Download or read book Models and Tools for Studying Genetic and Cultural Variation written by Ethan Macneil Jewett and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental goal of population genetics is to understand how historical events and processes, such as speciation, migration, natural selection, and drift, have contributed to genetic variation among modern individuals. In humans, factors that contribute to genetic variation also include cultural phenomena and practices such as marriage customs and membership in cultural or linguistic groups that act as either barriers to, or catalysts for, contact and mating. Mathematical models of genetic evolution can be applied to make inferences about factors that have influenced genetic variation among populations over time. Analyses of cultural data can enhance these analyses by identifying cultural phenomena that have contributed to contact and isolation among populations and by providing an additional source of information that can be used to infer demographic histories. In this thesis, I first describe work on mathematical modeling approaches that can be used to infer the historical relationships among populations, and to model the effects of these relationships on present-day genetic diversity. Next, I describe empirical analyses of cultural variation that shed light on recent cultural, geographic, and demographic factors that have influenced both cultural and genetic diffusion among populations. The first three chapters focus on mathematical models of genetic variation. In Chapter 1, I apply a coalescent model to reduce the expected error in an existing algorithm (the GLASS method) for inferring the historical relationships among populations or species. The new method I develop provides fast and accurate estimates of the topological and temporal relationships among a set of extant populations. These estimates can be used to obtain accurate null models for downstream analyses, such as comparative genetic studies to identify signals of adaptation. In Chapter 2, I extend the model of Chapter 1 to derive expressions for the theoretical accuracy of algorithms that perform genotype imputation, a key component of many genome-wide association studies of the genetic bases of phenotypic traits. The expressions I derive can be used to guide sampling designs for collecting panels of imputation reference haplotypes, thus improving the power of genome-wide association studies to detect the genetic variants that underlie phenotypic variation. Coalescent models like those presented in chapters 1 and 2 can be computationally difficult to implement on modern genomic data sets with many sampled individuals. The complexity of these computations can be reduced by making use of an approximation to the coalescent model in which the number of ancestral alleles in a population is assumed to change deterministically as time moves backwards. In Chapter 3, I describe general procedures for applying this deterministic approximation to obtain functionally simple and computationally fast approximations to coalescent formulas that are otherwise challenging to compute on data sets with many sampled individuals. In chapters 4 and 5, I present empirical analyses designed to identify cultural factors that can affect genetic variation, as well as factors that can affect both genetic and cultural differences among populations. In Chapter 4, I present an analysis of linguistic and cultural diversity in the United States, with the goal of understanding factors that have contributed to cultural isolation and diffusion among demographic groups over time. In Chapter 5, I present a joint analysis of genetic and linguistic data in Cape Verde, an archipelago near the coast of western Africa with a long history of genetic and linguistic admixture between European and African populations. This analysis sheds light on demographic and geographical factors that affect both genetic and linguistic variation, and on the degree to which linguistic inheritance parallels genetic inheritance. The modeling approaches, theory, and analyses presented in this thesis provide a set of tools that facilitate studies of the factors that affect genetic and cultural variation within and among populations.
Download or read book In the Light of Evolution written by National Academy of Sciences and published by . This book was released on 2007 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.
Download or read book Evaluating Human Genetic Diversity written by National Research Council and published by National Academies Press. This book was released on 1998-01-19 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.
Download or read book Systems Genetics written by Florian Markowetz and published by Cambridge University Press. This book was released on 2015-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
Download or read book Culture Evolves written by Andrew Whiten and published by Oxford University Press. This book was released on 2012 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Culture shapes vast swathes of our lives and has allowed the human species to dominate the planet in an evolutionarily unique way. This book is unique in focusing on the evolutionary continuities in culture, providing an interdisciplinary exploration of culture, written by leading authorities from the biological and cognitive sciences.
Download or read book Genes Behavior and the Social Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2006-12-07 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.
Download or read book Not By Genes Alone written by Peter J. Richerson and published by University of Chicago Press. This book was released on 2008-06-20 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans are a striking anomaly in the natural world. While we are similar to other mammals in many ways, our behavior sets us apart. Our unparalleled ability to adapt has allowed us to occupy virtually every habitat on earth using an incredible variety of tools and subsistence techniques. Our societies are larger, more complex, and more cooperative than any other mammal's. In this stunning exploration of human adaptation, Peter J. Richerson and Robert Boyd argue that only a Darwinian theory of cultural evolution can explain these unique characteristics. Not by Genes Alone offers a radical interpretation of human evolution, arguing that our ecological dominance and our singular social systems stem from a psychology uniquely adapted to create complex culture. Richerson and Boyd illustrate here that culture is neither superorganic nor the handmaiden of the genes. Rather, it is essential to human adaptation, as much a part of human biology as bipedal locomotion. Drawing on work in the fields of anthropology, political science, sociology, and economics—and building their case with such fascinating examples as kayaks, corporations, clever knots, and yams that require twelve men to carry them—Richerson and Boyd convincingly demonstrate that culture and biology are inextricably linked, and they show us how to think about their interaction in a way that yields a richer understanding of human nature. In abandoning the nature-versus-nurture debate as fundamentally misconceived, Not by Genes Alone is a truly original and groundbreaking theory of the role of culture in evolution and a book to be reckoned with for generations to come. “I continue to be surprised by the number of educated people (many of them biologists) who think that offering explanations for human behavior in terms of culture somehow disproves the suggestion that human behavior can be explained in Darwinian evolutionary terms. Fortunately, we now have a book to which they may be directed for enlightenment . . . . It is a book full of good sense and the kinds of intellectual rigor and clarity of writing that we have come to expect from the Boyd/Richerson stable.”—Robin Dunbar, Nature “Not by Genes Alone is a valuable and very readable synthesis of a still embryonic but very important subject straddling the sciences and humanities.”—E. O. Wilson, Harvard University
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Cultural Evolution written by Peter J. Richerson and published by MIT Press. This book was released on 2013-11-01 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scholars report on current research that demonstrates the central role of cultural evolution in explaining human behavior. Over the past few decades, a growing body of research has emerged from a variety of disciplines to highlight the importance of cultural evolution in understanding human behavior. Wider application of these insights, however, has been hampered by traditional disciplinary boundaries. To remedy this, in this volume leading researchers from theoretical biology, developmental and cognitive psychology, linguistics, anthropology, sociology, religious studies, history, and economics come together to explore the central role of cultural evolution in different aspects of human endeavor. The contributors take as their guiding principle the idea that cultural evolution can provide an important integrating function across the various disciplines of the human sciences, as organic evolution does for biology. The benefits of adopting a cultural evolutionary perspective are demonstrated by contributions on social systems, technology, language, and religion. Topics covered include enforcement of norms in human groups, the neuroscience of technology, language diversity, and prosociality and religion. The contributors evaluate current research on cultural evolution and consider its broader theoretical and practical implications, synthesizing past and ongoing work and sketching a roadmap for future cross-disciplinary efforts. Contributors Quentin D. Atkinson, Andrea Baronchelli, Robert Boyd, Briggs Buchanan, Joseph Bulbulia, Morten H. Christiansen, Emma Cohen, William Croft, Michael Cysouw, Dan Dediu, Nicholas Evans, Emma Flynn, Pieter François, Simon Garrod, Armin W. Geertz, Herbert Gintis, Russell D. Gray, Simon J. Greenhill, Daniel B. M. Haun, Joseph Henrich, Daniel J. Hruschka, Marco A. Janssen, Fiona M. Jordan, Anne Kandler, James A. Kitts, Kevin N. Laland, Laurent Lehmann, Stephen C. Levinson, Elena Lieven, Sarah Mathew, Robert N. McCauley, Alex Mesoudi, Ara Norenzayan, Harriet Over, Jürgen Renn, Victoria Reyes-García, Peter J. Richerson, Stephen Shennan, Edward G. Slingerland, Dietrich Stout, Claudio Tennie, Peter Turchin, Carel van Schaik, Matthijs Van Veelen, Harvey Whitehouse, Thomas Widlok, Polly Wiessner, David Sloan Wilson
Download or read book Safety of Genetically Engineered Foods written by National Research Council and published by National Academies Press. This book was released on 2004-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.
Download or read book Human Population Genetics and Genomics written by Alan R. Templeton and published by Academic Press. This book was released on 2018-11-08 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. Comprehensively explains the use of population genetics and genomics in medical applications and research Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now
Download or read book C Elegans II written by Donald L. Riddle and published by Firefly Books. This book was released on 1997 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book How People Learn II written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-09-27 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many reasons to be curious about the way people learn, and the past several decades have seen an explosion of research that has important implications for individual learning, schooling, workforce training, and policy. In 2000, How People Learn: Brain, Mind, Experience, and School: Expanded Edition was published and its influence has been wide and deep. The report summarized insights on the nature of learning in school-aged children; described principles for the design of effective learning environments; and provided examples of how that could be implemented in the classroom. Since then, researchers have continued to investigate the nature of learning and have generated new findings related to the neurological processes involved in learning, individual and cultural variability related to learning, and educational technologies. In addition to expanding scientific understanding of the mechanisms of learning and how the brain adapts throughout the lifespan, there have been important discoveries about influences on learning, particularly sociocultural factors and the structure of learning environments. How People Learn II: Learners, Contexts, and Cultures provides a much-needed update incorporating insights gained from this research over the past decade. The book expands on the foundation laid out in the 2000 report and takes an in-depth look at the constellation of influences that affect individual learning. How People Learn II will become an indispensable resource to understand learning throughout the lifespan for educators of students and adults.
Download or read book Paleogenomics written by Charlotte Lindqvist and published by Springer. This book was released on 2019-01-07 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genome-scale DNA sequencing technologies have revolutionized genetic research on ancient organisms, extinct species, and past environments. When it is recoverable after hundreds or thousands of years of unintended preservation, “ancient DNA” (or aDNA) is often highly degraded, necessitating specialized handling and analytical approaches. Paleogenomics defines the field of reconstructing and analyzing the genomes of historic or long-dead organisms, most often through comparison with modern representatives of the same or similar species. The opportunity to isolate and study paleogenomes has radically transformed many fields, spanning biology, anthropology, agriculture, and medicine. Examples include understanding evolutionary relationships of extinct species known only from fossils, the domestication of plants and animals, and the evolution and geographical spread of certain pathogens. This pioneering book presents a snapshot view of the history, current status, and future prospects of paleogenomics, taking a broad viewpoint that covers a range of topics and organisms to provide an up-to-date status of the applications, challenges, and promise of the field. This book is intended for a variety of readerships, including upper-level undergraduate and graduate students, professionals and experts in the field, as well as anyone excited by the extraordinary insights that paleogenomics offers.
Download or read book Decolonizing Colonial Development Models in Africa written by Luke Amadi and published by Rowman & Littlefield. This book was released on 2022-01-17 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decolonizing Colonial Development Models in Africa: A New Postcolonial Critique confronts colonial development models to decolonize methodologies, epistemologies, and the history and practice of development in postcolonial African societies and advocates for Afrocentric alternatives. By taking a critical approach and drawing on postcolonial, postmodern, post-developmental, and post-structural theories, the contributors identify and analyze the effects of global inequality, racism, white supremacy, crisis, climate change, increasing environmental insecurity, underdevelopment, chronic diseases, and the vulnerability of the postcolonial societies of the global South. Together, the collection calls for and theorizes a new direction of development that incorporates indigenous-Afrocentric alternatives.
Download or read book Cultural Evolution written by Alex Mesoudi and published by University of Chicago Press. This book was released on 2011-07-30 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Charles Darwin changed the course of scientific thinking by showing how evolution accounts for the stunning diversity and biological complexity of life on earth. Recently, there has also been increased interest in the social sciences in how Darwinian theory can explain human culture. Covering a wide range of topics, including fads, public policy, the spread of religion, and herd behavior in markets, Alex Mesoudi shows that human culture is itself an evolutionary process that exhibits the key Darwinian mechanisms of variation, competition, and inheritance. This cross-disciplinary volume focuses on the ways cultural phenomena can be studied scientifically—from theoretical modeling to lab experiments, archaeological fieldwork to ethnographic studies—and shows how apparently disparate methods can complement one another to the mutual benefit of the various social science disciplines. Along the way, the book reveals how new insights arise from looking at culture from an evolutionary angle. Cultural Evolution provides a thought-provoking argument that Darwinian evolutionary theory can both unify different branches of inquiry and enhance understanding of human behavior.
Download or read book The Selfish Gene written by Richard Dawkins and published by Oxford University Press, USA. This book was released on 1989 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science
