Download or read book Modulation of Signal Transduction in the Brain by Lithium written by Mary Blanche Williams and published by . This book was released on 1995 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bipolar Disorders written by Gershon Samuel and published by CRC Press. This book was released on 2000-04-25 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this
Download or read book Signal Transduction and Human Disease written by Toren Finkel and published by John Wiley & Sons. This book was released on 2003-07-18 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
Download or read book Bipolar Medications written by Husseini K. Manji and published by American Psychiatric Pub. This book was released on 2008-11-01 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lithium, the treatment of choice for mania since its usefulness was first reported, has been shown to have varied effects on multiple biological systems, including electrolyte flux and neurochemistry. Recent advances in cellular and molecular biology promise to provide clinicians with a better understanding of the etiology of bipolar disorder and new options for treatment. Bipolar Medications: Mechanisms of Action presents the treatment and prophylaxis of bipolar disorder. More than 40 investigators share research and insight into the neurobiological mechanisms that help to explain the powerful effects of new antibipolar drugs. This comprehensive text Examines valproic acid, lamotrigine, inositol monophosphatase inhibitors, and protein kinase C inhibitors that have the potential to revolutionize clinical practice and provide new hypotheses on the etiology of bipolar disorder Presents the current understanding of the cellular mechanisms of action of mood-stabilizing agents Discusses the emergence of valproate as a powerful lithium alternative and examines the preliminary indications that lamotrigine will be an effective option Examines the issue of withdrawal rebound, which can make lithium ineffective or even counterproductive, and reviews inositol monophosphatase inhibitors that mimic lithium action in patients Compares lithium, carbamazepine, and valproate and their differential mechanisms, which could form the basis of a "rational polypharmacy" of manic depressive illness Examines behavioral models important in the screening of new antibipolar compounds and the effects of antibipolar compounds on immediate early genes Complete with extensive references, tables, and figures, this text is essential reading for any clinician who treats patients with bipolar disorder. It thoroughly documents the latest in psychopharmacology, as well as projecting future advances in the treatment of bipolar disorder.
Download or read book Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press. This book was released on 2005-07-21 with total page 1267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.
Download or read book Bipolar Disorder written by Steven E. Hyman and published by Routledge. This book was released on 2019-03-13 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a revolution in our understanding of mental illness and its effect on society. The science of mental illness has made enormous strides based on the just-completed decade of the brain and is poised to make quantum progress again based on the completion of the Human Genome Project. These and other developments are covered in this new multi-volume set, which brings together in one in-depth collection the most significant recent scholarship on mental and addictive disorders. The volumes are organized to provide cutting-edge views of the epidemiology, genetics, evolutionary perspectives, and brain and behavioral science of mental illness, as well as selected papers on treatment. The papers are selected from leading journals in the US and worldwide based on their significance and on the need to provide a balanced perspective. The collection offers a comprehensive and up-to-date overview, and includes introductions that make the technical aspects of the papers accessible.
Download or read book Signal Transduction in Affective Disorders written by Hiroki Ozawa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent progress in brain science has been remarkable, especially with regard to advances in the area of neuroscience. Particularly in the past decade, there have been many important discoveries about signal transduction in the brain. With this background, biological research in affective disorders has become well developed in relation to neural signaling. However, this field is fairly hard to understand comprehensively, and there is relatively little integrative work with clinical psychiatry in spite of the involvement of a wide variety of scien tific disciplines. This monograph brings together up-to-date reviews from several young Japanese scientists who work in basic and clinical neuroscience. The intention is to explain in plain language the information that has evolved on signal transduction in terms of the biological abnormalities and mechanisms of anti depressants. The model shown on the cover (and on page 24) is intended to help the reader understand signal transduction in the brain and the patho physiology of affective disorders as well as the mechanisms of antidepressants.
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1991 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropsychopharmacology written by Kenneth L. Davis and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Download or read book Canadian Journal of Physiology and Pharmacology written by and published by . This book was released on 2000 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Psychopharmacogenetics written by Philip Gorwood and published by Springer Science & Business Media. This book was released on 2006-08-27 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the basic and advanced knowledge on psychiatric disorders for non-clinicians. The volume compiles in-depth information on the psychopharmacogenetic, representing an important area of research that is based on various specialties including clinical psychiatry, pharmacology, neurobiology and genetics. The book also addresses questions related to the field of psychiatric disorders that are not usually addressed in one work. The questions considered include: What is schizophrenia? What are the risk factors? What are the core symptoms? How is it treated? What are the efficacy and side effects of the available treatments?
Download or read book Biomedical Index to PHS supported Research written by and published by . This book was released on 1989 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Science and Practice of Lithium Therapy written by Gin S. Malhi and published by Springer. This book was released on 2016-11-24 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects. Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide, and those that are recipients of lithium therapy.
Download or read book Metal Ions and Neurodegenerative Disorders written by Paolo Zatta and published by World Scientific. This book was released on 2003 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on ?Metals and the Brain: From Neurochemistry to Neurodegeneration? (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.
Download or read book Metal Ions And Neurodengenerative Disorders written by Paolo Zatta and published by World Scientific. This book was released on 2003-11-03 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on “Metals and the Brain: From Neurochemistry to Neurodegeneration” (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.
Download or read book Bipolar Disorder written by Jarrett Barnhill and published by BoD – Books on Demand. This book was released on 2012-02-24 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bipolar Disorder: Portrait of a Complex Mood Disorder is a step towards integrating many diverse perspectives on BD. As we shall see, such diversity makes it difficult to clearly define the boundaries of BD. It is helpful to view BD from this perspective, as a final common pathway arises from multiple frames of reference. The integration of epigenetics, molecular pharmacology, and neurophysiology is essential. One solution involves using this diverse data to search for endophenotypes to aid researchers, even though most clinicians prefer broader groupings of symptoms and clinical variables. Our challenge is to consolidate this new information with existing clinical practice in a usable fashion. This need for convergent thinkers who can integrate the findings in this book remains a critical need. This book is a small step in that direction and hopefully guides researchers and clinicians towards a new synthesis of basic neurosciences and clinical psychiatry
Download or read book Brain Injury and Mental Retardation written by C. Thomas Gualtieri and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative resource is ideal for those caring for patients wit h traumatic brain injury (TBI) and mental retardation (MR) syndromes. The text is structured in an easy to follow format: five chapters on b rain injury syndromes, five chapters on mental retardation syndromes, four chapters devoted to other neuropathic conditions that are common to both, and six chapters that feature the drugs and how to use them. The drug section is tailored to the psychiatric disorders relevant to these specific patient populations.
