Download or read book Mineralizing Vesicles written by Massimo Bottini and published by Elsevier. This book was released on 2023-11-30 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease presents the state-of-the art in the properties of mineralizing EVs and their potential clinical applications. The first chapter presents foundational biochemical and biological aspects of EVs. Next, the title coves the role of EVs in bone ossification and in cardiovascular and cartilage-related diseases. Considering the unique ability of this class of EVs to form apatite minerals assigned to their special biochemical machinery, three chapters of the book then focus on the enzymes catalysing the inorganic phosphate and calcium turn-over and the dynamic properties of the vesicles’ peripheral proteins. Chapters describe the role of inorganic phosphate and calcium ions and of autophagy on the biogenesis and function of mineralizing EVs. Recent studies show that the lumen of mineralizing EVs is partially filled with miRNA, and a chapter therefore considers research on the possible function of these vesicles as signalosomes. The final five chapters of the book describe practical aspects of working with mineralizing EVs, including their purification, proteomic and biophysical analyses, the use of biomimetic models and mineralizing EVs in regenerative medicine. This title presents, for the first time, a comprehensive account of mineralizing EVs and their potential clinical applications. It will be invaluable to researchers in the field. • Covers all aspects of mineralizing EVs, from their composition to their function in physiological and pathological processes, and their clinical potential • Presents mineralizing EVs systematically using clear accessible language • Describes practical aspects of working with mineralizing EVs • Integrates an account of the biochemistry and biophysics of vesicles with their functions • Takes a multidisciplinary perspective, offering an exhaustive and cutting-edge account of mineralizing EVs and human health

Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.

Download or read book Annexins written by Joanna Bandorowicz-Pikula and published by Springer Science & Business Media. This book was released on 2003-07-31 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Annexins is focused on a specific family of calcium and membrane-binding proteins, annexins, ubiquitously spread within living organisms, including animals, plants and fungi. The volume covers important areas of annexinology. The characterization of structural-functional relationship within the annexin family of proteins, together with emerging transgenic animal models, provides an up-to-date overview of potential physiological roles of annexins. Growing evidence of participation of annexins in human diseases, called annexinopathies, related to disturbances in signal transduction, vesicular traffic, ion homeostasis and energy metabolism within the cell. The book will attract a broad scientific audience, not only scientists interested in annexins, but also others involved in multidisciplinary studies, as well as undergraduate and postgraduate students. It can be used in courses relating to special topics such as calcium homeostasis, calcium-binding proteins, membrane structure and transport properties, various signal transduction pathways, and membrane trafficking.

Download or read book Origin Evolution and Modern Aspects of Biomineralization in Plants and Animals written by Rex E. Crick and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Biomineralization Symposium was held in May 1986 at The University of Texas at Arlington, Arlington, Texas. The chosen theme was the origin, evolution and modern aspects of biomineralization in plants and animals. Thus, the symposium was designed to bring together experts in ocean and atmospheric chemistry, geochemistry, paleontology, biology, medicine and related fields to share accumulated knowledge and to broaden research horizons. The contents of this volume reflect the diversified interests and views of contributors from these fields. Topics range from contrasting views of the origin of ocean chemistry, the cause or causes for the biomineralization among plants and animals, the evolution of style and structure of biomineralization, and the role of inorganic and organic compounds in biomineraliza tion. It was clear from those gathered in Arlington that the efforts of all researchers in any aspect of biomineralization can be strengthened and extended by greater exposure to the work of others in allied fields. At the time of this printing, several collaborative efforts have grown from interest and contacts developed during the symposium. Rex E. Crick viii ACKNOWLEDGEMENTS The symposium would not have occurred with the financial support of The Organized Research Fund of The University of Texas at Arlington and The Sea Grant Program administered by Texas A & M University. The staff of the Department of Geology of The University of Texas at Arlington were largely responsible for providing a pleasant atmosphere for learning.

Download or read book Dynamics of Bone and Cartilage Metabolism written by Markus J. Seibel and published by Elsevier. This book was released on 2006-07-24 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Download or read book Ten Cate s Oral Histology written by Antonio Nanci and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "150 color images with legends, 472 book figures with legends, 438 multiple choice test questions, and 119 interactive drag-and-drop exercises." -- from CD-ROM Welcome screen.

Download or read book International Cell Biology 1980 1981 written by Hans G. Schweiger and published by Springer. This book was released on 2013-12-14 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September, 1976, the International Federation for Cell Biology held its first congress in Boston. On this occasion Berlin was chosen as the site for the next congress. This meant an acknowledgement and at the same time a heavy burden for the still young European Cell Biology Organization, which repre sents a junction of European societies and groups for cell biology. In practical terms, this meant that the members of the young and, compared to the Ame rican Society for Cell Biology, small German Society for Cell Biology had to do a good deal of the organizing of the Cell Biology Congress. This is an op portunity for me, as Chairman of the Organizing Committee, and also on be half of the German Society for Cell Biology, to express my gratitude to all those who have actively participated in the preparations for this Cell Biology Congress. The success of the Congress in Berlin was to a significant extent due to their work. In particular, I would like to especially thank the Secretary General ofECBO Werner Franke, Heidelberg, as well as the Chairman of the Local Organizing Committee, Peter Giesbrecht, Berlin, for the excellent job they did. The Congress in Berlin proved to be significantly larger than that in Boston in 1976. The number of abstracts increased from 1200 to more than 1800. They have been published in the European Journal of Cell Biology. In a simi lar way the number of symposia and workshops expanded.

Download or read book Cardiovascular Calcification and Bone Mineralization written by Elena Aikawa and published by Springer Nature. This book was released on 2020-07-01 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.

Download or read book The Comparative Molecular Biology of Extracellular Matrices written by Harold Slavkin and published by Academic Press. This book was released on 2012-12-02 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Comparative Molecular Biology of Extracellular Matrices reviews and assesses the comparative molecular biology of extracellular matrices. It covers six areas that are advanced to supplement this study. These include the molecular biology of collagen, monopolysaccharides, proteoglycans, and structural glycoproteins; development process of extracellular matrices; cell surfaces and interactions; evolution of bone and some tissues; and biophysical properties of connective tissues.

Download or read book Biological Mineralization and Demineralization written by G.H. Nancollas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: normal and pathological mineralization in vertebrates but also with the interesting problems involved in the formation of in tracellular deposits of calcium oxalate in plants. Here cal cium carbonate and silica may also be involved in the mineral ization processes. Calcium carbonate is an important component in the formation of mollusc and avian shells. The observation that both calcite and aragonite may be formed in biogenic cal cium carbonate raises important questions as to what factors control the formation of the final mineral phase. There is little doubt that thermodynamically less stable phases may be kinetically stabilized for long periods of time by other mole cules present in vivo. In normal mineralization, calcium salts may initially be deposited both within the cells and extracel lularly. In the latter case, the role of matrix vesicles and the ways in which the matrix components might control mineral ization were especially emphasized. There is clearly a need for more structural and functional information involving cells, matrix components, and their associated crystals. The develop ment of further techniques involving mutants, chromofluors, and fixatives for preservation of tissue and the ions present in vivo was recommended. In dealing with abnormal and pathological mineralization, the Workshop concentrated on urolithiasis, gout and pseudo-gout, and the formation of dental caries. Discussions based on the influence of media of low pH on mineral surfaces highlighted some of the factors of importance in controlling crystal dis solution.

Download or read book Biological Calcification written by Ermanno Bonucci and published by Springer Science & Business Media. This book was released on 2007-02-17 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, this book offers a critical review of the calcification process of the organic and inorganic phases of mineralized tissues focusing on the earliest phases. It includes a methodological chapter which provides the necessary practical information for making appropriate choices. The book is set to become an important reference source for the shelves of bone densitometry labs across the world.

Download or read book Oxford Textbook of Clinical and Biochemical Disorders of the Skeleton written by Roger Smith and published by Oxford University Press. This book was released on 2016 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated and revised textbook provides comprehensive coverage of common polygenic and rare monogenic disorders, emphasising advances in bone cell biology and human skeletal disease. Accessible and well-illustrated, this concise account of metabolic bone disease is designed for postgraduates and clinicians.

Download or read book Prevention and Treatment of Osteoporosis in the High Risk Patient written by Cyrus Cooper and published by CRC Press. This book was released on 2005-01-25 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outcome of recent clinical trials in osteoporosis was the impetus for this volume. In these studies of two bisphosphonates, an interaction between bone mineral density (BMD) and the treatment effect was seen, such that these agents appeared to lose their effect as BMD increased. To practitioners this is counter-intuitive. Why should treatment w

Download or read book The Chemistry and Biology of Mineralized Tissues written by Melvin J. Glimcher and published by CRC Press. This book was released on 1989 with total page 1096 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proceedings of the Third International Conference (on title) held in Chatham, Mass., October, 1988. Presents coverage of many areas of the skeletal system, including new experimental techniques, research areas, ideas, and hypotheses. Discusses at length the chemical nature and structure of organic matrix components and their influence with respect to regulation of cell function. Annotation copyrighted by Book News, Inc., Portland, OR

Download or read book Mineralized Collagen Bone Graft Substitutes written by Xiu-Mei Wang and published by Woodhead Publishing. This book was released on 2019-04-18 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mineralized Collagen Bone Graft Substitutes presents a comprehensive study of biomimetic mineralized collagen, synthesized in vitro, a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the clinical use of this novel material, the book provides a complete examination, from bench to bedside. Chapters discuss natural bone and familiar biomaterials for bone repair, the preparation and safety of mineralized collagen, products made of mineralized collagen, and present clinical case studies. This book is an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. Provides a deep analysis of synthetic collagen, from bench to bedside Systematically examines the structure, principles, properties, biomimetic synthesis and characterization of mineralized collagen for bone repair Includes case studies that look at a range of clinical bone repair applications of Mineralized collagen and their clinical results

Download or read book Extracellular Matrix Biomineralization of Dental Tissue Structures written by Michel Goldberg and published by Springer Nature. This book was released on 2021-09-30 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Download or read book Bone Pathology written by Jasvir S. Khurana and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.