Download or read book Modulation de la r ponse inflammatoire en parodontologie written by Alexia Larderet and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Résumé : les maladies parodontales sont des maladies inflammatoires à étiologie infectieuse, dont la thérapeutique initiale non chirurgicale consiste à supprimer mécaniquement les pathogènes par détartrage et curetage radiculaire. En fonction des caractéristiques de la lésion, l'approche chirurgicale trouve également ses indications, afin de réduire la charge bactérienne et l'inflammation. Ces procédures conduisent à la réduction de profondeur de poche et un gain d'attache clinique, mais ne conduisent pas à la régénération des tissus parodontaux en soi car elles ne restituent ni la forme, ni la fonction des tissus détruits. Nous nous intéressons de plus près à la modulation de la réponse infectieuse en tant que thérapie adjuvante, en parodontologie. L'utilisation de médicaments anti-inflammatoires non-stéroïdiens, notamment les inhibiteurs sélectifs de Cox2, ont montré une amélioration des résultats sur les tissus parodontaux après débridement mécanique. Cependant, l'intérêt de l'usage systémique de médicaments anti-inflammatoires en parodontologie reste limité et discutable, en raison des nombreux effets indésirables liés à l'administration de ces molécules. Afin de palier à ces risques, une nouvelle approche thérapeutique consiste à cibler de plus près les acteurs de la réponse inflammatoire dans la cicatrisation parodontale. Différentes stratégies ont été proposées afin de promouvoir la régénération parodontale via la modulation de cytokines, chimiokines et enzymes dérivées de l'hôte, dans le but d'inhiber les voies responsables de la destruction tissulaire et d'activer la prolifération et différenciation tissulaire. L'absence de régénération tissulaire est également due à la compétition tissulaire entre les différents tissus parodontaux et les taux variables de prolifération, maturation et différentiation des cellules parodontales lors de la cicatrisation, d'où l'usage des membranes en tant que barrière physique. Ces dernières années, ces membranes ont évolué jusqu'à devenir de véritables systèmes de délivrance de facteurs de croissance et différenciation et d'efficaces régulateurs de la réponse inflammatoire, rendant la perspective de régénération parodontale vraie envisageable.
Download or read book Modulation de la r ponse inflammatoire parodontale written by Théo Filloz and published by . This book was released on 2015 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book La modulation de la r ponse de l h te en parodontologie written by Morgane Moglia and published by . This book was released on 2011 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: La parodontite est une maladie inflammatoire d’origine infectieuse et multifactorielle, faisant intervenir des mécanismes étiopathogéniques complexes.Les thérapeutiques actuelles agissent principalement sur l’élimination de la plaque dentaire contenant les bactéries pathogènes. Mais qu’en est-il des recherches sur les traitements modulant la réponse inflammatoire défectueuse ? Ces médications, utilisées en tant qu’adjuvants aux thérapeutiques conventionnelles, pourraient permettre un contrôle plus efficace, plus rapide et plus pérenne des maladies parodontales.L’objet de cette thèse est de faire le point sur les thérapeutiques pouvant être utilisées à des fins de modulation de la réponse de l’hôte, dans le cadre de la parodontologie.
Download or read book R ponse inflammatoire gingivale aux biofilms dysbiotiques en condition d hyperglyc mie written by Sarah Lafleur and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ce projet porte sur l'impact de l'hyperglycémie sur la sécrétion de cytokines pro-inflammatoires et de métalloprotéinases matricielles par les cellules gingivales à la suite d'une stimulation de la réponse inflammatoire par des biofilms sous-gingivaux dysbiotiques. La maladie parodontale est une maladie inflammatoire induite par l'infiltration de bactéries parodontopathogènes et conduit à la destruction irréversible de l'ensemble des tissus de soutien de la dent. Celle-ci induit une inflammation qui joue un rôle important dans le développement d'une dysbiose du microbiome sous-gingival. Il a été suggéré qu'une dysbiose du microbiome sous-gingival augmentait le risque de parodontite chez des patients diabétiques à cause d'une inhibition de leurs réponses immunitaires et métaboliques. Cependant, l'impact de l'hyperglycémie sur la régulation de la réponse inflammatoire gingivale est peu connu et la modulation de cette réponse est peu étudiée. Nous avançons l'hypothèse qu'un environnement hyperglycémique peut affecter les interactions hôte-microbiome et par conséquent influencer la réponse inflammatoire d'un patient atteint de parodontite. Pour cela nous avons étudié la réponse inflammatoire d'un modèle de co-culture de fibroblastes gingivaux et de macrophages stimulés par des échantillons de plaque dentaire provenant d'individus sains ou atteints de parodontite, et ce, en présence de concentrations normales ou élevées de glucose. Le profil de sécrétion de cytokines pro-inflammatoires et métalloprotéinases matricielles a été par la suite analysé. Nous avons observé une augmentation significative des niveaux de sécrétions de plusieurs cytokines reflétant l'impact de l'environnement hyperglycémique sur la modulation de l'inflammation. Les résultats que nous avons obtenus permettront éventuellement de planifier des traitements parodontaux personnalisés et adaptés, ainsi que de développer des stratégies de prévention individualisées pour mieux contrôler le développement et la progression de la maladie parodontale chez les patients diabétiques.
Download or read book Modulation de la r ponse inflammatoire de l h te par les bact ries parodontopathog nes written by Charles Bodet and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book D veloppement de Strat gies Innovantes de R g n ration Parodontale Via la Modulation de la R ponse Inflammatoire written by Fareeha Batool and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Control of periodontal infection and inflammation is crucial for optimal periodontal wound healing and regeneration. For this purpose, three different and novel strategies were developed and tested for their impact on periodontal wound healing parameters in vitro and in vivo. Firstly, an ibuprofen-functionalized polycaprolactone (IBU-PCL) membrane was developed as an anti-inflammatory barrier membrane that successfully reduced inflammatory markers expression in gingival cells in vitro and decreased soft tissue inflammation, thus, improving periodontal tissue healing in an experimental periodontitis model in vivo. Secondly, chlorhexidine and ibuprofen containing in-situ forming implant (CHX-IBU ISFI) was developed to target both infection and inflammation that successfully reduced Porphyromonas gingivalis growth and inflammatory response of gingival cells in vitro as well as improved soft tissue periodontal wound healing in vivo. Lastly, a thermosensitive chitosan-based hydrogel functionalized with atorvastatin encapsulated in a nano-emulsion (ATV-KELP NE) was characterized and used to treat an induced bone defect in vivo that resulted in improved soft and hard tissue healing by counteracting infection and modulation of immuno-inflammatory response.
Download or read book In Vitro Methods in Toxicology written by C. K. Atterwill and published by Cambridge University Press. This book was released on 1987-10-22 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume brings together the once disparate knowledge of cultural techniques and thus provides an important reference work for industrial and academic toxicologists.
Download or read book Principles and Practice of Clinical Research written by John I. Gallin and published by Elsevier. This book was released on 2011-04-28 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.*Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research*Delves into data management and addresses how to collect data and use it for discovery*Contains valuable, up-to-date information on how to obtain funding from the federal government
Download or read book Clinical Transcutaneous Electrical Nerve Stimulation written by Jeffrey S. Mannheimer and published by F. A. Davis Company. This book was released on 1984 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Restorative Techniques in Paediatric Dentistry written by M S Duggal and published by CRC Press. This book was released on 2021-03-30 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This was one of the first books on the market to illustrate the various clinical techniques for restoration, which is increasingly favored over extraction for primary teeth. A revised and updated edition of this successful text offers, in addition, new material on plastic restorations. Restorative Techniques addresses the specific needs of the pediatric patient, and it helps the clinician manage the restoration with those needs in mind. As a classic volume, it is essential for every dentist, particularly those who work with children and adolescents and particularly those who perform restorative dentistry.
Download or read book The Relationship between Cognitive Biases and Psychosis Searching for Mechanisms written by Łukasz Gawęda and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Canine Olfaction Science and Law written by Tadeusz Jezierski and published by CRC Press. This book was released on 2016-04-20 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The value of the canine nose is well-documented, and working dogs are being utilized for their olfactory skills in an increasing number of fields. Not only are dogs used by police, security, and the military, but they are also now used in forensic science, in medical detection of disease, in calculating population trends of endangered species and e
Download or read book Peripheral Nerve Regeneration written by Giovanna Gambarotta and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gait Analysis in the Science of Rehabilitation written by Joel A. DeLisa and published by DIANE Publishing. This book was released on 1998 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Instrumented gait analysis systems offer objective evaluation of the effectiveness of the various rehabilitation treatments that are aimed at improving gait disabilities. There are four sections in this report: clinical observation; review of the instrumental gait analysis systems; the value of information resulting from instrumented gait analysis from the perspective of a psychiatrist, an orthopedic surgeon, & a physical therapist; & discussion of future trends for gait laboratories. The authors are experts from multiple rehabilitation specialties to give you an understanding of how gait analysis can be used to evaluate a person's walking abilities to maximize function & maintain or improve quality of life. Illustrations.
Download or read book Extracellular Vesicles in Health and Disease written by Paul Harrison and published by CRC Press. This book was released on 2014-05-02 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role in pathogenesis as well as their possible use as biomarkers. This book stems from the first international meeting on "Microvesicles and Nanovesicles in Health and Disease" held at Magdalen College, Oxford, in 2010. The purpose of the meeting was to bring together, for the first time, a range of experts from around the world to discuss the latest advances in this field. Key to the study of these vesicles is the availability of methodologies for their measurement in biological fluids. A major section of the meeting focused on a range of exciting new technologies which have been developed for this purpose. The presentations at this meeting form the basis of this book, which will appeal to basic scientists, clinicians, and those developing technology for the measurement of extracellular vesicles.
Download or read book Ovarialtumoren written by G. Dallenbach-Hellweg and published by Springer. This book was released on 1982-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die Ovarialtumoren gehoren heute mit zu den haufigsten Tumoren des weiblichen Genitale. Ihre morphologische Differentialdiagnostik und die sich darauf aufbauende gezielte Therapie ist aufgrund der Vielfalt dieser Tumoren ungleich viel komplizierter als in anderen Organen. Dement sprechend liegt der Schwerpunkt dieses Buches auf dem Gebiet der Histo pathologie. Spezialkenntnisse insbesondere tiber die selteneren Formen der Ovarialtumoren hangen von groBen Fallzahlen abo Hier ist der inter nationale Erfahrungsaustausch von vorrangiger Bedeutung. Die derzeit weltweit anerkannte histogenetische Klassifikation der WHO erfahrt an hand der Erfahrungen an drei deutschen Frauenkliniken kleine Erganzun gen und Variationen. Einige Lander, Z. B. Israel verfUgen tiber groBe epi demiologische Untersuchungen, deren Ergebnisse korrelierend aufgenom men sind. Zur klinischen Diagnostik wurden in den letzten lahren mo dernste Untersuchungsmt;thoden neu eingefUhrt; ihre Anwendung setzt jedoch individuell anzupassende kritische Indikationsstellungen voraus. AbschlieBend werden die sich sehr differenziert auf der histologischen Diagnostik aufbauenden modernen Moglichkeiten einer gezielten Thera pie der Ovarialtumoren ausfUhrlich diskutiert. Hier steht die Chemothera pie im Vordergrund. 1m Hinblick auf die Frage einer Hormonbehandlung kommt neuerdings auch dem Rezeptornachweis im Tumorgewebe Bedeu tung zu. Diese Zusammenstellung spricht somit gleichermaBen Pathologen, Onkologen und Gynakologen an und will versuchen, gegenseitige Infor mationslticken der Fachexperten auf dem Gesamtgebiet der Problematik der Ovarialtumoren in zumutbarer Klirze zu schlieJ3en. Daher nehmen ge rade die selteneren und bisher weniger bekannten Tumoren in Bild und Text einen verhaltnismaBig breiten Raum ein auf Kosten der hinlanglich bekannten haufigeren Formen, bei denen Spezia1fragen der Differenti- diagnostik aufgrund neuester Erkenntnisse im Vordergrund stehen.
Download or read book Buruli Ulcer written by Gerd Pluschke and published by Springer. This book was released on 2019-04-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.
