Download or read book Modelling Optimization and Control of Biomedical Systems written by Efstratios N. Pistikopoulos and published by John Wiley & Sons. This book was released on 2018-01-09 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Download or read book Mathematical Modelling in Biomedicine written by Y. Cherruault and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approach your problems from the right It isn't that they can't see the solution. It end and begin with the answers. Then is that they can't see the problem. one day, perhaps you will find the final question. G.K. Chesterton. The Scandal of Father Brown 'The point of a Pin'. 'The Hermit Clad in Crane Feathers' in R. van Gulik's The Chinese Maze Murders. Growing specialization and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the "tree" of knowledge of mathematics and related fields does not grow only by putting forth new branches. It also happens, quite often in fact, that branches which were thought to be completely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non-trivially) in regional and theoretical economics; algebraic geometry interacts with physics; the Minkowsky lemma, cod ing theory and the structure of water meet one another in packing and covering theory; quantum fields, crystal defects and mathematical pro gramming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces.

Download or read book Modelling and Control in Biomedical Systems 2006 written by David Dagan Feng and published by Elsevier. This book was released on 2006-09-19 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modelling and Control in Biomedical Systems (including Biological Systems) was held in Reims, France, 20-22 August 2006. This Symposium was organised by the University of Reims Champagne Ardenne and the Société de l’Electricité, de l’Electronique et des TIC (SEE). The Symposium attracted practitioners in engineering, information technology, mathematics, medicine and biology, and other related disciplines, with authors from 24 countries. Besides the abstracts of the four plenary lectures, this volume contains the 92 papers that were presented by their authors at the Symposium. The papers included two invited keynote presentations given by internationally prominent and well-recognised research leaders: Claudio Cobelli, whose talk is titled "Dynamic modelling in diabetes: from whole body to genes"; and Irving J. Bigio, whose talk is titled "Elastic scattering spectroscopy for non-invasive detection of cancer". Two prestigious industrial speakers were also invited to give keynote presentations: Terry O'Brien from LIDCO, whose talk is titled "LIDCO: From the laboratory to protocolized goal directed therapy"; and Lorenzo Quinzio of Philips, whose talk is titled "Clinical decision support in monitoring and information systems". A valuable source of information on the state-of- the-art in Modelling and Control in Biomedical Systems Including abstracts of four plenary lectures, and 92 papers presented by their authors

Download or read book Modeling and Control in the Biomedical Sciences written by H.T. Banks and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: These notes are based on (i) a series of lectures that I gave at the 14th Biennial Seminar of the Canadian Mathematical Congress held at the University of Western Ontario August 12-24, 1973 and (li) some of my lectures in a modeling course that I have cotaught in the Division of Bio-Medical Sciences at Brown during the past several years. An earlier version of these notes appeared in the Center for Dynamical Systems Lectures Notes series (CDS LN 73-1, November 1973). I have in this revised and extended version of those earlier notes incorporated a number of changes based both on classroom experience and on my research efforts with several colleagues during the intervening period. The narrow viewpoint of the present notes (use of optimization and control theory in biomedical problems) reflects more the scope of the CMC lectures given in August, 1973 than the scope of my own interests. Indeed, my real interests have included the modeling process itself as well as the contributions made by investiga tors who employ the techniques and ideas of control theory, systems analysis, dif ferential equations, and stochastic processes. Some of these contributions have quite naturally involved application of optimal control theory. But in my opinion many of the interesting efforts being made in modeling in the biomedical sciences encompass much more than the use of control theory.

Download or read book Control Applications for Biomedical Engineering Systems written by Ahmad Taher Azar and published by Academic Press. This book was released on 2020-01-22 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Control Applications for Biomedical Engineering Systems presents different control engineering and modeling applications in the biomedical field. It is intended for senior undergraduate or graduate students in both control engineering and biomedical engineering programs. For control engineering students, it presents the application of various techniques already learned in theoretical lectures in the biomedical arena. For biomedical engineering students, it presents solutions to various problems in the field using methods commonly used by control engineers. Points out theoretical and practical issues to biomedical control systems Brings together solutions developed under different settings with specific attention to the validation of these tools in biomedical settings using real-life datasets and experiments Presents significant case studies on devices and applications

Download or read book Uncertainty aware Integration of Control with Process Operations and Multi parametric Programming Under Global Uncertainty written by Vassilis M. Charitopoulos and published by Springer Nature. This book was released on 2020-02-05 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces models and methodologies that can be employed towards making the Industry 4.0 vision a reality within the process industries, and at the same time investigates the impact of uncertainties in such highly integrated settings. Advances in computing power along with the widespread availability of data have led process industries to consider a new paradigm for automated and more efficient operations. The book presents a theoretically proven optimal solution to multi-parametric linear and mixed-integer linear programs and efficient solutions to problems such as process scheduling and design under global uncertainty. It also proposes a systematic framework for the uncertainty-aware integration of planning, scheduling and control, based on the judicious coupling of reactive and proactive methods. Using these developments, the book demonstrates how the integration of different decision-making layers and their simultaneous optimisation can enhance industrial process operations and their economic resilience in the face of uncertainty.

Download or read book Modelling and Control in Biomedical Systems written by Claudio Cobelli and published by Pergamon. This book was released on 1989 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume provides a complete and up-to-date review of the recent developments and trends relating to modelling and control in biomedical systems in research, diagnosis and therapy. Focus is placed on methodological issues relevant to modelling and control as well as to the various physiological systems of the organism visited from a control viewpoint. Contains 98 papers.

Download or read book Optimization and Control of Dynamic Systems written by Henryk Górecki and published by Springer. This book was released on 2017-07-26 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive presentation of optimization and polyoptimization methods. The examples included are taken from various domains: mechanics, electrical engineering, economy, informatics, and automatic control, making the book especially attractive. With the motto “from general abstraction to practical examples,” it presents the theory and applications of optimization step by step, from the function of one variable and functions of many variables with constraints, to infinite dimensional problems (calculus of variations), a continuation of which are optimization methods of dynamical systems, that is, dynamic programming and the maximum principle, and finishing with polyoptimization methods. It includes numerous practical examples, e.g., optimization of hierarchical systems, optimization of time-delay systems, rocket stabilization modeled by balancing a stick on a finger, a simplified version of the journey to the moon, optimization of hybrid systems and of the electrical long transmission line, analytical determination of extremal errors in dynamical systems of the rth order, multicriteria optimization with safety margins (the skeleton method), and ending with a dynamic model of bicycle. The book is aimed at readers who wish to study modern optimization methods, from problem formulation and proofs to practical applications illustrated by inspiring concrete examples.

Download or read book Introduction to Modeling in Physiology and Medicine written by Claudio Cobelli and published by Elsevier. This book was released on 2008-02-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises

Download or read book System Modelling and Optimization written by J. Dolezal and published by Springer. This book was released on 2013-06-05 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings volume contains carefully selected papers presented during the 17th IFIP Conference on System Modelling and Optimization. Optimization theory and practice, optimal control, system modelling, stochastic optimization, and technical and non-technical applications of the existing theory are among areas mostly addressed in the included papers. Main directions are treated in addition to several survey papers based on invited presentations of leading specialists in the respective fields. Publication provides state-of-the-art in the area of system theory and optimization and points out several new areas (e.g fuzzy set, neural nets), where classical optimization topics intersects with computer science methodology.

Download or read book Biomimicry for Optimization Control and Automation written by Kevin M. Passino and published by Springer Science & Business Media. This book was released on 2005-12-06 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomimicry uses our scienti?c understanding of biological systems to exploit ideas from nature in order to construct some technology. In this book, we focus onhowtousebiomimicryof the functionaloperationofthe “hardwareandso- ware” of biological systems for the development of optimization algorithms and feedbackcontrolsystemsthatextendourcapabilitiestoimplementsophisticated levels of automation. The primary focus is not on the modeling, emulation, or analysis of some biological system. The focus is on using “bio-inspiration” to inject new ideas, techniques, and perspective into the engineering of complex automation systems. There are many biological processes that, at some level of abstraction, can berepresentedasoptimizationprocesses,manyofwhichhaveasa basicpurpose automatic control, decision making, or automation. For instance, at the level of everyday experience, we can view the actions of a human operator of some process (e. g. , the driver of a car) as being a series of the best choices he or she makes in trying to achieve some goal (staying on the road); emulation of this decision-making process amounts to modeling a type of biological optimization and decision-making process, and implementation of the resulting algorithm results in “human mimicry” for automation. There are clearer examples of - ological optimization processes that are used for control and automation when you consider nonhuman biological or behavioral processes, or the (internal) - ology of the human and not the resulting external behavioral characteristics (like driving a car). For instance, there are homeostasis processes where, for instance, temperature is regulated in the human body.

Download or read book Modelling and Control in Biomedical Systems 1997 including Biological Systems written by D. A. Linkens and published by Pergamon. This book was released on 1997 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paperback. This volume contains the 90 papers presented at the 3rd IFAC Symposium on Modelling and Control in Biomedical Systems held in Warwick, UK from 23-26 March 1997. Significant work in the field of biomedical systems analysis and design is taking place throughout the world and the opportunities for technological interchanges offered by symposia like this one are extremely valuable for the progress and stability of effort and vision in this important human-centred field.The symposium was multi- and inter-disciplinary in nature with the choice of topics solicited covering the major systems' components and functions of complex physiology. The remit was also extended, on this occasion, beyond mammalian physiology to that of biological systems. Therefore, a special session was devoted to the modelling and control of botanical systems with the aim of providing an exchange of ideas with biomathematicians.

Download or read book An Introduction to Modeling of Transport Processes written by Ashim K. Datta and published by . This book was released on 2010 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Organized around problem solving, this book gently introduces the reader to computational simulation of biomedical transport processes, bridging fundamental theory with real-world applications. Using this book the reader will gain a complete foundation to the subject, starting with problem simplification, implementation in software, through to interpretation of results, validation, and optimization"--Provided by publisher.

Download or read book Quantitative Systems Pharmacology written by Davide Manca and published by Elsevier. This book was released on 2018-07-18 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

Download or read book Biomedical Applications of Control Engineering written by Selim S. Hacısalihzade and published by Springer. This book was released on 2013-03-21 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Control Engineering is a lucidly written textbook for graduate control engineering and biomedical engineering students as well as for medical practitioners who want to get acquainted with quantitative methods. It is based on decades of experience both in control engineering and clinical practice. The book begins by reviewing basic concepts of system theory and the modeling process. It then goes on to discuss control engineering application areas like: Different models for the human operator,dosage and timing optimization in oral drug administration, measuring symptoms of and optimal dopaminergic therapy in Parkinson’s disease, measurement and control of blood glucose levels both naturally and by means of external controllers in diabetes, and control of depth of anaesthesia using inhalational anaesthetic agents like sevoflurane using both fuzzy and state feedback controllers. All chapters include three types of exercises constructed to: Review the concepts discussed in the chapter, allow the reader to apply the newly acquired techniques and subject related facts on simple problems, and indicate directions for open ended theses projects. Appendices on Optimal Control and Fuzzy Control meant as refreshers on those control engineering techniques used throughout the book are also included.

Download or read book Optimization in Medicine and Biology written by Gino J. Lim and published by CRC Press. This book was released on 2008-01-08 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures. Op

Download or read book Real Time Optimization by Extremum Seeking Control written by Kartik B. Ariyur and published by . This book was released on 2003 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's description: Extremum seeking is a method of adaptive control outside the classical paradigm or model reference and related schemes. The unique feature of extremum seeking as an optimization tool is that is is an on-line methodology, performed by feedback, and with the ability to achieve rapid convergence. A second distinction between classical adaptive control and extremum seeking is that the latter is not model based. Its non-model based character explains the remarkable popularity of extremum seeking in the last half decade: the recent applications in fluid flow combustion, and biomedical systems are all characterized by complex, unreliable models. Written by authorities in the field and pioneers in adaptive nonlinear control systems, this book presents both significant theoretic value and important practical potential.