Download or read book Metabolism and Side Effects of Cannabinoids written by Pharmacology University and published by Pharmacology University. This book was released on 2022-03-03 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the following ebook you will learn about biochemistry, metabolism, pharmacokinetics and side effects of cannabinoids. Cannabis is a plant species of the Cannabaceae family, which includes three strains: Cannabis indica, Cannabis sativa and Cannabis ruderalis. Thanks to its features, cannabis has been used in several fields throughout history. The first reference of its therapeutic use was in China, in the 4.000 B.C. in the most ancient pharmaceutical guide known: the Pen Ts’ao Ching, attributed to the emperor Shen Nung, where it was used against menstrual disorders, goute, malaria, constipation and muscular weakness; later, indications were extended to wound healing, against infectious processes, clearance of pus, treatment of rheumatism, and to decrease fever and anxiety. The growing interest in the biology, chemistry, pharmacology and toxicology of cannabis, has allowed the development of cannabinoid drugs, through the understanding of pharmacokinetics, its disposition in fluids and biological tissues, in order to understand the mechanism of action of cannabis and its therapeutic effects. Pharmacokinetics and metabolism of cannabinoids involve absorption through different routes of administration and drug prescriptions, distribution of their compounds throughout the body, metabolism by the liver and extrahepatic tissues, and elimination in feces, urine, sweat, oral fluids and hair, and excretion by different body fluids. Pharmacokinetic processes are dynamic, can change over time and can be affected by the frequency and magnitude of drug exposure. There is limited understanding of the expected side effects of cannabis use in a therapeutic context. Consequently, a significant amount of the data on this topic are derived from studies investigating the recreational use of cannabis, which implies caution in making conclusions regarding medicinal use. Specifically, the amount of cannabis used, methods of administration, and the existence of comorbidities differ significantly between recreational and medicinal cannabis-using populations. As a result, different side effects might be expected, but what has been documented to date refers to mild effects. At Pharmacology University we want you to understand the importance of cannabinoids through knowledge and education, understanding the biological, pharmacological, toxicological and medical implications so that through information you can connect with the world of cannabis and have a broad vision of this industry that has a very important potential and a promising future.
Download or read book The Health Effects of Cannabis and Cannabinoids written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-03-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.
Download or read book Marijuana and Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 1999-07-10 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€"the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.
Download or read book Marijuana Chemistry Pharmacology Metabolism and Clinical Effects written by Raphael Mechoulam and published by . This book was released on 1973 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Marihuana Biological Effects written by Gabriel G. Nahas and published by Elsevier. This book was released on 2013-10-22 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marihuana Biological Effects: Analysis, Metabolism, Cellular Responses, Reproduction and Brain contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held at Paris on July 22-23, 1978. Organized into four parts, this book begins with a discussion on the quantification of cannabinoids and their metabolites in the body fluids and tissues. Part II describes the cannabinoids and cellular metabolism. Parts III and IV explain the effects of cannabis on reproduction and brain.
Download or read book Therapeutic Uses of Cannabis written by British Medical Association and published by CRC Press. This book was released on 1997-11-18 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.
Download or read book The Medicinal Uses of Cannabis and Cannabinoids written by Geoffrey William Guy and published by . This book was released on 2004 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describing all the current research findings relating to the medicinal use of cannabis and cannabinoids, this title reports the latest information on the pharmacology, formulation, safety and efficacy of cannabis as a therapeutic agent.
Download or read book Marijuana As Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2000-12-30 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.
Download or read book The Cannabinoids Chemical Pharmacologic and Therapeutic Aspects written by Stig Agurell and published by Academic Press. This book was released on 2012-12-02 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cannabinoids: Chemical, Pharmacologic, and Therapeutic Aspects provides a comprehensive discussion of the various aspects of cannabis and its constituents. The book is organized into six sections. Section I covers the clinical aspects of cannabis including the health aspects, impact on memory function, and the characteristics and treatment of marijuana abusers. Section II on chemical aspects includes studies on the chemistry and structure-activity relationships of cannabinoids; smoking characteristics of marijuana cigarettes; and developments in cannabinoid analyses of body fluids. Section III on metabolic and pharmacokinetic aspects includes studies on the metabolism, disposition, and pharmacokinetics of delta-9-tetrahydrocannabinol (THC) in men and women; single dose kinetics of cannabidiol in man; and distribution and disposition of THC in different tissues of the rat. Section IV on reproductive aspects include studies on the effects of chronic administration of THC on the early embryonic development of mice; effects of cannabinoids on spermatogenesis in mice; and possible mechanism for the cellular effects of marijuana on male reproductive function. Section V on neuropharmacologic aspects includes studies on the discriminative stimulus properties of THC and the effects of cannabinoids on neurotransmitter receptors in the brain. Section VI on therapeutic aspects includes studies such as the possible anxiolytic effects of cannabidiol; tetrahydrocannabinol effects on extrapyramidal motor behaviors in Parkinson's disease; and the use of cannabinoids in glaucoma.
Download or read book Cannabis and Cannabinoids written by Franjo Grotenhermen and published by Psychology Press. This book was released on 2002 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of the benefits, drawbacks, and side effects of medical marijuana as a treatment for pain, nausea, anorexia, cachexia, glaucoma, ischemia, spastic disorders, and migraine. It examines all facets of the medical use of marijuana, including botany, history, biochemistry, pharmacology, clinical use, toxicology, and side effects. No other book available offers such a comprehensive, even-handed look at this deeply divisive subject.
Download or read book Handbook of Cannabis and Related Pathologies written by Victor R Preedy and published by Academic Press. This book was released on 2016-12-31 with total page 1382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug’s effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points Presents illustrations with at least six figures, tables, and diagrams per chapter Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse
Download or read book Phytocannabinoids written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-01-24 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.
Download or read book Marijuana and the Cannabinoids written by Mahmoud A. ElSohly and published by Springer Science & Business Media. This book was released on 2007-11-15 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.
Download or read book Cannabinoids and Pain written by Samer N. Narouze and published by Springer Nature. This book was released on 2021-07-01 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a well-balanced view of the potential medical use of cannabinoids in pain. It comprehensively covers the current challenges with medical cannabis utilization and provides recommendations for research and future directions. Organized into nine sections, the book begins with an introduction to medical cannabis, including its history, regulations, and the general attitudes of pain physicians on cannabis. Section two explores the biological effects of marijuana via the endocannabinoid system and its complex structure of receptors and enzymes. Sections three, four, and five then delve further into pharmacology and the mechanisms of action applicable to cannabinoids in managing pain. Timely and socially conscious, section six examines the benefits of substituting opioids with cannabinoids for preoperative management. Echoing the book's well-rounded content, sections seven and eight consider the challenges with medical cannabis, including safety and quality control, brain development risks, vaping hazards, and withdrawal. The book then closes with a look at the future of cannabis in medical research. Thoroughly and equitably composed, Cannabinoids and Pain is an invaluable resource for primary care physicians, pain and palliative care physicians, and oncologists.
Download or read book The Genetics of Alcoholism written by Henri Begleiter and published by Alcohol and Alcoholism. This book was released on 1995 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an in-depth look at the genetic influences that contribute to the development of alcoholism. Part I: Epidemiologic Studies contains five chapters that examine the various approaches employed in the study of the genetics of alcoholism. It provides a historical perspectiveand details all the essentials of this subject. Part II: Selective Breeding Studies highlights the results of research involving the selective breeding of rodents. This type of research has produced homogenous strains exhibiting specific behavioral responses considered significant in thedevelopment and maintenance of alcohol dependence. The studies presented in Part III: Phenotypic Studies investigate and analyze phenotypic markers that serve as correlates to the genotypic determinants of alcoholism. Through its broad scope, this volume provides for the first time a panoramic viewof the knowledge available on the hereditary influences of alcoholism.
Download or read book Diabetes Perspectives in Drug Therapy written by Mathias Schwanstecher and published by Springer Science & Business Media. This book was released on 2011-04-11 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters of this book report cutting-edge research on molecular events in adiposity and type 2 diabetes, thus opening the way for innovative drug-based therapeutic strategies. It addresses all those who wish to keep in touch with recent developments in the field.
Download or read book The Effects of Delta 9 THC on Brain Metabolism written by Barry L. Nazar and published by . This book was released on 1973 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
