Download or read book Modeling Electrokinetic Phenomana in Micro and Nanofluidic Technology written by Shizhi Qian and published by Wiley. This book was released on 2013-04-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on modeling electrokinetic phenomena, including electroosmosis, electrophoresis, and dielectrophoresis in micro- and nanofluidic devices, which play important roles in facilitating fluid transport and particle manipulation in micro- and nanofluidic devices. These have the potential to improve and reduce the cost of healthcare around the globe and revolutionize chemical and biological analysis by integrating and automating sophisticated diagnostic procedures in micro/nanofluidic devices. This high-level treatment offers an essential guide for researchers and advanced students in nanotechnology, mechanical engineering, and colloid science.
Download or read book Electrokinetics in Microfluidics written by Dongqing Li and published by Elsevier. This book was released on 2004-08-20 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: A lab-on-a-chip device is a microscale laboratory on a credit-card sized glass or plastic chip with a network of microchannels, electrodes, sensors and electronic circuits. These labs on a chip can duplicate the specialized functions as performed by their room-sized counterparts, such as clinical diagnoses, PCR and electrophoretic separation. The advantages of these labs on a chip include significant reduction in the amounts of samples and reagents, very short reaction and analysis time, high throughput and portability. Generally, a lab-on-a-chip device must perform a number of microfluidic functions: pumping, mixing, thermal cycling/incubating, dispensing, and separating. Precise manipulation of these microfluidic processes is key to the operation and performance of labs on a chip. The objective of this book is to provide a fundamental understanding of the interfacial electrokinetic phenomena in several key microfluidic processes, and to show how these phenomena can be utilised to control the microfluidic processes. For this purpose, this book emphasises the theoretical modelling and the numerical simulation of these electrokinetic phenomena in microfluidics. However, experimental studies of the electrokinetic microfluidic processes are also highlighted in sufficient detail. The first book which systematically reviews electrokinetic microfluidics processes for lab-on-a chip applications Covers modelling and numerical simulation of the electrokinetic microfluidics processes Providing information on experimental studies and details of experimental techniques, which are essential for those who are new to this field
Download or read book Electrokinetic Transport Phenomena in Nanochannels and Applications of Nanochannel based Devices in Nanoparticle Detection and Molecule Sensing written by Ran Peng and published by . This book was released on 2018 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanofluidics investigates transport phenomena, manipulation, and control of fluids and nano-sized objects in fluidic channels with an at least one-dimensional size smaller than 100 nm. At the nanoscale, fluids and objects exhibit lots of unique physical and mechanical behaviors which cannot be observed in micron-sized or macro-sized structures, especially for electrokinetically driven cases. Electrokinetic transport phenomena in nanochannels offer promising possibilities for new applications of nanofluidic systems, such as drug delivery, DNA sequencing, and biosensing. However, the current widely-used nanofabrication technologies are complicated, time-consuming and expensive. Fundamental research of electrokinetic transport phenomena at the nanoscale has been focused on analytical and numerical models, and very limited experimental studies have been conducted. Resistive pulse sensing (RPS) technology has been integrated with nanofluidics and applied in nanoparticle characterization; however, traditional nano-orifice-based RPS detection systems are not suitable for practical applications due to their bulky size, low sensitivity, and high cost. This thesis studies electrokinetic transport phenomena in polydimethylsiloxane (PDMS) nanochannels, as well as applications of nanochannel-based nanofluidic devices in nanoparticle detection and molecule sensing. At the beginning of this thesis, a cost-effective, productive and simple method for fabricating disposable PDMS nanofluidic devices by the solvent-induced cracking method and nanoimprint technique is developed. The channel size is controlled by the working parameters of the solvent-induced cracking method while the quantity and locations of these nanocracks are determined by artificial defects. A detailed guideline for making PDMS nanofluidic chips with single nanochannels or multiple nanochannels of controllable channel size and spacing is provided. Nanochannels of 20 nm in depth can be obtained easily by using this method. Two fundamental research projects are conducted on single-nanochannel-based nanofluidic chips to investigate electrokinetically driven fluids and particles in nanochannels. Electroosmotic flow (EOF) in single nanochannels is measured by the current slope method. Channel size effects, concentration effects and electric field effects upon EOF velocity in nanochannels are investigated systematically. The decrease of EOF velocity due to overlapping of electric double layers (EDLs) is demonstrated by experiments. The experimental results are in good agreement with the numerical simulation results. Electrokinetic (EK) motion of single nanoparticles in single PDMS nanochannels is investigated by particle tracing method systematically. Effects of ionic concentration of the electrolyte media, applied electric field, and particle-to-channel size ratio on particle velocity are studied. The velocity of nanoparticles inside the single nanochannels is suppressed by the confined nanospace due to interactions between EDLs. Lastly, by using the nanochannel-based nanofluidic chips, two applications are developed to detect nanoparticles, cations as well as DNA molecules by the RPS technique. A mathematic model for single-gate differential RPS detection systems is developed to evaluate the RPS signals; working parameters involved in particle detection by using the nanochannel-based differential RPS chips are studied experimentally. The signal-to-noise ratio (SNR) of the PDMS nanochannel-based differential RPS systems is also explored by experiments. To enhance the resolution of the nanochannel-based RPS devices, carbon nanotubes (CNTs) are integrated into differential RPS nanofluidic chips to work as the sensing gates. Novel methods to isolate and cut individual CNTs for CNT-based nanofluidic devices are also created. The CNT-channel-based differential RPS chips are used to detect single cations and individual ssDNA molecules. Distinguishing of 15-nt ssDNAs and 30-nt ssDNAs with high resolution has been achieved. This thesis provides the nanofluidic research community with a comprehensive working procedure for fabricating cost-effective PDMS-based nanofluidic chips. The fundamental studies in this thesis expand our understanding of electrokinetic transport phenomena at the nanoscale, and the differential RPS detection systems developed on the nanochannel-based nanofluidic chips open a new avenue to nanoparticle detection as well as molecule sensing.
Download or read book Electrokinetic Particle Transport in Micro Nanofluidics written by Shizhi Qian and published by CRC Press. This book was released on 2012-06-19 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous applications of micro-/nanofluidics are related to particle transport in micro-/nanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micro/nanofluidics. Therefore, a comprehensive understanding of electrokinetic particle transport in micro-/nanoscale channels is crucial to the development of micro-/nanofluidic devices. Electrokinetic Particle Transport in Micro-/Nanofluidics: Direct Numerical Simulation Analysis provides a fundamental understanding of electrokinetic particle transport in micro-/nanofluidics involving electrophoresis, dielectrophoresis, electroosmosis, and induced-charge electroosmosis. The book emphasizes the direct numerical simulation of electrokinetic particle transport phenomena, plus several supportive experimental studies. Using the commercial finite element package COMSOL Multiphysics®, it guides researchers on how to predict the particle transport subjected to electric fields in micro-/nanoscale channels. Researchers in the micro-/nanofluidics community, who may have limited experience in writing their own codes for numerical simulations, can extend the numerical models and codes presented in this book to their own research and guide the development of real micro-/nanofluidics devices. Corresponding COMSOL® script files are provided with the book and can be downloaded from the author’s website.
Download or read book Modelling of Electrokinetic Phenomena Involving Confined Polymers written by Frédéric Tessier and published by . This book was released on 2006 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrokinetic Phenomena in Micro Nanofluidics Flow Field Ionic Transport Concentration Polarization Effect and Its Application written by 黃冠達 and published by . This book was released on 2008 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrokinetic Trapping of Biomolecules written by Ying-Chih Wang and published by . This book was released on 2007 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) By manipulating analyte concentrations, this integrated device not only increases the detection sensitivity, but also expands the dynamic range of given antibody-antigen couples. In addition, we also investigated the ion transfer at the micro-/nano-fluidic interface. Depending on the strength of the applied electric field across the nanochannel array, various phenomena such as concentration polarization, charge depletion, and nonlinear electrokinetic flows in the adjacent microfluidic channel can be observed and studied in situ by fluorescent microscopy. In summary, the nanofluidic concentrator we developed in this thesis facilitates sample preparation and detection of biomolecules from complex biological matrices and facilitates a further understanding of nanoscale molecular/fluid/ion transport phenomena by providing a well-controlled experimental platform.
Download or read book Electrokinetically Driven Microfluidics and Nanofluidics written by Hsueh-Chia Chang and published by Cambridge University Press. This book was released on 2009-11-09 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrokinetics is currently the mechanism of choice for fluid actuation and bioparticle manipulation at microscale and nanoscale dimensions. There has recently been widespread interest in the use of AC electric fields, given the many advantages it offers over DC electrokinetics. Nevertheless, a fundamental understanding of the governing mechanisms underlying the complex and nonlinear physicochemical hydrodynamics associated with these systems is required before practical microfluidic and nanofluidic devices can be engineered. This text aims to provide a comprehensive treatise on both classical equilibrium electrokinetic phenomena as well as the more recent non-equilibrium phenomena associated with both DC and AC electrokinetics in the context of their application to the design of microfluidic and nanofluidic technology. In particular, Leslie Yeo and Hsueh-Chia Chang discuss the linear and nonlinear theories underlying electroosmosis, electrophoresis, and dielectrophoresis pertaining to electrolytes as well as dielectric systems. Interfacial electrokinetic phenomena such as electrospraying, electrospinning, and electrowetting are also discussed.
Download or read book Microfluidics and Microfabrication written by Suman Chakraborty and published by Springer Science & Business Media. This book was released on 2009-12-15 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics and Microfabrication discusses the interconnect between microfluidics, microfabrication and the life sciences. Specifically, this includes fundamental aspects of fluid mechanics in micro-scale and nano-scale confinements and microfabrication. Material is also presented discussing micro-textured engineered surfaces, high-performance AFM probe-based, micro-grooving processes, fabrication with metals and polymers in bio-micromanipulation and microfluidic applications. Editor Suman Chakraborty brings together leading minds in both fields who also: Cover the fundamentals of microfluidics in a manner accessible to multi-disciplinary researchers, with a balance of mathematical details and physical principles Discuss the explicit interconnection between microfluiodics and microfabrication from an application perspective Detail the amalgamation of microfluidics with logic circuits and applications in micro-electronics Microfluidics and Microfabrication is an ideal book for researchers, engineers and senior-level graduate students interested in learning more about the two fields.
Download or read book Modeling and Simulation of Electrokinetic Manipulation of Biological Particles written by Talukder Zaki Nuruddin Jubery and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent experimental studies show that electrophoretic and dielectrophoretic these two electrokinetic forces can manipulate biological particles efficiently in micro/nanofluidic devices. Electrokinetic forces in those devices depend on various parameters related to properties of the particle, surrounding fluid and device. Therefore, to design an effective micro/nanofluidic platform for a specific manipulation, it is necessary to analyze the effect of the above parameters using mathematical models and numerical simulations. To reduce computational cost, a point based method or smaller domain or single particle is used in the conventional modeling and simulation. However, these methods produce erroneous results when particle and device sizes are comparable, and often ignore detail physics in the devices.
Download or read book Micro and Nanoflows written by Valery Ya. Rudyak and published by Springer. This book was released on 2018-04-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes physical, mathematical and experimental methods to model flows in micro- and nanofluidic devices. It takes in consideration flows in channels with a characteristic size between several hundreds of micrometers to several nanometers. Methods based on solving kinetic equations, coupled kinetic-hydrodynamic description, and molecular dynamics method are used. Based on detailed measurements of pressure distributions along the straight and bent microchannels, the hydraulic resistance coefficients are refined. Flows of disperse fluids (including disperse nanofluids) are considered in detail. Results of hydrodynamic modeling of the simplest micromixers are reported. Mixing of fluids in a Y-type and T-type micromixers is considered. The authors present a systematic study of jet flows, jets structure and laminar-turbulent transition. The influence of sound on the microjet structure is considered. New phenomena associated with turbulization and relaminarization of the mixing layer of microjets are discussed. Based on the conducted experimental investigations, the authors propose a chart of microjet flow regimes. When addressing the modeling of microflows of nanofluids, the authors show where conventional hydrodynamic approaches can be applied and where more complicated models are needed, and they analyze the hydrodynamic stability of the nanofluid flows. The last part of the book is devoted the statistical theory of the transport processes in fluids under confined conditions. The authors present the constitutive relations and the formulas for transport coefficients. In conclusion the authors present a rigorous analysis of the viscosity and diffusion in nanochannels and in porous media.
Download or read book Nanofluidics written by Zhigang R. Li and published by CRC Press. This book was released on 2018-12-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will cover main topics about the fundamentals and applications of nanofluidics. These would be nanofluidics, how it differs from classic fluid mechanics, as well as describing the methodologies of nanofluidics, including numerical approaches, e.g. molecular dynamics simulation and experimental techniques. Fundamental physics and new phenomena in nanofluidics follows, with numerous applications incorporated. Lastly, challenges and future topics are addressed.This book can be viewed as a starting point for studying nanofluidics. It can also be used as a reference in various areas, including lab-on-a-chip technology, medicine, analytical chemistry, physics and engineering.
Download or read book Nanofluidics written by Joshua Benno Edel and published by Royal Society of Chemistry. This book was released on 2009 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his celebrated lecture at the APS meeting in 1959, Richard Feynman pondered the potential of miniaturization in the physical sciences and proposed a variety of new nano-tools. Since then, many of these predictions have become reality including the development and application of nanofluidics. This timely book fills a gap in the current reference literature in this exciting and growing field and is dedicated to the field of nanofluidics with a focus on bioanalytical applications. These nanoscale analytical instruments employ micromachined features and are able to manipulate fluid samples with high precision and efficiency. The book is written at a level accessible to experts and non-experts alike and is essential reading for all advanced nanobiotechnology courses within academic institutions.
Download or read book Micro Nano Chip Electrokinetics Volume III written by Xiangchun Xuan and published by MDPI. This book was released on 2021-02-24 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Micro/nanofluidics-based lab-on-a-chip devices have found extensive applications in the analysis of chemical and biological samples over the past two decades. Electrokinetics is the method of choice in these micro/nano-chips for transporting, manipulating, and sensing various analyte species (e.g., ions, molecules, fluids, and particles). This book aims to highlight the recent developments in the field of micro/nano-chip electrokinetics, ranging from the fundamentals of electrokinetics to the applications of electrokinetics to both chemo- and bio-sample handling.
Download or read book Microfluidics written by Bastian E. Rapp and published by Elsevier. This book was released on 2022-10-07 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics: Modeling, Mechanics and Mathematics, Second Edition provides a practical, lab-based approach to nano- and microfluidics, including a wealth of practical techniques, protocols and experiments ready to be put into practice in both research and industrial settings. This practical approach is ideally suited to researchers and R&D staff in industry. Additionally, the interdisciplinary approach to the science of nano- and microfluidics enables readers from a range of different academic disciplines to broaden their understanding. Alongside traditional fluid/transport topics, the book contains a wealth of coverage of materials and manufacturing techniques, chemical modification/surface functionalization, biochemical analysis, and the biosensors involved. This fully updated new edition also includes new sections on viscous flows and centrifugal microfluidics, expanding the types of platforms covered to include centrifugal, capillary and electro kinetic platforms. Provides a practical guide to the successful design and implementation of nano- and microfluidic processes (e.g., biosensing) and equipment (e.g., biosensors, such as diabetes blood glucose sensors) Provides techniques, experiments and protocols that are ready to be put to use in the lab, or in an academic or industry setting Presents a collection of 3D-CAD and image files on a companion website
Download or read book Nonlinear Electrokinetic Phenomena in Micro and Nano fluids written by Gilad Yossifon and published by . This book was released on 2007 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Micro Nano Chip Electrokinetics written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
