Download or read book Microdosimetry for Boron Neutron Capture Therapy written by and published by . This book was released on 2000 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: The specific aims of the research proposal were as follows: (1) To design and construct small volume tissue equivalent proportional counters for the dosimetry and microdosimetry of high intensity thermal and epithermal neutron beams used in BNCT, and of modified fast neutron beams designed for boron neutron capture enhanced fast neutron therapy (BNCEFNT). (2) To develop analytical methods for estimating the biological effectiveness of the absorbed dose in BNCT and BNCEFNT based on the measured microdosimetric spectra. (3) To develop an analytical framework for comparing the biological effectiveness of different epithermal neutron beams used in BNCT and BNCEFNT, based on correlated sets of measured microdosimetric spectra and radiobiological data. Specific aims (1) and (2) were achieved in their entirety and are comprehensively documented in Jay Burmeister's Ph. D. dissertation entitled ''Specification of physical and biologically effective absorbed dose in radiation therapies utilizing the boron neutron capture reaction'' (Wayne State University, 1999). Specific aim (3) proved difficult to accomplish because of a lack of sufficient radiobiological data.
Download or read book The Physics Dosimetry and Microdosimetry of Boron Neutron Capture Therapy written by Zamir Ghani and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A validated experimental and numerical procedure is described detailing macroscopic and microscopic dose calculations forming the basis of a protocol for the pre-clinical biological characterisation of the University of Birmingham's BNCT facility. Fundamental reference dosimetric measurements have been carried out at the University of Birmingham's accelerator based NCT facility and the Massachusetts Institute of Technology (MIT) research reactor to characterise macroscopic and microscopic doses and derive correction factors for the irradiation of V79 cells incubated in boric acid and irradiated as monolayers. On and off-axis thermal neutron, fast neutron and photon doses have been measured and calculated with standard macroscopic dosimetry techniques (foils and ion chambers) from which normalised MCNPX calculations are used to derive perturbation factors and off-axis corrections for cell flask irradiations. Microdosimetric correction factors are calculated for the boron dose component using Monte Carlo methods to simulate lithium ion and alpha particle tracks in semi-stochastic geometries representative of cell monolayer irradiations, incubated in a medium with 50ppm boric acid. Further simulations of recoil protons from nitrogen capture reactions allow for the calculation of correction factors for the non-uniform distribution of the nitrogen dose at the cellular level.
Download or read book Subcellular Distribution and Microdosimetry Studies for Boron Neutron Capture Therapy written by Tien Nguyen and published by . This book was released on 1991 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of a Comprehensive Computer Based Microdosimetry Analysis Application for Boron Neutron Capture Therapy written by Joseph A. Palano and published by . This book was released on 1995 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Micro and Macroscopic Modelling of Boron Neutron Capture Therapy written by Corine Vroegindeweij and published by . This book was released on 1997 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Physics Dosimetry and Microdosimetry of Boron Neutron Capture Theraphy written by Zamir Ghani and published by . This book was released on 2012 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microdosimetric Investigations at the Fast Neutron Therapy Facility at Fermilab written by Katja Maria Langen and published by . This book was released on 1997 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spectral Tailoring for Boron Neutron Capture Therapy written by Victor Alexander Nievaart and published by IOS Press. This book was released on 2007 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first clinical trials on Boron Neutron Capture Therapy in the 1950s, BNCT research has been mainly focussed on the treatment of (deep-seated) brain tumours, in particular, glioblastoma multiforme. Promising work to treat other cancers at other locations and even other diseases are in progress. Therefore, the chemists, medical doctors, physicists and biologists involved in BNCT are not only continuing to investigate and improve the (brain) clinical results, but are also investigating the new applications in BNCT. The work presented in this thesis is in the field of physics and deals, from three different viewpoints, with obtaining the optimal source neutron energy to optimise BNCT. The optimal source neutron energy is defined such as to obtain as many as possible (n, a)-absorptions due to 10B in the tumours and as low as possible total neutron dose in the healthy tissues and organs at risk
Download or read book Microdosimetric Investigations at the Fast Neutron Therapy Facility at Fermilab written by and published by . This book was released on 1997 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microdosimetry was used to investigate three issues at the neutron therapy facility (NTF) at Fermilab. Firstly, the conversion factor from absorbed dose in A-150 tissue equivalent plastic to absorbed dose in ICRU tissue was determined. For this, the effective neutron kerma factor ratios, i.e. oxygen tissue equivalent plastic and carbon to A-150 tissue equivalent plastic, were measured in the neutron beam. An A-150 tissue equivalent plastic to ICRU tissue absorbed dose conversion factor of 0.92 " 0.04 determined. Secondly, variations in the radiobiological effectiveness (RBE) in the beam were mapped by determining variations in two related quantities, e{sup *} and R, with field size and depth in tissue. Maximal variation in e{sup *} and R of 9% and 15% respectively were determined. Lastly, the feasibility of utilizing the boron neutron capture reaction on boron-10 to selectively enhance the tumor dose in the NTF beam was investigated. In the unmodified beam, a negligible enhancement for a 50 ppm boron loading was measured. To boost the boron dose enhancement to 3% it was necessary to change the primary proton energy from 66 MeV and to filter the beam by 90 mm of tungsten.
Download or read book Frontiers in neutron capture therapy written by M. Frederick Hawthorne and published by Springer Science & Business Media. This book was released on 2001 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Download or read book Topics in Dosimetry and Treatment Planning for Neutron Capture Therapy written by Robert G. Zamenhof and published by . This book was released on 1994 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron Neutron Capture Therapy written by United States. Congress. Senate. Committee on Energy and Natural Resources and published by . This book was released on 1994 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microdosimetric Studies for Neutron Capture Therapy and Techniques for Capture Element Selection written by Chun-Shan Yam and published by . This book was released on 1995 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment written by Narayan S Hosmane and published by World Scientific. This book was released on 2012-03-07 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere.
Download or read book Advances in Boron Neutron Capture Therapy written by International Atomic Energy Agency and published by . This book was released on 2023-07-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron neutron capture therapy (BNCT) is a neutron-based technique that allows selective cancer treatment at the tumour cellular level. BNCT is especially suitable for the treatment of brain, head, neck and skin cancers. Using the reaction between a neutron and boron to selectively destroy cancer cells, BNCT is a treatment that differs radically from conventional radiotherapy and promises to become a more widely adopted option for cancer treatment. BNCT is undergoing a major resurgence of interest around the world as some recent progress in accelerator technology allows the procedure to be undertake in clinics. In addition, the approval of BNCT in Japan as a routine clinical treatment for certain tumour types offers valuable insights for other states considering a similar approach. This publication comprehensively reports on the current state of the science as well as the supporting technology. It covers accelerator-based neutron sources, beam design, physical dosimetry, facility design and operation, pharmaceuticals, radiobiology, dose calculation, treatment planning and clinical trials. It has been written to assist in decision making at the national level as well as offering practical guidance for all those involved in implementation and ongoing management of BNCT programmes.
Download or read book HRQAR to Determine Microscopic Distributions of B 10 in Neutron Capture Therapy written by Thomas Cameron Harris and published by . This book was released on 2006 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success of Boron Neutron Capture Therapy (BNCT) is heavily dependent on the microscopic distribution of B-10 in tissue. High Resolution Quantitative Auto-Radiography (HRQAR) is a potentially valuable analytical tool due to its ability to simultaneously visualize boron distributions and tissue histology. While powerful, the technique has fallen into disuse, largely due to its complexity. HRQAR was reconstituted, and its accuracy was verified with test samples. Numerous improvements were made to make the process easier and more efficient. Permanent staff members at the Institute were trained in the technique, ensuring the continued vitality of HRQAR. The image acquisition equipment and analysis software were modernized, and made more user-friendly. The microdosimetry analysis software was updated to current versions of programming environments and personal computer operating systems. Verification tests were conducted to ensure the continued accuracy of the underlying algorithms. Several experiments were conducted to demonstrate the applications of HRQAR. One focus of current BNCT research is the development of new boron delivery agents, so a potential new compound was compared with a current-generation boron compound. In order to underscore the broader range of utility of HRQAR, another experiment was conducted using the auto-radiography technique as verification of selective microvasculature irradiation.
