Download or read book Amorphous Solid Dispersions written by Navnit Shah and published by Springer. This book was released on 2014-11-21 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

Download or read book Crystallization in Multiphase Polymer Systems written by Sabu Thomas and published by Elsevier. This book was released on 2017-09-15 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystallization in Multiphase Polymer Systems is the first book that explains in depth the crystallization behavior of multiphase polymer systems. Polymeric structures are more complex in nature than other material structures due to their significant structural disorder. Most of the polymers used today are semicrystalline, and the subject of crystallization is still one of the major issues relating to the performance of semicrystalline polymers in the modern polymer industry. The study of the crystallization processes, crystalline morphologies and other phase transitions is of great significance for the understanding the structure-property relationships of these systems. Crystallization in block copolymers, miscible blends, immiscible blends, and polymer composites and nanocomposites is thoroughly discussed and represents the core coverage of this book. The book critically analyzes the kinetics of nucleation and growth process of the crystalline phases in multi-component polymer systems in different length scales, from macro to nanoscale. Various experimental techniques used for the characterization of polymer crystallization process are discussed. Written by experts in the field of polymer crystallization, this book is a unique source and enables professionals and students to understand crystallization behavior in multiphase polymer systems such as block copolymers, polymer blends, composites and nanocomposites. - Covers crystallization of multiphase polymer systems, including copolymers, blends and nanocomposites - Features comprehensive, detailed information about the basic research, practical applications and new developments for these polymeric materials - Analyzes the kinetics of nucleation and growth process of the crystalline phases in multi-component polymer systems in different length scales, from macro to nanoscale

Download or read book Polymer Blends Volume 1 written by Donald R Paul and published by Elsevier. This book was released on 2012-12-02 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer Blends, Volume 1 highlights the importance of polymer blends as a major new branch of macromolecular science. Topics range from polymer-polymer compatibility and the statistical thermodynamics of polymer blends to the phase separation behavior of polymer-polymer mixtures, transport phenomena in polymer blends, and mechanical properties of multiphase polymer blends. The optical behavior, solid state transition behavior, and rheology of polymer blends are also discussed. This book is organized into 10 chapters and begins with an overview of polymer blends, with emphasis on terminology and the effect of molecular weight on the thermodynamics of polymer blends as well as phase equilibria and transitions. The discussion then turns to the miscibility of homopolymers and copolymers, in bulk and in solution, from the experimental and theoretical viewpoints. The chapters that follow explore the statistical thermodynamics of polymer blends, paying particular attention to the Flory and lattice fluid theories, along with the phase relationship in polymer mixtures. The interfacial energy, structure, and adhesion between polymers in relation to the properties of polymer blends are considered. The final chapter examines the phenomena of low molecular weight penetrant transport. Currently accepted models for unsteady-state and steady-state permeation of polymeric materials are presented. A discussion of unsteady-state absorption and desorption behavior observed in a variety of polymer blends complements the treatment of permeation behavior. This book is intended to provide academic and industrial research scientists and technologists with a broad background in current principles and practice concerning mixed polymer systems.

Download or read book Characterization of Polymer Blends written by Sabu Thomas and published by John Wiley & Sons. This book was released on 2015-02-09 with total page 972 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap for a reference dedicated to the characterization of polymer blends and their micro and nano morphologies, this book provides comprehensive, systematic coverage in a one-stop, two-volume resource for all those working in the field. Leading researchers from industry and academia, as well as from government and private research institutions around the world summarize recent technical advances in chapters devoted to their individual contributions. In so doing, they examine a wide range of modern characterization techniques, from microscopy and spectroscopy to diffraction, thermal analysis, rheology, mechanical measurements and chromatography. These methods are compared with each other to assist in determining the best solution for both fundamental and applied problems, paying attention to the characterization of nanoscale miscibility and interfaces, both in blends involving copolymers and in immiscible blends. The thermodynamics, miscibility, phase separation, morphology and interfaces in polymer blends are also discussed in light of new insights involving the nanoscopic scale. Finally, the authors detail the processing-morphology-property relationships of polymer blends, as well as the influence of processing on the generation of micro and nano morphologies, and the dependence of these morphologies on the properties of blends. Hot topics such as compatibilization through nanoparticles, miscibility of new biopolymers and nanoscale investigations of interfaces in blends are also addressed. With its application-oriented approach, handpicked selection of topics and expert contributors, this is an outstanding survey for anyone involved in the field of polymer blends for advanced technologies.

Download or read book Thermodynamics of Polymer Blends Volume I written by Anatoly E. Nesterov and published by CRC Press. This book was released on 2020-02-03 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thermodynamics is an indispensable tool for developing a large and growing fraction of new polymers and polymer blends. These two volumes show the researcher how thermodynamics can be used to rank polymer pairs in order of immiscibility, including the search for suitable chemical structure of compatibilizers. Because of the great current commercial interest in this most dynamic sector of the polymer industry, there is high interest in studying their physical and mechanical properties, their structures, and the processes of their formation and manufacture. These Books are dedicated to Analysis of the Thermodynamics of Polymer Blends. Thermodynamic behavior of blends determines the compatibility of the components, their morphological features, rheological behavior, and microphase structures. As a result, the most important physical and mechanical characteristics of blends can be identified. The information in these two volumes will be useful to all those involved in polymer research, development, analysis and advanced process engineering.

Download or read book Polymer Blends Handbook written by L. A. Utracki and published by . This book was released on 2014-01-31 with total page 1800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an international group of highly respected contributors, this fundamental reference work covers all aspects of polymer blends: science, engineering, technology and applications.

Download or read book Encyclopedia of Polymer Blends Volume 1 written by Avraam I. Isayev and published by John Wiley & Sons. This book was released on 2016-09-12 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete and timely overview of the topic, this volume of the encyclopedia imparts knowledge of fundamental principles of polymer blends. Each article is uniformly structured for easy navigation, containing the latest research & development and its basic principles and applications.

Download or read book Polymer Blends and Mixtures written by D.J. Walsh and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: A couple of years ago a small group of people began discus sing the possibility of running an advanced summer school in the area of polymer blends. There had been a number of recent advan ces in this field, and given the considerable interest in these new polymeric materials, we thought such a meeting would be well received both by industry and academia. We wanted it to contain a wide range of background science and technology and also up to date recent advances in the field. It became clear as the discus sion progressed that the experts in the field were scattered over the length and breadth of Europe and North America and thus the cost of bringing them together for a summer school would necessi tate a high registration fee which would deter many of the research workers we wished to attract. The NATO Advanced Study Institute programme enables a subject to be covered in depth and by giving generous funds to cover lecturers' costs ensures that a wide spectrum of research workers can attend. We decided to apply to NATO and this book contains the results of our request. The ASI was funded under the 'Double-Jump' Programme which is not a new Olympic event but a way of supporting courses on sub jects of direct industrial interest. The Institute was also backed by donations from several companies and approximately half those attending were from industrial organisations.

Download or read book Encyclopedia of Polymer Blends Volume 3 written by Avraam I. Isayev and published by John Wiley & Sons. This book was released on 2016-09-13 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete and timely overview of the topic, this Encyclopedia imparts knowledge of fundamental principles and their applications for academicians, scientists and researchers, while informing engineers, industrialists and entrepreneurs of the current state of the technology and its utilization. The most comprehensive source on polymer blends available on the market Offers a complete and timely overview of the topic Each article presents up to date research & development on a topic and its basic principles and applications, integrates case studies, laboratory and pilot plant experiments, and gives due reference to published and patented literature Equips academics, scientists and researchers with knowledge of fundamentals principles and their applications, and informs the engineers, industrialists and entrepreneurs about the state of the art technology and its applications

Download or read book Polymer Blends and Composites written by Muralisrinivasan Natamai Subramanian and published by John Wiley & Sons. This book was released on 2017-03-23 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because it is critically important to manufacture quality products, a reasonable balance must be drawn between control requirements and parameters for improved processing method with respect to plastics additives. An important contribution to the commercial polymer industry, Polymer Blends and Composites is one of the first books to combine plastics additives, testing, and quality control. The book is a comprehensive treatise on properties that provides detailed guidelines for selecting and using blends and composites for applications. A valuable resource for operators, processors, engineers, chemists, the book serves to stimulate those already active in natural polymer composites.

Download or read book Polymer Blends written by D.R. Paul and published by Elsevier. This book was released on 2012-12-02 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer Blends, Volume 2 aims to show the importance of mixed polymer systems as a major branch of macromolecular science and provides a broad background of principles and practices in this field. Starting from where the first volume left off, the book covers topics in the area of polymer blends in Chapters 11-23. Areas of coverage include interpenetrating polymer networks; interfacial agents for polymer blends; rubber modification of plastics; fracture phenomena; coextruded multilayer polymer films and sheets; polymeric plasticizers; and polyolefin blends and their applications. The book is recommended for scientists, technologists, and engineers in the academe, research, and related industry, especially those who wish to be updated with its advances as a science.

Download or read book Nanostructured Polymer Blends written by Sabu Thomas and published by William Andrew. This book was released on 2013-11-28 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 30% of commercial polymers are blends or alloys or one kind or another. Nanostructured blends offer the scientist or plastics engineer a new range of possibilities with characteristics including thermodynamic stablility; the potential to improve material transparency, creep and solvent resistance; the potential to simultaneously increase tensile strength and ductility; superior rheological properties; and relatively low cost. Nanostructured Polymer Blends opens up immense structural possibilities via chemical and mechanical modifications that generate novel properties and functions and high-performance characteristics at a low cost. The emerging applications of these new materials cover a wide range of industry sectors, encompassing the coatings and adhesives industry, electronics, energy (photovoltaics), aerospace and medical devices (where polymer blends provide innovations in biocompatible materials). This book explains the science of nanostructure formation and the nature of interphase formations, demystifies the design of nanostructured blends to achieve specific properties, and introduces the applications for this important new class of nanomaterial. All the key topics related to recent advances in blends are covered: IPNs, phase morphologies, composites and nanocomposites, nanostructure formation, the chemistry and structure of additives, etc. - Introduces the science and technology of nanostructured polymer blends – and the procedures involved in melt blending and chemical blending to produce new materials with specific performance characteristics - Unlocks the potential of nanostructured polymer blends for applications across sectors, including electronics, energy/photovoltaics, aerospace/automotive, and medical devices (biocompatible polymers) - Explains the performance benefits in areas including rheological properties, thermodynamic stablility, material transparency, solvent resistance, etc.

Download or read book Functional Polymeric Composites written by Chin Hua Chia and published by CRC Press. This book was released on 2017-11-23 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new work, Functional Polymeric Composites: Macro to Nanoscales, focuses on new challenges, findings, opportunities, and applications in the area of polymer composites. The chapters, written prominent researchers from academia, industry, and research institutes from around the world, present contemporary research and developments on advanced polymeric materials, including polymer blends, polymer electrolytes, bio-based polymer, polymer nanocomposites, etc. Several chapters also cover the applications of the polymeric systems in current industry development and synthesis and characterization of the products.

Download or read book Handbook of Polymer Crystallization written by Ewa Piorkowska and published by John Wiley & Sons. This book was released on 2013-05-30 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric crystals are more complex in nature than other materials' crystal structures due to significant structural disorder present. The only comprehensive reference on polymer crystallization, Handbook of Polymer Crystallization provides readers with a broad, in-depth guide on the subject, covering the numerous problems encountered during crystallization as well as solutions to resolve those problems to achieve the desired result. Edited by leading authorities in the field, topics explored include neat polymers, heterogeneous systems, polymer blends, polymer composites orientation induced crystallization, crystallization in nanocomposites, and crystallization in complex thermal processing conditions.

Download or read book Encyclopedia of Polymer Blends Volume 3 written by Avraam I. Isayev and published by John Wiley & Sons. This book was released on 2016-06-07 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete and timely overview of the topic, this Encyclopedia imparts knowledge of fundamental principles and their applications for academicians, scientists and researchers, while informing engineers, industrialists and entrepreneurs of the current state of the technology and its utilization. The most comprehensive source on polymer blends available on the market Offers a complete and timely overview of the topic Each article presents up to date research & development on a topic and its basic principles and applications, integrates case studies, laboratory and pilot plant experiments, and gives due reference to published and patented literature Equips academics, scientists and researchers with knowledge of fundamentals principles and their applications, and informs the engineers, industrialists and entrepreneurs about the state of the art technology and its applications

Download or read book Polymer Polymer Miscibility written by Olagoke Olabis and published by Elsevier. This book was released on 2012-12-02 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer–Polymer Miscibility discusses miscibility of polymeric mixtures. This book explains the theoretical and practical aspects of polymer miscibility, which has become a considerable area of research in many academic and industrial laboratories. Comprised of seven chapters, this book starts with an overview of the physical nature of the variations of the basic polymer structure. This monograph then discusses the two cases of miscible polymer blends, namely, poly(vinyl chloride) (PVC)–butadiene/acrylonitrile copolymer (NBR) and polystyrene–poly(2,6-dimethyl-1,4-phenylene oxide) (PPO) blends. This text explores the useful and unique properties of blends of poly(vinyl chloride) and butadiene/acrylonitrile copolymer rubber. Other chapters discuss the thermodynamic theories for the phase separation of block copolymers. The reader is also introduced to other variations of chemical structure, which can result in the permanent attachment of polymers to each other through block and graft copolymers. This text also explores the feasibility of covalent bonding of polymer components. This book is intended for chemical engineers and materials scientists.

Download or read book Dosage Form Design Parameters written by and published by Academic Press. This book was released on 2018-07-25 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dosage Form Design Parameters, Volume II, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. - Examines the history and recent developments in drug dosage forms for pharmaceutical sciences - Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism - Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design