Download or read book Modeling Pas Sensors Through in Silico and Genetic Approaches written by Brenda Rojas (Ph.D.) and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PAS family of transcription factors play vital roles in important physiological processes. Within this family, PAS sensors, with their characteristic domain, are of interest because they modulate circadian rhythms, xenobiotic metabolism, and oxygen homeostasis, in addition to other functions. The PAS domain was named from the three founding members - Period, Aryl hydrocarbon nuclear translocator, and Sim. Structurally, the domain has been labeled in many ways, however we stick to the PAS A and B nomenclature Our central hypothesis is that PAS proteins are part of a network that coordinate physiological responses to stressors through obscure interactions. To test our hypothesis, we worked on the following aims: (1) To develop a lexicon for the structures partaking in PAS-PAS dimerization, we mined the Protein Data Bank for mammalian proteins. This information helped us refine the terminology and showcase differences between PAS A-PAS A and PAS B-PAS B repeat interactions. Moreover, it taught us that PAS proteins interact with other regions outside their PAS counterpart, thus PAS A-PAS B repeat interconnectivity is common. (2) To determine the ability of our yeast system, based on Saccharomyces cerevisiae strain L40, to accommodate steroid receptor signaling, we introduced and activated the mineralocorticoid, androgen, glucocorticoid, and estrogen Îł receptors individually and exposed them to various ligands. Results from these experiments argue for the possibility of turning our L40 system into a "one-cell system" that can accommodate multiple pathways for complex receptor mixtures. (3) To determine dimerization between PAS B repeats in the prototypical AhR:ARNT complex, we again used our L40 system. We found that PAS B repeats are necessary for successful interconnectivity. Additionally, we took advantage of the new AlphaFold and SwarmDock algorithms to predict PAS B interactions between the AhR and ARA9 and ARA3. This work is significant because it also has the potential to detect biomarkers of disease progression that can function as targets for therapeutic treatments and drugs

Download or read book Modeling Pas Sensors Through in Silico and Genetic Approaches written by Brenda Rojas (Ph.D.) and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PAS family of transcription factors play vital roles in important physiological processes. Within this family, PAS sensors, with their characteristic domain, are of interest because they modulate circadian rhythms, xenobiotic metabolism, and oxygen homeostasis, in addition to other functions. The PAS domain was named from the three founding members - Period, Aryl hydrocarbon nuclear translocator, and Sim. Structurally, the domain has been labeled in many ways, however we stick to the PAS A and B nomenclature Our central hypothesis is that PAS proteins are part of a network that coordinate physiological responses to stressors through obscure interactions. To test our hypothesis, we worked on the following aims: (1) To develop a lexicon for the structures partaking in PAS-PAS dimerization, we mined the Protein Data Bank for mammalian proteins. This information helped us refine the terminology and showcase differences between PAS A-PAS A and PAS B-PAS B repeat interactions. Moreover, it taught us that PAS proteins interact with other regions outside their PAS counterpart, thus PAS A-PAS B repeat interconnectivity is common. (2) To determine the ability of our yeast system, based on Saccharomyces cerevisiae strain L40, to accommodate steroid receptor signaling, we introduced and activated the mineralocorticoid, androgen, glucocorticoid, and estrogen Îł receptors individually and exposed them to various ligands. Results from these experiments argue for the possibility of turning our L40 system into a "one-cell system" that can accommodate multiple pathways for complex receptor mixtures. (3) To determine dimerization between PAS B repeats in the prototypical AhR:ARNT complex, we again used our L40 system. We found that PAS B repeats are necessary for successful interconnectivity. Additionally, we took advantage of the new AlphaFold and SwarmDock algorithms to predict PAS B interactions between the AhR and ARA9 and ARA3. This work is significant because it also has the potential to detect biomarkers of disease progression that can function as targets for therapeutic treatments and drugs

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Encyclopedia of Animal Behavior written by and published by Elsevier. This book was released on 2009-04-01 with total page 2662 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Animal Behavior, Three Volume Set has engaged with great success the efforts of many of the best behavioral biologists of the 21st century. Section editors drawn from the most accomplished behavioral scientists of their generation have enrolled an international cast of highly respected thinkers and writers all of whom have taken great care and joy in illuminating every imaginable corner of animal behavior. This comprehensive work covers not only the usual topics such as communication, learning, sexual selection, navigation, and the history of the field, but also emerging topics in cognition, animal welfare, conservation, and applications of animal behavior. The large section on animal cognition brings together many of the world's experts on the subject to provide a comprehensive overview of this rapidly developing area. Chapters relating to animal welfare give a full view of behavioral interactions of humans with companion animals, farm animals, and animals in the wild. The key role of animal behavior in conservation biology receives broad attention, including chapters on topics such as the effects of noise pollution, captive breeding, and how the behavioral effects of parasites interacts with conservation issues. Animal behavior in environmental biology is highlighted in chapters on the effects of endocrine disruptors on behavior and a large number of chapters on key species, such as wolves, chimpanzees, hyenas and sharks. Clear, accessible writing complements a wealth of information for undergraduate college students about the essential concepts of animal behavior and the application of those concepts across the field. In-depth coverage of concepts, methods, and exemplar organisms serves the needs of graduate students and professionals in the field. From the use of behavior in assessing the welfare of pigs to the social behavior of insects, from animal empathy to bat brains, this authoritative reference, with its in-depth introductory articles, rich array of illustrations, interactive cross-referenced links, and numerous suggested readings, can guide the student or the professional to an expanded appreciation of the far-flung world of animal behavior. An invaluable tool for teaching and a source of enrichment and detail for any topic covered in an animal behavior course, the Encyclopedia of Animal Behavior is the definitive reference work in its field and will be for years to come. Comprehensive work which covers the usual topics along with emerging areas of animal behavior This encyclopedia contains clear, accessible writing and is well illustrated, including an online video, complimenting a wealth of information As an online reference, this work will be subject to period updating. This ensures that the work always remains current Contains in-depth introductions to the material that make each well-illustrated section come alive with the best the new content the discipline has to offer Glossary includes a compendium of behavioral terms that form a succinct mosaic of virtually every concept and phenomenon related to animal behavior Section editors, drawn from around the world, represent the best and the brightest among today's behavioral biologists and have recruited a broad range of internationally recognized experts Editors-in-Chief are experienced scientists and writers who between them have authored or edited eight books and teach courses in animal behavior at their respective universities

Download or read book Encyclopedia of Animal Behavior G P written by Michael D. Breed and published by Academic Press is. This book was released on 2010 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries examine a broad array of different species and behavior patterns, using techniques that range from molecular approaches to the study of behavior to analyses of individuals, populations, species, and ecosystems.

Download or read book Trends in Quorum Sensing and Quorum Quenching written by V. Ravishankar Rai and published by CRC Press. This book was released on 2020-05-04 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies developed for quorum sensing inhibition. The topics covered are multidisciplinary and wide-ranging,and includes quorum sensing phenomenon in pathogenic bacteria, food spoilers, and agriculturally relevant bacteria. The applications of quorum sensing inhibitors such as small molecules, bioactives, natural compounds, and quorum quenching enzymes in controlling bacterial infections in clinical settings, agriculture and aquaculture are discussed. The potential use of quorum quenching enzymes for mitigating biofouling is also covered. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests and marine environments. Key features: Covers the fundamental aspects, the progress and challenges in the field of quorum sensing and quorum quenching Reviews quorum sensing in Gram-positive and Gram-negative bacteria of clinical, agricultural, and industrial relevance Discusses the application and future trends of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on molecular mechanisms in bacterial signaling

Download or read book Experimental models and model organisms in cardiac electrophysiology Opportunities and challenges written by Ruben Coronel and published by Frontiers Media SA. This book was released on 2023-10-05 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biotechnological Applications of Quorum Sensing Inhibitors written by Vipin Chandra Kalia and published by Springer. This book was released on 2018-05-30 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the practical applications of quorum sensing inhibitors for both human and plant health. Quorum sensing inhibitors that disrupt microbial biofilms can be employed to treat bacterial infections. The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors. Quorum sensing is the mechanism through which bacteria develop antibiotic resistance. Intended to provide a clearer understanding of the practical applications of quorum sensing inhibitors, the book details how the problem of antibiotic resistance can be countered through the intelligent application of quorum sensing inhibitors.

Download or read book Sub molecular Mechanism of Genetic Epilepsy written by Weiping Liao and published by Frontiers Media SA. This book was released on 2022-08-29 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book World Malaria Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2016-01-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2015assesses global malaria disease trends and changes in the coverage and financing of malaria control programs between 2000 and 2015. It also summarizes progress towards international targets, and provides regional and country profiles that summarize trends in each WHO region and each country with malaria. The report is produced with the help of WHO regional and country offices, ministries of health in endemic countries, and a broad range of other partners. The data presented are assembled from the 96 countries and territories with ongoing malaria transmission, and a further five countries that have recently eliminated malaria. Most data are those reported for 2014 and 2015, although in some cases projections have been made into 2015, to assess progress towards targets for 2015.

Download or read book World Malaria Report 2018 written by World Health Organization and published by World Health Organization. This book was released on 2019-02-12 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This year s report shows that after an unprecedented period of success in global malaria control progress has stalled. Data from 2015?2017 highlight that no significant progress in reducing global malaria cases was made in this period. There were an estimated 219 million cases and 435 000 related deaths in 2017. The World malaria report 2018 draws on data from 90 countries and areas with ongoing malaria transmission. The information is supplemented by data from national household surveys and databases held by other organizations.

Download or read book Drug Absorption Studies written by Carsten Ehrhardt and published by Springer Science & Business Media. This book was released on 2007-12-22 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.

Download or read book Artificial Intelligence in Drug Discovery written by Nathan Brown and published by Royal Society of Chemistry. This book was released on 2020-11-04 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.

Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Download or read book Ion Channels written by James N. C. Kew and published by . This book was released on 2010 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.

Download or read book The Journal of Cell Biology written by and published by . This book was released on 2005 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-

Download or read book Simulation of Ecophysiological Processes of Growth in Several Annual Crops written by F. W. T. Penning de Vries and published by Int. Rice Res. Inst.. This book was released on 1989 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: