Download or read book Microbiota in skin inflammatory diseases written by Hariom Yadav and published by Frontiers Media SA. This book was released on 2023-07-04 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Skin Microbiome Handbook written by Nava Dayan and published by John Wiley & Sons. This book was released on 2020-09-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive detailed summary of current status on skin microbiome research in health and disease as well as key regulatory and legal aspects. In the past decade, interest and technology have greatly advanced to unravel the nature and effect of skin microbiome on our health. Diseases such as atopic dermatitis and acne are at the forefront of this research, but also other conditions such as skin cancer are under investigation. In addition, mapping of the skin microbiome has gone from basic to more detailed with attempts to correlate it to various ages, ethnicities and genders. In parallel to mapping it, a great deal of research is dedicated to understanding its functionality and communication (and hence effect) on human cells. The Skin Microbiome Handbook is a summary of current status of knowledge, research tools and approaches in skin microbiome, in health and disease. It contains the following categories: healthy skin microbiome and oral-skin interaction; skin microbiome observational research; skin microbiome in disequilibrium and disease; skin's innate immunity; testing and study design; regulatory and legal aspects for skin microbiome related products. The 18 chapters of the book are written by carefully selected leaders in the academia and industry exhibiting extensive experience and understanding in the areas of interest.

Download or read book The Gut Skin Axis Interaction of Gut Microbiome and Skin Diseases written by Jianmin Chai and published by Frontiers Media SA. This book was released on 2024-06-13 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: More and more evidence has demonstrated that gut microbiome plays critical roles in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The new conception ‘gut-skin axis’ refers to the bidirectional relationship between the gut microbiome and skin health. Several mechanisms, such as intestinal barrier, inflammatory mediators, and metabolites, have been proposed for gut-skin axis. Currently, there have been various studies regarding the presence of the gut-skin axis and its resulting inflammatory effect due to gut microbiome imbalance. In addition, dysbiosis of the skin and gut microbiota is also observed in skin disorders. Therefore, understanding the gut-skin axis, especially in terms of microbiome modulation, is important for the gut and skin health, which may lead to development of novel therapies for skin disease.

Download or read book Global Report on Psoriasis written by World Health Organization and published by . This book was released on 2016-02-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This WHO Global report on psoriasis brings the public health impact of psoriasis into focus. The report is written to help raise awareness of the range of ways that psoriasis can affect peoples' lives. It intends to empower policy-makers with practical solutions to improve the health care and social inclusion of people living with psoriasis in their populations. The report highlights that much of the suffering caused by this common and complex disease can be avoided. Improving access to early diagnosis and appropriate treatment for psoriasis requires universally accessible health-care systems that provide people-centered care for patients with complex, lifelong conditions. Governments also have a key role to play in seeking to address the unnecessary social consequences of psoriasis by the challenging the myths and behaviors that lead to the exclusion of patients from healthcare settings and daily life.

Download or read book Skin Autoimmunity written by Ralf J. Ludwig and published by Frontiers Media SA. This book was released on 2021-05-25 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Skin and Arthropod Vectors written by Nathalie Boulanger and published by Academic Press. This book was released on 2018-01-20 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approx.500 pagesApprox.500 pages

Download or read book The Role of the Gut Microbiota in Health and Inflammatory Diseases written by Javier Ochoa-Reparaz and published by Frontiers Media SA. This book was released on 2020-12-04 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book The Human Microbiota and Chronic Disease written by Luigi Nibali and published by John Wiley & Sons. This book was released on 2016-10-03 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

Download or read book The Interplay of Microbiome and Immune Response in Health and Diseases written by Gwendolyn Barcel´o-Coblijn and published by MDPI. This book was released on 2019-11-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: [Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]

Download or read book Linking Gut to Skin written by Hester Eppinga and published by . This book was released on 2016 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Allergy Epidemic written by Susan Prescott and published by Apollo Books. This book was released on 2011 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: As an internationally renowned specialist in childhood allergy and immunology, Prof. Susan Prescott takes us on a journey into the science behind the allergy epidemic. As both an allergy specialist working in a busy children's hospital and as a cutting edge research scientist, Prescott is perfectly placed to explore how and why we are experiencing an epidemic rise in allergic diseases, as well as the practical side of dealing with these potentially serious conditions. With clear, no-nonsense explanations and a very personable style, Prescott informs, assures, and educates in this book.

Download or read book Microbial Endocrinology The Microbiota Gut Brain Axis in Health and Disease written by Mark Lyte and published by Springer. This book was released on 2014-07-05 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.​

Download or read book Skin Barrier Function written by T. Agner and published by Karger Medical and Scientific Publishers. This book was released on 2016-02-04 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.

Download or read book Good Bacteria for Healthy Skin written by Paula Simpson and published by Simon and Schuster. This book was released on 2019-08-20 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nourish your skin’s ecosystem for a clear, youthful glow: “A thorough primer on skin health and how the microbiome interacts with it.” —Dr. Shirley Madhere, Founder, Holistic Plastic Surgery and Creator, Forever F.A.B Podcast You probably know all about your gut microbiome. But what about the microbiome on your body’s biggest organ? Studies show that a diverse and thriving ecosystem of bacteria and other microbes on your skin affects a wide array of health issues. Your body’s flora is the first line of defense against infection and impacts many skin conditions like psoriasis, eczema, and acne. It protects your skin from harmful invaders and strengthens its moisture barrier. So how can you take care of the good bacteria that maintains balanced, healthy skin? Written by a skin microbiome expert, Good Bacteria for Healthy Skin is a friendly, comprehensive, science-backed exploration of what this complex system is, what it does, and how to nourish it. You’ll learn about how your lifestyle affects your skin microbiome, how microbiome imbalances impact skin conditions, and the benefits of probiotics and prebiotics. You’ll also discover a skin detox plan and a beauty wellness regimen to keep your good bacteria happy and your skin looking healthy, youthful, and fresh!

Download or read book Innate Immunology and Microbial Diversity in Human Skin Diseases written by Andrea Schneider and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The work encompassed in this dissertation aims to elucidate interactions between our skin and the environment to understand their impact on health and disease. Ultraviolet (UV) radiation from the sun is an environmental exposure which leads to inflammation, genetic mutations, and non-melanoma skin cancer (NMSC). We observed that NMSCs expressed Toll-like-receptor 3 (TLR3) protein in both basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (cSCCs). We hypothesized that UVB-induced keratinocyte damage leads to TLR3-dependent signaling which promotes an epithelial-to-mesenchymal transition (EMT) contributing to NMSC initiation. We observed TLR3 activation and a sustained EMT morphology in normal human epidermal keratinocytes (NHEKs) exposed to UVB or polyinosinic-polycytidylic acid (poly(I:C)), a synthetic TLR3 agonist. EMT-associated transcription factors (ZEB1, SNAI1, TWIST1), mesenchymal proteins (fibronectin, vimentin), and invasion capacity were all increased in NHEKs following TLR3 activation. In addition, this process was specific to TLR3 as activation of other TLRs did not induce this phenotypic change and both pharmacological and genetic inhibition of TLR3 attenuated EMT. Finally, TLR3 activation of EMT relied, in part, on NF-[kappa]B signaling in keratinocytes. All together, these data suggest that TLR3 activation leads to EMT changes in keratinocytes which likely contribute to NMSC development. The skin is also home to a number of bacteria, viruses, and fungi, which can impact its overall health. Dysbiosis of the skin microbiome has been associated with a number of skin diseases including acne, where cutaneous bacteria contribute to increased inflammation, and atopic dermatitis, where bacteria enhance disruption of the skin barrier. We investigated the microbial environment in hidradenitis suppurativa (HS), an inflammatory skin disease characterized by painful nodules and abscesses in the axilla and groin regions where the role of cutaneous bacteria is not well understood. We sampled the follicular and skin surface microbiome of the axilla and groin of HS patients (non-lesion and lesion) and healthy individuals using 16S rRNA gene sequencing (V3-V4). Overall, we noted a global dysbiosis of the skin microbiome in HS patients that was characterized by a significant decrease in the skin commensal Cutibacterium and an increased abundance of opportunistic anaerobic pathogens. In addition, while healthy controls had distinct microbial signatures by body site and skin niche, HS patients lost this heterogeneity. Finally, using a computational approach, we identified significant alterations in the metabolic pathways of the HS microbiome compared to healthy controls and which microbes likely contributed to these metabolic pathways. Altogether, our data suggests that skin microbial dysbiosis in HS is influenced by the changing skin architecture and microenvironment and that the presence of these "abnormal" bacteria greatly influence the overall metabolic function of the skin community. How the skin microbial community and the skin interact with each other is important to restoring a healthy microbiome and skin microenvironment. Finally, we shifted our focus to understanding which features of the host can impact the microbial environment. To address this, we examined the effects of puberty and acne on the skin microbiome composition. In this study we sampled 48 individuals, ages 7-17, with and without acne. A significant shift in both [alpha]-diversity and [beta]-diversity occurred between consecutive Tanner stages 2 and 3, highlighting a natural shift in the microbiome between early (T1-T2) and late (T3-T5) stages of puberty. The timing of this shift strongly coincided with the increase in sebum production in subjects. This shift was further characterized by a decrease in the numbers of distinct bacterial species and an increased abundance of Cutibacterium acnes, in both normal and acne patients. [beta]-diversity was very similar in children regardless of acne status, but an "acne microbiome signature" emerged for acne patients during late puberty. Strain level analysis of C. acnes demonstrated a significant shift in [beta]-diversity in normal subjects from early to late puberty, and in late puberty between normal and acne patients. This strain level diversity in C. acnes was primarily driven by changes in single locus sequencing type (SLST) clusters A and D. Finally, functional analysis by network mapping identified a significant shift in two metabolic pathways, Porphyrin and Chlorophyll Metabolism and Histidine Metabolism, which were most active in late (T3-T5) acne patients. Overall, we showed that puberty has the largest influence over changes in the skin microbiome, but as children mature, a distinct acne microbiome signature emerges in those patients with acne. In summary, our skin has the remarkable ability to withstand and respond to a variety of insults. The data presented in this dissertation illustrates the complexity of the interactions between the skin and its environment. In the long term, an understanding of these interactions may be key to optimizing or developing novel therapeutics for a variety of skin diseases.

Download or read book The Chemistry of Microbiomes written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-19 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 21st century has witnessed a complete revolution in the understanding and description of bacteria in eco- systems and microbial assemblages, and how they are regulated by complex interactions among microbes, hosts, and environments. The human organism is no longer considered a monolithic assembly of tissues, but is instead a true ecosystem composed of human cells, bacteria, fungi, algae, and viruses. As such, humans are not unlike other complex ecosystems containing microbial assemblages observed in the marine and earth environments. They all share a basic functional principle: Chemical communication is the universal language that allows such groups to properly function together. These chemical networks regulate interactions like metabolic exchange, antibiosis and symbiosis, and communication. The National Academies of Sciences, Engineering, and Medicine's Chemical Sciences Roundtable organized a series of four seminars in the autumn of 2016 to explore the current advances, opportunities, and challenges toward unveiling this "chemical dark matter" and its role in the regulation and function of different ecosystems. The first three focused on specific ecosystemsâ€"earth, marine, and humanâ€"and the last on all microbiome systems. This publication summarizes the presentations and discussions from the seminars.

Download or read book Cosmetic Dermatology written by Zoe Diana Draelos and published by John Wiley & Sons. This book was released on 2015-10-14 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Back for a new edition, Zoe Draelos' outstanding resource to cosmetic dermatology again provides a highly-illustrated, clinical guide to the full range of cosmetic skin treatments. Bringing together experts from research, industry, surgery and practice, it is structured in four distinct parts for easy navigation by the busy clinician: Basic Concepts - giving an overview of the physiology pertinent to cosmetic dermatology and the delivery systems by which treatments can take effect; Hygiene Products - evaluating cleansing and moisturising products; Adornment - looking at aesthetic techniques such as cosmetics, nail protheses and hair treatment; Antiaging - ie, injectables, resurfacing and skin contouring techniques, and the rapidly growing area of Cosmeceuticals. With over 300 high-quality images and key summary boxes throughout, this new edition incorporates the newest procedural innovations in this rapidly developing field. Perfect for all dermatologists, especially those specialising in cosmetic dermatology and whether hospital-based or in private practice, it provides the complete cosmetic regimen for your patients and will be an indispensable tool to consult over and over again.