Download or read book Microspheres and Drug Therapy written by Stanley S. Davis and published by Elsevier Publishing Company. This book was released on 1984 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Microspheres and Regional Cancer Therapy written by Neville Willmott and published by CRC Press. This book was released on 2020-10-28 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.

Download or read book Drug Encapsulated Aerosolized Microspheres as a Biodegradable Intelligent Glioma Therapy written by Julee Alaina Floyd and published by . This book was released on 2015 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Delivery Systems in Cancer Therapy written by Dennis M. Brown and published by Springer Science & Business Media. This book was released on 2003-09-08 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Download or read book Microspheres written by Leonardo Fernandes Fraceto and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents to the reader an interdisciplinary vision of microspheres including its concepts and applications. The book ranges from the preparation of microspheres using different methodologies (such as sol-gel processes) through different characterisation techniques as well as the use of these systems for diagnostic diseases (cancer and hemodynamics fields). In addition, this book discusses aspects of the use of microspheres in: i) catalysis and separation sciences; ii) theoretical studies for applications in optical devices; iii) development of new systems aiming biomedical applications and iv) development of carrier systems for bioactive compounds. Thus this book covers a wide range of areas such as physics, chemistry, mathematics, biology, biomedical engineering, medical, and food, among others. This book presents new advances in the use of microspheres and, in this way, we intend to contribute to students, teachers, researchers, research centres, companies, and industries which have interest in these topics. The book is organised into eleven chapters written in a clear and concise form with illustrations that will help readers comprehend all subjects. Furthermore, this book will contribute to the generation of knowledge in this field.

Download or read book Polymeric Nanoparticles and Microspheres written by P. Guiot and published by CRC Press. This book was released on 2018-01-18 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributors were asked to emphasize their own experience with nanoparticles or microspheres. They were also encouraged to provide aspects normally not stipulated in specialized reviews. The objective was to produce a book which although written by specialists, presented a subject which could be easily understood by people in different fields of life sciences. Another goal was to set up a condensed work covering many aspects of nanoparticles and microspheres. That is the reason why, although mainly dealing with synthetic drug carriers, the first chapter is related to preparation and physicochemical properties of nanoparticles constructed from natural polymers. This is followed by two chapters involving the application of polymeric drug carriers in cancer therapy. The second chapter extensively describes in vitro and in vivo behaviour of purely synthetic nanoparticles. As ub the case of liposomes, a problem can be that some particles are preferentially taken up by the reticuloendothelial system. Magnetic drug carriers provide a partial answer to this problem since their tropism can be managed by an external magnet. The third chapter is entirely devoted to this aspect. A brief but original application of nanoparticles is given in the fourth chapter by reviewing their use in ocular therapy. Finally, two general applications of polymeric microspheres are discussed in chapters 5 and 6.

Download or read book Silk based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.

Download or read book Novel Bioresponsive Drug Eluting Microspheres to Enhance Chemoembolisation Therapy written by Koorosh Ashrafi and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Drug Delivery Systems 6 written by James M. Anderson and published by Elsevier. This book was released on 2013-10-22 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.

Download or read book Floating Drug Delivery System A Novel Technology written by Deepika Singh and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present work, floating microspheres of AZH were formulated to provide site specific delivery of drug with a view to providing an effective and safe therapy for eradication of H.pylori with a reduced dose and reduced duration of therapy. The developed floating microspheres of AZH have excellent buoyant ability, high encapsulation and good release pattern. The slow but complete drug release in the stomach is expected to increase bioavailability of the drug as well its complete utilization which may results to lower dose and GI side effects. It can be concluded that optimized multi-unit floating AZH microspheres floating more than 8 hrs in stomach. The floating microsphere is a potential system for delivery of AZH in the stomach. So it is expected to provide clinicians with a new choice of an economical, safe and low dose formulation in the management of eradication of H.pylori.

Download or read book Formulation Development and Evaluation of Microspheres of Anti HIV Drugs written by Ameeta Argal and published by LAP Lambert Academic Publishing. This book was released on 2015-02-12 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amongst the various route of drug administration, oral route is the most preferable one by the patients as it is easy and economical. Oral dosage forms may be conventional, sustained or controlled release. The best one is controlled release drug delivery system as it provides drug release at a predetermined, predictable and controlled rate. Earlier the patient had to take many drugs in combination and sometimes at different intervals for chronic diseases like diabetes mellitus, cancer and HIV. This treatment is prolonged, leading to patient non compliance, irritability or missing of dose resulting difficulty in treating the disease. Therefore mucoadhesive microspheres were prepared to overcome some of the problems of conventional drug delivery systems and also improve therapeutic efficacy of the drug. Mucoadhesive microspheres have a core of drug coated entirely with a mucoadhesive polymer. They have the potential to adhere to mucosa thus offering a targeted and controlled release drug delivery system.

Download or read book Fabrication and Characterization of Double Walled Microsphere as a Drug Delivery System for Stroke Treatment written by Danni Zou and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a medical condition in which poor blood flow to the brain results in cell death. The current treatment options are limited and only very few patients can benefit from these treatments. Stroke causes brain swelling and often a decompressive craniectomy is performed for some of the patients to release intracranial pressure to prevent further damage. As a result, a duraplasty is implanted to replace the surgically-damaged dura mater to protect the brain. In view of that, the purpose of this project was to develop double-walled microspheres (DWMS) which can be used as a drug delivery system when incorporated into duraplasty to promote endogenous stem cell therapy to treat stroke. The DWMS were composed of poly (l-lactic acid) (PLLA) and poly (lactic-co-glycolic acid) (PLGA) using a solvent evaporation method. Bovine serum albumin (BSA), as a model protein, was entrapped within these DWMS with different core-shell thicknesses and compositions to investigate the distribution of protein, encapsulation efficiency, and in vitro release. The fabrication process parameters of DWMS were also optimized to attain higher yields, and the phase separation and surface morphology were examined by differential scanning calorimetry and scanning electron microscopy.

Download or read book Drug Delivery Devices Fabricated by Microfluidic Method and Their Applications in Long Term Antimicrobial Therapy written by Jun Wu and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Drug Delivery Devices Fabricated by Microfluidic Method and Their Applications in Long-term Antimicrobial Therapy" by Jun, Wu, 吴隽, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Controlled drug delivery devices provide numerous advantages such as reduced side effects, higher therapeutic efficiency and improved patient compliance. Biodegradable polymer has become the most important material for controlled drug delivery device because of the excellent biocompatibility and tunable physicochemical properties. Biodegradable polymeric drug delivery devices are usually processed into various types of micro-particles due to the ease of fabrication and administration. However, controlling the drug release kinetics of these microparticles is still a challenge. One important reason is that drug release kinetics is significantly influenced by the microstructure of drug delivery devices, which is difficult to control. Microfluidic method is a group of technologies involved in the manipulation of fluids using channels in the scale of micrometers. Microfluidic method is particularly useful in controlling the structure of micro-droplets and generating homogeneous droplets. Therefore, microfluidics suggests great potential in controlling microstructures of drug delivery devices and drug release kinetics. In this study, biodegradable polymer based controlled drug delivery devices were fabricated using microfluidic method. Various types of microstructures were developed such as microspheres, core-shell microspheres, hollow microspheres and hydrogel microspheres. The results showed that microstructures were well controlled by fluid flow rates and geometries of capillary microfluidic devices. Both hydrophobic and hydrophilic drugs could be delivered by choosing drug delivery devices with suitable microstructures. Drug release kinetics of biodegradable polymeric microspheres has been studies a lot, yet complete understanding is still to be achieved. The diameter is an important factor which contributes to the drug release kinetics. However, the influence of diameter has not been systemically studied because monodisperse microspheres are difficult to obtain. Using microfluidic method, monodisperse PLGA microspheres with different diameters were fabricated to study the influence of diameter on drug release kinetics. It was found that diameter only influence the duration of the first phase (lag phase) in drug release process and smaller microspheres exhibited shorter lag phase. The relatively faster expansion of smaller microspheres was found to be responsible for the size effect by monitoring physicochemical changes during drug release. Rifampicin, a broad-spectrum antibiotic, was encapsulated by PLGA microspheres and PLGA-alginate core-shell microspheres. The long-term antimicrobial effects of drug loaded microspheres were investigated by drug release test and antimicrobial test against Staphylococcus aureus. The results showed that drug delivery devices could provide antimicrobial effect for more than one month. These drug delivery devices show potential in applications of controlled drug delivery and long-term antimicrobial therapy. In conclusion, drug delivery devices with different microstructures were fabricated using microfluidic method. The diameter of PLGA microspheres only influence the first phase of drug release profile (lag phase) and smaller microspheres exhibited shorter lag phase. The size effect is due to the relatively faster expansion rate of smaller microspheres. Rifampicin loaded PLGA microspheres and PLGA-alg

Download or read book Nanostructures for Oral Medicine written by Ecaterina Andronescu and published by Elsevier. This book was released on 2017-04-11 with total page 1036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices

Download or read book Utilization of Microspheres in Controlled Drug Delivery written by Wasfy Obeidat and published by LAP Lambert Academic Publishing. This book was released on 2011-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book initially provides a review of controlled drug delivery systems and an overview of microencapsulation methods with emphasis on the emulsion solvent removal methods. The book then presents studies conducted on producing microspheres containing commonly used drugs such as Theophylline, Piroxicam and Propylthiouracil. The book also discusses various formulation and processing parameters affecting microsphere-drug products. Such factors include the effects of polymer solution phase viscosity and molecular weight the on the properties microspheres. It also discusses the use of single and combinations of polymers of different properties that are manipulated in a way to achieve goals such as controlled release, enteric properties, masking taste or drug and body protection. Interesting results were found in many preparations and many are published in international journals.

Download or read book Drug Delivery Systems Advanced Technologies Potentially Applicable in Personalised Treatment written by Jorge Coelho and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.

Download or read book Experimental and Computational Investigations of Therapeutic Drug Release from Biodegradable Poly lactide co glycolide plg Microspheres written by Nader Samir Berchane and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The need to tailor release-rate profiles from polymeric microspheres remains one of the leading challenges in controlled drug delivery. Microsphere size, which has a significant effect on drug release rate, can potentially be varied to design a controlled drug delivery system with desired release profile. In addition, drug release rate from polymeric microspheres is dependent on material properties such as polymer molecular weight. Mathematical modeling provides insight into the fundamental processes that govern the release, and once validated with experimental results, it can be used to tailor a desired controlled drug delivery system. To these ends, PLG microspheres were fabricated using the oil-in-water emulsion technique. A quantitative study that describes the size distribution of poly(lactide-coglycolide) (PLG) microspheres is presented. A fluid mechanics-based correlation that predicts the mean microsphere diameter is formulated based on the theory of emulsification in turbulent flow. The effects of microspheres0́9 mean diameter, polydispersity, and polymer molecular weight on therapeutic drug release rate from poly(lactide-co-glycolide) (PLG) microspheres were investigated experimentally. Based on the experimental results, a suitable mathematical theory has been developed that incorporates the effect of microsphere size distribution and polymer degradation on drug release. In addition, a numerical optimization technique, based on the least squares method, was developed to achieve desired therapeutic drug release profiles by combining individual microsphere populations. The fluid mechanics-based mathematical correlation that predicts microsphere mean diameter provided a close fit to the experimental results. We show from in vitro release experiments that microsphere size has a significant effect on drug release rate. The initial release rate decreased with an increase in microsphere size. In addition, the release profile changed from first order to concave-upward (sigmoidal) as the microsphere size was increased. The mathematical model gave a good fit to the experimental release data. Using the numerical optimization technique, it was possible to achieve desired release profiles, in particular zero-order and pulsatile release, by combining individual microsphere populations at the appropriate proportions. Overall, this work shows that engineering polymeric microsphere populations having predetermined characteristics is an effective means to obtain desired therapeutic drug release patterns, relevant for controlled drug delivery.