Download or read book Mitochondria in Skeletal Muscle Health Aging and Diseases written by Gilles Gouspillou and published by Frontiers Media SA. This book was released on 2017-02-09 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells.
Download or read book Mitochondria in Skeletal Muscle Health Aging and Diseases written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells.Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells.
Download or read book Mitochondria in Health and Diseases written by Sabzali Javadov and published by . This book was released on 2020-09-04 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.
Download or read book Mitochondrial Involvement and Plasticity in Muscle Aging and Age related Disease written by Yana Konokhova and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Skeletal muscle plasticity is highly dependent on mitochondrial function. Mitochondria regulate critical intracellular functions, including energy production in the form of oxidative phosphorylation and intrinsic pathways of apoptosis. As such, mitochondrial impairments are implicated in adverse muscle impact seen in numerous age-associated diseases as well as healthy aging. For example, low mitochondrial content and impaired oxidative capacity are well-characterized features of locomotor muscle of patients with Chronic Obstructive Pulmonary Disease (COPD). High oxidative stress and physical inactivity are typical of COPD pathophysiology and have been proposed to contribute to low muscle oxidative capacity. At the single fiber level, oxidative capacity can be compromised from insufficient quantities of functional mitochondrial DNA (mtDNA). Our investigations revealed that the high oxidative stress milieu of COPD muscle corresponded to increased incidence of mtDNA mutations and a significantly higher prevalence of fibers lacking cytochrome oxidase (COX) activity secondary to high mtDNA mutation load, compared to age-matched healthy controls. Importantly, in healthy controls, these COX-deficient fibers, though infrequent in prevalence, exhibited a focal increase in mitochondrial biogenesis (including upregulation of mitochondrial biogenesis signals and resulting increases in mtDNA content) to try to reverse the cellular energetic insufficiency. However in COPD muscle, these fibers were much more abundant and the focal compensatory response was absent. Furthermore, our second investigation demonstrated that an endurance-training program (a potent stimulus to upregulate mitochondrial biogenesis) did not ameliorate the abnormal signaling in COX-deficient fibers and did not restore the blunted mtDNA replicative response in such fibers compared to untrained, but healthy controls. Collectively, these results point towards an impairment in mitochondrial biogenesis in COPD muscle that goes beyond that which can be ascribed to the very low physical activity seen in patients. Mitochondria have also been implicated in age-related muscle loss. As such, clinically significant loss of muscle mass and function occur with aging even in the absence of chronic disease. Dysregulated mitochondrial function and increased apoptosis have been previously implicated, particularly in fast-twitch muscle. As such, the third project investigated very old muscles with divergent fiber types and revealed that after accounting for age-related shifting in myosin heavy chain composition, mitochondria in atrophying muscles are more susceptible to initiating apoptosis irrespective of muscle fiber type composition. Furthermore, there was a marked increase in the nuclear translocation of the mitochondrial-derived pro-apoptotic factor, apoptosis inducing factor (AIF), in muscles undergoing atrophy irrespective of fiber type composition. Notably, there was no sensitization to apoptosis or change in myonuclear AIF in a muscle that did not atrophy in very advanced age (adductor longus muscle). As such, these results are consistent with the notion that mitochondrial-mediated apoptosis secondary to sensitization of the mitochondria to permeability transition is involved in the atrophy of skeletal muscle with aging and that this process is independent of the muscle fiber type composition. In summary, this thesis presents evidence of an impairment in mitochondrial biogenesis in COPD locomotor muscle secondary to impaired mtDNA replication that is not restored by exercise training. Furthermore, my results provide the first evidence that a sensitization to permeability transition and translocation of mitochondrial-derived pro-apoptotic factors occurs exclusively in atrophying fast and slow twitch muscles with aging, identifying a process that may help explain the atrophy of aging skeletal muscle irrespective of muscle fiber type composition." --
Download or read book Sarcopenia written by Alfonso J. Cruz-Jentoft and published by John Wiley & Sons. This book was released on 2021-06-15 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: SARCOPENIA An in-depth examination of sarcopenia’s underexplored yet widespread impact within the field of gerontology Sarcopenia is common in older men and women, and yet awareness of its clinical relevance is still relatively low. Only formally included in the International Classification of Diseases in 2016, the condition may impact societies with serious health-related and financial consequences unless consistent, effective methods of identification and management are adopted. This second edition of Sarcopenia provides geriatricians and other healthcare professionals with a revised and expanded examination of this understudied and underdiagnosed condition. Edited by two leading authorities on the subject, it covers the epidemiology and diagnosis of sarcopenia, as well as treatment options and possible prevention strategies. Eight newly written chapters build upon existing knowledge with fresh data on topics including sarcopenia’s biomarkers and its impact on the healthcare economy. This important text: Defines sarcopenia and explains its clinical relevance Covers all recent scientific evidence Outlines treatment options Considers prevention strategies Discusses sarcopenia as a public health priority Features eight new chapters covering topics such as sarcopenia’s clinical management, its biomarkers, and its financial impact Containing vital information for clinicians and other professionals working in geriatric care, nursing homes, nutrition, cancer, endocrinology, surgery, sports medicine and many other specialties, Sarcopenia, second edition, is a groundbreaking and essential new resource.
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Download or read book Mitochondrial Dysfunction in Ageing and Diseases written by Jaime M. Ross and published by MDPI. This book was released on 2018-09-28 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS
Download or read book Understanding the Process of Aging written by Lester Packer and published by CRC Press. This book was released on 1999-01-12 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the research of over 55 experts in the area, Understanding the Process of Aging covers the functions of nitric oxide and peroxynitrite in mitochondria integrates several views on the role of mitochondria in the development of apoptosis gives a quantitative analysis of mutations of mitochondrial DNA during human aging highlights mitochondrial free radical production introduces new roles of ubiquinone in mitochondrial functions offers new antioxidant-based complementary therapeutic strategies details aspects of intact cells and whole organisms in health and disease and more! Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.
Download or read book Skeletal Muscle Mitochondrial Function in Human Health and Disease written by Saskia Gehrig and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Protein and Amino Acids in Sustaining and Enhancing Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1999-09-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Download or read book Mitochondria in Health and Disease written by Carolyn D. Berdanier and published by CRC Press. This book was released on 2005-06-09 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses f
Download or read book Mitochondrial Dysfunction A Functional Medicine Approach to Aging and Diseases written by John Binnington and published by Foster Academics. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are double-membrane-bound organelles found in eukaryotic cells. They build cable-like structures and deliver energy to cells with the help of oxidative phosphorylation (OXPHOS) process. Aging causes a wide range of interrelated conditions and is also a leading cause of various human diseases. The age-associated changes in mitochondria are linked with deterioration in mitochondrial function. The accumulation of oxidative damage and mutations caused by reactive oxygen species (ROS), mitochondrial functionality, and DNA volume and integrity decline with age. Mitochondrial dysfunction includes an increase in oxidative damage and a reduction in oxidative capacity, and plays a significant role in biological aging. The accumulation of dysfunctional mitochondria occurs in all the tissues with aging, including brain, liver and skeletal muscle. These dysfunctional mitochondria are marked and removed through an autophagic process named mitophagy. Mitochondrial dysfunction occurs in many neurodegenerative diseases such as Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), Friedreich's ataxia (FRDA) and Alzheimer's disease (AD). This book explores all the important aspects of mitochondrial dysfunction and its impact on aging and diseases. Experts and students actively engaged in researches on mitochondrial dysfunction will find it full of crucial and unexplored concepts.
Download or read book Life The Epic Story of Our Mitochondria written by Lee Know ND and published by FriesenPress. This book was released on 2014-08-19 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion-mitochondria and bioenergetics. This legendary saga began over two billion years ago, when one bacterium entered another without being digested, ultimately creating the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that are responsible for this life-giving energy. Yet, current research has also revealed a dark side; many seemingly unconnected degenerative diseases have their roots in dysfunctional mitochondria. Modern research, however, has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. By reading this book, you are about to dive into this epic story, and learn how to add years to your life, and life to your years."--Back cover.
Download or read book Mitochondrial Function and Dysfunction written by Anthony Schapira and published by Elsevier. This book was released on 2003-01-10 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease. * Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction* Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases* Includes outstanding list of contributing authors
Download or read book Life in Motion written by University of Florida and published by University Press of Florida. This book was released on 2020-02-02 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: The University of Florida has an ambitious goal: to harness the power of its faculty, staff, students, and alumni to solve some of society’s most pressing problems and to become a resource for the state of Florida, the nation, and the world. In the upcoming decades, an unprecedented demographic shift will take place; the eighty-five and over population is projected to climb far higher than any other age group. To keep the current elderly population healthy and help prevent future generations from experiencing poor health outcomes, researchers are studying crucial connections between skeletal muscles and whole-body health. The University of Florida is at the forefront of this research, utilizing its nationally recognized excellence in the fields of muscle biology and exercise physiology to discover unique ways to preserve muscle health in the aging and those with diseases. Find out how the proteins within muscle can be manipulated to reduce recovery times for individuals who are bedridden. Learn how older, elite athletes have resisted the inevitable degeneration that comes with aging, and how intermittent fasting may help you live longer and healthier. Step inside the lab where a researcher is uncovering the origins of cancer cachexia—a wasting syndrome responsible for 20 percent of cancer deaths worldwide—to improve the lives of patients. The loss of skeletal muscle through disease, disuse, or aging is associated with a host of poor health outcomes, but promising new avenues of research are being studied every day at the University of Florida to make for a healthier tomorrow. The stories chronicled in GATORBYTES span all colleges and units across the UF campus. They detail the far-reaching impact of UF’s research, technologies, and innovations—and the UF faculty members dedicated to them. Gatorbytes describe how UF is continuing to build on its strengths and extend the reach of its efforts so that it can help even more people in even more places.
Download or read book Assessment of Mitochondrial Function in Skeletal Muscle During Disease Disuse and Normal Aging written by Martin Picard and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: These studies: i) demonstrate that mitochondrial function is altered by the standard mitochondrial isolation process; ii) establish differences in mitochondrial function in COPD; iii) establish that changes in mitochondrial function across muscle fiber-types with aging is unrelated to age-related muscle atrophy; and iv) define metabolic and mitochondrial alterations of complete diaphragmatic disuse. Future work should consist in deciphering the mechanisms that establish mitochondrial functional specialization, and in evaluating the physiological consequences of changes in mitochondrial function on intracellular signaling pathways in health and disease." --
Download or read book Mitochondria and the Future of Medicine written by Lee Know and published by Chelsea Green Publishing. This book was released on 2018 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.
