Download or read book Minor Histocompatibility Antigens written by Derry Roopenian and published by CRC Press. This book was released on 1999-08-01 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the widespread application of solid tissue and bone marrow transplantation as a treatment for an array of life threatening disorders, there is a pressing need for clinicians and experimentalists to understand the basis of immunological rejection of tissue transplants. While much previous work focuses on characterization of antigens encoded by

Download or read book Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation written by Gerard Socie and published by Academic Press. This book was released on 2018-11-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation, Second Edition once again provides clinical and scientific researchers with a deep understanding of the current research in this field and the implications for translational practice. By providing an overview of the immune biology of HSCT, an explanation of immune rejection, and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes, and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future. The second edition is fully revised and includes new chapters on microbiome, metabolism, kinase targets, micro-RNA and mRNA regulatory mechanisms, signaling pathways in GVHD, innate lymphoid system development, recovery and function in GVHD, genetically engineered T-cell therapies, immune system engagers for GVHD and graft-versus-tumor, and hematopoietic cell transplant for tolerance induction in solid organ grafts. Brings together perspectives from leading laboratories and clinical research groups to highlight advances from bench to the bedside Guides readers through the caveats that must be considered when drawing conclusions from studies with animal models before correlating to clinical allogeneic hematopoietic stem cell transplantation (HSCT) scenarios Categorizes the published advances in various aspects of immune biology of allogeneic HSCT to illustrate opportunities for clinical applications

Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field

Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Download or read book Characterization and Recognition of Minor Histocompatibility Antigens written by and published by . This book was released on 2016 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Histocompatibility Antigens Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: Histocompatibility Antigens—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Histocompatibility Antigens in a compact format. The editors have built Histocompatibility Antigens—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Histocompatibility Antigens in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Histocompatibility Antigens—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Minor Histocompatibility Antigens written by Rimke Oostvogels and published by . This book was released on 2015 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book Identification of Human Minor Histocompatibility Antigens written by and published by . This book was released on 1997 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The HLA Complex in Biology and Medicine written by Narinder K Mehra and published by Boydell & Brewer Ltd. This book was released on 2010-11-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

Download or read book Human Immunogenetics written by S. D. Litwin and published by CRC Press. This book was released on 1989-01-10 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delineating fundamental concepts of contemporary immunogenetics, this reference/text examines specific immunogenetic systems in terms of molecular biochemistry and immunophysiology. Covers material in diverse fields, including infectious diseases, cell biology, virology, molecular genetics. Comprise

Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Download or read book Identification and Characterization of Human Minor Histocompatibility Antigens written by Richard Allan Pierce and published by . This book was released on 2001 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification of Human Minor Histocompatibility Antigens written by Johanna Martina Maria den Haan and published by . This book was released on 1997 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification of Minor Histocompatibility Antigens written by Slavoljub Milosevic and published by . This book was released on 2003 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification of Minor Histocompatibility Antigens by Reverse Immunology written by and published by . This book was released on 2014 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Minor Histocompatibility Antigens in Tissue Transplant Rejection written by Moheeb A. Al-Awwami and published by . This book was released on 2007 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic stem cell transplantation (HSCT) is an affective treatment for many malignant diseases including hematological malignancies, solid tumors that are sensitive to myeloablative therapy, non malignant diseases and severe autoimmune diseases. Graft versus host disease (GVHD) is the most serious and life-threatening complication post HSCT. The immune response that causes GVHD in HSCT between major histocompatibility complex matched donors and recipients are directed mainly against few immunodominant minor histocompatibility antigens (mHAgs) despite the presence of numerous other mHAgs. Remarkably >30% of the total CD8+ T cells immune response to the mHAgs was directed against a single mHAg (H60). The mechanism by which H60 achieves its immunodominance is unknown. A major goal of the study is to investigate the mechanism by which H60 overwhelmingly dominates other mHAgs and determine the kinetics of CD8 + T cells immune response to various immunodominant mHAgs in immunization and GVHD settings. Furthermore, we sought to determine the relative impact of matching or mismatching of a single or multiple mHAgs in development of GVHD following bone marrow (BM) transplantation between MHC matched background disparate mouse strains. We generated H60 transgenic mice and a battery of congenic mice for single and multiple combinations of mHAgs and we performed several immunizations and BM and spleen cell transfers. We hypothesized that the immunodominance of H60 is due to the lack of self analog in the responding mice that cause loss of T cells negative selection in the thymus which lead to presence of high T cell precursor frequency specific for H60. Herein we show that introduction of self analog of H60 in mice that do not express H60 did not ameliorate their immune response to H60, thus we ruled out this mechanism for the immunodominance of H60. Furthermore, we show that any of the tested single mHAgs are not a risk factor for lethal GVHD; however, we show that matching for mHAgs resulted in the attenuation of GVHD. Understanding the mechanism of immunodominance is of importance in transplantation, immunotherapy targeting mHAgs in cancer treatment and vaccine development.