Download or read book Modulation of Oxidative Stress in Heart Disease written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-10 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Download or read book Oxidative Stress in Heart Diseases written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-06 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.
Download or read book Oxidative Stress and Vascular Disease written by John F. Keaney Jr. and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.
Download or read book Mechanisms and Modulation of Oxidative Stress written by Emmett Allison and published by States Academic Press. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress refers to a condition caused by an imbalance between the systemic expression of reactive oxygen species (ROS) and the ability of a biological system to quickly detoxify the reactive intermediates or repair the harm. Strand breaks in DNA and base damage are caused by oxidative stress. It can interrupt normal mechanisms of cellular signaling and has been linked to the development of a number of diseases such as cancer, cardiovascular diseases and neurodegenerative diseases. Modulation of oxidative stress is done specifically through the regulation of gene transcription, such as the activation or inhibition of Nrf2. It is regarded as an important strategy for developing new drugs for some of the pathologies, including neoplastic and cardiovascular diseases, that are resistant to other treatments. This book provides significant information to help develop a good understanding of oxidative stress mechanisms and modulation. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of this subject.
Download or read book Oxidative Stress in Microbial Diseases written by Sajal Chakraborti and published by Springer. This book was released on 2019-11-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.
Download or read book Modulators of Oxidative Stress written by Hande Gurer-Orhan and published by MDPI. This book was released on 2020-11-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.
Download or read book Antioxidants in Sport Nutrition written by Manfred Lamprecht and published by CRC Press. This book was released on 2014-09-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.
Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Download or read book Modulation of Oxidative Stress written by Luciano Saso and published by Elsevier. This book was released on 2023-08-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modulation of Oxidative Stress: Biochemical, Physiological and Pharmacological Aspects explores the field using an interdisciplinary approach, including chemical, biological, physiological, pharmaceutical, pharmacological and physicochemical perspectives. The book is comprised of three main parts, with the first discussing the biochemical aspects of oxidative stress modulation. Other sections cover physiological and pathophysiological aspects on relevant conditions, including aging, neurological diseases, cerebral cavernous malformation, maternal and early-life malnutrition, Alzheimer’s disease, liver transplant, and cancer. Final content is dedicated to pharmacological aspects and includes chapters on phytotherapy and flavonoids. This book is a strong reference for pharma researchers in academia and industry considering leveraging modulation of oxidative stress as a strategy for the development of new drugs. Biochemists and Nutritionists may also benefit of the foundational understanding of cellular redox processes laid out. Provides the latest updates in the fast-developing field of REDOX biochemistry and pharmacology Presents content that is clear and easy to read Useful for researchers and instructors in many fields
Download or read book A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2016-12-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.
Download or read book Oxidative Stress and Chronic Degenerative Diseases written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2013-05-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.
Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Download or read book Vitamin D written by Adrian F. Gombart and published by CRC Press. This book was released on 2012-11-21 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. F
Download or read book A Critical Evaluation of Vitamin D written by Sivakumar Joghi Thatha Gowder and published by . This book was released on 2017-04-12 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Aging Research in Yeast written by Michael Breitenbach and published by Springer Science & Business Media. This book was released on 2011-11-19 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes contributions by the leading experts in the field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and other fungal organisms provide models for aging research that are relevant to organismic aging and to the aging processes occurring in the human body. Replicative aging, in which only the mother cell ages while the daughter cell resets the clock to zero is a model for the aging of stem cell populations in humans, while chronological aging (measured by survival in stationary phase) is a model for the aging processes in postmitotic cells (for instance, neurons of the brain). Most mechanisms of aging are studied in yeast. Among them, this book discusses: mitochondrial theories of aging, emphasizing oxidative stress and retrograde responses; the role of autophagy and mitophagy; the relationship of apoptosis to aging processes; the role of asymmetric segregation of damage in replicative aging; the role of replication stress; and the role of the cytoskeleton in aging. Modern methods of yeast genetics and genomics are described that can be used to search for aging-specific functions in a genome-wide unbiased fashion. The similarities in the pathology of senescence (studied in yeast) and of cancer cells, including genome instability, are examined.
Download or read book Myocardial Protection written by Tomas A. Salerno and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.
Download or read book Oxidative Stress in Skeletal Muscle written by Abraham Z. Reznick and published by Springer Science & Business Media. This book was released on 1998 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radicals and oxidative damage in biology and medicine: An introduction.- Oxidative metabolism in skeletal muscle.- Strategies to assess oxidative stress.- The course of exercise-induced skeletal muscle fibre injury.- Free radical mechanisms in exercise-related muscle damage.- The effects of exercise, ageing and caloric restriction on protein oxidation and DNA damage in skeletal muscle.- Antioxidant enzyme response to exercise and training in the skeletal muscle.- Glutathione: A key role in skeletal muscle metabolism.- Vitamin E and its effect on skeletal muscle.- Differential susceptibility of skeletal muscle proteins to free radical-induced oxidative damage in vitro.- Oxidative stress and Ca2+ transport in skeletal and cardiac sarcoplasmic reticulum.- Oxidative stress in skeletal muscle atrophy induced by immobilization.- Effect of growth hormone on oxidative stress in immobilized muscles of old animals.- The diaphragm and oxidative stress.- Oxidative damage after ischemia/reperfusion in skeletal muscle.- Oxidative damage in rat skeletal muscle after excessive L-tryptophan and atherogenic diets.- Oxidative stress and muscle wasting of cachexia.- Free radicals and antioxidants in the pathogenesis of alcoholic myopathy.- Drug-induced muscle damage.- Free radicals and diseases of animal muscle.- Therapeutic trials of antioxidants in muscle diseases.
