Download or read book Microglia in Health and Disease written by Marie-Ève Tremblay and published by Springer. This book was released on 2014-09-22 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.
Download or read book Microglia in Health and Disease written by Marie-Ève Tremblay and published by . This book was released on 2014-10-31 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dual Role of Microglia in Health and Disease Pushing the Balance Towards Repair written by Raquel Ferreira and published by Frontiers Media SA. This book was released on 2020-10-27 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Microglia in Health and Disease A Unique Immune Cell Population written by Alessandro Michelucci and published by Frontiers Media SA. This book was released on 2018-10-05 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
Download or read book Glial Cells in Health and Disease of the CNS written by Rommy von Bernhardi and published by Springer. This book was released on 2016-10-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.
Download or read book Microglia in Health and Disease A Unique Immune Cell Population written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
Download or read book Microglia written by Olga Garaschuk and published by Humana. This book was released on 2020-08-14 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive toolkit of versatile techniques for studying microglia under different experimental settings along with a brief summary of knowledge, accumulated in microglial research over the last decades. Beginning with recently discovered roles of microglia in health and disease, the volume continues by covering in vitro analyses of microglia, in vivo studies, and “omics” analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Microglia: Methods and Protocols serves as a vital guide to these important cells and an inspiration for scientists interested in expanding our knowledge of their role in the nervous system.
Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by and published by Academic Press. This book was released on 2013-05-06 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells
Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer Science & Business Media. This book was released on 2008-03-21 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroimmune pharmacology seeks to harness the immune system to provide pharmacological intervention to combat neurodegenerative diseases. This book provides a comprehensive overview of topics that embrace the link between the immune system and the pathogenesis of neurodegenerative disorders. Results from recent studies strongly suggest that a major part of the process in diseases including Alzheimer’s and Parkinson’s as well as Prion diseases, comes from changes in the innate and adaptive arms of the brain and peripheral immune systems. Thus, the book provides an in-depth study of numerous fields including immunology, pharmacology, neuroscience and neurovirology. It is accompanied by a CD-ROM that includes access to lectures, slide presentations, and question and answers on neuroimmune pharmacology.
Download or read book Alzheimer s Disease written by Jolanta Dorszewska and published by BoD – Books on Demand. This book was released on 2018-07-18 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.
Download or read book The Angel and the Assassin written by Donna Jackson Nakazawa and published by Ballantine Books. This book was released on 2021-01-19 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thrilling story of scientific detective work and medical potential that illuminates the newly understood role of microglia—an elusive type of brain cell that is vitally relevant to our everyday lives. “The rarest of books: a combination of page-turning discovery and remarkably readable science journalism.”—Mark Hyman, MD, #1 New York Times bestselling author of Food: What the Heck Should I Eat? NAMED ONE OF THE BEST BOOKS OF THE YEAR BY WIRED Until recently, microglia were thought to be helpful but rather boring: housekeeper cells in the brain. But a recent groundbreaking discovery has revealed that they connect our physical and mental health in surprising ways. When triggered—and anything that stirs up the immune system in the body can activate microglia, including chronic stressors, trauma, and viral infections—they can contribute to memory problems, anxiety, depression, and Alzheimer’s. Under the right circumstances, however, microglia can be coaxed back into being angelic healers, able to make brain repairs in ways that help alleviate symptoms and hold the promise to one day prevent disease. With the compassion born of her own experience, award-winning journalist Donna Jackson Nakazawa illuminates this newly understood science, following practitioners and patients on the front lines of treatments that help to “reboot” microglia. In at least one case, she witnesses a stunning recovery—and in others, significant relief from pressing symptoms, offering new hope to the tens of millions who suffer from mental, cognitive, and physical health issues. Hailed as a “riveting,” “stunning,” and “visionary,” The Angel and the Assassin offers us a radically reconceived picture of human health and promises to change everything we thought we knew about how to heal ourselves.
Download or read book Neuroglia in Neurodegenerative Diseases written by Alexei Verkhratsky and published by Springer Nature. This book was released on 2019-10-03 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.
Download or read book The Neuronal Environment written by Wolfgang Walz and published by Springer Science & Business Media. This book was released on 2001-12-26 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading neuroscience researchers offer a fresh perspective on neuronal function by examining all its many components-including their pertubation during major disease states-and relate each element to neuronal demands. Topics range from the dependency of neurons on metabolic supply, as well as on both ion and transmitter homeostasis, to their close interaction with the myelin sheath. Also addressed are the astrocytic signaling system that controls synaptic transmission, the extracellular matrix and space as communication systems, the role of blood flow regulation in neuronal demand and in blood-brain barrier function, and inflammation and the neuroimmune system. Insightful and integrative, The Neuronal Environment: Brain Homeostasis in Health and Disease demonstrates a clear new understanding that neurons do not work in isolation, that they need constant interactions with other brain components to process information, and that they are not the only information processing system in the brain.
Download or read book Microglia written by Charanjit Kaur and published by Nova Science Publishers. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pioneering studies by several leading researchers in the early part of the last century first described the existence of microglial cells both in the early brain development and in pathological conditions. Microglial cells were later established to be the resident brain macrophages and immunocompetent cells present ubiquitously in the central nervous system including the retina in association with other glial cells, neurons and blood vessels. The book should be of interest to cell biologists and neuroscientists in general. Basic scientists, neuroimmunologists, neurologists, neuropathologists and neurosurgeons should find the latest information on microglial cells useful in their continued effort in searching and designing potential therapeutic strategies for treatment of neurological disease for which microglial cells are implicated.
Download or read book Glial Neurobiology written by Alexei Verkhratsky and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume is a very valuable and much needed contribution." –Quarterly Review of Biology AT LAST - A comprehensive, accessible textbook on glial neurobiology! Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease. Features of this book: an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more a wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells Written by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It is also an invaluable resource for researchers in neuroscience, physiology, pharmacology and pharmaceutics.
Download or read book Glia in Health and Disease written by Margaret S. Ho and published by Frontiers Media SA. This book was released on 2019-08-16 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Quality Control of Cellular Protein in Neurodegenerative Disorders written by Uddin, Md. Sahab and published by IGI Global. This book was released on 2020-02-14 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
