Download or read book Modulation de la r ponse inflammatoire parodontale written by Théo Filloz and published by . This book was released on 2015 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modulation de la r ponse inflammatoire en parodontologie written by Alexia Larderet and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Résumé : les maladies parodontales sont des maladies inflammatoires à étiologie infectieuse, dont la thérapeutique initiale non chirurgicale consiste à supprimer mécaniquement les pathogènes par détartrage et curetage radiculaire. En fonction des caractéristiques de la lésion, l'approche chirurgicale trouve également ses indications, afin de réduire la charge bactérienne et l'inflammation. Ces procédures conduisent à la réduction de profondeur de poche et un gain d'attache clinique, mais ne conduisent pas à la régénération des tissus parodontaux en soi car elles ne restituent ni la forme, ni la fonction des tissus détruits. Nous nous intéressons de plus près à la modulation de la réponse infectieuse en tant que thérapie adjuvante, en parodontologie. L'utilisation de médicaments anti-inflammatoires non-stéroïdiens, notamment les inhibiteurs sélectifs de Cox2, ont montré une amélioration des résultats sur les tissus parodontaux après débridement mécanique. Cependant, l'intérêt de l'usage systémique de médicaments anti-inflammatoires en parodontologie reste limité et discutable, en raison des nombreux effets indésirables liés à l'administration de ces molécules. Afin de palier à ces risques, une nouvelle approche thérapeutique consiste à cibler de plus près les acteurs de la réponse inflammatoire dans la cicatrisation parodontale. Différentes stratégies ont été proposées afin de promouvoir la régénération parodontale via la modulation de cytokines, chimiokines et enzymes dérivées de l'hôte, dans le but d'inhiber les voies responsables de la destruction tissulaire et d'activer la prolifération et différenciation tissulaire. L'absence de régénération tissulaire est également due à la compétition tissulaire entre les différents tissus parodontaux et les taux variables de prolifération, maturation et différentiation des cellules parodontales lors de la cicatrisation, d'où l'usage des membranes en tant que barrière physique. Ces dernières années, ces membranes ont évolué jusqu'à devenir de véritables systèmes de délivrance de facteurs de croissance et différenciation et d'efficaces régulateurs de la réponse inflammatoire, rendant la perspective de régénération parodontale vraie envisageable.
Download or read book La modulation de la r ponse de l h te en parodontologie written by Morgane Moglia and published by . This book was released on 2011 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: La parodontite est une maladie inflammatoire d’origine infectieuse et multifactorielle, faisant intervenir des mécanismes étiopathogéniques complexes.Les thérapeutiques actuelles agissent principalement sur l’élimination de la plaque dentaire contenant les bactéries pathogènes. Mais qu’en est-il des recherches sur les traitements modulant la réponse inflammatoire défectueuse ? Ces médications, utilisées en tant qu’adjuvants aux thérapeutiques conventionnelles, pourraient permettre un contrôle plus efficace, plus rapide et plus pérenne des maladies parodontales.L’objet de cette thèse est de faire le point sur les thérapeutiques pouvant être utilisées à des fins de modulation de la réponse de l’hôte, dans le cadre de la parodontologie.
Download or read book D veloppement de Strat gies Innovantes de R g n ration Parodontale Via la Modulation de la R ponse Inflammatoire written by Fareeha Batool and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Control of periodontal infection and inflammation is crucial for optimal periodontal wound healing and regeneration. For this purpose, three different and novel strategies were developed and tested for their impact on periodontal wound healing parameters in vitro and in vivo. Firstly, an ibuprofen-functionalized polycaprolactone (IBU-PCL) membrane was developed as an anti-inflammatory barrier membrane that successfully reduced inflammatory markers expression in gingival cells in vitro and decreased soft tissue inflammation, thus, improving periodontal tissue healing in an experimental periodontitis model in vivo. Secondly, chlorhexidine and ibuprofen containing in-situ forming implant (CHX-IBU ISFI) was developed to target both infection and inflammation that successfully reduced Porphyromonas gingivalis growth and inflammatory response of gingival cells in vitro as well as improved soft tissue periodontal wound healing in vivo. Lastly, a thermosensitive chitosan-based hydrogel functionalized with atorvastatin encapsulated in a nano-emulsion (ATV-KELP NE) was characterized and used to treat an induced bone defect in vivo that resulted in improved soft and hard tissue healing by counteracting infection and modulation of immuno-inflammatory response.
Download or read book R ponse inflammatoire gingivale aux biofilms dysbiotiques en condition d hyperglyc mie written by Sarah Lafleur and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ce projet porte sur l'impact de l'hyperglycémie sur la sécrétion de cytokines pro-inflammatoires et de métalloprotéinases matricielles par les cellules gingivales à la suite d'une stimulation de la réponse inflammatoire par des biofilms sous-gingivaux dysbiotiques. La maladie parodontale est une maladie inflammatoire induite par l'infiltration de bactéries parodontopathogènes et conduit à la destruction irréversible de l'ensemble des tissus de soutien de la dent. Celle-ci induit une inflammation qui joue un rôle important dans le développement d'une dysbiose du microbiome sous-gingival. Il a été suggéré qu'une dysbiose du microbiome sous-gingival augmentait le risque de parodontite chez des patients diabétiques à cause d'une inhibition de leurs réponses immunitaires et métaboliques. Cependant, l'impact de l'hyperglycémie sur la régulation de la réponse inflammatoire gingivale est peu connu et la modulation de cette réponse est peu étudiée. Nous avançons l'hypothèse qu'un environnement hyperglycémique peut affecter les interactions hôte-microbiome et par conséquent influencer la réponse inflammatoire d'un patient atteint de parodontite. Pour cela nous avons étudié la réponse inflammatoire d'un modèle de co-culture de fibroblastes gingivaux et de macrophages stimulés par des échantillons de plaque dentaire provenant d'individus sains ou atteints de parodontite, et ce, en présence de concentrations normales ou élevées de glucose. Le profil de sécrétion de cytokines pro-inflammatoires et métalloprotéinases matricielles a été par la suite analysé. Nous avons observé une augmentation significative des niveaux de sécrétions de plusieurs cytokines reflétant l'impact de l'environnement hyperglycémique sur la modulation de l'inflammation. Les résultats que nous avons obtenus permettront éventuellement de planifier des traitements parodontaux personnalisés et adaptés, ainsi que de développer des stratégies de prévention individualisées pour mieux contrôler le développement et la progression de la maladie parodontale chez les patients diabétiques.
Download or read book Modulation de la r ponse inflammatoire de l h te par les bact ries parodontopathog nes written by Charles Bodet and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Endocrinology of Dogs and Cats written by A. Rijnberk and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical endocrinology is a fascinating field requiring the challenging combination of broad pathophysiological interest and specific expertise in the field of endocrinology, thereby occupying a common ground between biochemistry, physiology and clinical medicine. In the majority of cases the clinician's notion of the presence of an endocrine disease is largely based upon pattern recognition, in which physical changes play an important role. Therefore many color illustrations have been included throughout the text. In addition there are many full color graphs and illustrations of diagnostic imaging and pathology. With over 350 illustrations the book represents a richly illustrated text on the diseases of endocrine glands. For each gland there is an introductory section on the relevant morphology and physiology, followed by descriptions of the disorders of the gland. When endocrine diseases are quite different in dogs and cats, separate descriptions are given for these species. Protocols for function tests and emergency treatments are presented in the last chapters. Consequently the book provides the user with both comprehensive descriptions and quick references. The book has been written by leading clinicians in the field, with contributions from two biochemists, a radiologist and pathologist. As such a valuable textbook for veterinary students and practitioners has been compiled to fulfil the need for an up-to-date and complete book on endocrine diseases of dogs and cats.
Download or read book Periodontal Diseases written by Jane Manakil and published by BoD – Books on Demand. This book was released on 2012-02-03 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Periodontal diseases" is a web-based resource intended to reach the contemporary practitioners as well as educators and students in the field of periodontology. It is fully searchable and designed to enhance the learning experience. Within the book a description is presented of the current concepts presenting the complex interactions of microbial fingerprint, multiple genotypes, and host modulations. In addition, an overview is given of the clinical outcome of the disease's progression, as influenced by the epigenetic factors. Emerging concepts on periodontitis as a risk factor for various systemic diseases and as a bilateral modulating factor have been elucidated in detail as well.
Download or read book Principles and Practice of Clinical Research written by John I. Gallin and published by Elsevier. This book was released on 2011-04-28 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.*Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research*Delves into data management and addresses how to collect data and use it for discovery*Contains valuable, up-to-date information on how to obtain funding from the federal government
Download or read book In Vitro Methods in Toxicology written by C. K. Atterwill and published by Cambridge University Press. This book was released on 1987-10-22 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists.
Download or read book Clinical Transcutaneous Electrical Nerve Stimulation written by Jeffrey S. Mannheimer and published by F. A. Davis Company. This book was released on 1984 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Restorative Techniques in Paediatric Dentistry written by M S Duggal and published by CRC Press. This book was released on 2021-03-30 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This was one of the first books on the market to illustrate the various clinical techniques for restoration, which is increasingly favored over extraction for primary teeth. A revised and updated edition of this successful text offers, in addition, new material on plastic restorations. Restorative Techniques addresses the specific needs of the pediatric patient, and it helps the clinician manage the restoration with those needs in mind. As a classic volume, it is essential for every dentist, particularly those who work with children and adolescents and particularly those who perform restorative dentistry.
Download or read book Encyclopedia of Pathology written by and published by Springer. This book was released on 2016-07-14 with total page 10000 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of this 15-20-volume set encompasses the entire field of pathology ranging from general pathological terms to specific diseases to diagnostic methods. Each volume contains homogenously structured entries and a team of international experts guarantee that the essays and definitions are scientifically sound. The A-Z format allows searching for a single word in case the reader does not know to which pathological speciality the term belongs. The major advantage of the encyclopedia is manner in which it makes relevant information available not only to pathologists, but to all clinicians and researchers of the neighbouring disciplines working with pathologists who might wish to look up terms online.
Download or read book Canine Olfaction Science and Law written by Tadeusz Jezierski and published by CRC Press. This book was released on 2016-04-20 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The value of the canine nose is well-documented, and working dogs are being utilized for their olfactory skills in an increasing number of fields. Not only are dogs used by police, security, and the military, but they are also now used in forensic science, in medical detection of disease, in calculating population trends of endangered species and e
Download or read book The Relationship between Cognitive Biases and Psychosis Searching for Mechanisms written by Łukasz Gawęda and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Folk lore and Legends written by C. J. T. and published by . This book was released on 1889 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Marfan Syndrome written by Barbara A. Bernhardt and published by . This book was released on 1988-01-01 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
