Download or read book Modulators Mediators and Specifiers in Brain Function written by Y. H. Erlich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: While neuroanatomy and neurophysiology were defining the unique features of the synapse as a site for cell to cell signaling in the late fifties, neurochemistry was establishing the identity and studying the biosynthetic pathways of monoamine neurotransmitters. Meanwhile, neuropsychiatry was keeping a vigilant eye on the outcome of this concerted effort with the untold hope that a genetic defect in neurotransmitter metabolism would ac count for the pathogenesis of certain psychiatric ill nesses. Thus, when neurochemists in the early sixties began to study the feasibility of measuring the metabolism of brain neurotransmitters in vivo, clinical biochemists eagerly adopted these methods to their needs and sought to verify whether inborn errors of transmitter biogenesis were a cause for at least certain forms of depression, mania and schizophrenia. Undoubtedly, it is still too early to evaluate the outcome of these studies. However, current opinion holds that gross inborn errors in transmitter metabolism do not anpear to be operative as a primary cause of psychia tric disorders. Though monoamine metabolism appears to be defective in certain groups of psychiatric disorders, the cause of these changes can at best be associated with changes in patterns of neuronal firing. It is generally believed that these persistent changes are determined by a number of unknown factors operative in various psychia tric illnesses. In the attempt to identify the molecular nature of these unknown factors, the focus of current research is directed toward transmitter receptors.
Download or read book Modulators Mediators and Specifiers in Brain Function written by Y H Erlich and published by Springer. This book was released on 2014-01-15 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Calcium and Cell Function written by Wai Yiu Cheung and published by Academic Press. This book was released on 2013-09-03 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium and Cell Function, Volume III covers the many aspects of research on calcium, dealing with its biochemistry, biology, and pharmacology in animals as well as in plants. The book discusses a novel cellular signaling system based on the integration of phospholipid and calcium metabolism; the transport of calcium by sarcoplasmic reticulum; and the energetics and chemistry for interactions between calmodulin and calmodulin-binding proteins. The text also describes the specificity of trifluoperazine and related phenothiazines for calcium-binding proteins; the structure, function, and regulation of phosphorylase kinase; and the regulation of glycogen synthase by multiple protein kinases. The role of calmodulin in synaptic function and neurosecretion; the stimulation of the synthesis of neurotransmitters by calmodulin-dependent phosphorylation; as well as the role of calcium in axoplasmic transport in nerve are also considered. The book further tackles calcium control of the intestinal microvillus cytoskeleton; the possible role of calmodulin in the regulation of insulin release and protein phosphorylation by calcium and cyclic AMP; and the role of calcium in mediating cellular functions important for growth and development in higher plants. The text also looks into the localization of calmodulin in tissue culture cells; and the characterization and regulation of calcium-dependent neutral protease. Zoologists, cell biologists, biochemists, and pharmacologists will find the book invaluable.
Download or read book Calcium and Cell Physiology written by D. Marme and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the present volume is to give a comprehensive and up-to-date 2 survey of the nature and role of calcium ions (Ca +) in the regulation of cel 2 lular function. Since Ca + has gained in interest over the past years as a cel lular messenger in signal transduction, and since the discovery of its cellular receptor protein, calmodulin, has helped in understanding its mode of action in molecular terms, we felt that an interdisciplinary selection of topics from the calcium field could provide a good source of information for all those in terested in calcium-mediated physiology. The volume begins with an overview on the synarchic nature of the two 2 cellular messengers, cyclic AMP and Ca +. The next three chapters deal with 2 the various transport mechanisms for Ca +. The biochemistry and molecular biology of calmodulin, as well as the cellular localization of calmodulin and calmodulin-binding proteins, are reviewed. Calcium regulation of smooth muscle contraction introduces the pharmacology of calcium antagonists.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1976 with total page 1474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Neuronal Responsiveness written by Yigal H. Ehrlich and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
Download or read book Cyclic Nucleotides written by P. D. Kebabian and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 907 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotides are intimately involved in the consequences of either stimulation or blockade of receptors; therefore, an understanding of the biochemistry of cyclic nucleotides ought to be important for pharmacologists. Pharmacology is a science that among other things investigates chemical compounds that affect the physiology of cells, tissues and organs. Frequently pharmacologists account for the effect of low concentrations of a drug upon a tissue by invoking the presence of a receptor upon the surface of the cell. Traditional pharmacologists excelled at identifying and classifying the properties of receptors. A. J. CLARK'S monograph in the earlier series of the Handbook of Experimental Pharmacology (CLARK 1937) summarized the mathematics underlying the traditional pharmacological approach towards receptors. By its nature, however, classic pharmacology provided little useful information about the intracellular events occurring as a consequence of occupying a receptor; for example, ALQUIST (1948) identified the beta-adrenocep tor, but he did not provide any insight into how stimulation of the receptor produces tissue-specific physiological responses. The discovery of cyclic AMP by RALL and SUTHERLAND (see RALL, Vol. I) led to biochemical investigations of many different receptors (including ALQUIST'S beta-adrenoceptor) that share a cyclic nucleotide as a common factor in the biochemical mechanisms that translate the occupancy of receptors into physiological effects. Ten years ago, in the introduction to their monograph on cyclic nucleotides, ROBISON et al. (1971) commented on the rapid growth of interest in cyclic nucleotides over the preceding years.
Download or read book Memory and the Brain written by Magda B. Arnold and published by Psychology Press. This book was released on 2013-05-13 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in the year 1984, Memory and the Brain is a valuable contribution to the field of Neuropsychology.
Download or read book Adaptive Capabilities of the Nervous System written by and published by Elsevier. This book was released on 2011-09-22 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adaptive Capabilities of the Nervous System
Download or read book Neurochemical Transmitters and Modulators written by and published by . This book was released on 1980 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book International Review of Neurobiology written by and published by Academic Press. This book was released on 1984-05-31 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Neurobiology
Download or read book Scientific Directory and Annual Bibliography written by National Institutes of Health (U.S.) and published by . This book was released on with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Published Scientific Papers of the National Institutes of Health written by National Institutes of Health (U.S.) and published by . This book was released on 1981 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue lists papers published during the preceding year.
Download or read book Function and Structure of the Immune System written by Wolfgang Muller-Ruchholtz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the Proceedings of the VI. International Conference on Lymphatic Tissues and Germinal Centers in Immune Reactions. The Meeting took place in Damp, a small resort with great facilities on the shores of the Baltic Sea near Kiel on June 11 - 16, 1978. Both, the Genius loci and the God of Weathers were charming enough to stimulate the many participants from all continents and also to facilitate the establishment and/or maintenance of close contacts outside the sessions. The organizers of this Conference have tried to remind the scientific community of the necessity to (re-) consider sufficiently the role of morphological studies for a thorough understanding of immune reactions. Furthermore, they have been anxious to emphasize a closer connection between analytical work and biological relevance of the phenomena observed. Thus, three main trends were formulated: (1) connections and correlations between function and structure, (2) in-vivo relevance of in-vitro models and (3) clinical relevance of experimental models. The programme, induced by these outlines and reflected by the contents of this volume, covers a remarkably broad field of interests and activities. It is set in order under nine session chapters. Each of them may allow the reader to answer for himself the question how far the above trends have been recognized, especially when considering the variety of new methodological approaches reported.
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1980 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroethology written by J.-P. Ewert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically the search for the neural bases of behavior goes back a long way. Neuroethology, which is concerned with the experimental analysis ofthe releasing and control mech anisms of behavior, is a young discipline. Results from this multidisciplinary branch of research, which uses physical, chemical, and mathematical methods, have not yet been extensively treated in textbooks of neurophysiology and ethology. This book is intended as a first attempt to pose major questions of neuroethology and to demonstrate, by means of selected research examples, some of the ways by which these questions are being approached. Inevitably this cannot be a complete and in depth detailed treatment of all of the neurobiology examples, and I realize that such a selection is of a subjective nature. The overall goal ofthe book is to present an introduction. After outlining some of the very basic neurophysiological and ethological concepts (Chaps. 2 and 3), neuroethological questions and methods are demonstrated extensively by means of a particular example (Chap. 4). There are two reasons to choose the visually guided prey-catching and avoidance behavior of the Common Toad: (1) it is a system which I have inves tigated for about fifteen years and therefore know best, (2) the toad story is one of the most comprehensive neuro ethological approaches so far. Thus, it is possible here to outline the major concepts of neuroethology and to pose the basic questions.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
