Download or read book Modeling Human Atrial Patho Electrophysiology from Ion Channels to ECG Substrates Pharmacology Vulnerability and P Waves written by Loewe, Axel and published by KIT Scientific Publishing. This book was released on 2016-08-03 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.
Download or read book Modeling Human Atrial Patho Electrophysiology From Ion Channels to ECG Substrates Pharmacology Vulnerability and P Waves written by Axel Loewe and published by . This book was released on 2020-10-09 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Download or read book Cardiac Modeling Aiming for Optimization of Therapy written by Javier Saiz and published by Frontiers Media SA. This book was released on 2020-12-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Multiscale Cohort Modeling of Atrial Electrophysiology Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms written by Nagel, Claudia and published by KIT Scientific Publishing. This book was released on 2023-04-24 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: An early detection and diagnosis of atrial fibrillation sets the course for timely intervention to prevent potentially occurring comorbidities. Electrocardiogram data resulting from electrophysiological cohort modeling and simulation can be a valuable data resource for improving automated atrial fibrillation risk stratification with machine learning techniques and thus, reduces the risk of stroke in affected patients.
Download or read book Characterizing Cardiac Electrophysiology during Radiofrequency Ablation An Integrative Ex vivo In silico and In vivo Approach written by Pollnow, Stefan and published by KIT Scientific Publishing. This book was released on 2019-04-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation A Translational Study to Guide Ablation Therapy written by Sánchez Arciniegas, Jorge Patricio and published by KIT Scientific Publishing. This book was released on 2022-05-30 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.
Download or read book Multiscale Modeling of Cardiac Electrophysiology Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment written by Mathias Wilhelms and published by KIT Scientific Publishing. This book was released on 2014-05-22 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
Download or read book Ion Channel Regulation in the Pathophysiology of Atrial Fibrillation written by Birce Onal and published by . This book was released on 2017 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atrial fibrillation (AF) affects 2.5 million people per year in the U.S., and is associated with high morbidity and mortality. Both electrical and structural remodeling on the cardiac cell- and tissue-level contribute to AF, but the precise molecular pathways that lead to atrial fibrillation pathogenesis are not well understood. Mathematical modelling is ideally suited to understand the molecular basis of cardiac arrhythmias by allowing simulation of complex biological systems based on integrated data from individual populations of ion channels. A cross-platform multi-threaded graphical user interface LongQt was developed for advanced computational cardiac electrophysiology studies in sinoatrial, atrial, and ventricular cells to help bridge the gap between experimental and theoretical techniques in cardiac electrophysiology. A method of parameter sensitivity analysis is discussed to help define the contribution of individual ion channels to cell membrane excitability and action potential properties. Finally, a computational model of the human atrial cell was used to determine the mechanism for increased susceptibility to arrhythmogenic events in patients with defects in Ca2+/calmodulin-dependent protein kinase signaling pathways. An atrial computational model was extended to explore CaMKII activation of late sodium current (INa,L) and phosphorylation of downstream targets (L-type Ca2+ channel, phospholamban, ryanodine receptor). Both LongQt and the method of parameter sensitivity analysis were used to help identify the cellular pathway responsible for disrupted ion homeostasis and afterdepolarizations in atrial cells. Intracellular Ca2+ and Na+ accumulation, increased phosphorylation of RyR2 by CaMKII, and abnormal Ca2+ dynamics [e.g. beat-to-beat alteration (alternans)], and afterdepolarizations (early and late phase) was observed in mathematical models of the atrial cell with constitutive increase in INa,L, compared to wildtype control. These simulations define roles for previously unexplored ion channel regulation of CaMKII-mediated INa,L in the context of atrial fibrillation. Although INa,L is
Download or read book Modeling of Electrophysiology and Tension Development in the Human Heart written by Gunnar Seemann and published by . This book was released on 2005 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiology Explained written by Euan A. Ashley and published by Remedica. This book was released on 2004 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.
Download or read book J Wave Syndromes written by Charles Antzelevitch and published by Springer. This book was released on 2016-06-27 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delineates the state of the art of the diagnosis and treatment of J wave syndromes, as well as where future research needs to be directed. It covers basic science, translational and clinical aspects of these syndromes. The authors are leading experts in their respective fields, who have contributed prominently to the literature concerning these topics. J wave syndromes are one of the hottest topics in cardiology today. Cardiac arrhythmias associated with Brugada syndrome (BrS) or an early repolarization (ER) pattern in the inferior or infero-lateral ECG leads are thought to be mechanistically linked to accentuation of transient outward current (Ito)-mediated J waves. Although BrS and ER syndrome (ERS) differ with respect to magnitude and lead location of abnormal J waves, they are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. ERS is divided into three subtypes with the most severe, Type 3, displaying an ER pattern globally in the inferior, lateral and right precordial leads. BrS has been linked to mutations in 19 different genes, whereas ERS has been associated with mutations in 7 different genes. There is a great deal of confusion as to how to properly diagnose and treat the J wave syndromes as well as confusion about the underlying mechanisms. The demonstration of successful epicardial ablation of BrS has provided new therapeutic options for the management of this syndrome for which treatment alternatives are currently very limited, particularly in the case of electrical storms caused by otherwise uncontrollable recurrent VT/VF. An early repolarization pattern is observed in 2-5% of the US population. While it is clear that the vast majority of individuals exhibiting an ER pattern are not at risk for sudden cardiac death, the challenge moving forward is to identify those individuals who truly are at risk and to design safe and effective treatments.
Download or read book Clinical Arrhythmology and Electrophysiology E Book written by Ziad Issa and published by Elsevier Health Sciences. This book was released on 2018-08-07 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the highly regarded Braunwald’s family of cardiology references, Clinical Arrhythmology and Electrophysiology, 3rd Edition, offers complete coverage of the latest diagnosis and management options for patients with arrhythmias. Expanded clinical content and clear illustrations keep you fully abreast of current technologies, new syndromes and diagnostic procedures, new information on molecular genetics, advances in ablation, and much more.
Download or read book Cardiac Arrhythmias written by Ambrose S. Kibos and published by Springer Science & Business Media. This book was released on 2013-12-13 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all the major aspects associated with pathophysiological development of cardiac arrhythmias (covering enhanced or suppressed automaticity, triggered activity, or re-entry), from basic concepts through disease association, limitations of current pharmacotherapy and implant therapies and on-going trials and analysis of new biomarkers based on current knowledge of cellular interaction and signalling. The book describes novel and state-of-the-art methods for differentiating between the major types of arrhythmia, structural abnormalities and current practice guidelines and determination of risk stratification associated with sudden cardiac death. A particular focus is on arrhythmias associated with atrial fibrillation and includes details of associations with cardiac disease, current detection, analysis and imaging and future perspectives.
Download or read book Cardiac Electrophysiology and Arrhythmias written by Douglas P. Zipes and published by Saunders. This book was released on 1985 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Genetics of Cardiac Electrophysiology written by C. Berul and published by Springer Science & Business Media. This book was released on 2000-04-30 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.
Download or read book Atrial Fibrillation from an Engineering Perspective written by Leif Sörnmo and published by Springer. This book was released on 2018-05-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atrial Fibrillation from an Engineering Perspective provides an up-to-date overview of techniques developed for acquisition, modeling, and analysis of noninvasive, bioelectrical signals reflecting this common arrhythmia. Special emphasis is put on emerging technologies for monitoring of atrial fibrillation in connection with ischemic stroke, interventional ablation procedures, and pharmacological treatment, applications which all depend on the availability of techniques for detecting and characterizing episodes of paroxysmal atrial fibrillation. Detectors exploring both rhythm and morphology are described, as well as detectors confined to rhythm and better suited for low power implementation. A wide variety of approaches to modeling and characterization of atrial activity are described, emanating from a statistical and deterministic starting points. This book is suitable for graduate students, researchers, and engineers who want a comprehensive treatise of atrial fibrillation from an engineering perspective. It may be used for self-study, as a supplement to courses in signal processing, or as a modern monograph by researchers in the field of atrial fibrillation.
Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
