Download or read book Modelling Light Transport Through Biological Tissue Using the Simplified Spherical Harmonics Approximation written by Michael Chu and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical tomography is a medical imaging modality that can be used to non-invasively image functional changes within the body. As near-infrared light is highly scattered by biological tissue, the process of image reconstruction is ill-posed and, in general, is also under-determined. As such, model based iterative image reconstruction methods are used. These methods require an accurate model of light propagation through tissue, also known as the forward model. The diffusion approximation (DA) to the radiative transport equation is one of the most widely used forward models. It is based on the assumption that scattering events dominate over absorption events resulting in a diffuse light distribution. This is valid in cases with low absorption coefficients or large geometries (greater than a few scattering lengths). In many cases, however, such as in small animal imaging where the source-detector separation is small, this assumption is not valid and so a higher-ordered approximation is required. In this thesis, a three-dimensional frequency domain forward model based on the simplified spherical harmonics (SPN) approximation to the radiative transport equation is introduced. By comparison with a Monte- Carlo model, the SPN approximation is shown to be more accurate than the DA, especially in regions near to the sources and detectors and the increase in accuracy is greater in cases with stronger absorption. This is particularly important for bioluminescent imaging of small animals which involve both small geometries and strong absorption. Due to the asymptotic nature of the3SPN approximation, the highest ordered model was not necessarily the most accurate, but all models with N>1 were more accurate than the DA. The SPN based forward model has also been implemented into an image reconstruction algorithm. Despite the fact that the SPN approximation does not combine the scattering coefficient and anisotropy factor into a single variable, as is the case in the DA, it was found that it is not possible to reconstruct them uniquely. The SPN based models were shown to be able to reconstruct optical maps with greater accuracy than the DA. However, due to the increased number of unknowns to be recovered, the SP7 based reconstructed images contained significant artefact and cross-talk. Finally, a SPN-Diffusion hybrid model was developed in which the SPN model was used in the regions near to the source and the DA elsewhere. This model provides the increase of accuracy of the SPN models in the regions where the DA is insufficient, whilst retaining the computational efficiency of the DA. It was shown that the hybrid model leads to increased accuracy not only in the regions solved using the SPN model, but also in the DA based regions where as in a pure DA model, the errors near the source were propagated throughout the domain. It is also shown that the hybrid model can be solved in half the time of the full SPN model.
Download or read book Selected Topics in Photonics written by Asima Pradhan and published by Springer. This book was released on 2017-10-27 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises chapters on the cutting-edge research in photonics undertaken at IIT Kanpur. Photonics requires scientists and engineers to work closely together in addressing challenges which are interdisciplinary in nature. At IIT Kanpur, research is being pursued in several key areas of photonics namely fiber-optics, nanophotonics, quantum optics, optical spectroscopy and imaging, biophotonics, and photonic devices. This volume brings together contributions from experts to obtain a contemporary perspective in photonics research. The reader will find articles about coherent optical communications, novel photonic nanostructures, nano-structured materials for light control, optical tweezers with nanoscale applications, quantum coherence and entanglement, photodiode arrays and quantum metrology. The volume also includes chapters on cancer diagnostics with optical tomography, protein fluctuations at microsecond scale at single-molecule level, and visualization of motion in a droplet which are interdisciplinary in nature. The contents of this book will be of use to researchers, students, and professionals working across all domains of photonics.
Download or read book Light Scattering Reviews 7 written by Alexander A. Kokhanovsky and published by Springer Science & Business Media. This book was released on 2012-08-23 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Light Scattering Reviews (vol.7) is aimed at the description of modern advances in radiative transfer and light scattering. The following topics will be considered: the general - purpose discrete - ordinate algorithm DISORT for radiative transfer, fast radiative transfer techniques, use of polarization in remote sensing, Markovian approach for radiative transfer in cloudy atmospheres, coherent and incoherent backscattering by turbid media and surfaces,advances in radiative transfer methods as used for luminiscence tomography, optical properties of aerosol, ice crystals, snow, and oceanic water. This volume will be a valuable addition to already published volumes 1-6 of Light Scattering Reviews.
Download or read book Light Propagation Through Biological Tissue and Other Diffusive Media written by Fabrizio Martelli and published by Society of Photo Optical. This book was released on 2010 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Book includes a CD-ROM. This book provides foundational information on modeling light propagation through diffusive media, with special emphasis on biological tissue. A summary of the theoretical background on light propagation through diffusive media is provided with the aid of easy-to-use software designed to calculate the solutions of the diffusion equation. The book also provides: The basic theory of photon transport with the analytical solutions of the diffusion equation for several geometries Detailed coverage of the radiative transfer equation and the diffusion equation The theories and the formulae based on the diffusion equation that have been widely used for biomedical applications The general concepts and the physical quantities necessary to describe light propagation through absorbing and scattering media A description of the software provided on the CD-ROM, along with the accuracy of the presented solutions. Although the theoretical and computational tools provided with this book and CD-ROM have their primary use in the field of biomedical optics, there are many other applications in which they can be used, including agricultural products, forest products, food products, plastic materials, pharmaceutical products, and many others.
Download or read book Handbook of Mathematical Methods in Imaging written by Otmar Scherzer and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 1626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Mathematical Methods in Imaging provides a comprehensive treatment of the mathematical techniques used in imaging science. The material is grouped into two central themes, namely, Inverse Problems (Algorithmic Reconstruction) and Signal and Image Processing. Each section within the themes covers applications (modeling), mathematics, numerical methods (using a case example) and open questions. Written by experts in the area, the presentation is mathematically rigorous. The entries are cross-referenced for easy navigation through connected topics. Available in both print and electronic forms, the handbook is enhanced by more than 150 illustrations and an extended bibliography. It will benefit students, scientists and researchers in applied mathematics. Engineers and computer scientists working in imaging will also find this handbook useful.
Download or read book Handbook of Biomedical Optics written by David A. Boas and published by CRC Press. This book was released on 2016-04-19 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental
Download or read book Light Scattering Reviews 8 written by Alexander A. Kokhanovsky and published by Springer Science & Business Media. This book was released on 2013-06-12 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: Light scattering review (vol 8) is aimed at the presentation of recent advances in radiative transfer and light scattering optics. The topics to be covered include: scattering of light by irregularly shaped particles suspended in atmosphere (dust, ice crystals), light scattering by particles much larger as compared the wavelength of incident radiation, atmospheric radiative forcing, astrophysical radiative transfer, radiative transfer and optical imaging in biological media, radiative transfer of polarized light, numerical aspects of radiative transfer.
Download or read book Fluorescent Imaging in Medicinal Chemistry written by Zhen Cheng and published by Springer Nature. This book was released on 2020-05-28 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the most recent developments of fluorescent imaging techniques for medicinal chemistry research and biomedical applications, including cell imaging, in vitro diagnosis and in vivo imaging. Fluorescent imaging techniques play an important role in basic research, drug discovery and clinical translation. They have great impact to many fields including chemical biology, cell biology, medical imaging, cancer diagnosis and treatment, pharmaceutical science, among others, and they have facilitated our understanding of diseases and helped to develop many novel powerful tools for imaging and treatment of diseases. This book will appeal to scientists from numerous fields such as chemistry, pharmaceutical science, biology, materials science, and medicine, and it will serve as a very useful and handy resource for readers with different levels of scientific knowledge, ranging from entry level to professional level.
Download or read book Optical Molecular Imaging in Cancer Research written by Guanglei Zhang and published by Frontiers Media SA. This book was released on 2022-04-20 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optical Imaging of Biological Tissues written by Jorge Bouza Dominguez and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, a new time-dependent model for describing light propagation in biological media is proposed. The model is based on the simplified spherical harmonics approximation and is represented by a set of coupled parabolic partial differential equations (TD-pSPN equations). In addition, the model is extended for modeling the time-dependent response of fluorescent agents in biological tissues and the ensuing time-domain propagation of light therein. In a comparison with Monte Carlo simulations, it is shown that the TD-pSPN equations present unique features in its derivation that makes it a more accurate alternative to the diffusion equation (DE). The TD-pSPN model (for orders N > 1) outperforms the DE in the description of the propagation of light in near-nondiffusive media and in all the physical situations where DE fails. Often, only small orders of the SP N approximation are needed to obtain accurate results. A diffuse optical tomography (DOT) algorithm is also implemented based on the TD-pSPN equations as the forward model using constrained optimization methods. The algorithm uses time-dependent (TD) data directly. Such an approach is benefited from both the accuracy of the SPN models and the richness of TD data. In the calculation of the gradient of the objective function, a time-dependent adjoint differentiation method is introduced that reduces computation time. Several numerical experiments are performed for small geometry media with embedded inclusions that mimic small animal imaging. In these experiments, the values of the optical coefficients are varied within realistic bounds that are representative of those found in the range of the near-infrared spectrum, including high absorption values. Single and multi-parameter reconstructions (absorption and diffusion coefficients) are performed. The reconstructed images based on the TD-pSPN equations (N > 1) give better estimates of the optical properties of the media than the DE. On the other hand, crosstalk effects and small artifacts appeared in all the cases (more intense in the DE images). Comparatively, the reconstructed images show a lesser influence of these undesirable 'effects than other approaches found in the literature. The results suggest that the DOT algorithm based on the TD-pSPN model is an accurate alternative to the DE for imaging optical properties of biological media. These results directly benefict the fields of therapeutics and time-domain optical imaging of biological tissues. Particularly, the presented work is a decisive step in the elaboration of an optical scanner for small animal imaging at our lab. Thus, a positive impact in the areas of clinical diagnosis and biomedical research are expected.
Download or read book Tissue Engineering written by Norbert Pallua and published by Springer Science & Business Media. This book was released on 2010-12-16 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering is a multidisciplinary field incorporating the principles of biology, chemistry, engineering, and medicine to create biological substitutes of native tissues for scientific research or clinical use. Specific applications of this technology include studies of tissue development and function, investigating drug response, and tissue repair and replacement. This area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure. This abundantly illustrated and well-structured guide serves as a reference for all clinicians and researchers dealing with tissue engineering issues in their daily practice.
Download or read book Handbook of Small Animal Imaging written by George C. Kagadis and published by CRC Press. This book was released on 2018-09-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.
Download or read book Image and Graphics written by Yao Zhao and published by Springer Nature. This book was released on 2019-11-27 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume set LNCS 11901, 11902, and 11903 constitutes the refereed conference proceedings of the 10thth International Conference on Image and Graphics, ICIG 2019, held in Beijing, China, in August 2019. The 183 full papers presented were selected from 384 submissions and focus on advances of theory, techniques and algorithms as well as innovative technologies of image, video and graphics processing and fostering innovation, entrepreneurship, and networking.
Download or read book Tomography and Inverse Transport Theory written by Guillaume Bal and published by American Mathematical Soc.. This book was released on 2011 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains research and review articles written by participants of two related international workshops ``Mathematical Methods in Emerging Modalities of Medical Imaging'' (October 2009) and ``Inverse Transport Theory and Tomography'' (May 2010), which were held at the Banff International Research Station in Banff, Canada. These workshops brought together mathematicians, physicists, engineers, and medical researchers working at the cutting edge of medical imaging research and addressed the demanding mathematical problems arising in this area. The articles, written by leading experts, address important analytic, numerical, and physical issues of the newly developing imaging modalities (e.g., photoacoustics, current impedance imaging, hybrid imaging techniques, elasticity imaging), as well as the recent progress in resolving outstanding problems of more traditional modalities, such as SPECT, ultrasound imaging, and inverse transport theory. Related topics of invisibility cloaking are also addressed.
Download or read book Molecular Imaging of Small Animals written by Habib Zaidi and published by Springer. This book was released on 2014-05-27 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Download or read book Light Scattering Reviews 4 written by Alexander A. Kokhanovsky and published by Springer Science & Business Media. This book was released on 2009-07-25 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth volume of Light Scattering Reviews is composed of three parts. The ?rstpartisconcernedwiththeoreticalandexperimentalstudiesofsinglelightsc- tering by small nonspherical particles. Light scattering by small particles such as, for instance, droplets in the terrestrial clouds is a well understood area of physical optics. On the other hand, exact theoretical calculations of light scattering p- terns for most of nonspherical and irregularly shaped particles can be performed only for the restricted values of the size parameter, which is proportional to the ratio of the characteristic size of the particle to the wavelength?. For the large nonspherical particles, approximations are used (e. g. , ray optics). The exact th- retical techniques such as the T-matrix method cannot be used for extremely large particles, such as those in ice clouds, because then the size parameter in the v- iblex=2?a/???,wherea is the characteristic size (radius for spheres), and the associated numerical codes become unstable and produce wrong answers. Yet another problem is due to the fact that particles in many turbid media (e. g. , dust clouds) cannot be characterized by a single shape. Often, refractive indices also vary. Because of problems with theoretical calculations, experimental (i. e. , la- ratory) investigations are important for the characterization and understanding of the optical properties of such types of particles. The ?rst paper in this volume, written by B. Gustafson, is aimed at the descr- tionofscaledanalogueexperimentsinelectromagneticscattering.
Download or read book Quantitative Biomedical Optics written by Irving J. Bigio and published by Cambridge University Press. This book was released on 2016-01-07 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the textbook and reference resource that instructors, students, and researchers in biomedical optics have been waiting for. Comprehensive and up to date, it covers a broad range of areas in biomedical optics, from light interactions at the single-photon and single-biomolecule levels, to the diffusion regime of light propagation in tissue. Subjects covered include spectroscopic techniques (fluorescence, Raman, infrared, near-infrared, and elastic scattering), imaging techniques (diffuse optical tomography, photoacoustic imaging, several forms of modern microscopy, and optical coherence tomography), and laser-tissue interactions, including optical tweezers. Topics are developed from the fundamental principles of physical science, with intuitive explanations, while rigorous mathematical formalisms of theoretical treatments are also provided. For each technique, descriptions of relevant instrumentation and examples of biomedical applications are outlined, and each chapter benefits from references and suggested resources for further reading, and exercise problems with answers to selected problems.
