Download or read book Science of Synthesis Metal Catalyzed Cyclization Reactions written by Shuanhu Gao and published by Thieme. This book was released on 2016-12-14 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation.
Download or read book Metal catalyzed Cyclization Reactions written by J. M. Alderson and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal Catalyzed Cyclization Reactions 1 written by S. Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal catalyzed Cyclization Reactions written by Shengming Ma and published by Thieme Chemistry. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. Science of Synthesis: Metal-Catalyzed Cyclization Reactions presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 1 covers intramolecular coupling reactions (including Heck reactions), intramolecular allylations, and cyclopropane and cyclopropene ring openings. Also included are cyclization reactions of alkenes, alkynes, and allenes, cycloisomerizations, and intramolecular C-N and C-O bond formation. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
Download or read book Science of Synthesis Metal Catalyzed Cyclization Reactions written by Shengming Ma and published by Thieme. This book was released on 2016-12-14 with total page 1198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
Download or read book Metal Catalyzed Cyclization Reactions 2 written by S. Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Science of Synthesis written by Shengming Ma and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal catalyzed Cyclization 2 written by U. Bora and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal Catalyzed Cascade Reactions written by Thomas J.J. Müller and published by Springer. This book was released on 2010-11-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights cyclization via carbopalladation and acylpalladation and Heck-pericyclic sequences. They discuss p-allyl palladium-based cascade reactions, Michael-type additions as an entry to transition-metal-promoted cyclizative transformations, and sequential or consecutive palladium-catalyzed processes, and show Pauson-Khand cascades, metal-catalyzed cyclizations of acyclic precursors, as well as cascade and sequential ruthenium-catalyzed transformations. This is a comprehensive overview of an exciting and highly dynamic, and innovative methodological concept.
Download or read book Handbook of Cyclization Reactions written by Shengming Ma and published by Wiley-VCH. This book was released on 2010 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate and only reference source in this field, this handbook discusses the latest advances on the reactions leading to the formation of cyclic structures and includes chapters presenting the most synthetically attractive cyclization reactions. Leading chemists from around the world provide authoritative first-hand information, including experimental procedures that offer readers valuable practical information that is otherwise unavailable. An aid for every organic chemist in grasping and applying these new reactions.
Download or read book Metal Catalyzed Reductive C C Bond Formation written by Michael J. Krische and published by Springer Science & Business Media. This book was released on 2007-07-20 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: TheprototypicalcatalyticreductiveC-Cbondformations,theFischer-Tropsch reaction [1] and alkene hydroformylation [2], were discovered in 1922 and 1938, respectively [3,4]. These processes, which involve reductive coupling to carbon monoxide, have long been applied to the industrial manufacture of commodity chemicals [5]. Notably, alkene hydroformylation, also known as the oxo-synthesis, has emerged as the largest volume application of homo- neous metal catalysis, accounting for the production of over 7 million metric tons of aldehyde annually. Despite the impact of these prototypical reductive C-C bond formations, this ?eld of research lay fallow for several decades. Eventually, the increased availability of mild terminal reductants, in part- ular silanes, led to a renaissance in the area of catalytic reductive C-C bond formation.Forexample,the'rstcatalyticreductiveC-Ccouplingsbeyond- droformylation, which involve the hydrosilylative dimerization of conjugated dienes [6-12], appeared in 1969 - approximately 16 years after the ?rst - ported metal-catalyzed alkene hydrosilylation [13]. Following these seminal studies, the ?eld of catalytic reductive C-C bond formation underwent exp- sivegrowth,culminatingintheemergenceofanevergrowingbodyofresearch encompassing a powerful set of transformations. To our knowledge, no thematic volumes devoted solely to metal-catalyzed reductive C-C bond formationhave been assembled. For the ?rst time, in this issue of Topics in Current Chemistry,wepresent acompilation ofmonographs from several leaders in this burgeoning area of research. This collection of reviews serves to capture the diversity of catalytic reductive C-C couplings presently available and, in turn, the remarkable range of reactivity embodied by such transformations. There is no indication that this ?eld has reached its zenithanditisthehopeofthepresentauthorthatthisvolumewillfuelfurther progress.
Download or read book Metal catalyzed Cross coupling Reactions written by François Diederich and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon bond forming reactions are arguably the most important processes in chemistry, as they represent key steps in the building of complex molecules from simple precursors. Among these reactions, metal-catalyzed cross-coupling reactions are extensively employed in a wide range of areas of preparative organic chemistry, ranging from the synthesis of complex natural products, to supramolecular chemistry, and materials science. In this work, a dozen internationally renowned experts and leaders in the field bring the reader up to date by documenting and critically analyzing current developments and uses of metal-catalyzed cross-coupling reactions. A particularly attractive and useful feature, that enhances the practical value of this monograph, is the inclusion of key synthetic protocols, in experimental format, chosen for broad utility and application. This practice-oriented book can offer the practitioner short cuts to ensure they remain up-to-date with the latest developments.
Download or read book Explorations on Transition Metal Catalyzed Enantioselective Cyclization Reactions and Applications of Thiourea Ligands written by Min Yang and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Explorations on Transition Metal-catalyzed Enantioselective Cyclization Reactions and Applications of Thiourea Ligands" by Min, Yang, 楊敏, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled EXPLORATIONS ON TRANSITION METAL- CATALYZED ENANTIOSELECTIVE CYCLIZATION REACTIONS AND APPLICATIONS OF THIOUREA LIGANDS submitted by Yang Min for the Degree of Doctor of Philosophy at The University of Hong Kong in November 2005 Transition metal-catalyzed carbon-carbon bond formation and carbon- heteroatom bond formation are powerful tools in synthetic chemistry, and have been widely applied in the construction of cyclic compounds. The aim of this project is to develop enantioselective cyclization reactions by the application of transition metals and chiral ligands. A chiral Lewis acid-promoted highly enantioselective intramolecular carbonyl ene cyclization reaction of unsaturated α-keto esters has been developed (Scheme 1). In the presence of chiral Lewis acids such as [Sc((R, R)-Ph- pybox)](OTf) and [Cu((S, S)-Ph-box)](OTf), unsaturated α-keto esters (1.1c-f) 3 2 underwent carbonyl ene reactions smoothly under mild conditions to give cis-1- hydroxyl-2-vinyl esters (1.2c-f) with two new chiral centers, including a quaternary one, in good yields (> 81%), excellent cis stereoselectivities (diastereomeric ratio up to 50:1), and good to excellent enantiomer excesses (up to 99%). This easy entry to the highly functionalized chiral cyclic products under mild conditions will definitely make this catalytic enantioselective method a useful tool for the construction of the chiral skeletons of many medicinal agents and bioactive molecules. A new palladium-catalyzed enantioselective oxidative tandem cyclization method has been developed. In the presence of a catalytic amount of Pd(tfa) /(-)- sparteine with cheap and environmentally benign molecular oxygen as the terminal oxidant, a series of polycyclic indoline derivatives 2.2 with up to two stereocenters (2.2fb) are readily prepared in a single step in good yields and moderate to good enantiomer excesses (up to 91%; Scheme 2). These represent the first examples of enantioselective oxidative tandem cyclization reactions under aerobic conditions. A class of sterically bulky cyclic thiourea ligands (L1-11, Figure 1) have been synthesized. Ligand L1, with bulky t-butyl groups on the aryl moiety, was found to be effective in the palladium-catalyzed oxidation of alcohols under aerobic conditions, in which L1 exhibited good stability to oxidizing agents and efficiently prevented palladium from undergoing aggregation (Scheme 3). This new catalyst system has been applied to a wide variety of substrates such as benzylic alcohols, aliphatic secondary alcohols and allylic alcohols, producing the desired carbonyl compounds in moderate to excellent yields. However, the attempts to apply the chiral thiourea ligands (L7-11) to the palladium-catalyzed oxidative kinetic resolution of secondary alcohols did not give satisfactory results. Scheme 1 Chiral Lewis acid OEt OEt OH 81 87% yield n CH Cl, rt H 2 2 dr > 50:1 75 91% ee _ _ 1.1c 1.2c d d n = 1, 2 Chiral Lewis Acid: or Sc(OTf), Cu(OTf), 2 NN N N Ph Ph Ph Ph Cu(OTf) (20 mol%) 5R 5R 1R OR 1S OR OR L* (22 mol%), CH Cl, rt 2 2 OH 2R 2S OH L* = NN major 1.3e/f 1.1e R = CH 1.2e/f Ph Ph R = Bn 1.1f 91 94% yie
Download or read book Metal Catalyzed Reductive C C Bond Formation written by Michael J Krische and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Download or read book Transition Metal Catalyzed Heterocycle Synthesis via C H Activation written by Xiao-Feng Wu and published by John Wiley & Sons. This book was released on 2016-03-07 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.
Download or read book Early Main Group Metal Catalysis written by Sjoerd Harder and published by John Wiley & Sons. This book was released on 2020-04-06 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early Main Group Metal Catalysis gives a comprehensive overview of catalytic reactions in the presence of group 1 and group 2 metals. Chapters are ordered to reaction type, contain educational elements and deal with concepts illustrated by examples that cover the main developments. After a short introduction on polar organometallic chemistry and synthesis of early main group metal complexes, a variety of catalytic reactions are described, e.g. polymerization of alkenes, hydroamination and phosphination reactions, hydrosilylation, hydroboration and hydrogenation catalysis, as well as enantioselective and Lewis-acid catalysis. The book addresses organic chemists and researchers in industry interested in the state-of-the-art and new possibilities of early main group metal catalysis as well as newcomers to the field. Written by a team of leaders in the field, it is a very welcome addition to the area of main group metal chemistry, and to the field of catalysis.
Download or read book Metal catalyzed Intramolecular Cyclization Reactions of Alkynyl Alpha Diazoketones written by Christopher John Dinsmore and published by . This book was released on 1991 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
