Download or read book Advances in Mitochondrial Medicine written by Roberto Scatena and published by Springer Science & Business Media. This book was released on 2012-02-09 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Download or read book Mitochondrial Medicine written by Anna Gvozdjáková and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Download or read book Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma Volume 1 written by Ganji Purnachandra Nagaraju and published by Academic Press. This book was released on 2022-02-16 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume One: Biology and Pathophysiology provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This volume discusses topics such as tumor microenvironment in hepatocellular carcinoma, endoplasmic reticulum stress and unfolded protein response, effects of cirrhosis and hepatitis on the prognosis of HCC, mitochondrial metabolism, next generation sequencing, and telomerase. In addition, it discusses exosomes role in HCC progression, metastasis and chemokines. This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer for their research work or clinical setting. Provides an updated literature review and detailed understanding of liver cancer tumor biology Discusses abnormal changes in the liver caused, resulting from, or associated with hepatocellular carcinoma from a holistic view Presents the content with fully colored images and summarizing tables for easy understanding of complex topics

Download or read book Geriatric Medicine written by Christine K. Cassel and published by Springer Science & Business Media. This book was released on 2006-05-29 with total page 1282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the third edition of Geriatric Medicine,extraordinary advances have occurred in the science of aging and the potential for biomedical research to give us answers to many, if not most, of the age-related disorders that threaten the quality of life in older years. At the most basic level, the successful mapping of the human genome was declared complete in the fall of 2000. Understanding the map of the human genome is as important as understanding the map of genomes of important laboratory species, ranging from the microscopic worms and fruit?ies used in most classic genetic studies to rodents such as laboratory mice, and eventually to primates, on which much of the research on the aging human brain is done. The genetic maps of all of these species,including our own,does not answer clinical questions,but it does open the door to dramatic, rapid, and ef?cient answers to questions about the genetic polymorphisms related to diseases in humans. The telomerase story also unfolded since the third edition. Telomerase is an enzyme responsible for maintaining the telomeres—the redundant DNA portions at the end of chromosomes—whose shortening seems to be linked directly to cell senescence,ap- tosis,and the control over cell death,which,at the level of the individual cell,seems to be linked to the decline of organ function and eventually aging and death within the org- ism.

Download or read book Mitochondrial Dynamics in Cardiovascular Medicine written by Gaetano Santulli and published by Springer. This book was released on 2017-05-25 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

Download or read book Pocket Prescriber Emergency Medicine written by Anthony FT Brown and published by CRC Press. This book was released on 2013-08-30 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug prescribing errors are a common cause of hospital admission, and adverse reactions can have devastating effects, some even fatal. Pocket Prescriber Emergency Medicine is a concise, up-to-date prescribing guide containing all the "must have" information on a vast range of drugs that staff from junior doctors to emergency nurses, nurse prescribers, paramedics and other pre-hospital providers may encounter in the emergency setting. Key features: • A–Z list of over 500 of the most commonly prescribed drugs with each entry containing the key prescribing information • Safety issues, warnings, drug errors and adverse effects • Practical guidance on drug selection, plus protocols and resuscitation guidelines • Advice and reference information for complicated prescriptions • Concise management summaries for common medical and surgical emergencies • Essential advice for pain relief—from acute pain management to procedural sedation • Clinically useful reminders of key facts from basic pharmacology to acute poisoning syndromes Pocket Prescriber Emergency Medicine supplies all your information needs concerning commonly prescribed drugs at a glance, enabling on-the-spot decision-making to provide the highest standard of care whilst mitigating prescribing errors.

Download or read book Cell Biology and Translational Medicine Volume 18 written by Kursad Turksen and published by Springer Nature. This book was released on 2023-03-22 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 18th volume of a continuing series.

Download or read book Genetic Testing in Reproductive Medicine written by Rajender Singh and published by Springer Nature. This book was released on with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functional Medicine An Issue of Physical Medicine and Rehabilitation Clinics of North America E Book written by Elizabeth P. Bradley and published by Elsevier Health Sciences. This book was released on 2022-08-24 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Physical Medicine and Rehabilitation Clinics, guest editor Dr. Elizabeth Bradley brings her considerable expertise to the topic of Functional Medicine. Functional medicine offers a holistic, patient-centered approach that focuses on identifying and addressing the root cause of disease. It encourages patients to take an active role in their health and physicians to look beyond the symptoms at the larger picture. In this issue, top experts provide state-of-the-art coverage of a wide variety of topics, including food sensitivities, mold and chronic diseases, frequency-specific microcurrent (FSM); community outreach and functional medicine, and more. Contains 11 practice-oriented topics including food as medicine; women's health, diet and functional medicine; Patient-Reported Outcomes Measurement Information System (PROMIS); fasting mimicking diet, longevity and its relationship to chronic diseases; environmental medicine: exploring the pollutome for solutions to chronic diseases; and more. Provides in-depth clinical reviews on functional medicine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Download or read book From Nucleic Acids Sequences to Molecular Medicine written by Volker A. Erdmann and published by Springer Science & Business Media. This book was released on 2012-06-13 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a half century of structural, biophysical and biochemical investigations of ribonucleic acids, they are still mysterious. RNAs stand at fertile crossroads of disciplines, integrating concepts from genomics, proteomics, dynamics as well as biochemistry and molecular biology. From 20 years it is clear, that genetic regulation of eukaryotic organisms has been misunderstood for the last years that the expression of genetic information is effected only by proteins. Basic understanding of nucleic acids has enhanced our foundation to probe novel biological functions. This is especially evident for RNA molecules whose functionality, maturation, and regulation require formation of correct secondary structure through encoded base-pairing interactions.

Download or read book Science In Medicine written by Ushma S. Neill and published by Jones & Bartlett Learning. This book was released on 2007-10-31 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science in Medicine: The JCI Textbook of Molecular Medicine is a collection of acclaimed articles published in the Journal of Clinical Investigation during the Journal’s tenure at Columbia University. The society that publishes the JCI, the American Society for Clinical Investigation (ASCI), is an honor society of physician scientists, representing those who are at the forefront of translating findings in the laboratory to the advancement of clinical practice. This textbook brings together state-of-the-art reviews written by the world's leading authorities, including many ASCI members. The reviews examine the molecular mechanisms underlying a wide array of diseases and disorders affecting all major organ systems. The fundamentals of the organ or physiological systems in question are present alongside the underlying genetic or physiological abnormalities that result in disease. This text illustrates the translation of basic scientific knowledge into the current practice of clinical medicine. The reviews provide an authoritative and comprehensive overview by building on known scientific concepts and treatment of human disease while exploring where these advances might take medicine over the next decade. The book is a valuable resource for medical students, graduate students, house staff, attending and practicing physicians, and biomedical researchers.

Download or read book The Bartonellas and Peruvian Medicine written by Graciela S Alarcón and published by Rutgers University Press. This book was released on 2019-01-08 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bartonellas and Peruvian Medicine explores the events surrounding the discovery of the etio-pathogenic agent of the Oroya Fever by Dr. Alberto Barton. The book recounts Barton's persistent work against skepticism and obstacles imposed by members of Peru's medical elites, as well as his eventual successful scientific career and the delayed global recognition of his contributions.

Download or read book Mitochondrial Medicine written by Volkmar Weissig and published by Springer Nature. This book was released on 2021-05-31 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume II guides readers through chapters on mitochondrial dysfunction, functional’ mitochondria, mitochondrial retrograde, mitochondrial dNTP pool quantification, mitochondrial ADP-ribosylation, blue-native gel approach, 3D optical cryo-imaging method, mitochondrial ATP and ROS production, protocol for untargeted metabolomic analysis, and methods for analysis of nitrotyrosine-containing proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 2: Assessing Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Download or read book Nutrition and Integrative Medicine for Clinicians written by Aruna Bakhru and published by CRC Press. This book was released on 2023-02-28 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mystery illness can be helped, and this book lays the groundwork for it! Can a water-damaged building ruin your health and cause debilitating exhaustion, chronic pain, insomnia, anxiety, obesity and "brain fog?" Could a flood or wet basement make you sick even if it has long dried out? Building on its predecessor, Nutrition and Integrative Medicine for Clinicians: Volume Two is an essential, peer-reviewed resource for practitioners to help patients with various illnesses found in society, including those contracted from water-damaged structures, that can lay the groundwork for a healthy road to recovery. Written by authors at the forefront of their respective fields, this book presents information for people "written off" as having a "mystery illness," fibromyalgia or chronic fatigue. Chronic inflammatory response syndrome (CIRS) is ubiquitous and affects many body systems, yet it is largely unrecognized by doctors, who misdiagnose CIRS patients daily. This book is a comprehensive guide on evaluating illnesses that are difficult to diagnose, including CIRS. This volume contains information on various subjects, including: Illnesses resulting from water-damaged buildings and subsequent change in the microbiome of the building. Steps to heal from mold/mycotoxin illnesses. Legal and ethical considerations in health issues from exposure to a water-damaged building as well as introducing the "building science" to clinicians. Effects of CIRS on metabolism and insulin resistance. Environmental hormone disruptors. Myalgic encephalitis/chronic fatigue syndrome. Regenerative agriculture. Pediatric sleep-related breathing disorders and their effects on growth and development. Circadian effects of artificial light and their effects on mitochondria. Nutritional support in Covid. The design nature of sound and its relationship to neural networks. The human body as a biological sound healing instrument. The use of color in clinical application. Art in medicine. Living life with intentionality and mindfulness. Making childbirth a positive experience.

Download or read book Studies on Veterinary Medicine written by Lester Mandelker and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.

Download or read book Advances in Integrative Medicine for Neurodegenerative Diseases From Basic Research to Clinical Practice written by Shoanan Liu and published by Frontiers Media SA. This book was released on 2024-03-08 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases (NDs) are disorders characterized by progressive loss of neurons and may finally lead to severe impairments even death. NDs are age-dependent disorders, growing evidence suggests that nearly all aged brains exhibit characteristic changes that are associated with neurodegeneration. As the global rapidly aging population, the prevalence of NDs is which have become the most dreaded disease of aged people. Studies report that the expenses of these older patients with NDs exceed the total medical expenses of patients with cancer and cardiovascular diseases.

Download or read book Bibliography of the History of Medicine written by and published by . This book was released on 1993 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt: