Download or read book Metal Catalyzed Cyclization Reactions 2 written by S. Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Science of Synthesis Metal Catalyzed Cyclization Reactions written by Shengming Ma and published by Thieme. This book was released on 2016-12-14 with total page 1198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
Download or read book Metal catalyzed Cyclization 2 written by U. Bora and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Science of Synthesis Metal Catalyzed Cyclization Reactions written by Shuanhu Gao and published by Thieme. This book was released on 2016-12-14 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation.
Download or read book Metal catalyzed Cyclization Reactions written by Shengming Ma and published by Thieme Chemistry. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. Science of Synthesis: Metal-Catalyzed Cyclization Reactions presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
Download or read book Metal Catalyzed Cyclization Reactions 1 written by S. Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal catalyzed Cyclization Reactions written by J. M. Alderson and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Explorations on Transition Metal Catalyzed Enantioselective Cyclization Reactions and Applications of Thiourea Ligands written by Min Yang and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Explorations on Transition Metal-catalyzed Enantioselective Cyclization Reactions and Applications of Thiourea Ligands" by Min, Yang, 楊敏, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled EXPLORATIONS ON TRANSITION METAL- CATALYZED ENANTIOSELECTIVE CYCLIZATION REACTIONS AND APPLICATIONS OF THIOUREA LIGANDS submitted by Yang Min for the Degree of Doctor of Philosophy at The University of Hong Kong in November 2005 Transition metal-catalyzed carbon-carbon bond formation and carbon- heteroatom bond formation are powerful tools in synthetic chemistry, and have been widely applied in the construction of cyclic compounds. The aim of this project is to develop enantioselective cyclization reactions by the application of transition metals and chiral ligands. A chiral Lewis acid-promoted highly enantioselective intramolecular carbonyl ene cyclization reaction of unsaturated α-keto esters has been developed (Scheme 1). In the presence of chiral Lewis acids such as [Sc((R, R)-Ph- pybox)](OTf) and [Cu((S, S)-Ph-box)](OTf), unsaturated α-keto esters (1.1c-f) 3 2 underwent carbonyl ene reactions smoothly under mild conditions to give cis-1- hydroxyl-2-vinyl esters (1.2c-f) with two new chiral centers, including a quaternary one, in good yields (> 81%), excellent cis stereoselectivities (diastereomeric ratio up to 50:1), and good to excellent enantiomer excesses (up to 99%). This easy entry to the highly functionalized chiral cyclic products under mild conditions will definitely make this catalytic enantioselective method a useful tool for the construction of the chiral skeletons of many medicinal agents and bioactive molecules. A new palladium-catalyzed enantioselective oxidative tandem cyclization method has been developed. In the presence of a catalytic amount of Pd(tfa) /(-)- sparteine with cheap and environmentally benign molecular oxygen as the terminal oxidant, a series of polycyclic indoline derivatives 2.2 with up to two stereocenters (2.2fb) are readily prepared in a single step in good yields and moderate to good enantiomer excesses (up to 91%; Scheme 2). These represent the first examples of enantioselective oxidative tandem cyclization reactions under aerobic conditions. A class of sterically bulky cyclic thiourea ligands (L1-11, Figure 1) have been synthesized. Ligand L1, with bulky t-butyl groups on the aryl moiety, was found to be effective in the palladium-catalyzed oxidation of alcohols under aerobic conditions, in which L1 exhibited good stability to oxidizing agents and efficiently prevented palladium from undergoing aggregation (Scheme 3). This new catalyst system has been applied to a wide variety of substrates such as benzylic alcohols, aliphatic secondary alcohols and allylic alcohols, producing the desired carbonyl compounds in moderate to excellent yields. However, the attempts to apply the chiral thiourea ligands (L7-11) to the palladium-catalyzed oxidative kinetic resolution of secondary alcohols did not give satisfactory results. Scheme 1 Chiral Lewis acid OEt OEt OH 81 87% yield n CH Cl, rt H 2 2 dr > 50:1 75 91% ee _ _ 1.1c 1.2c d d n = 1, 2 Chiral Lewis Acid: or Sc(OTf), Cu(OTf), 2 NN N N Ph Ph Ph Ph Cu(OTf) (20 mol%) 5R 5R 1R OR 1S OR OR L* (22 mol%), CH Cl, rt 2 2 OH 2R 2S OH L* = NN major 1.3e/f 1.1e R = CH 1.2e/f Ph Ph R = Bn 1.1f 91 94% yie
Download or read book Metal catalyzed Cross coupling Reactions written by François Diederich and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon bond forming reactions are arguably the most important processes in chemistry, as they represent key steps in the building of complex molecules from simple precursors. Among these reactions, metal-catalyzed cross-coupling reactions are extensively employed in a wide range of areas of preparative organic chemistry, ranging from the synthesis of complex natural products, to supramolecular chemistry, and materials science. In this work, a dozen internationally renowned experts and leaders in the field bring the reader up to date by documenting and critically analyzing current developments and uses of metal-catalyzed cross-coupling reactions. A particularly attractive and useful feature, that enhances the practical value of this monograph, is the inclusion of key synthetic protocols, in experimental format, chosen for broad utility and application. This practice-oriented book can offer the practitioner short cuts to ensure they remain up-to-date with the latest developments.
Download or read book Science of Synthesis written by Shengming Ma and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal Catalyzed Reductive C C Bond Formation written by Michael J Krische and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Download or read book Cyclization Reactions written by C. Thebtaranonth and published by CRC Press. This book was released on 1993-05-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclization Reactions provides a quick update of the latest advances in cyclization reactions. It covers the basic principles of cyclization chemistry, emphasizing practical applications. Chapters are organized according to the different cyclization intermediates-cationic, radical, anionic, and metal complex intermediates. The last chapter covers macrolactonization, vicinal tricarbonal, and Bergman (enediyne) reactions, which are of particular interest today. More than 2,600 structures illustrate key concepts throughout the book. Various cyclizations are organized into mechanistic groups to help researchers choose and change between methods when searching for maximum efficiency in synthesis. Critical coverage of the literature up to 1992 is provided. Cyclization Reactions is essential reading for anyone involved in the synthesis of ring compounds or who is seeking a rapid overview of the field. Newcomers as well as experienced researchers will benefit from this book. It also is excellent reference material for students at the advanced undergraduate and graduate levels.
Download or read book Synthesis of Heterocycles via Metal Catalyzed Reactions that Generate One or More Carbon Heteroatom Bonds written by John P. Wolfe and published by Springer. This book was released on 2013-09-11 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Carboamination or Carboalkoxylation Reactions, by John P. Wolfe Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Diamination, Aminoalkoxylation, or Dialkoxylation Reactions, by Sherry R. Chemler Synthesis of Heterocycles via Metal-Catalyzed Wacker-Type Oxidative Cyclization Reactions of Alkoxy- or Amino-Alkenes, by Wanbin Zhang Synthesis of Saturated Heterocycles via Metal-Catalyzed Hydroamination or Hydroalkoxylation Reactions, by Lisa D. Julian Synthesis of Saturated Heterocycles via Metal-Catalyzed Allylic Alkylation Reactions, by Aaron Aponick Synthesis of Heterocycles via Metal-Catalyzed Cascade/Domino Reactions that Generate a C–N or C–O Bond, by Mark Lautens Synthesis of Saturated Heterocycles via Metal-Catalyzed Formal Cycloaddition Reactions that Generate a C–N or C–O Bond, by Jerome Waser
Download or read book Tunable Transition Metal catalyzed Group Transfer Reactions and Subsequent Cyclization Reactions written by Alicia Marie Phelps and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Controlling the outcome of transition metal-catalyzed group transfer reactions represents a powerful strategy for assembling complex synthesis targets. Herein, we describe two such selective methods, as well as a further method for the functionalization of allene products. First, a carbene transfer in an allene substrate that is controlled by selection of transition metal catalyst is described. These products represent the building blocks of complex frameworks, and a gold-catalyzed carbocyclization from these products is described that leads to fully functionalized cyclopentane rings in only a few steps from the allene substrate. Finally, a silver-catalyzed C-H insertion method that can select between different types of C-H bonds is shown. This methodology complements the others as a strategy for late-stage functionalization of the constructed scaffolds.
Download or read book Base Metal Catalysis 2 written by Naohiko Yoshikai and published by Georg Thieme Verlag. This book was released on 2023-09-06 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in catalytic methods based on earth-abundant metals are discussed. Catalysis with earth-abundant metals, often referred to as base metals, is having a transformative impact on synthetic chemistry. Research in this area is driven not only by the common interest in the sustainability of chemical synthesis but also by the vast opportunity to discover and develop novel reaction chemistry that is not attainable with rare and precious metal catalysts. This work provides representative developments in base-metal catalysis, specifically catalysis with 3d-transition metals, in a format suitable for practitioners of organic synthesis. Volume 2 is focused on recent advances in catalysis involving cobalt, iron, manganese, and chromium. Topics covered include various types of cross-coupling processes, hydrofunctionalization of alkenes and alkynes, C-H functionalizations, and catalytic Nozaki–Hiyama–Kishi-type reactions.
Download or read book Heterocycles from Double Functionalized Arenes written by Xiao-Feng Wu and published by Royal Society of Chemistry. This book was released on 2015 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to transition metal catalyzed coupling reactions of double-functionalized arenes in heterocycle synthesis.
Download or read book Synthesis and Modification of Heterocycles by Metal Catalyzed Cross coupling Reactions written by Tamás Patonay and published by Springer. This book was released on 2016-06-15 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
