by and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This ASSERT proposal supports graduate assistants working on projects related to the parent grant, Molecular Approaches to Optical Biosensors, which proposes to optimize a carbonic anhydrase-based fluorescence biosensor for detecting metals. Our current goals were to use mutagenesis to prepare carbonic anhydrase variants with: (1) altered metal ion specificity by varying the size, geometry and chemical structure of direct and indirect metal ligands; and (2) increased protein stability by insertion of disulfide bonds. The metal ion specificity of CA variants with alterations in the histidines that coordinate the metal ion is altered significantly compared to wild-type. For example, the Cu/Zn affinity ratio varies from 1 for H119Q CAII to 10 for wild-type CAII to 6 x 10(exp 4) for H119N CAII. These variants should be useful for either preparing copper-specific sensors or for measuring multiple metal ions simultaneously using a CA-based biosensor. Furthermore, analysis of double cysteine variants indicates that the PAIRWISE potential is a good predictor of the strength of a novel disulfide bond, however, the destabilizing effects of cysteine substitutions on the native state and the stabilization of compact non-native states by the disulfide can override any stabilizing effect of the crosslink.
Download or read book Optical Biosensors written by Frances S. Ligler and published by Elsevier. This book was released on 2011-10-13 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Biosensors, Second Edition describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field. Comprehensive analysis and review of the underlying principles by optical biosensors Updates and informs on all the latest developments and hot topic areas Evaluates current methods showing the advantages and disadvantages of various systems involved
Download or read book Biosensors and Biodetection written by Avraham Rasooly and published by . This book was released on 2017 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive and detailed technical protocols on current biosensor and biodetection technologies and examples of their applications and capabilities. Chapters in Biosensors and Biodetection: Methods and Protocols, Volume 1: Optical-Based Detectors, Second Edition chapters focus on direct and indirect optical detectors including surface plasmon resonance, interferometric sensors, charge-coupled device (CCD) based detectors, spectrometry, and many other cutting-edge optical biosensors technologies. Written in the format of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, tips on troubleshooting and avoiding known pitfalls, and step-by-step, readily reproducible laboratory protocols. Authoritative and practical, Biosensors and Biodetection: Methods and Protocols, Volume 1: Optical-Based Detectors, Second Edition offers descriptions of major technologies by leading experts in the field in extensive technical detail. The aim of the book is to make biosensors more accessible and understandable to engineers, students, medical professionals, molecular biologists, chemical, and physical science researchers developing biosensor technologies, allowing readers to both understand the technology and to construct similar devices.
Download or read book Optical Guided wave Chemical and Biosensors II written by Mohammed Zourob and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, distinguished scientists from key institutions worldwide provide a comprehensive approach to optical sensing techniques employing the phenomenon of guided wave propagation for chemical and biosensors. This includes both state-of the-art fundamentals and innovative applications of these techniques. The authors present a deep analysis of their particular subjects in a way to address the needs of novice researchers such as graduate students and post-doctoral scholars as well as of established researchers seeking new avenues. Researchers and practitioners who need a solid foundation or reference will find this work invaluable. This second of two volumes covers the incorporation of periodic structures in waveguides to exploit the Bragg phenomenon, optical fiber sensors, hollow waveguides and micro-resonators as well as a review of the tremendous expansion of terahertz technology for sensing applications.
Download or read book Biomolecular Sensors written by Electra Gizeli and published by CRC Press. This book was released on 2002-05-16 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of devices that incorporate biological assemblies is impacting analytical and biomedical research. Today, scientists can monitor vital biological interactions-such as the binding of DNA to proteins-in real time, deriving unique information necessary to understanding biochemical pathways and thus aiding the design of drugs to regulat
Download or read book Nanomaterials for Biosensors written by Bansi D. Malhotra and published by William Andrew. This book was released on 2017-10-26 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included. Provides a detailed study on how nanomaterials are used to enhance sensing capabilities in biosensors Explains the properties, characterization methods and preparation techniques of the nanomaterials used in biosensing Arranged in a material-by-material way, making it clear how each nanomaterial should be used
Download or read book Novel Approaches in Biosensors and Rapid Diagnostic Assays written by Zvi Liron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the medical, food, and environmental fields there is a continuous demand for inexpensive and sensitive analytical devices that are reliable, rapid, capable of high-throughput screening, and have low cost per test unit. Small and portable biosensor devices are designed to fulfill most of these requirements, and can be used in laboratory and on-site field testing. This volume discusses major issues in optical, acoustic and electrochemical-based biosensors, biochips, sensing recognition elements, and biosensors for medical and environmental applications. The papers presented at the conference represent basic and applied research studies in the fields of diagnostic assays and biosensor development. Novel technologies, such as arrays of sensors using high-density fiber optics to sense labeled or unlabeled oligonucleotides, and patterned arrays of recognition elements, demonstrated the capability of biosensors to analyze multiple analytes.
Download or read book Optical Biosensors Present Future written by Frances S. Ligler and published by Gulf Professional Publishing. This book was released on 2002-04-16 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Biosensors: Present & Future
Download or read book Biosensors and Biodetection written by Avraham Rasooly and published by Humana. This book was released on 2017-03-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive and detailed technical protocols on current biosensor and biodetection technologies and examples of their applications and capabilities. Chapters in Biosensors and Biodetection: Methods and Protocols, Volume 1: Optical-Based Detectors, Second Edition chapters focus on direct and indirect optical detectors including surface plasmon resonance, interferometric sensors, charge-coupled device (CCD) based detectors, spectrometry, and many other cutting-edge optical biosensors technologies. Written in the format of the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, tips on troubleshooting and avoiding known pitfalls, and step-by-step, readily reproducible laboratory protocols. Authoritative and practical, Biosensors and Biodetection: Methods and Protocols, Volume 1: Optical-Based Detectors, Second Edition offers descriptions of major technologies by leading experts in the field in extensive technical detail. The aim of the book is to make biosensors more accessible and understandable to engineers, students, medical professionals, molecular biologists, chemical, and physical science researchers developing biosensor technologies, allowing readers to both understand the technology and to construct similar devices.
Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Download or read book Biophotonics and Biosensing written by Andrea Armani and published by Elsevier. This book was released on 2024-06-03 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophotonics and Biosensing: From Fundamental Research to Clinical Trials Through Advances of Signal and Image Processing brings together the knowledge of the basic principles of the field of light-biological tissue interaction, detection methods, data processing techniques, and research, diagnostic and clinical applications. It is suitable for new entrants, while also highlighting the latest developments for experts in the field. This volume includes perspectives by leading experts from the biophotonics, biomedical engineering, and data science communities. The reader will receive a basic grounding in the key theoretical principles and practical components of biophotonics and biosensing. Working principles of devices used in spectroscopy, microscopy, and optical sensing are presented along with their application domains. The reader will learn about existing microscopy-based techniques used in biomedical applications for diagnosis and get to know different signal processing algorithms as used in biophotonics. Finally, through concrete examples, including sample preparation and measurement approaches, see how the field has developed thanks to the integration of biophotonics and optical biosensing with signal processing. Introduces key principles of light-biological tissue interactions and biosensing Discusses how the most promising optical diagnostic methods can exploit contemporary signal and image processing algorithms and data analytics Includes examples of clinical studies with detailed descriptions of their implementation, along with practical guidance
Download or read book Biomedical Optical Sensors written by Richard De La Rue and published by Springer Nature. This book was released on 2020-09-28 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides wide-ranging coverage of current developments in biomedical sensing based on photonic techniques. Biomedical sensing is a dynamic topic that promises to deliver much in the future evolution of medical diagnostics, delivering advanced tools for fundamental research in biology at the micrometre and nanometre scales. The book explores a variety of alternative physical and biological methodologies that have become available for application, such as plasmonic sensors and photonic crystal biosensors. At the same time, it addresses issues that potentially limit the capability of biomedical optical sensing techniques, while reviewing the state-of-the-art in biomedical optical sensing for the future work that will lead to near-universal applications of such techniques. Edited and written by leading experts in this domain, this book is ideal as a comprehensive manual for researchers and graduate students.
Download or read book Biosensors and Molecular Technologies for Cancer Diagnostics written by Keith E. Herold and published by Taylor & Francis. This book was released on 2012-05-29 with total page 841 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between research and clinical application, Biosensors and Molecular Technologies for Cancer Diagnostics explores the use of biosensors as effective alternatives to the current standard methods in cancer diagnosis and detection. It describes the major aspects involved in detecting and diagnosing cancer as well as the basic elements
Download or read book Immunosensors written by Minhaz Uddin Ahmed and published by Royal Society of Chemistry. This book was released on 2019-08-28 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunosensors are widely used and are particularly important for fast diagnosis of diseases in remote environments as well as point-of-care devices. In this book, expert scientists are covering a selection of high quality representative examples from the past five years explaining how this area has developed. It is a compilation of recent advances in several areas of immunosensors for multiple target analysis using laboratory based or point-of-care set-up, for example graphene-, ISFET- and nanostructure-based immunosensors, electrochemical magneto immunosensors and nanoimprinted immunosensors. Filling a gap in the literature, it showcases the multidisciplinary, innovative developments in this highly important area and provides pointers towards commercialisation. Delivering a single, comprehensive work, it appeals to graduate students and professional researchers across academia and industry.
Download or read book Optical Sensor Systems in Biotechnology written by Govind Rao and published by Springer Science & Business Media. This book was released on 2009-11-02 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of all things natural, light is the most sublime. From the very existential belief of the origins of the universe to its role in the evolution of life on earth, light has been inextricably woven into every aspect of our lives. I am grateful to Springer-Verlag and Thomas Scheper for this invitation to organize this volume that continues to expand the use of light to create next generation sensing applications. Indeed, the very act of expanding the frontiers of learning and knowledge are referred to in many languages and cultures as enlightenment. Early optical instruments relied largely on simple combinations of mirrors, prisms and lenses. With these simple devices, substantial progress was made in our understanding of the properties of light and of its interactions with matter. Things got more complicated with the evolution of optical instruments in labo- tory use. Early systems used bulky and expensive hardware to generate light, split it into the desired wavelengths and finally collect it for analysis. The discovery of the laser pushed the technology further, but did not do much to make its adoption more widespread as the lasers themselves were large and required substantial el- trical power to operate. The true revolution is just beginning. Advances in mic- electronics have resulted in the possibility of truly low-cost (using the consumer electronics industry as a parallel) devices that exploit optical measurement technology.
