Download or read book Molecular Analysis of the Human Immunoglobulin V lambda II Gene Family and Its Relation to 8 12 Idiotypic Specificity written by Macarena Irigoyen and published by . This book was released on 1996 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunoglobulin Genes written by Tasuku Honjo and published by Academic Press. This book was released on 2012-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells.
Download or read book The Genetic Markers of Human Immunoglobulins written by Rune E. Grubb and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has long been known that every individual has a large number of antibodies of different specificities. Antibodies are gammaglobulins, and protein structure in cells is genetically determined. The extreme multiplicity of structure of the combining sites of antibodies relative to the degree of multiplicity generated by ordinary genetic mechanisms is a fascinating problem of bio-medical importance. The functional heterogeneity of reactions mediated by immunoglobulins-is remarkable, ranging from protection against life-threatening toxins and microbes to the production of laryngeal edema leading to suffocation and death from anaphylaxis. An approach to the understanding of immunoglobulin polymorphism based upon "a knowledge of genetic markers of immunoglobulin structure is not biased by the question of whether or not this polymorphism is related to combining site diversity. Though several recent reviews of the multifacetted problems related to immuno globulins are available, it was decided to publish this survey in the belief that know ledge of the genetic markers of immunoglobulins prqvides such information about immunoglobulin differentiation and its control as cannot be obtained from other sources. Several of the human genetic im~unoglobulin markers are well understood at the molecular level. The Gm system may serv~ as a model for other immuno genetic systems. The published data on the human immunoglobulin factors are widely scattered in journals of different perspectives. There is a need for a systematic presentation of these data and for their critical evaluation.
Download or read book Systemic Lupus Erythematosus written by Robert G. Lahita and published by Academic Press. This book was released on 2010-10-29 with total page 1155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. Highly illustrated and in full color throughout Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice
Download or read book Molecular Genetics of Immunoglobulin written by F. Calabi and published by Elsevier. This book was released on 1987-12-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the molecular genetics of immunoglobulins has been enormously advanced by the application of recombinant DNA technology. This new volume in the popular series New Comprehensive Biochemistry contains eight chapters that draw together reviews summarising the research into immunoglobulins and the arrangement, rearrangement and expression of their gene structure.Molecular Genetics of Immunoglobulin will be of particular importance to those working in the areas of genetics and molecular biology, immunology, and cell biology.
Download or read book Abridged Index Medicus written by and published by . This book was released on 1989 with total page 1590 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Biology of Idiotypes written by Mark Greene and published by Springer. This book was released on 1984-10 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The phenomenon of idiotypy was discovered almost thirty years ago, but it was only during the past decade that it attracted widespread interest and became the subject of numerous research investigations. From the outset, much of the interest in idiotypy was based on its implications with respect to the repertoire of antibodies. Kunkel showed, for example, that idiotypes associated with certain human myeloma or Bence-Jones proteins were present in normal human globulins at levels of less than one part per million. Also, Oudin's original definition of idiotypy implied that idiotypes could be uniquely associated with individual rabbits as well as with particular antigen-binding specificities. Such observations provided some of the earliest evidence for an extensive repertoire of immunoglobulin molecules. The implications of these findings have been amply confirmed by recent studies of protein struc ture and molecular genetics; many of these studies are reviewed in the present volume. It is known now that the diversity of antibodies is based on the presence of numerous V and L V H genes, on recombinatorial events involving D and] segments, on somatic mutations, and on processes involving deletion of DNA followed by repair with errors, including inser tions. Each of these parameters is capable of influencing the idiotype expressed by the final immunoglobulin product. Regulation of the immune response is another area in which idiotypy has significantly influenced modern immunology.
Download or read book Manual of Clinical Laboratory Immunology written by Noel R. Rose and published by . This book was released on 1997 with total page 1310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflects changes being thrust upon the laboratory community.
Download or read book Immunoglobulin Idiotypes written by Charles A. Janeway and published by . This book was released on 1981 with total page 954 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Immunoglobulin Genetics written by Azad K. Kaushik and published by CRC Press. This book was released on 2014-05-01 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contemporary book covers significant new knowledge that has emerged during the last two decades and, thus, provides novel antibody phylogenetic perspectives relevant to development of new antibody-based therapeutics and vaccines. It fills a much-needed niche in the area of immunoglobulin genetics across species from a comparative perspective.
Download or read book Studies on the Specificity of Human Anti immunoglobulin G Antibodies written by Sharon Hunt Gerardo and published by . This book was released on 1990 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Journal of Immunology written by and published by . This book was released on 1995-10 with total page 1340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Human IgG Subclasses written by F. Shakib and published by Pergamon. This book was released on 1990 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features contributions from internationally renowned scientists from Europe and the USA covering aspects of immunoglobulin subclasses from a molecular and mechanistic approach. The first section presents a detailed discussion of the molecular structure and segmental flexibility of IgG subclasses, including how this controls their effector function. Structure-function relationships are fully developed in the second section by means of a functional approach to the study of complement activation and opsonization by IgG subclasses. The final section contains a generous account of the regulation of IgG subclass expressions.
Download or read book Immunoglobulin Gene Expression in Development and Disease written by Paolo Casali and published by . This book was released on 1995 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms underlying human immunoglobulin variable gene expression are poorly understood. For instance, certain immunoglobulin variable gene segments are preferentially used both during early development and in various autoimmune disorders and B-cell neoplasms. This volume addresses topics - such as human immunoglobulin gene organisation, rearrangement, transcription and somatic mutation, and B-cell and immunoglobulin gene repertoire development - selected for their relevance to the interpretation of the multitude of human immunoglobulin gene studies in the normal B-cell repertoire and in various B-cell disorders.
Download or read book The Genetic Markers of Human Immunoglobulins written by Rune E. Grubb and published by Springer. This book was released on 2012-03-19 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has long been known that every individual has a large number of antibodies of different specificities. Antibodies are gammaglobulins, and protein structure in cells is genetically determined. The extreme multiplicity of structure of the combining sites of antibodies relative to the degree of multiplicity generated by ordinary genetic mechanisms is a fascinating problem of bio-medical importance. The functional heterogeneity of reactions mediated by immunoglobulins-is remarkable, ranging from protection against life-threatening toxins and microbes to the production of laryngeal edema leading to suffocation and death from anaphylaxis. An approach to the understanding of immunoglobulin polymorphism based upon "a knowledge of genetic markers of immunoglobulin structure is not biased by the question of whether or not this polymorphism is related to combining site diversity. Though several recent reviews of the multifacetted problems related to immuno globulins are available, it was decided to publish this survey in the belief that know ledge of the genetic markers of immunoglobulins prqvides such information about immunoglobulin differentiation and its control as cannot be obtained from other sources. Several of the human genetic im~unoglobulin markers are well understood at the molecular level. The Gm system may serv~ as a model for other immuno genetic systems. The published data on the human immunoglobulin factors are widely scattered in journals of different perspectives. There is a need for a systematic presentation of these data and for their critical evaluation.
Download or read book Molecular Immunology written by and published by . This book was released on 1993 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt:
