Download or read book Metalloproteins and Metalloenzymes Roles and Mechanisms of Metals in Functional Proteins written by Xiangshi Tan and published by World Scientific Publishing Company. This book was released on 2015-09-30 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metalloproteins and Motor Proteins written by and published by Elsevier. This book was released on 2024-07-12 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins and Motor Proteins, Volume 141 focuses on recent advances in studying metalloproteins and motor proteins, along with their roles in different pathologies and drug-resistance. Chapters include Transcriptomic Analysis Reveals Zinc-Mediated Virulence and Pathogenicity in Multidrug-Resistant Acinetobacter baumannii, The Mechanistic Insights into Different Aspects of Promiscuity in Metalloenzymes, Role of Metal ion in ion channel Mechanisms, A model of microtubule depolymerization by kinesin-8 motor proteins, Metalloproteins and metalloproteomics in health and disease, Decoding Genetic and Pathophysiological Mechanisms in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis: A Comparative Study of Differentially Expressed Genes and Implicated Pathways in Motor Neuron Disorders, and much more. Additional chapters cover Exploring the effect of disease causing mutations in metal binding sites of human ARSA in Metachromatic Leukodystrophy, Role of transmembrane proteins in regulating metalloproteins and motor proteins in human cancer, Role of transmembrane proteins in metalloproteins and motor proteinsin human neurogenesis, Role of transmembrane proteins in metalloproteins and motor proteins in human aging, Vesicle transport of metalloproteinases, Motor proteins and spermatogenesis, and much more. Integrates experimental and computational methods for studying structure and function of metalloproteins and motor proteins and their implication in drug design Presents timely chapters written by well-renowned authorities in their field Contains a high number of high quality illustrations, figures, and tables and targets a very wide audience of specialists, researchers, and students
Download or read book Handbook on Metalloproteins written by Ivano Bertini and published by CRC Press. This book was released on 2001-06-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the commo
Download or read book Metalloproteins Metal proteins with non redox roles written by Pauline M. Harrison and published by Wiley-VCH. This book was released on 1985 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book High Resolution EPR written by Graeme Hanson and published by Springer Science & Business Media. This book was released on 2009-06-19 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofactors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of high-resolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.
Download or read book Metalloproteins written by P.M. Harrison and published by Springer. This book was released on 1985-06-18 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemistry of Metalloproteins written by Joseph J. Stephanos and published by John Wiley & Sons. This book was released on 2014-07-22 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
Download or read book Metal Containing Enzymes written by and published by Academic Press. This book was released on 2014-11-24 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in metal-containing enzymes Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables
Download or read book Metalloproteins written by Art E. Cho and published by CRC Press. This book was released on 2015-04-17 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role
Download or read book Trace Metals and Infectious Diseases written by Jerome O. Nriagu and published by MIT Press. This book was released on 2024-06-11 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang
Download or read book High Resolution EPR written by Graeme Hanson and published by Springer. This book was released on 2009-06-29 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofactors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of high-resolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.
Download or read book Metals in Biology written by Graeme Hanson and published by Springer. This book was released on 2010-03-11 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease. While X-ray crystallography has provided snapshots of the geometric structures of the active site redox cofactors in these proteins, the application of high resolution EPR spectroscopy in conjunction with quantum chemistry calculations has enabled, in many cases, a detailed understanding of a metalloenzymes mechanism through investigations of the geometric and electronic structure of the resting, enzyme-substrate intermediates and product complexes. This volume, Part II of a two-volume set demonstrates the application of high resolution EPR spectroscopy in determining the geometric and electronic structure of active site metal ion centers in iron sulfur cluster containing metalloproteins, mononuclear molybdenum metalloenzymes, manganese-containing enzymes and novel metalloproteins.
Download or read book Metal Ions in Biological Systems written by Helmut Sigel and published by CRC Press. This book was released on 1994-02-08 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted solely to the research area of metalloenzymes involving amino acid-residue and related radicals. Topics covered include: general considerations; structure, function and engineering of peroxidases; and ribonucleotide reductase in mammalian systems.
Download or read book Cadmium From Toxicity to Essentiality written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.
Download or read book The Biological Chemistry of the Elements written by J. J. R. Frausto da Silva and published by Oxford University Press. This book was released on 2001-08-16 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text describes the functional role of the twenty inorganic elements essential to life in living organisms.
Download or read book Metalloprotein Active Site Assembly written by Michael K. Johnson and published by John Wiley & Sons. This book was released on 2017-08-30 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.
Download or read book Peptide Protein and Enzyme Design written by and published by Academic Press. This book was released on 2016-08-27 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. Continues the legacy of this premier serial with quality chapters on de novo enzyme design Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism
