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Book Metallothioneins in Biochemistry and Pathology

Download or read book Metallothioneins in Biochemistry and Pathology written by Paolo Zatta and published by World Scientific. This book was released on 2008 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Book Metallothioneins in Biochemistry and Pathology

Download or read book Metallothioneins in Biochemistry and Pathology written by Paolo Zatta and published by World Scientific. This book was released on 2008 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Book Metallothionein IV

    Book Details:
  • Author : C. Klaasen
  • Publisher : Birkhäuser
  • Release : 2012-12-06
  • ISBN : 3034888473
  • Pages : 641 pages

Download or read book Metallothionein IV written by C. Klaasen and published by Birkhäuser. This book was released on 2012-12-06 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

Book Metallothionein in Biology and Medicine

Download or read book Metallothionein in Biology and Medicine written by Curtis D. Klaassen and published by CRC Press. This book was released on 1991-08-27 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together work from leading researchers to present the most recent advances in research on metallothionein. This protein interests toxicologists because it is thought that metallothionein protects against metal toxicity and possibly against oxidative stress. It is of interest to pharmacologists because modification of metallothionein levels might have a role in cancer chemotherapy. Nutritionists have an interest in this protein because it appears to be a major storage protein for zinc. Biochemists and molecular biologists will be interested in the mechanisms of regulation of this protein because it is extremely inducible.

Book Metallothioneins and Related Chelators

Download or read book Metallothioneins and Related Chelators written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2015-07-24 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: These sulfur-rich chelators, being important in metal ion homeostasis, find increasing attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic. The reader is supported by about 20 tables, more than 80 illustrations and nearly 2000 references. This book is an essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine.

Book Metallothionein III

    Book Details:
  • Author : Kazuo T. Suzuki
  • Publisher : Birkhauser
  • Release : 1993
  • ISBN :
  • Pages : 504 pages

Download or read book Metallothionein III written by Kazuo T. Suzuki and published by Birkhauser. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Metallothionein IV

    Book Details:
  • Author : C Klaasen
  • Publisher :
  • Release : 1998-12-01
  • ISBN : 9783034888486
  • Pages : 700 pages

Download or read book Metallothionein IV written by C Klaasen and published by . This book was released on 1998-12-01 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Metallothioneins in Normal and Cancer Cells

Download or read book Metallothioneins in Normal and Cancer Cells written by Piotr Dziegiel and published by Springer. This book was released on 2016-02-04 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the structures of Metallothionein (MT) family members and the cellular functions of MT-1, MT-2 and MT-4 isoforms, as well as provides insights into divergent biological roles of MT-3. The authors explain the involvement of MT molecules in various processes related to carcinogenesis, including an organ-specific presentation of current data concerning their potential impact on the progression of various tumors and the regulatory role of MT family members in the function of the immune system.

Book Metallothionin III

    Book Details:
  • Author : K.T. Suzuki
  • Publisher : Birkhäuser
  • Release : 1993-01-01
  • ISBN : 9783764327699
  • Pages : 483 pages

Download or read book Metallothionin III written by K.T. Suzuki and published by Birkhäuser. This book was released on 1993-01-01 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the biological roles and medical implications of metallothioneins, and related chemical and biochemical developments. The contributors present and discuss findings on the roles of metallothionein in various kinds of stress conditions, including exposure to heavy metals.

Book Hydrolith 2  Surrealist Research   Investigations

Download or read book Hydrolith 2 Surrealist Research Investigations written by Oyster Moon Press and published by Lulu.com. This book was released on 2013-08-12 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magazine. Poetry. Fiction. Literary Nonfiction. Art. Translation. "This second issue of HYDROLITH is a continuation of what the first volume started, which was and is to assemble a stimulating selection of exclusively recent work by groups and individuals of the international Surrealist movement, to facilitate intellectual exchange and collaboration, enabling us to concentrate the echoes of our commonalities as well as the shadows of our differences. In so doing, this volume aspires to reduce all manner of distances that exist between us. All works in this book are in English, while many of them are translations from the Dutch, French, Greek, Portuguese, Romanian, Spanish and Turkish languages."--from the Preface

Book Research Communications in Molecular Pathology and Pharmacology

Download or read book Research Communications in Molecular Pathology and Pharmacology written by and published by . This book was released on 1998 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Molecular Biology and Toxicology of Metals

Download or read book Molecular Biology and Toxicology of Metals written by Rudolfs K. Zalups and published by CRC Press. This book was released on 2000-02-24 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.

Book The Role of Glia in Neurotoxicity

Download or read book The Role of Glia in Neurotoxicity written by Michael Aschner and published by CRC Press. This book was released on 1996-03-27 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.

Book Comprehensive Toxicology

Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Book Physiological Mechanisms Of Marine Pollutant Toxicity

Download or read book Physiological Mechanisms Of Marine Pollutant Toxicity written by Winona Vernberg and published by Elsevier. This book was released on 2012-12-02 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological Mechanisms of Marine Pollutant Toxicity contains the proceedings of a symposium on ""Pollution and Marine Organisms"" held at the University of South Carolina in Columbia, South Carolina, on November 30 to December 3, 1981. It explores the effects of pollutants, such as petroleum hydrocarbons, heavy metals, and pesticides, on the physiology of marine organisms, along with the functional aspects of detoxification and the environmental health implications of pollution. Organized into three sections encompassing 24 chapters, this volume begins with a discussion of subcellular accumulation and detoxification of metals in aquatic animals such as fishes, crabs, and polychaetes. The reader is then introduced to the physiological mechanisms of pollutant toxicity, including the sublethal effects of pollutants on the gill morphology of the scallop, Placopecten magellanicus; mechanisms underlying the tolerance of killifish embryos to heavy metals; increased sensitivity of smolts in seawater to petroleum hydrocarbons, such as toluene and naphthalene; and physiological effects of sublethal concentrations of benzene and dimethylnaphthalene on blue crab juveniles. The book concludes by outlining research directions for linking cause and effect concerning pollution and marine organisms. This book will be a valuable resource for marine scientists, ecologists, and students.

Book New Approaches to Monitoring Aquatic Eco systems

Download or read book New Approaches to Monitoring Aquatic Eco systems written by Terence P. Boyle and published by ASTM International. This book was released on 1987 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Phylogenetic Perspectives on the Vertebrate Immune System

Download or read book Phylogenetic Perspectives on the Vertebrate Immune System written by Gregory Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused gathering) allowed for participation by investigators at all levels of their careers. We further agreed that we should search for a forum that would allow this meeting to continue. The FASEB Summer Research Conference was an excellent vehicle for this type of meeting. Furthermore, this year's participants decided to continue this meeting as a regularly scheduled FASEB sponsored event. This was a unique conference in the sense that it focused upon mechanisms of development and defense in protostome and deuterostome invertebrates and lower vertebrates. There was a strong emphasis on evolutionary cell biology, phylogenetic inferences and the evolution of recognition and regulatory systems.